Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1504369911', 'doi': 'https://doi.org/10.18632/oncotarget.4125', 'title': 'Micro-RNA-155 is induced by K-Ras oncogenic signal and promotes ROS stress in pancreatic cancer', 'display_name': 'Micro-RNA-155 is induced by K-Ras oncogenic signal and promotes ROS stress in pancreatic cancer', 'publication_year': 2015, 'publication_date': '2015-05-12', 'ids': {'openalex': 'https://openalex.org/W1504369911', 'doi': 'https://doi.org/10.18632/oncotarget.4125', 'mag': '1504369911', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26020803', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4673256'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.4125', 'pdf_url': 'https://www.oncotarget.com/article/4125/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/4125/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100395961', 'display_name': 'Peng Wang', 'orcid': 'https://orcid.org/0000-0002-0102-4544'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210146711', 'display_name': 'Sun Yat-sen University Cancer Center', 'ror': 'https://ror.org/0400g8r85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146711']}, {'id': 'https://openalex.org/I4210097354', 'display_name': 'Sun Yat-sen Memorial Hospital', 'ror': 'https://ror.org/01px77p81', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097354']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Peng Wang', 'raw_affiliation_strings': ['Department of Emergency Medicine, Sun Yat-sen Memorial Hospital, Guangzhou, China', 'Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Emergency Medicine, Sun Yat-sen Memorial Hospital, Guangzhou, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210097354']}, {'raw_affiliation_string': 'Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210146711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100946179', 'display_name': 'Chao-feng Zhu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210146711', 'display_name': 'Sun Yat-sen University Cancer Center', 'ror': 'https://ror.org/0400g8r85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146711']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chao-feng Zhu', 'raw_affiliation_strings': ['Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210146711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101757452', 'display_name': 'Ming-zhe Ma', 'orcid': 'https://orcid.org/0000-0002-2796-3662'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210146711', 'display_name': 'Sun Yat-sen University Cancer Center', 'ror': 'https://ror.org/0400g8r85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146711']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ming-zhe Ma', 'raw_affiliation_strings': ['Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210146711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100389268', 'display_name': 'Gang Chen', 'orcid': 'https://orcid.org/0000-0002-4864-1451'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gang Chen', 'raw_affiliation_strings': ['Department of Translational Molecular Pathology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Translational Molecular Pathology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003877780', 'display_name': 'Ming Song', 'orcid': 'https://orcid.org/0000-0001-7495-5895'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210146711', 'display_name': 'Sun Yat-sen University Cancer Center', 'ror': 'https://ror.org/0400g8r85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146711']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ming Song', 'raw_affiliation_strings': ['Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210146711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041386762', 'display_name': 'Zhao-Lei Zeng', 'orcid': 'https://orcid.org/0000-0003-4420-5625'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210146711', 'display_name': 'Sun Yat-sen University Cancer Center', 'ror': 'https://ror.org/0400g8r85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146711']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhao-lei Zeng', 'raw_affiliation_strings': ['Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210146711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103514223', 'display_name': 'Wen-Hua Lu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210146711', 'display_name': 'Sun Yat-sen University Cancer Center', 'ror': 'https://ror.org/0400g8r85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146711']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wen-hua Lu', 'raw_affiliation_strings': ['Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China', 'institution_ids': ['https://openalex.org/I4210146711', 'https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100449592', 'display_name': 'Jing Yang', 'orcid': 'https://orcid.org/0000-0001-6612-7854'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210146711', 'display_name': 'Sun Yat-sen University Cancer Center', 'ror': 'https://ror.org/0400g8r85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146711']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jing Yang', 'raw_affiliation_strings': ['Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210146711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077344585', 'display_name': 'Shijun Wen', 'orcid': 'https://orcid.org/0000-0002-9347-8243'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210146711', 'display_name': 'Sun Yat-sen University Cancer Center', 'ror': 'https://ror.org/0400g8r85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146711']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shijun Wen', 