Publication Information

{'id': 'https://openalex.org/W148544652', 'doi': 'https://doi.org/10.1096/fasebj.20.5.a1162-b', 'title': 'Protein Kinase C activates glucose‐6‐phosphate dehydrogenase and NAD(P)H oxidase in failing human myocardium', 'display_name': 'Protein Kinase C activates glucose‐6‐phosphate dehydrogenase and NAD(P)H oxidase in failing human myocardium', 'publication_year': 2006, 'publication_date': '2006-03-01', 'ids': {'openalex': 'https://openalex.org/W148544652', 'doi': 'https://doi.org/10.1096/fasebj.20.5.a1162-b', 'mag': '148544652'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1096/fasebj.20.5.a1162-b', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5078903290', 'display_name': 'Brian Marks', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Brian Marks', 'raw_affiliation_strings': ['Physiology & Surgery'], 'affiliations': [{'raw_affiliation_string': 'Physiology & Surgery', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112090739', 'display_name': 'Robert J. Levine', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Robert J Levine', 'raw_affiliation_strings': ['Physiology'], 'affiliations': [{'raw_affiliation_string': 'Physiology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103335946', 'display_name': 'Venkataramana Vijay', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181190671', 'display_name': 'New York Medical College', 'ror': 'https://ror.org/03dkvy735', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181190671']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Vijay Venkataramana', 'raw_affiliation_strings': ['SurgeryNew York Medical CollegeBSB Rm #626, Grassland ReservationValhallaNY10595'], 'affiliations': [{'raw_affiliation_string': 'SurgeryNew York Medical CollegeBSB Rm #626, Grassland ReservationValhallaNY10595', 'institution_ids': ['https://openalex.org/I181190671']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056591779', 'display_name': 'Mohan R. Sarabu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181190671', 'display_name': 'New York Medical College', 'ror': 'https://ror.org/03dkvy735', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181190671']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mohan R Sarabu', 'raw_affiliation_strings': ['SurgeryNew York Medical CollegeBSB Rm #626, Grassland ReservationValhallaNY10595'], 'affiliations': [{'raw_affiliation_string': 'SurgeryNew York Medical CollegeBSB Rm #626, Grassland ReservationValhallaNY10595', 'institution_ids': ['https://openalex.org/I181190671']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065206443', 'display_name': 'Pawel M. Kaminski', 'orcid': 'https://orcid.org/0000-0003-2427-974X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Pawel M Kaminski', 'raw_affiliation_strings': ['Physiology'], 'affiliations': [{'raw_affiliation_string': 'Physiology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009822156', 'display_name': 'Fabio A. Recchia', 'orcid': 'https://orcid.org/0000-0002-4189-8465'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Fabio A Recchia', 'raw_affiliation_strings': ['Physiology'], 'affiliations': [{'raw_affiliation_string': 'Physiology', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040548588', 'display_name': 'Michael S. Wolin', 'orcid': 'https://orcid.org/0000-0002-3329-969X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Michael S Wolin', 'raw_affiliation_strings': ['Physiology'], 'affiliations': [{'raw_affiliation_string': 'Physiology', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5033512267', 'display_name': 'Sachin A. Gupte', 'orcid': 'https://orcid.org/0000-0001-7453-8303'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Sachin A Gupte', 'raw_affiliation_strings': ['Physiology'], 'affiliations': [{'raw_affiliation_string': 'Physiology', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 61}, 'biblio': {'volume': '20', 'issue': '5', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10155', 'display_name': 'Nitric Oxide and Endothelin Effects', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10155', 'display_name': 'Nitric Oxide and Endothelin Effects', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11057', 'display_name': 'Cardiac Ischemia and Reperfusion', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11597', 'display_name': 'Neutrophil, Myeloperoxidase and Oxidative Mechanisms', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/apocynin', 'display_name': 'Apocynin', 'score': 0.95742524}, {'id': 'https://openalex.org/keywords/staurosporine', 'display_name': 'Staurosporine', 'score': 0.63672423}, {'id': 'https://openalex.org/keywords/nad', 'display_name': 'NAD(P)H oxidase', 'score': 0.5449357}, {'id': 'https://openalex.org/keywords/mitochondrial-ros', 'display_name': 'Mitochondrial ROS', 'score': 0.43497735}], 'concepts': [{'id': 'https://openalex.org/C2777209548', 'wikidata': 'https://www.wikidata.org/wiki/Q414754', 'display_name': 'Apocynin', 'level': 4, 'score': 0.95742524}, {'id': 'https://openalex.org/C2779719074', 'wikidata': 'https://www.wikidata.org/wiki/Q2038057', 'display_name': 'NADPH oxidase', 'level': 3, 'score': 0.94218767}, {'id': 'https://openalex.org/C2780795997', 'wikidata': 'https://www.wikidata.org/wiki/Q413283', 'display_name': 'Superoxide', 'level': 3, 'score': 0.699695}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.69074935}, {'id': 'https://openalex.org/C38485361', 'wikidata': 'https://www.wikidata.org/wiki/Q576379', 