Publication Information

{'id': 'https://openalex.org/W2096118127', 'doi': 'https://doi.org/10.4049/jimmunol.156.8.2716', 'title': 'The EMT/ITK/TSK (EMT) tyrosine kinase is activated during TCR signaling: LCK is required for optimal activation of EMT.', 'display_name': 'The EMT/ITK/TSK (EMT) tyrosine kinase is activated during TCR signaling: LCK is required for optimal activation of EMT.', 'publication_year': 1996, 'publication_date': '1996-04-15', 'ids': {'openalex': 'https://openalex.org/W2096118127', 'doi': 'https://doi.org/10.4049/jimmunol.156.8.2716', 'mag': '2096118127', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8609388'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.156.8.2716', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/156/8/2716/1072596/2716.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://journals.aai.org/jimmunol/article-pdf/156/8/2716/1072596/2716.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5008948746', 'display_name': 'Spencer B. Gibson', 'orcid': 'https://orcid.org/0000-0003-0119-732X'}, 'institutions': [{'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}, {'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}, {'id': 'https://openalex.org/I1311191458', 'display_name': 'La Jolla Institute for Immunology', 'ror': 'https://ror.org/05vkpd318', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1311191458']}, {'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['CA', 'US'], 'is_corresponding': False, 'raw_author_name': 'S Gibson', 'raw_affiliation_strings': ['La Jolla Institute for Allergy and Immunology', 'Molecular Oncology, Division of Medicine, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA.', 'University of Toronto'], 'affiliations': [{'raw_affiliation_string': 'Molecular Oncology, Division of Medicine, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA.', 'institution_ids': ['https://openalex.org/I4210150208', 'https://openalex.org/I1343551460']}, {'raw_affiliation_string': 'University of Toronto', 'institution_ids': ['https://openalex.org/I185261750']}, {'raw_affiliation_string': 'La Jolla Institute for Allergy and Immunology', 'institution_ids': ['https://openalex.org/I1311191458']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000896541', 'display_name': 'Avery August', 'orcid': 'https://orcid.org/0000-0003-4968-3415'}, 'institutions': [{'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}, {'id': 'https://openalex.org/I83399316', 'display_name': 'Rockefeller University', 'ror': 'https://ror.org/0420db125', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I83399316']}, {'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'A August', 'raw_affiliation_strings': ['Molecular Oncology, Division of Medicine, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA.', 'Rockefeller University'], 'affiliations': [{'raw_affiliation_string': 'Molecular Oncology, Division of Medicine, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA.', 'institution_ids': ['https://openalex.org/I4210150208', 'https://openalex.org/I1343551460']}, {'raw_affiliation_string': 'Rockefeller University', 'institution_ids': ['https://openalex.org/I83399316']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5107483314', 'display_name': 'Yu Kawakami', 'orcid': 'https://orcid.org/0009-0009-8592-2912'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}, {'id': 'https://openalex.org/I1311191458', 'display_name': 'La Jolla Institute for Immunology', 'ror': 'https://ror.org/05vkpd318', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1311191458']}, {'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Y Kawakami', 'raw_affiliation_strings': ['LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY.', 'Molecular Oncology, Division of Medicine, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA.'], 'affiliations': [{'raw_affiliation_string': 'Molecular Oncology, Division of Medicine, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA.', 'institution_ids': ['https://openalex.org/I1343551460', 'https://openalex.org/I4210150208']}, {'raw_affiliation_string': 'LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY.', 'institution_ids': ['https://openalex.org/I1311191458']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046096831', 'display_name': 'Takao Kawakami', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}, {'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}, {'id': 'https://openalex.org/I1311191458', 'display_name': 'La Jolla Institute for Immunology', 'ror': 'https://ror.org/05vkpd318', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1311191458']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'T Kawakami', 'raw_affiliation_strings': ['LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY.', 'Molecular Oncology, Division of Medicine, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA.'], 'affiliations': [{'raw_affiliation_string': 'Molecular Oncology, Division of Medicine, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA.', 'institution_ids': ['https://openalex.org/I1343551460', 'https://openalex.org/I4210150208']}, {'raw_affiliation_string': 'LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY.', 'institution_ids': ['https://openalex.org/I1311191458']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080022431', 'display_name': 'Bo Dupont', 'orcid': 