Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2089273599', 'doi': 'https://doi.org/10.1093/carcin/bgr002', 'title': 'Hepatomas with activating Ctnnb1 mutations in ‘ Ctnnb1 -deficient’ livers: a tricky aspect of a conditional knockout mouse model', 'display_name': 'Hepatomas with activating Ctnnb1 mutations in ‘ Ctnnb1 -deficient’ livers: a tricky aspect of a conditional knockout mouse model', 'publication_year': 2011, 'publication_date': '2011-01-07', 'ids': {'openalex': 'https://openalex.org/W2089273599', 'doi': 'https://doi.org/10.1093/carcin/bgr002', 'mag': '2089273599', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21216847'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/carcin/bgr002', 'pdf_url': 'https://academic.oup.com/carcin/article-pdf/32/4/622/17289041/bgr002.pdf', 'source': {'id': 'https://openalex.org/S184620562', 'display_name': 'Carcinogenesis', 'issn_l': '0143-3334', 'issn': ['0143-3334', '1460-2180'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/carcin/article-pdf/32/4/622/17289041/bgr002.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5001211200', 'display_name': 'Shigeki Sekine', 'orcid': 'https://orcid.org/0000-0003-0884-8981'}, 'institutions': [{'id': 'https://openalex.org/I54696188', 'display_name': 'National Cancer Research Institute', 'ror': 'https://ror.org/02mp0vf47', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I54696188']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Shigeki Sekine', 'raw_affiliation_strings': ['Pathology Division, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, Japan 104-0045.'], 'affiliations': [{'raw_affiliation_string': 'Pathology Division, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, Japan 104-0045.', 'institution_ids': ['https://openalex.org/I54696188']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058443782', 'display_name': 'Reiko Ogawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I54696188', 'display_name': 'National Cancer Research Institute', 'ror': 'https://ror.org/02mp0vf47', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I54696188']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Reiko Ogawa', 'raw_affiliation_strings': ['Pathology Division, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, Japan 104-0045.'], 'affiliations': [{'raw_affiliation_string': 'Pathology Division, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, Japan 104-0045.', 'institution_ids': ['https://openalex.org/I54696188']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5074419698', 'display_name': 'Yae Kanai', 'orcid': 'https://orcid.org/0000-0002-7904-9506'}, 'institutions': [{'id': 'https://openalex.org/I54696188', 'display_name': 'National Cancer Research Institute', 'ror': 'https://ror.org/02mp0vf47', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I54696188']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Yae Kanai', 'raw_affiliation_strings': ['Pathology Division, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, Japan 104-0045.'], 'affiliations': [{'raw_affiliation_string': 'Pathology Division, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, Japan 104-0045.', 'institution_ids': ['https://openalex.org/I54696188']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4428, 'currency': 'USD', 'value_usd': 4428, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.555, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 18, 'citation_normalized_percentile': {'value': 0.643781, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '32', 'issue': '4', 'first_page': '622', 'last_page': '628'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10929', 'display_name': 'Wnt/β-catenin signaling in development and cancer', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10929', 'display_name': 'Wnt/β-catenin signaling in development and cancer', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12065', 'display_name': 'Hippo pathway signaling and YAP/TAZ', 'score': 0.9952, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10966', 'display_name': 'Liver physiology and pathology', 'score': 