'raw_affiliation_strings': ['Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210146711']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068301962', 'display_name': 'Paul J. Chiao', 'orcid': 'https://orcid.org/0000-0001-7003-6605'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Paul J. Chiao', 'raw_affiliation_strings': ['Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007256692', 'display_name': 'Yumin Hu', 'orcid': 'https://orcid.org/0000-0003-3089-9945'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210146711', 'display_name': 'Sun Yat-sen University Cancer Center', 'ror': 'https://ror.org/0400g8r85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146711']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yumin Hu', 'raw_affiliation_strings': ['Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210146711']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100644445', 'display_name': 'Peng Huang', 'orcid': 'https://orcid.org/0000-0002-2152-9152'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}, {'id': 'https://openalex.org/I4210146711', 'display_name': 'Sun Yat-sen University Cancer Center', 'ror': 'https://ror.org/0400g8r85', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210146711']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Peng Huang', 'raw_affiliation_strings': ['Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210146711']}, {'raw_affiliation_string': 'Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.678, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 106, 'citation_normalized_percentile': {'value': 0.9999, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '6', 'issue': '25', 'first_page': '21148', 'last_page': '21158'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA Regulation in Cancer and Development', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA Regulation in Cancer and Development', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10515', 'display_name': 'Role of Long Noncoding RNAs in Cancer and Development', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA Methylation and Modification in Gene Expression', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/mrna-modification', 'display_name': 'mRNA modification', 'score': 0.54913}, {'id': 'https://openalex.org/keywords/rna-regulation', 'display_name': 'RNA Regulation', 'score': 0.514512}, {'id': 'https://openalex.org/keywords/rna-methylation', 'display_name': 'RNA methylation', 'score': 0.507491}, {'id': 'https://openalex.org/keywords/gene-expression-regulation', 'display_name': 'Gene Expression Regulation', 'score': 0.500175}], 'concepts': [{'id': 'https://openalex.org/C2780210213', 'wikidata': 'https://www.wikidata.org/wiki/Q212961', 'display_name': 'Pancreatic cancer', 'level': 3, 'score': 0.6739954}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.62779343}, {'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.56692445}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.56047326}, {'id': 'https://openalex.org/C57074206', 'wikidata': 'https://www.wikidata.org/wiki/Q14197552', 'display_name': 'MAPK/ERK pathway', 'level': 3, 'score': 0.5165033}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.4728846}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4255782}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.41599062}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.35315236}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.2985509}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2615018}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.17893556}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.14186528}], 'mesh': [{'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011905', 'descriptor_name': 'Genes, ras', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010190', 'descriptor_name': 'Pancreatic Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018631', 'descriptor_name': 'ras Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000975', 'descriptor_name': 'Antioxidants', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000975', 'descriptor_name': 'Antioxidants', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004318', 'descriptor_name': 'Doxycycline', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004318', 'descriptor_name': 'Doxycycline', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071316', 'descriptor_name': 'Forkhead Box Protein O3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051858', 'descriptor_name': 'Forkhead Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051858', 'descriptor_name': 'Forkhead Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016086', 'descriptor_name': 'Lentivirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009368', 'descriptor_name': 'Neoplasm Transplantation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010084', 'descriptor_name': 'Oxidation-Reduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010190', 'descriptor_name': 'Pancreatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018631', 'descriptor_name': 'ras Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.4125', 'pdf_url': 'https://www.oncotarget.com/article/4125/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4673256', 'pdf_url': 'https://europepmc.org/articles/pmc4673256?