Publication Information

{'id': 'https://openalex.org/W102043283', 'doi': None, 'title': 'Itk, a T cell-specific tyrosine kinase, is required for CD2-mediated interleukin-2 promoter activation in the human T cell line Jurkat.', 'display_name': 'Itk, a T cell-specific tyrosine kinase, is required for CD2-mediated interleukin-2 promoter activation in the human T cell line Jurkat.', 'publication_year': 1997, 'publication_date': '1997-04-01', 'ids': {'openalex': 'https://openalex.org/W102043283', 'mag': '102043283', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9130632'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9130632', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101593797', 'display_name': 'Nobuyuki Tanaka', 'orcid': 'https://orcid.org/0000-0002-0229-8061'}, 'institutions': [{'id': 'https://openalex.org/I201537933', 'display_name': 'Tohoku University', 'ror': 'https://ror.org/01dq60k83', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201537933']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'N Tanaka', 'raw_affiliation_strings': ['Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan.', 'institution_ids': ['https://openalex.org/I201537933']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032983935', 'display_name': 'Hiromi Abe', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'H Abe', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109873114', 'display_name': 'H Yagita', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'H Yagita', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088986458', 'display_name': 'Ko Okumura', 'orcid': 'https://orcid.org/0000-0003-3238-6422'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'K Okumura', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009516767', 'display_name': 'Masatsugu Nakamura', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'M Nakamura', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5087838405', 'display_name': 'Kazuo Sugamura', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'K Sugamura', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4120, 'currency': 'USD', 'value_usd': 4120, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.008, 'has_fulltext': False, 'cited_by_count': 36, 'citation_normalized_percentile': {'value': 0.691422, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '27', 'issue': '4', 'first_page': '834', 'last_page': '41'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9911, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9911, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10031', 'display_name': 'T-cell and B-cell Immunology', 'score': 0.9896, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11016', 'display_name': 'Monoclonal and Polyclonal Antibodies Research', 'score': 0.9789, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/jurkat-cells', 'display_name': 'Jurkat cells', 'score': 0.76142263}, {'id': 'https://openalex.org/keywords/nfat', 'display_name': 'NFAT', 'score': 0.72922045}], 'concepts': [{'id': 'https://openalex.org/C179464577', 'wikidata': 'https://www.wikidata.org/wiki/Q1632589', 'display_name': 'Jurkat cells', 'level': 4, 'score': 0.76142263}, {'id': 'https://openalex.org/C189938988', 'wikidata': 'https://www.wikidata.org/wiki/Q24744925', 'display_name': 'NFAT', 'level': 4, 'score': 0.72922045}, {'id': 'https://openalex.org/C148125776', 'wikidata': 'https://www.wikidata.org/wiki/Q1622348', 'display_name': 'CD28', 'level': 4, 'score': 0.7172852}, {'id': 'https://openalex.org/C19317047', 'wikidata': 'https://www.wikidata.org/wiki/Q412037', 'display_name': 'T-cell receptor', 'level': 4, 'score': 0.6982768}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6721548}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.65428776}, {'id': 'https://openalex.org/C114684123', 'wikidata': 'https://www.wikidata.org/wiki/Q419458', 'display_name': 'CD3', 'level': 4, 'score': 0.6302903}, {'id': 'https://openalex.org/C2777553839', 'wikidata': 'https://www.wikidata.org/wiki/Q14330986', 'display_name': 'Tyrosine phosphorylation', 'level': 3, 'score': 0.60471445}, {'id': 'https://openalex.org/C42362537', 'wikidata': 'https://www.wikidata.org/wiki/Q87099740', 'display_name': 'Tyrosine kinase', 'level': 3, 'score': 0.60375434}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.5405951}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4746621}, {'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.4683373}, {'id': 'https://openalex.org/C2776165026', 'wikidata': 'https://www.wikidata.org/wiki/Q188017', 'display_name': 'Tyrosine', 'level': 2, 'score': 0.44604555}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.43725625}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.30542436}, {'id': 'https://openalex.org/C167672396', 'wikidata': 'https://www.wikidata.org/wiki/Q417800', 'display_name': 'CD8', 'level': 3, 'score': 