Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W115216328', 'doi': 'https://doi.org/10.1007/bf02861863', 'title': 'Arsenic trioxide inhibits proliferation in K562 cells by changing cell cycle and survivin expression', 'display_name': 'Arsenic trioxide inhibits proliferation in K562 cells by changing cell cycle and survivin expression', 'publication_year': 2004, 'publication_date': '2004-08-01', 'ids': {'openalex': 'https://openalex.org/W115216328', 'doi': 'https://doi.org/10.1007/bf02861863', 'mag': '115216328', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15587394'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/bf02861863', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210178822', 'display_name': 'Current Medical Science', 'issn_l': '2523-899X', 'issn': ['2523-899X', '2096-5230'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5047141996', 'display_name': 'Xiaofei Wu', 'orcid': 'https://orcid.org/0000-0002-4142-8869'}, 'institutions': [{'id': 'https://openalex.org/I4210129222', 'display_name': 'Wuhan Union Hospital', 'ror': 'https://ror.org/0371fqr87', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129222']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wu Xiaofei', 'raw_affiliation_strings': ['Department of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China', 'institution_ids': ['https://openalex.org/I4210129222']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100619470', 'display_name': 'Zhichao Chen', 'orcid': 'https://orcid.org/0000-0001-5785-0741'}, 'institutions': [{'id': 'https://openalex.org/I4210129222', 'display_name': 'Wuhan Union Hospital', 'ror': 'https://ror.org/0371fqr87', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129222']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chen Zhichao', 'raw_affiliation_strings': ['Department of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China', 'institution_ids': ['https://openalex.org/I4210129222']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077135144', 'display_name': 'Zhongping Liu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210129222', 'display_name': 'Wuhan Union Hospital', 'ror': 'https://ror.org/0371fqr87', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129222']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Liu Zhongping', 'raw_affiliation_strings': ['Department of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China', 'institution_ids': ['https://openalex.org/I4210129222']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058766870', 'display_name': 'Hao Zhou', 'orcid': 'https://orcid.org/0000-0003-1635-1764'}, 'institutions': [{'id': 'https://openalex.org/I4210129222', 'display_name': 'Wuhan Union Hospital', 'ror': 'https://ror.org/0371fqr87', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129222']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhou Hao', 'raw_affiliation_strings': ['Department of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China', 'institution_ids': ['https://openalex.org/I4210129222']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052101363', 'display_name': 'You Yong', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210129222', 'display_name': 'Wuhan Union Hospital', 'ror': 'https://ror.org/0371fqr87', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129222']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'You Yong', 'raw_affiliation_strings': ['Department of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China', 'institution_ids': ['https://openalex.org/I4210129222']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100695254', 'display_name': 'Weiming Li', 'orcid': 'https://orcid.org/0000-0001-5437-1518'}, 'institutions': [{'id': 'https://openalex.org/I4210129222', 'display_name': 'Wuhan Union Hospital', 'ror': 'https://ror.org/0371fqr87', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129222']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Li Weiming', 'raw_affiliation_strings': ['Department of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China', 'institution_ids': ['https://openalex.org/I4210129222']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5067439447', 'display_name': 'Ping Zou', 'orcid': 'https://orcid.org/0000-0002-0699-8487'}, 'institutions': [{'id': 'https://openalex.org/I4210129222', 'display_name': 'Wuhan Union Hospital', 'ror': 'https://ror.org/0371fqr87', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129222']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zou Ping', 'raw_affiliation_strings': ['Department of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China', 'institution_ids': ['https://openalex.org/I4210129222']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.119, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.432882, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 71, 'max': 74}, 'biblio': {'volume': '24', 'issue': '4', 'first_page': '342', 'last_page': '344'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11559', 'display_name': 'Retinoids in leukemia and cellular processes', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11559', 'display_name': 'Retinoids in leukemia and cellular processes', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11668', 'display_name': 'interferon and immune responses', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.9928, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/survivin', 'display_name': 'Survivin', 'score': 0.9736124}, {'id': 'https://openalex.org/keywords/arsenic-trioxide', 'display_name': 'Arsenic Trioxide', 'score': 0.8616576}, {'id': 'https://openalex.org/keywords/k562-cells', 'display_name': 'K562 cells', 'score': 0.7715769}, {'id': 'https://openalex.org/keywords/mtt-assay', 'display_name': 'MTT assay', 'score': 0.4149975}], 'concepts': [{'id': 'https://openalex.org/C2775975398', 'wikidata': 'https://www.wikidata.org/wiki/Q906904', 'display_name': 'Survivin', 'level': 3, 'score': 0.9736124}, {'id': 'https://openalex.org/C2780386689', 'wikidata': 'https://www.wikidata.org/wiki/Q7739', 'display_name': 'Arsenic trioxide', 'level': 3, 'score': 0.8616576}, {'id': 'https://openalex.org/C171122931', 'wikidata': 'https://www.wikidata.org/wiki/Q6324626', 'display_name': 'K562 cells', 'level': 3, 'score': 0.7715769}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.7342846}, {'id': 'https://openalex.org/C553184892', 'wikidata': 'https://www.wikidata.org/wiki/Q1141429', 'display_name': 'Flow cytometry', 'level': 2, 'score': 0.6964063}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.67807865}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.5833654}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.49005663}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.47518173}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4333219}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.42495653}, {'id': 'https://openalex.org/C2780783641', 'wikidata': 'https://www.wikidata.org/wiki/Q738686', 'display_name': 'MTT assay', 'level': 3, 'score': 0.4149975}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.40410137}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.11834267}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D001152', 'descriptor_name': 'Arsenicals', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D008869', 'descriptor_name': 'Microtubule-Associated Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D010087', 'descriptor_name': 'Oxides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000951', 'descriptor_name': 'Antigens, Neoplasm', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000951', 'descriptor_name': 'Antigens, Neoplasm', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D000951', 'descriptor_name': 'Antigens, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077237', 'descriptor_name': 'Arsenic Trioxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001152', 'descriptor_name': 'Arsenicals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051034', 'descriptor_name': 'Inhibitor of Apoptosis Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020014', 'descriptor_name': 'K562 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008869', 'descriptor_name': 'Microtubule-Associated Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008869', 'descriptor_name': 'Microtubule-Associated Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010087', 'descriptor_name': 'Oxides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000077022', 'descriptor_name': 'Survivin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/bf02861863', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210178822', 'display_name': 'Current Medical Science', 'issn_l': '2523-899X', 'issn': ['2523-899X', '2096-5230'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15587394', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 6, 'referenced_works': ['https://openalex.org/W1662899239', 'https://openalex.org/W1863167619', 'https://openalex.org/W1968262266', 'https://openalex.org/W2026035187', 'https://openalex.org/W2043195965', 'https://openalex.org/W2077587772'], 'related_works': ['https://openalex.org/W4254004086', 'https://openalex.org/W3171350128', 'https://openalex.org/W3151141465', 'https://openalex.org/W3032354441', 'https://openalex.org/W2580481553', 'https://openalex.org/W2402094694', 'https://openalex.org/W2392173947', 'https://openalex.org/W2381151173', 'https://openalex.org/W2374590552', 'https://openalex.org/W2357909182'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W115216328', 'counts_by_year': [], 'updated_date': '2024-12-13T12:07:40.472769', 'created_date': '2016-06-24'}