0.9949, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/conditional-gene-knockout', 'display_name': 'Conditional gene knockout', 'score': 0.86073804}, {'id': 'https://openalex.org/keywords/knockout-mouse', 'display_name': 'Knockout mouse', 'score': 0.83736247}, {'id': 'https://openalex.org/keywords/gene-knockout', 'display_name': 'Gene knockout', 'score': 0.6561827}], 'concepts': [{'id': 'https://openalex.org/C164659718', 'wikidata': 'https://www.wikidata.org/wiki/Q5159266', 'display_name': 'Conditional gene knockout', 'level': 4, 'score': 0.86073804}, {'id': 'https://openalex.org/C182704531', 'wikidata': 'https://www.wikidata.org/wiki/Q1364740', 'display_name': 'Knockout mouse', 'level': 3, 'score': 0.83736247}, {'id': 'https://openalex.org/C2776200302', 'wikidata': 'https://www.wikidata.org/wiki/Q827450', 'display_name': 'Hepatocyte', 'level': 3, 'score': 0.68219566}, {'id': 'https://openalex.org/C77957584', 'wikidata': 'https://www.wikidata.org/wiki/Q1133550', 'display_name': 'Gene knockout', 'level': 3, 'score': 0.6561827}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.59050596}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.46933427}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.46077934}, {'id': 'https://openalex.org/C141035611', 'wikidata': 'https://www.wikidata.org/wiki/Q5532934', 'display_name': 'Genetically modified mouse', 'level': 4, 'score': 0.42660314}, {'id': 'https://openalex.org/C102230213', 'wikidata': 'https://www.wikidata.org/wiki/Q430117', 'display_name': 'Transgene', 'level': 3, 'score': 0.36945283}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.33779186}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.30032617}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.27805707}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.07342404}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.059601277}], 'mesh': [{'descriptor_ui': 'D022781', 'descriptor_name': 'Hepatocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008114', 'descriptor_name': 'Liver Neoplasms, Experimental', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D051176', 'descriptor_name': 'beta Catenin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D022781', 'descriptor_name': 'Hepatocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019426', 'descriptor_name': 'Integrases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019426', 'descriptor_name': 'Integrases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008114', 'descriptor_name': 'Liver Neoplasms, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011995', 'descriptor_name': 'Recombination, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051176', 'descriptor_name': 'beta Catenin', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D051176', 'descriptor_name': 'beta Catenin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/carcin/bgr002', 'pdf_url': 'https://academic.oup.com/carcin/article-pdf/32/4/622/17289041/bgr002.pdf', 'source': {'id': 'https://openalex.org/S184620562', 'display_name': 'Carcinogenesis', 'issn_l': '0143-3334', 'issn': ['0143-3334', '1460-2180'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21216847', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/carcin/bgr002', 'pdf_url': 'https://academic.oup.com/carcin/article-pdf/32/4/622/17289041/bgr002.pdf', 'source': {'id': 'https://openalex.org/S184620562', 'display_name': 'Carcinogenesis', 'issn_l': '0143-3334', 'issn': ['0143-3334', '1460-2180'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.54, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1516399701', 'https://openalex.org/W1523950660', 'https://openalex.org/W1529442571', 'https://openalex.org/W1615764257', 'https://openalex.org/W1952698983', 'https://openalex.org/W1967137553', 'https://openalex.org/W1974549459', 'https://openalex.org/W1975667412', 'https://openalex.org/W1983712244', 'https://openalex.org/W1990563353', 'https://openalex.org/W1995612506', 'https://openalex.org/W1995856733', 'https://openalex.org/W1998832402', 'https://openalex.org/W2000101394', 'https://openalex.org/W2002085824', 'https://openalex.org/W2010942899', 'https://openalex.org/W2012437520', 