'https://orcid.org/0000-0001-9069-105X'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}, {'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'B Dupont', 'raw_affiliation_strings': ['Molecular Oncology, Division of Medicine, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA.'], 'affiliations': [{'raw_affiliation_string': 'Molecular Oncology, Division of Medicine, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA.', 'institution_ids': ['https://openalex.org/I1343551460', 'https://openalex.org/I4210150208']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5000366516', 'display_name': 'G B Mills', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210150208', 'display_name': 'Molecular Oncology (United States)', 'ror': 'https://ror.org/04rtkc841', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210150208']}, {'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}, {'id': 'https://openalex.org/I4210155419', 'display_name': 'Center for Systems Biology', 'ror': 'https://ror.org/05r3dyn47', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I136199984', 'https://openalex.org/I4210087915', 'https://openalex.org/I4210155419', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'G B Mills', 'raw_affiliation_strings': ['Molecular Oncology, Division of Medicine, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA.', 'Systems Biology'], 'affiliations': [{'raw_affiliation_string': 'Molecular Oncology, Division of Medicine, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA.', 'institution_ids': ['https://openalex.org/I4210150208', 'https://openalex.org/I1343551460']}, {'raw_affiliation_string': 'Systems Biology', 'institution_ids': ['https://openalex.org/I4210155419']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 6, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.326, 'has_fulltext': False, 'cited_by_count': 92, 'citation_normalized_percentile': {'value': 0.893259, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '156', 'issue': '8', 'first_page': '2716', 'last_page': '2722'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11503', 'display_name': 'Cytokine Signaling Pathways and Interactions', 'score': 0.9844, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11503', 'display_name': 'Cytokine Signaling Pathways and Interactions', 'score': 0.9844, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11016', 'display_name': 'Monoclonal and Polyclonal Antibodies Research', 'score': 0.9824, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10755', 'display_name': 'HER2/EGFR in Cancer Research', 'score': 0.9657, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/jurkat-cells', 'display_name': 'Jurkat cells', 'score': 0.8869848}, {'id': 'https://openalex.org/keywords/src-family-kinase', 'display_name': 'Src family kinase', 'score': 0.5551698}, {'id': 'https://openalex.org/keywords/tyrosine-protein-kinase-csk', 'display_name': 'Tyrosine-protein kinase CSK', 'score': 0.44048172}, {'id': 'https://openalex.org/keywords/zap70', 'display_name': 'ZAP70', 'score': 0.4394102}], 'concepts': [{'id': 'https://openalex.org/C179464577', 'wikidata': 'https://www.wikidata.org/wiki/Q1632589', 'display_name': 'Jurkat cells', 'level': 4, 'score': 0.8869848}, {'id': 'https://openalex.org/C148125776', 'wikidata': 'https://www.wikidata.org/wiki/Q1622348', 'display_name': 'CD28', 'level': 4, 'score': 0.7501077}, {'id': 'https://openalex.org/C19317047', 'wikidata': 'https://www.wikidata.org/wiki/Q412037', 'display_name': 'T-cell receptor', 'level': 4, 'score': 0.744613}, {'id': 'https://openalex.org/C42362537', 'wikidata': 'https://www.wikidata.org/wiki/Q87099740', 'display_name': 'Tyrosine kinase', 'level': 3, 'score': 0.64762414}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.62328124}, {'id': 'https://openalex.org/C2777553839', 'wikidata': 'https://www.wikidata.org/wiki/Q14330986', 'display_name': 'Tyrosine phosphorylation', 'level': 3, 'score': 0.5724756}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.570572}, {'id': 'https://openalex.org/C2779976819', 'wikidata': 'https://www.wikidata.org/wiki/Q7582406', 'display_name': 'Src family kinase', 'level': 4, 'score': 0.5551698}, {'id': 'https://openalex.org/C108636557', 'wikidata': 'https://www.wikidata.org/wiki/Q21109354', 'display_name': 'Proto-oncogene tyrosine-protein kinase Src', 'level': 3, 'score': 0.55458707}, {'id': 'https://openalex.org/C114684123', 'wikidata': 'https://www.wikidata.org/wiki/Q419458', 'display_name': 'CD3', 'level': 4, 'score': 0.48046964}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.4711472}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.4594243}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.44874403}, {'id': 'https://openalex.org/C183141693', 'wikidata': 'https://www.wikidata.org/wiki/Q5005962', 'display_name': 'Tyrosine-protein kinase CSK', 'level': 5, 'score': 0.44048172}, {'id': 'https://openalex.org/C120642132', 'wikidata': 'https://www.wikidata.org/wiki/Q14907110', 'display_name': 'ZAP70', 'level': 5, 'score': 0.4394102}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.41916123}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34878677}, {'id': 'https://openalex.org/C197153747', 'wikidata': 'https://www.wikidata.org/wiki/Q24780316', 'display_name': 'SH2 domain', 'level': 4, 'score': 0.29636365}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.19371188}, {'id': 'https://openalex.org/C167672396', 