'display_name': 'Oxidase test', 'level': 3, 'score': 0.6655159}, {'id': 'https://openalex.org/C2779084600', 'wikidata': 'https://www.wikidata.org/wiki/Q5957181', 'display_name': 'Staurosporine', 'level': 4, 'score': 0.63672423}, {'id': 'https://openalex.org/C2777989768', 'wikidata': 'https://www.wikidata.org/wiki/Q28747', 'display_name': 'Nicotinamide adenine dinucleotide phosphate', 'level': 4, 'score': 0.6236314}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5877809}, {'id': 'https://openalex.org/C2781252958', 'wikidata': 'https://www.wikidata.org/wiki/Q2038057', 'display_name': 'NAD(P)H oxidase', 'level': 4, 'score': 0.5449357}, {'id': 'https://openalex.org/C195794163', 'wikidata': 'https://www.wikidata.org/wiki/Q420877', 'display_name': 'Protein kinase C', 'level': 3, 'score': 0.49106073}, {'id': 'https://openalex.org/C2778175917', 'wikidata': 'https://www.wikidata.org/wiki/Q17125553', 'display_name': 'Mitochondrial ROS', 'level': 3, 'score': 0.43497735}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.43337297}, {'id': 'https://openalex.org/C2776317432', 'wikidata': 'https://www.wikidata.org/wiki/Q412547', 'display_name': 'Dehydrogenase', 'level': 3, 'score': 0.42748356}, {'id': 'https://openalex.org/C75520062', 'wikidata': 'https://www.wikidata.org/wiki/Q15321392', 'display_name': 'NAD+ kinase', 'level': 3, 'score': 0.41483194}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.34789813}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3257057}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.22460291}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1096/fasebj.20.5.a1162-b', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.49, 'id': 'https://metadata.un.org/sdg/2', 'display_name': 'Zero hunger'}], 'grants': [{'funder': 'https://openalex.org/F4320306230', 'funder_display_name': 'American Heart Association', 'award_id': '0435070N'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'HL 31069'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'HL66331'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'HL43023'}], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W801223904', 'https://openalex.org/W4381839077', 'https://openalex.org/W2914337889', 'https://openalex.org/W2768707145', 'https://openalex.org/W2620719158', 'https://openalex.org/W2348440302', 'https://openalex.org/W2239900934', 'https://openalex.org/W2170641422', 'https://openalex.org/W2069306894', 'https://openalex.org/W1624688314'], 'abstract_inverted_index': {'Elevation': [0], 'of': [1, 14, 35, 45, 57, 86, 96, 140, 165, 180, 193], 'reactive': [2], 'oxygen': [3], 'species': [4], '(ROS)': [5], 'in': [6, 16, 37, 118, 209], 'heart': [7], 'failure': [8], 'is': [9, 31, 189], 'well': [10], 'documented.': [11], 'However,': [12], 'sources': [13], 'ROS': [15, 36], 'the': [17, 87, 141, 166, 181], 'failing': [18, 38, 210], 'myocardium': [19, 59], 'are': [20, 207], 'still': [21], 'unknown.': [22], 'In': [23], 'this': [24], 'study,': [25], 'we': [26], 'examined': [27], 'whether': [28], 'NADPH': [29, 61, 97, 110, 187, 196, 198, 205], 'oxidase': [30, 63, 98, 188, 199, 206], 'a': [32, 43, 133, 148, 155, 190], 'major': [33, 191], 'source': [34, 192], 'human': [39, 58], 'myocardium.': [40], 'Superoxide': [41], '(O2−),': [42], 'precursor': [44], 'ROS,': [46], 'levels': [47, 91], 'were': [48], 'detected': [49], 'by': [50, 105, 109, 129, 213, 218], 'lucigenin': [51], '(5': [52, 131], 'uM)': [53, 71, 112], 'chemiluminescence.': [54], 'The': [55], 'pre-incubation': [56], 'with': [60], '(Nox)': [62], 'inhibitors,': [64], 'respectively,': [65, 117, 164], 'gp91dstat': [66], '(50': [67], 'uM),': [68, 76, 116], 'apocynin': [69], '(100': [70, 111, 115, 146], 'and': [72, 84, 107, 113, 120, 151, 162, 173, 178, 201, 204, 222], 'diphenyleneiodonium': [73], '(DPI;': [74], '10': [75], 'significantly': [77], 'inhibited': [78, 128], 'O2−': [79, 90, 102, 125, 175], 'generation': [80, 103], 'to': [81, 138, 160, 176], '48.0,': [82], '21.4,': [83], '16.4%': [85], 'untreated': [88, 142, 167], 'control': [89, 168], '(378±102': [92], 'Units/mg': [93], 'protein).': [94], 'Determination': [95], 'activity': [99, 169], 'indicates': [100], 'that': [101, 186], 'increased': [104], '9.6-': [106], '2.9-fold': [108], 'NADH': [114], 'DPI-': [119], 'gp91dstat-inhibitable': [121], 'manner.': [122], 'Interestingly,': [123], 'myocardial': [124, 174], 'was': [126], 'also': [127], '6-aminonicotinamide': [130], 'mM),': [132, 154], 'glucose-6-phosphate': [134], 'dehydrogenase': [135], '(G6PD)': [136], 'inhibitor,': [137, 150, 157], '53.5%': [139], 'control.': [143, 182], 'Furthermore,': [144], 'staurosporine': [145], 'nM),': [147], 'PKC': [149], 'PP2': [152], '(0.010': [153], 'Src': [156], 'attenuated': [158], 'G6PD': [159, 203], '2.2': [161], '49.1%,': [163], '(0.29±0.04': [170], 'nM/min/mg': [171], 'protein)': [172], '62.1': [177], '58.7%': [179], 'Our': [183], 'data': [184], 'suggest': [185], 'ROS.': [194], 'G6PD-derived': [195], 'fuel': [197], 'activity,': [200], 'both': [202], 'activated': [208], 'cardiac': [211], 'muscle': [212], 'PKC-Src': [214], 'signaling': [215], 'pathways.': [216], '(Supported': [217], 'AHA': [219], 'grant': [220], '0435070N': [221], 'NIH': [223], 'grants': [224], 'HL': [225], '31069,': [226], 'HL43023,': [227], 'HL66331).': [228]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W148544652', 'counts_by_year': [], 'updated_date': '2024-12-24T09:57:01.543953', 'created_date': '2016-06-24'}