Title: Enzymes of DNA synthesis in rat bone marrow during chronic exposure to radiation. [. gamma. rays]
Abstract:The activity of enzymes of DNA synthesis in bone marrow during long-term exposure to radiation in a dosage of 25 R, which leads to formation of a chronic radiation lesion was investigated. Experiments...The activity of enzymes of DNA synthesis in bone marrow during long-term exposure to radiation in a dosage of 25 R, which leads to formation of a chronic radiation lesion was investigated. Experiments were conducted on male Wistar rats which were exposed to radiation daily from a cesium ..gamma..-source in a dosage of 25 R at a dose rate of 10.3 R/min. The activity of enzymes of phosphorylation of thmydine and thymidylic acid to TTP and DNA polymerase was measured. For the first 11 experimental days, kinase activity was 1.5 times higher than the control levels. At subsequent times, there was a decrease in activity of these enzymes to the normal level. These changes in DNA polymerase activity were not statistically significant in the bone marrow of irradiated animals, as compared to the control, throughout the irradiation period. No perceptible changes in number of myelokaryocytes were demonstrable in bone marrow during exposure of the rats to radiation under the same conditions. Thus, this study demonstrated that there was little change in activity of the enzymes of DNA synthesis in bone marrow cells in the course of chronic exposure of rats to radiation (daily dose 25 R). At the same time,more » with a lower daily dose (25), statistically reliable changes in cell composition of bone marrow tissue were also absent. (ERB)« lessRead More
Publication Year: 1979
Publication Date: 1979-06-01
Language: en
Type: article
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