Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1508110130', 'doi': 'https://doi.org/10.4049/jimmunol.163.4.1906', 'title': 'Expression and Function of TNF-Related Apoptosis-Inducing Ligand on Murine Activated NK Cells', 'display_name': 'Expression and Function of TNF-Related Apoptosis-Inducing Ligand on Murine Activated NK Cells', 'publication_year': 1999, 'publication_date': '1999-08-15', 'ids': {'openalex': 'https://openalex.org/W1508110130', 'doi': 'https://doi.org/10.4049/jimmunol.163.4.1906', 'mag': '1508110130', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10438925'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.163.4.1906', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/163/4/1906/1496081/im169901906p.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://journals.aai.org/jimmunol/article-pdf/163/4/1906/1496081/im169901906p.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5046332347', 'display_name': 'Nobuhiko Kayagaki', 'orcid': 'https://orcid.org/0000-0001-8129-1740'}, 'institutions': [{'id': 'https://openalex.org/I34077901', 'display_name': 'Juntendo University', 'ror': 'https://ror.org/01692sz90', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I34077901']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Nobuhiko Kayagaki', 'raw_affiliation_strings': ['*Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan;'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan;', 'institution_ids': ['https://openalex.org/I34077901']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065116495', 'display_name': 'Noriko Yamaguchi', 'orcid': 'https://orcid.org/0000-0002-4735-8144'}, 'institutions': [{'id': 'https://openalex.org/I4210086780', 'display_name': 'Japan Science and Technology Agency', 'ror': 'https://ror.org/00097mb19', 'country_code': 'JP', 'type': 'government', 'lineage': ['https://openalex.org/I4210086780']}, {'id': 'https://openalex.org/I34077901', 'display_name': 'Juntendo University', 'ror': 'https://ror.org/01692sz90', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I34077901']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Noriko Yamaguchi', 'raw_affiliation_strings': ['*Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan;', '†Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan; and'], 'affiliations': [{'raw_affiliation_string': '†Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan; and', 'institution_ids': ['https://openalex.org/I4210086780']}, {'raw_affiliation_string': '*Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan;', 'institution_ids': ['https://openalex.org/I34077901']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079208906', 'display_name': 'M. NAKAYAMA', 'orcid': 'https://orcid.org/0000-0002-9839-7143'}, 'institutions': [{'id': 'https://openalex.org/I34077901', 'display_name': 'Juntendo University', 'ror': 'https://ror.org/01692sz90', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I34077901']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masafumi Nakayama', 'raw_affiliation_strings': ['*Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan;'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan;', 'institution_ids': ['https://openalex.org/I34077901']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074513079', 'display_name': 'Kazuyoshi Takeda', 'orcid': 'https://orcid.org/0000-0002-5539-310X'}, 'institutions': [{'id': 'https://openalex.org/I34077901', 'display_name': 'Juntendo University', 'ror': 'https://ror.org/01692sz90', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I34077901']}, {'id': 'https://openalex.org/I4210086780', 'display_name': 'Japan Science and Technology Agency', 'ror': 'https://ror.org/00097mb19', 'country_code': 'JP', 'type': 'government', 'lineage': ['https://openalex.org/I4210086780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazuyoshi Takeda', 'raw_affiliation_strings': ['*Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan;', '†Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan; and'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan;', 'institution_ids': ['https://openalex.org/I34077901']}, {'raw_affiliation_string': '†Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan; and', 'institution_ids': ['https://openalex.org/I4210086780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026853110', 'display_name': 'Hisaya Akiba', 'orcid': 'https://orcid.org/0000-0002-1565-1098'}, 'institutions': [{'id': 'https://openalex.org/I34077901', 'display_name': 'Juntendo University', 'ror': 'https://ror.org/01692sz90', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I34077901']}, {'id': 'https://openalex.org/I4210086780', 'display_name': 'Japan Science