0.19323778}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.17269036}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.17202714}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15462628}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.10932398}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.05181077}], 'mesh': [{'descriptor_ui': 'D018801', 'descriptor_name': 'CD2 Antigens', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D007376', 'descriptor_name': 'Interleukin-2', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D011505', 'descriptor_name': 'Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D018801', 'descriptor_name': 'CD2 Antigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018106', 'descriptor_name': 'CD28 Antigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018106', 'descriptor_name': 'CD28 Antigens', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D017252', 'descriptor_name': 'CD3 Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017252', 'descriptor_name': 'CD3 Complex', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007376', 'descriptor_name': 'Interleukin-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007376', 'descriptor_name': 'Interleukin-2', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D019169', 'descriptor_name': 'Jurkat Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050778', 'descriptor_name': 'NFATC Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D011505', 'descriptor_name': 'Protein-Tyrosine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011505', 'descriptor_name': 'Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011505', 'descriptor_name': 'Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011948', 'descriptor_name': 'Receptors, Antigen, T-Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011948', 'descriptor_name': 'Receptors, Antigen, T-Cell', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D013379', 'descriptor_name': 'Substrate Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013379', 'descriptor_name': 'Substrate Specificity', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014443', 'descriptor_name': 'Tyrosine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014443', 'descriptor_name': 'Tyrosine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9130632', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3172183594', 'https://openalex.org/W2188425307', 'https://openalex.org/W2167625024', 'https://openalex.org/W2140842690', 'https://openalex.org/W2096118127', 'https://openalex.org/W2093635634', 'https://openalex.org/W1991600917', 'https://openalex.org/W1576400113', 'https://openalex.org/W1515057524', 'https://openalex.org/W102043283'], 'abstract_inverted_index': {'We': [0], 'investigated': [1], 'the': [2, 10, 55, 89, 112, 120, 128, 142, 163, 174], 'functional': [3], 'role': [4, 152], 'of': [5, 9, 21, 38, 71, 84, 100, 105, 111, 115, 123, 134, 141, 160, 166], 'Itk,': [6, 39], 'a': [7, 95, 151, 157], 'member': [8], 'cytoplasmic': [11], 'tyrosine': [12, 36, 51, 98], 'kinase': [13, 52, 90], 'Tec': [14], 'family,': [15], 'in': [16, 54, 97, 127, 153, 162], 'T': [17, 25, 117, 167], 'cell': [18, 26, 168], 'activation.': [19], 'Stimulation': [20, 104], 'either': [22], 'CD2': [23, 106], 'or': [24, 107], 'receptor': [27], '(TCR)/CD3': [28], 'on': [29], 'Tcells': [30], 'by': [31, 69, 81, 139, 170], 'monoclonal': [32], 'antibody-mediated': [33], 'cross-linking': [34, 70], 'induced': [35, 109], 'phosphorylation': [37, 99], 'which': [40, 124], 'was': [41, 58, 78, 136], 'maximal': [42], 'as': [43, 45], 'early': [44], '1': [46], 'min': [47], 'after': [48], 'stimulation.': [49], 'The': [50, 92, 132], 'activity': [53, 67], 'anti-Itk': [56], 'immunoprecipitate': [57], 'significantly': [59, 79], 'activated': [60, 116], 'upon': [61], 'these': [62], 'stimulations.': [63], 'Interleukin-2': [64], '(IL-2)': [65], 'promoter': [66], 'stimulated': [68], 'CD2,': [72, 177], 'TCR/CD3,': [73], 'and': [74, 178], 'CD28': [75], 'with': [76], 'antibodies': [77], 'reduced': [80], 'transient': [82], 'expression': [83, 140], 'an': [85], 'Itk': [86, 143, 149, 161], 'mutant': [87], 'lacking': [88], 'activity.': [91], 'reduction': [93], 'paralleled': [94], 'decrease': [96], 'endogenous': [101], 'wild-type': [102], 'Itk.': [103], 'TCR/CD3': [108, 175], 'activation': [110, 133, 169], 'nuclear': [113], 'factor': [114], 'cells': [118], '(NFAT),': [119], 'binding': [121], 'site': [122], 'is': [125], 'included': [126], 'IL-2': [129, 154], 'gene': [130], 'promoter.': [131], 'NFAT': [135], 'also': [137], 'impaired': [138], 'mutant.': [144], 'These': [145], 'results': [146], 'demonstrate': [147], 'that': [148], 'plays': [150], 'production,': [155], 'indicating': [156], 'critical': [158], 'involvement': [159], 'initial': [164], 'stage': [165], 'mediating': [171], 'signals': [172], 'from': [173], 'complex,': [176], 'CD28.': [179]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W102043283', 'counts_by_year': [{'year': 2018, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-14T18:06:14.544189', 'created_date': '2016-06-24'}