Publication Information

{'id': 'https://openalex.org/W1514229478', 'doi': 'https://doi.org/10.1096/fasebj.29.1_supplement.lb221', 'title': 'Identifying Transcriptional Changes in a Conditional Knockout Mouse', 'display_name': 'Identifying Transcriptional Changes in a Conditional Knockout Mouse', 'publication_year': 2015, 'publication_date': '2015-04-01', 'ids': {'openalex': 'https://openalex.org/W1514229478', 'doi': 'https://doi.org/10.1096/fasebj.29.1_supplement.lb221', 'mag': '1514229478'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1096/fasebj.29.1_supplement.lb221', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5069231498', 'display_name': 'Richard Burgan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I51812067', 'display_name': 'Juniata College', 'ror': 'https://ror.org/01ayg2409', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I51812067']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Richard Burgan', 'raw_affiliation_strings': ['1Chemistry Juniata College Huntingdon PA United States'], 'affiliations': [{'raw_affiliation_string': '1Chemistry Juniata College Huntingdon PA United States', 'institution_ids': ['https://openalex.org/I51812067']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051057068', 'display_name': 'Daniel R. Dries', 'orcid': 'https://orcid.org/0000-0002-0530-5212'}, 'institutions': [{'id': 'https://openalex.org/I51812067', 'display_name': 'Juniata College', 'ror': 'https://ror.org/01ayg2409', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I51812067']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniel Dries', 'raw_affiliation_strings': ['1Chemistry Juniata College Huntingdon PA United States'], 'affiliations': [{'raw_affiliation_string': '1Chemistry Juniata College Huntingdon PA United States', 'institution_ids': ['https://openalex.org/I51812067']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5044342845', 'display_name': 'Gang Yu', 'orcid': 'https://orcid.org/0000-0003-4932-5757'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gang Yu', 'raw_affiliation_strings': ['2NEUROSCIENCE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER DALLAS TX United States'], 'affiliations': [{'raw_affiliation_string': '2NEUROSCIENCE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER DALLAS TX United States', 'institution_ids': ['https://openalex.org/I867280407']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 66}, 'biblio': {'volume': '29', 'issue': 'S1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9373, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9373, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/conditional-gene-knockout', 'display_name': 'Conditional gene knockout', 'score': 0.900825}, {'id': 'https://openalex.org/keywords/knockout-mouse', 'display_name': 'Knockout mouse', 'score': 0.76520497}], 'concepts': [{'id': 'https://openalex.org/C164659718', 'wikidata': 'https://www.wikidata.org/wiki/Q5159266', 'display_name': 'Conditional gene knockout', 'level': 4, 'score': 0.900825}, {'id': 'https://openalex.org/C182704531', 'wikidata': 'https://www.wikidata.org/wiki/Q1364740', 'display_name': 'Knockout mouse', 'level': 3, 'score': 0.76520497}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.7065449}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.60237455}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.52572316}, {'id': 'https://openalex.org/C162317418', 'wikidata': 'https://www.wikidata.org/wiki/Q252857', 'display_name': 'Transcriptome', 'level': 4, 'score': 0.50582576}, {'id': 'https://openalex.org/C104292427', 'wikidata': 'https://www.wikidata.org/wiki/Q899781', 'display_name': 'Protein subunit', 'level': 3, 'score': 0.44216907}, {'id': 'https://openalex.org/C2776412080', 'wikidata': 'https://www.wikidata.org/wiki/Q7431605', 'display_name': 'Schizophrenia (object-oriented programming)', 'level': 2, 'score': 0.4397034}, {'id': 'https://openalex.org/C175344181', 'wikidata': 'https://www.wikidata.org/wiki/Q907198', 'display_name': 'Presenilin', 'level': 4, 'score': 0.4177915}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.3638107}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.35160172}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.29558942}, {'id': 'https://openalex.org/C502032728', 'wikidata': 'https://www.wikidata.org/wiki/Q11081', 'display_name': "Alzheimer's disease", 'level': 3, 'score': 0.27817655}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.19970232}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.19808203}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.14308497}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.09808472}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1096/fasebj.29.1_supplement.lb221', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Partnerships for the goals', 'id': 'https://metadata.un.org/sdg/17', 'score': 0.58}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4386894844', 'https://openalex.org/W3046263479', 'https://openalex.org/W2417555070', 'https://openalex.org/W2369646821', 'https://openalex.org/W2195257333', 'https://openalex.org/W2089273599', 'https://openalex.org/W1989514551', 'https://openalex.org/W1854224221', 'https://openalex.org/W1546309763', 'https://openalex.org/W1514229478'], 'abstract_inverted_index': {'gamma‐secretase': [0, 23, 39], 'is': [1, 7], 'a': [2, 17, 41], 'multi‐subunit,': [3], 'proteolytic': [4], 'complex': [5, 73], 'that': [6, 69], 'directly': [8], 'involved': [9], 'in': [10, 21], 'the': [11, 31, 35, 52, 72], 'pathogenicity': [12], 'of': [13, 28, 34, 38, 47, 54, 62, 90], "Alzheimer's": [14], 'disease.': [15], 'Recently,': [16], 'mouse': [18], 'was': [19, 24], 'developed': [20], 'which': [22], 'conditionally': [25], 'knocked': [26], 'out': [27], 'oligodendrocytes,': [29], 'or': [30], 'myelinating': [32], 'cells': [33], 'brain.': [36], 'Knockout': [37], 'produced': [40], 'striking': [42], 'non‐cognitive': [43], 'neurological': [44, 74], 'phenotype,': [45], 'reminiscent': [46], 'schizophrenia.': [48], 'Here,': [49], 'we': [50], 'compare': [51], 'transcriptomes': [53], 'cKO': [55], 'mice': [56, 59], 'and': [57, 93], 'control': [58], 'by': [60, 77, 87], 'means': [61], 'RNA‐seq': [63], 'analysis': [64], 'to': [65], 'identify': [66], 'candidate': [67], 'genes': [68], 'may': [70], 'explain': [71], 'phenotype': [75], 'exhibited': [76], 'our': [78], 'conditional': [79], 'knockout': [80], 'mice.': [81], 'Grant': [82, 95], 'Funding': [83], 'Source': [84], ':': [85], 'Supported': [86], 'National': [88], 'Institute': [89], 'Neurological': [91], 'Disorders': [92], 'Stroke': [94], '1R01NS079796': [96]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1514229478', 'counts_by_year': [], 'updated_date': '2024-12-13T09:18:06.412747', 'created_date': '2016-06-24'}