and Technology Agency', 'ror': 'https://ror.org/00097mb19', 'country_code': 'JP', 'type': 'government', 'lineage': ['https://openalex.org/I4210086780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hisaya Akiba', 'raw_affiliation_strings': ['*Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan;', '†Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan; and'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan;', 'institution_ids': ['https://openalex.org/I34077901']}, {'raw_affiliation_string': '†Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan; and', 'institution_ids': ['https://openalex.org/I4210086780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005867340', 'display_name': 'Hiroko Tsutsui', 'orcid': 'https://orcid.org/0000-0001-7928-4875'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hiroko Tsutsui', 'raw_affiliation_strings': ['‡Department of Immunology and Medical Zoology and'], 'affiliations': [{'raw_affiliation_string': '‡Department of Immunology and Medical Zoology and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057490410', 'display_name': 'Haruki Okamura', 'orcid': 'https://orcid.org/0000-0003-3624-9679'}, 'institutions': [{'id': 'https://openalex.org/I137459256', 'display_name': 'Hyogo Medical University', 'ror': 'https://ror.org/001yc7927', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I137459256']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Haruki Okamura', 'raw_affiliation_strings': ['§Laboratory of Host Defenses, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Hyogo, Japan'], 'affiliations': [{'raw_affiliation_string': '§Laboratory of Host Defenses, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Hyogo, Japan', 'institution_ids': ['https://openalex.org/I137459256']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049211831', 'display_name': 'Kenji Nakanishi', 'orcid': 'https://orcid.org/0000-0002-0223-9088'}, 'institutions': [{'id': 'https://openalex.org/I137459256', 'display_name': 'Hyogo Medical University', 'ror': 'https://ror.org/001yc7927', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I137459256']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kenji Nakanishi', 'raw_affiliation_strings': ['§Laboratory of Host Defenses, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Hyogo, Japan', '‡Department of Immunology and Medical Zoology and'], 'affiliations': [{'raw_affiliation_string': '§Laboratory of Host Defenses, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Hyogo, Japan', 'institution_ids': ['https://openalex.org/I137459256']}, {'raw_affiliation_string': '‡Department of Immunology and Medical Zoology and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088986458', 'display_name': 'Ko Okumura', 'orcid': 'https://orcid.org/0000-0003-3238-6422'}, 'institutions': [{'id': 'https://openalex.org/I4210086780', 'display_name': 'Japan Science and Technology Agency', 'ror': 'https://ror.org/00097mb19', 'country_code': 'JP', 'type': 'government', 'lineage': ['https://openalex.org/I4210086780']}, {'id': 'https://openalex.org/I34077901', 'display_name': 'Juntendo University', 'ror': 'https://ror.org/01692sz90', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I34077901']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ko Okumura', 'raw_affiliation_strings': ['*Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan;', '†Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan; and'], 'affiliations': [{'raw_affiliation_string': '†Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan; and', 'institution_ids': ['https://openalex.org/I4210086780']}, {'raw_affiliation_string': '*Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan;', 'institution_ids': ['https://openalex.org/I34077901']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5070494006', 'display_name': 'Hideo Yagita∥', 'orcid': 'https://orcid.org/0000-0003-4279-9343'}, 'institutions': [{'id': 'https://openalex.org/I34077901', 'display_name': 'Juntendo University', 'ror': 'https://ror.org/01692sz90', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I34077901']}, {'id': 'https://openalex.org/I4210086780', 'display_name': 'Japan Science and Technology Agency', 'ror': 'https://ror.org/00097mb19', 'country_code': 'JP', 'type': 'government', 'lineage': ['https://openalex.org/I4210086780']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hideo Yagita', 'raw_affiliation_strings': ['*Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan;', '†Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan; and'], 'affiliations': [{'raw_affiliation_string': '*Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan;', 