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673256', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26020803', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.4125', 'pdf_url': 'https://www.oncotarget.com/article/4125/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.72, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 34, 'referenced_works': ['https://openalex.org/W144423133', 'https://openalex.org/W1486040868', 'https://openalex.org/W1809723326', 'https://openalex.org/W1965009601', 'https://openalex.org/W1972779889', 'https://openalex.org/W1981868559', 'https://openalex.org/W1982146148', 'https://openalex.org/W1992724001', 'https://openalex.org/W1993238109', 'https://openalex.org/W2017481656', 'https://openalex.org/W2025970479', 'https://openalex.org/W2026834760', 'https://openalex.org/W2027443731', 'https://openalex.org/W2047833751', 'https://openalex.org/W2058461613', 'https://openalex.org/W2063163336', 'https://openalex.org/W2063382154', 'https://openalex.org/W2065294001', 'https://openalex.org/W2080011121', 'https://openalex.org/W2088293068', 'https://openalex.org/W2098150383', 'https://openalex.org/W2099023480', 'https://openalex.org/W2109031404', 'https://openalex.org/W2115212992', 'https://openalex.org/W2119370602', 'https://openalex.org/W2128569634', 'https://openalex.org/W2128733367', 'https://openalex.org/W2136627088', 'https://openalex.org/W2137881107', 'https://openalex.org/W2138498601', 'https://openalex.org/W2145428487', 'https://openalex.org/W2166087647', 'https://openalex.org/W3023299375', 'https://openalex.org/W62932861'], 'related_works': ['https://openalex.org/W582905479', 'https://openalex.org/W4327518501', 'https://openalex.org/W4214698807', 'https://openalex.org/W3176872974', 'https://openalex.org/W3030550923', 'https://openalex.org/W2996239022', 'https://openalex.org/W2900494214', 'https://openalex.org/W2592007767', 'https://openalex.org/W2080599553', 'https://openalex.org/W2026862129'], 'abstract_inverted_index': {'//': [0, 130, 134], 'Peng': [1, 46, 131], 'Wang': [2], '1,2,*': [3], ',': [4, 8, 12, 16, 20, 24, 28, 32, 36, 41], 'Chao-feng': [5], 'Zhu': [6], '1,*': [7, 11], 'Ming-zhe': [9], 'Ma': [10], 'Gang': [13], 'Chen': [14], '3,*': [15], 'Ming': [17], 'Song': [18], '1': [19, 23, 27, 31, 35, 44, 49], 'Zhao-lei': [21], 'Zeng': [22], 'Wen-hua': [25], 'Lu': [26], 'Jing': [29], 'Yang': [30], 'Shijun': [33], 'Wen': [34], 'Paul': [37], 'J.': [38], 'Chiao': [39], '4': [40, 99], 'Yumin': [42, 127], 'Hu': [43], 'and': [45, 103, 168, 216, 229, 257, 259, 273], 'Huang': [47], '1,3': [48], 'Sun': [50, 76], 'Yat-sen': [51, 77], 'University': [52, 89, 107], 'Cancer': [53, 67, 94, 112], 'Center,': [54, 95, 113], 'State': [55], 'Key': [56], 'Laboratory': [57], 'of': [58, 66, 73, 84, 90, 101, 108, 175, 191, 219, 227, 235, 243, 247, 252, 270], 'Oncology': [59], 'in': [60, 173, 194, 221, 237, 278, 292], 'South': [61], 'China,': [62], 'Collaborative': [63], 'Innovation': [64], 'Center': [65], 'Medicine,': [68, 75], 'Guangzhou,': [69, 80], 'China': [70, 81], '2': [71], 'Department': [72, 83, 100], 'Emergency': [74], 'Memorial': [78], 'Hospital,': [79], '3': [82], 'Translational': [85], 'Molecular': [86, 102], 'Pathology,': [87], 'The': [88, 106, 160], 'Texas': [91, 109], 'MD': [92, 110], 'Anderson': [93, 111], 'Houston,': [96, 114], 'TX,': [97, 115], 'USA': [98, 116], 'Cellular': [104], 'Oncology,': [105], '*': [117], 'These': [118], 'authors': [119], 'contributed': [120], 'equally': [121], 'to': [122, 183, 185, 198, 239, 250], 'this': [123], 'work': [124], 'Correspondence': [125], 'to:': [126], 'Hu,': [128], 'email:': [129, 133], 'Huang,': [132], 'Keywords': [135], ':': [136, 145, 150, 155], 'K-Ras,': [137, 271], 'miR-155,': [138], 'reactive': [139], 'oxygen': [140], 'species,': [141], 'pancreatic': [142, 176, 261, 280], 'cancer': [143, 281], 'Received': [144], 'November': [146], '05,': [147], '2014': [148], 'Accepted': [149], 'May': [151, 156], '02,': [152], '2015': [153, 158], 'Published': [154], '12,': [157], 'Abstract': [159], 'oncogenic': [161, 293], 'K-Ras': [162, 195, 220, 240, 294], 'can': [163], 'transform': [164], 'various': [165], 'mammalian': [166], 'cells': [167], 'plays': [169, 288], 'a': [170, 222], 'critical': [171], 'role': [172, 291], 'development': [174], 'cancer.': [177], 'MicroRNAs': [178], '(miRNA)': [179], 'have': [180], 'been': [181], 'shown': [182], 'contribute': [184], 'tumorigenic': [186], 'progression.': [187], 'However,': [188], 'the': [189, 209, 233], 'nature': [190], 'miRNAs': [192], 'involved': [193], 'transformation': [196, 295], 'remains': [197], 'be': [199], 'investigated.': [200], 'Here,': [201], 'by': [202, 265, 297], 'using': [203], 'microarray': [204], 'we': [205, 284], 'identified': [206], 'miR-155': [207, 236, 244, 272, 287], 'as': [208], 'most': [210], 'upregulated': [211], 'miRNA': [212], 'after': [213], 'both': [214], 'acute': [215], 'prolonged': [217], 'activation': [218], 'doxycyline-inducible': [223], 'system.': [224], 'Pharmacological': [225], 'inhibition': [226, 246], 'MAPK': [228], 'NF-κB': [230], 'pathway': [231], 'blocked': [232], 'induction': [234], 'response': [238], 'activation.': [241], 'Overexpression': [242], 'caused': [245], 'Foxo3a,': [248], 'leading': [249], 'decrease': [251], 'major': [253], 'antioxidants': [254], 'including': [255], 'SOD2': [256], 'catalase,': [258], 'enhanced': [260], 'cell': [262], 'proliferation': [263], 'induced': [264], 'ROS': [266], 'generation.': [267], 'Importantly,': [268], 'correlations': [269], 'Foxo3a': [274], 'were': [275], 'also': [276], 'validated': [277], 'human': [279], 'tissues.': [282], 'Therefore,': [283], 'propose': [285], 'that': [286], 'an': [289], 'important': [290], 'mediated': [296], 'cellular': [298], 'redox': [299], 'regulation.': [300]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1504369911', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 14}, {'year': 2021, 'cited_by_count': 15}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 12}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 8}], 'updated_date': '2024-09-09T00:41:07.158849', 'created_date': '2016-06-24'}