'https://openalex.org/W2022792733', 'https://openalex.org/W2027519844', 'https://openalex.org/W2037599820', 'https://openalex.org/W2038927157', 'https://openalex.org/W2044409986', 'https://openalex.org/W2076097783', 'https://openalex.org/W2081681675', 'https://openalex.org/W2082381304', 'https://openalex.org/W2085398028', 'https://openalex.org/W2101036473', 'https://openalex.org/W2103597610', 'https://openalex.org/W2108860907', 'https://openalex.org/W2115581142', 'https://openalex.org/W2128459167', 'https://openalex.org/W2144870266', 'https://openalex.org/W2160687366', 'https://openalex.org/W2163653659', 'https://openalex.org/W2333862858', 'https://openalex.org/W3143997204', 'https://openalex.org/W4285719527', 'https://openalex.org/W70299657'], 'related_works': ['https://openalex.org/W2412234206', 'https://openalex.org/W2122188779', 'https://openalex.org/W2083269049', 'https://openalex.org/W2053738949', 'https://openalex.org/W2017330739', 'https://openalex.org/W2002156069', 'https://openalex.org/W1973459962', 'https://openalex.org/W1970015400', 'https://openalex.org/W1939881446', 'https://openalex.org/W191444021'], 'abstract_inverted_index': {'Conditional': [0], 'knockout': [1, 22, 74, 110, 187], 'mice,': [2, 100], 'based': [3], 'on': [4], 'the': [5, 37, 41, 45, 73, 86, 89, 105, 109, 119, 128, 161, 207], 'Cre-loxP': [6, 208], 'system,': [7], 'are': [8, 151, 192], 'a': [9, 101], 'widely': [10], 'used': [11], 'model': [12], 'for': [13, 140], 'examining': [14], 'organ-specific': [15], 'gene': [16], 'functions.': [17], 'To': [18], 'date,': [19], 'efficient': [20, 62, 78], 'hepatocyte-specific': [21, 186], 'has': [23, 33], 'been': [24, 34], 'reported': [25], 'in': [26, 82, 108, 171], 'many': [27], 'different': [28, 57, 190], 'models,': [29], 'but': [30, 167], 'little': [31], 'attention': [32], 'paid': [35], 'to': [36, 59], 'long-term': [38], 'stability': [39], 'of': [40, 56, 71, 80, 93, 104, 127, 149, 153, 189, 206], 'recombination': [42, 63, 179], 'efficiency.': [43], 'In': [44, 98, 194], 'present': [46, 175], 'study,': [47], 'we': [48], 'characterized': [49], 'Alb-Cre;Ctnnb1': [50], 'flox/flox': [51], "'hepatocyte-specific": [52], 'Ctnnb1': [53, 162], "knockout'": [54], 'mice': [55, 87, 130, 188], 'ages': [58, 191], 'test': [60], 'whether': [61], 'is': [64], 'maintained': [65], 'over': [66], 'time.': [67], 'At': [68], '2': [69], 'months': [70], 'age,': [72], 'mouse': [75, 111], 'livers': [76, 112], 'achieved': [77], 'deletions': [79], 'β-catenin': [81, 141, 155], 'hepatocytes.': [83], 'However,': [84], 'as': [85, 202], 'aged,': [88], 'reappearance': [90], 'and': [91, 135, 142, 146], 'expansion': [92], 'β-catenin-expressing': [94], 'hepatocytes': [95, 107, 121], 'were': [96, 113, 138, 164], 'observed.': [97], '1-year-old': [99, 129], 'significant': [102], 'proportion': [103], 'pericentral': [106], 'replaced': [114], 'with': [115], 'β-catenin-positive': [116], 'hepatocytes,': [117], 'whereas': [118], 'periportal': [120], 'mostly': [122], 'remained': [123], 'β-catenin-negative.': [124], 'Furthermore,': [125], 'most': [126], 'spontaneously': [131], 'developed': [132], 'hepatocellular': [133], 'adenomas': [134], 'carcinomas': [136], 'that': [137, 160, 178], 'positive': [139], 'overexpressed': [143], 'glutamine': [144], 'synthetase': [145], 'Slc1a2,': [147], 'both': [148], 'which': [150], 'hallmarks': [152], 'active': [154], 'signaling.': [156], 'Sequencing': [157], 'analysis': [158], 'revealed': [159], 'alleles': [163], 'not': [165], 'inactivated': [166], 'had': [168], 'activating': [169], 'mutations': [170, 198], 'these': [172], 'tumors.': [173], 'The': [174], 'study': [176], 'suggests': [177], 'efficiency': [180], 'should': [181, 199], 'be': [182, 200], 'carefully': [183], 'examined': [184], 'when': [185], 'analyzed.': [193], 'addition,': [195], 'illegitimate': [196], 'deletion': [197], 'recognized': [201], 'potential': [203], 'adverse': [204], 'effects': [205], 'system.': [209]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2089273599', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-09T01:21:36.090471', 'created_date': '2016-06-24'}