'institution_ids': ['https://openalex.org/I34077901']}, {'raw_affiliation_string': '†Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan; and', 'institution_ids': ['https://openalex.org/I4210086780']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.94, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 330, 'citation_normalized_percentile': {'value': 0.957169, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '163', 'issue': '4', 'first_page': '1906', 'last_page': '1913'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10371', 'display_name': 'Immune Response and Inflammation', 'score': 0.9886, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/fas-ligand', 'display_name': 'Fas ligand', 'score': 0.8054335}, {'id': 'https://openalex.org/keywords/lymphokine-activated-killer-cell', 'display_name': 'Lymphokine-activated killer cell', 'score': 0.570641}], 'concepts': [{'id': 'https://openalex.org/C2776062744', 'wikidata': 'https://www.wikidata.org/wiki/Q21103279', 'display_name': 'Perforin', 'level': 4, 'score': 0.81870055}, {'id': 'https://openalex.org/C66008609', 'wikidata': 'https://www.wikidata.org/wiki/Q14866113', 'display_name': 'Fas ligand', 'level': 4, 'score': 0.8054335}, {'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.661769}, {'id': 'https://openalex.org/C28651165', 'wikidata': 'https://www.wikidata.org/wiki/Q4259786', 'display_name': 'Lymphokine-activated killer cell', 'level': 5, 'score': 0.570641}, {'id': 'https://openalex.org/C17991360', 'wikidata': 'https://www.wikidata.org/wiki/Q21173843', 'display_name': 'Tumor necrosis factor alpha', 'level': 2, 'score': 0.5538614}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.49490184}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.47507876}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4744583}, {'id': 'https://openalex.org/C129374314', 'wikidata': 'https://www.wikidata.org/wiki/Q909381', 'display_name': 'Interleukin 21', 'level': 4, 'score': 0.46610272}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.45779}, {'id': 'https://openalex.org/C49382859', 'wikidata': 'https://www.wikidata.org/wiki/Q286498', 'display_name': 'Lymphokine', 'level': 3, 'score': 0.43861753}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.39032876}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.33353525}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.30053645}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.29918337}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.2160461}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.097506136}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.07848778}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D007694', 'descriptor_name': 'Killer Cells, Natural', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007694', 'descriptor_name': 'Killer Cells, Natural', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D008213', 'descriptor_name': 'Lymphocyte Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051017', 'descriptor_name': 'Apoptosis Regulatory Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003602', 'descriptor_name': 'Cytotoxicity, Immunologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019409', 'descriptor_name': 'Interleukin-15', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D019409', 'descriptor_name': 'Interleukin-15', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007376', 'descriptor_name': 'Interleukin-2', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007376', 'descriptor_name': 'Interleukin-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007694', 'descriptor_name': 'Killer Cells, Natural', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008024', 'descriptor_name': 'Ligands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008213', 'descriptor_name': 'Lymphocyte Activation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011916', 'descriptor_name': 'Rats, Inbred F344', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D053221', 'descriptor_name': 'TNF-Related Apoptosis-Inducing Ligand', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.163.4.1906', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/163/4/1906/1496081/im169901906p.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10438925', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.163.4.1906', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/163/4/1906/1496081/im169901906p.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.64}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W1483963831', 'https://openalex.org/W1484817497', 'https://openalex.org/W1501446536', 'https://openalex.org/W1514942862', 'https://openalex.org/W1517678415', 'https://openalex.org/W1542886054', 'https://openalex.org/W1556867369', 'https://openalex.org/W1575837553', 'https://openalex.org/W1674283941', 'https://openalex.org/W1704370583', 'https://openalex.org/W1829424702', 'https://openalex.org/W1943839210', 'https://openalex.org/W1954011194', 'https://openalex.org/W1981182552', 'https://openalex.org/W1997296950', 'https://openalex.org/W2002503549', 'https://openalex.org/W2008794819', 'https://openalex.org/W2010645451', 'https://openalex.org/W2018597572', 'https://openalex.org/W2025128734', 'https://openalex.org/W2025418275', 'https://openalex.org/W2028091596', 'https://openalex.org/W2035799757', 'https://openalex.org/W2036376304', 'https://openalex.org/W2056217426', 'https://openalex.org/W2056924500', 'https://openalex.org/W2064706357', 'https://openalex.org/W2068324509', 'https://openalex.org/W2073914550', 'https://openalex.org/W2077793109', 'https://openalex.org/W2089476060', 'https://openalex.org/W2092508425', 'https://openalex.org/W2096477855', 'https://openalex.org/W2100677570', 'https://openalex.org/W2110893132', 'https://openalex.org/W2110925966', 'https://openalex.org/W2113505777', 'https://openalex.org/W2120872281', 'https://openalex.org/W2122534786', 'https://openalex.org/W2125010485', 'https://openalex.org/W2130988210', 'https://openalex.org/W2140288892', 'https://openalex.org/W2142211339', 'https://openalex.org/W2146960175', 'https://openalex.org/W2153279598', 'https://openalex.org/W2163105800', 'https://openalex.org/W2171831396', 'https://openalex.org/W2174505927', 'https://openalex.org/W2278523282', 'https://openalex.org/W3154617585', 'https://openalex.org/W4313310005', 'https://openalex.org/W4313342428'], 'related_works': ['https://openalex.org/W2805264087', 'https://openalex.org/W2435664177', 'https://openalex.org/W2133759650', 'https://openalex.org/W2114548624', 'https://openalex.org/W2096574716', 'https://openalex.org/W1991849460', 'https://openalex.org/W1978551452', 'https://openalex.org/W1967360579', 'https://openalex.org/W1673532903', 'https://openalex.org/W1542886054'], 'abstract_inverted_index': {'Abstract': [0], 'TNF-related': [1], 'apoptosis-inducing': [2], 'ligand': [3, 28], '(TRAIL),': [4], 'a': [5, 71, 79], 'new': [6], 'member': [7], 'of': [8, 15, 32, 48, 74, 82, 115, 125, 131, 142, 168], 'TNF': [9], 'family,': [10], 'induces': [11], 'apoptotic': [12], 'cell': [13, 36, 147], 'death': [14], 'various': [16], 'tumor': [17], 'cells.': [18, 117], 'We': [19], 'recently': [20], 'showed': [21], 'that': [22], 'TRAIL': [23, 49, 58, 75, 83, 101, 132, 169], 'mediates': [24], 'perforin-': [25], 'and': [26, 46, 123, 161, 176], 'Fas': [27], '(FasL)-independent': [29], 'cytotoxic': [30], 'activity': [31, 114], 'human': [33], 'CD4+': [34], 'T': [35], 'clones.': [37], 'In': [38, 99, 118], 'the': [39, 44, 139], 'present': [40], 'study,': [41], 'we': [42], 'investigated': [43], 'expression': [45, 84, 102, 167], 'function': [47], 'on': [50, 76, 88, 170], 'murine': [51], 'lymphocytes': [52], 'by': [53, 106, 127, 133], 'using': [54], 'newly': [55], 'generated': [56], 'anti-murine': [57], 'mAbs.': [59], 'Although': [60], 'freshly': [61], 'isolated': [62], 'T,': [63], 'B,': [64], 'or': [65, 97, 144, 172], 'NK': [66, 91, 116, 146, 174], 'cells': [67, 92, 175], 'did': [68], 'not': [69, 104], 'express': [70], 'detectable': [72], 'level': [73, 81], 'their': [77], 'surface,': [78], 'remarkable': [80], 'was': [85, 103, 136], 'induced': [86, 105], 'preferentially': [87], 'CD3−': [89], 'NK1.1+': [90], 'after': [93], 'stimulation': [94], 'with': [95], 'IL-2': [96], 'IL-15.': [98], 'contrast,': [100], 'IL-18,': [107], 'whereas': [108], 'it': [109], 'efficiently': [110], 'potentiated': [111], 'lymphokine-activated': [112, 181], 'killer': [113, 182], 'addition': [119], 'to': [120, 158], 'perforin': [121], 'inactivation': [122], 'neutralization': [124, 130], 'FasL': [126, 160], 'anti-FasL': [128], 'mAb,': [129], 'anti-TRAIL': [134], 'mAb': [135], 'needed': [137], 'for': [138], 'complete': [140], 'inhibition': [141], 'IL-2-': [143, 171], 'IL-15-activated': [145, 173], 'cytotoxicity': [148], 'against': [149], 'mouse': [150], 'fibrosarcoma': [151], 'L929': [152], 'target': [153], 'cells,': [154], 'which': [155], 'were': [156], 'susceptible': [157], 'both': [159], 'TRAIL.': [162], 'These': [163], 'results': [164], 'indicated': [165], 'preferential': [166], 'its': [177], 'potential': [178], 'involvement': [179], 'in': [180], 'activity.': [183]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1508110130', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 16}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 11}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-12T01:48:40.275246', 'created_date': '2016-06-24'}