'wikidata': 'https://www.wikidata.org/wiki/Q417800', 'display_name': 'CD8', 'level': 3, 'score': 0.16530472}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.08806503}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.0734427}], 'mesh': [{'descriptor_ui': 'D011505', 'descriptor_name': 'Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D011948', 'descriptor_name': 'Receptors, Antigen, T-Cell', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D019061', 'descriptor_name': 'src-Family Kinases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D018106', 'descriptor_name': 'CD28 Antigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018106', 'descriptor_name': 'CD28 Antigens', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D003432', 'descriptor_name': 'Cross-Linking Reagents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004357', 'descriptor_name': 'Drug Synergism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019860', 'descriptor_name': 'Lymphocyte Specific Protein Tyrosine Kinase p56(lck)', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016399', 'descriptor_name': 'Lymphoma, T-Cell', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D016399', 'descriptor_name': 'Lymphoma, T-Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016399', 'descriptor_name': 'Lymphoma, T-Cell', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011505', 'descriptor_name': 'Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D011505', 'descriptor_name': 'Protein-Tyrosine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011948', 'descriptor_name': 'Receptors, Antigen, T-Cell', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D011948', 'descriptor_name': 'Receptors, Antigen, T-Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011948', 'descriptor_name': 'Receptors, Antigen, T-Cell', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013601', 'descriptor_name': 'T-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019061', 'descriptor_name': 'src-Family Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019061', 'descriptor_name': 'src-Family Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.156.8.2716', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/156/8/2716/1072596/2716.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8609388', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4049/jimmunol.156.8.2716', 'pdf_url': 'https://journals.aai.org/jimmunol/article-pdf/156/8/2716/1072596/2716.pdf', 'source': {'id': 'https://openalex.org/S38008053', 'display_name': 'The Journal of Immunology', 'issn_l': '0022-1767', 'issn': ['0022-1767', '1550-6606'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4320800377', 'host_organization_name': 'American Association of Immunologists', 'host_organization_lineage': ['https://openalex.org/P4320800377'], 'host_organization_lineage_names': ['American Association of Immunologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4571852', 'https://openalex.org/W4250662472', 'https://openalex.org/W4230467858', 'https://openalex.org/W2725320657', 'https://openalex.org/W2151766517', 'https://openalex.org/W2145023069', 'https://openalex.org/W2032523932', 'https://openalex.org/W1995083433', 'https://openalex.org/W1628918534', 'https://openalex.org/W1496101665'], 'abstract_inverted_index': {'Functional': [0], 'T': [1, 90, 117, 164, 185], 'lymphocyte': [2], 'activation': [3, 53], 'requires': [4], 'concurrent': [5, 74], 'stimulation': [6, 156], 'of': [7, 34, 41, 45, 76, 88, 108, 114, 157, 172, 181, 191, 211], 'the': [8, 23, 42, 46, 77, 89, 104, 115, 122, 135, 158, 161, 182, 199, 203, 212], 'TCR': [9, 47, 78, 136, 159], 'complex': [10, 48], 'and': [11, 59, 66, 79, 147], 'an': [12, 221], 'accessory': [13], 'molecule,': [14], 'most': [15], 'frequently': [16], 'CD28.': [17, 35], 'We': [18, 36], 'have': [19], 'previously': [20], 'demonstrated': [21], 'that': [22, 39, 167, 202], 'TEC': [24], 'family': [25, 124], 'tyrosine': [26, 64, 145, 205], 'kinase': [27, 67, 125, 149, 206], 'EMT/ITK/TSK': [28], '(EMT)': [29], 'is': [30, 207], 'activated': [31, 208], 'following': [32, 155, 209], 'cross-linking': [33, 40, 75, 210], 'demonstrate': [37], 'herein': [38], 'CD3': [43], 'component': [44], 'also': [49, 152], 'leads': [50], 'to': [51, 129], 'EMT': [52, 63, 109, 138, 144, 178, 195, 204], 'as': [54, 140], 'indicated': [55], 'by': [56, 142, 188], 'a': [57, 83, 100, 173, 214], 'rapid': [58], 'transient': [60], 'increase': [61, 85], 'in': [62, 69, 82, 86, 99, 103, 160, 177, 216], 'phosphorylation': [65, 146], 'activity': [68], 'anti-EMT': [70], 'immunoprecipitates.': [71], 'However,': [72], 'although': [73], 'CD28': [80], 'results': [81], 'marked': [84], 'production': [87], 'cell': [91, 112, 118, 165, 186], 'growth': [92], 'factor': [93], 'IL-2,': [94], 'it': [95], 'does': [96], 'not': [97], 'result': [98], 'significant': [101], 'alteration': [102], 'magnitude': [105], 'or': [106], 'duration': [107], 'activation.': [110, 196], 'Somatic': [111], 'mutants': [113, 166], 'Jurkat': [116, 163, 184], 'line,': [119], 'which': [120, 217], 'lack': [121, 168], 'SRC': [123], 'LCK': [126, 176, 192, 218], '(JCaM1.6),': [127], 'fail': [128], 'produce': [130], 'IL-2': [131], 'when': [132], 'stimulated': [133], 'through': [134], 'complex.': [137], 'activation,': [139, 179], 'evidenced': [141], 'increased': [143], 'EMT-associated': [148], 'activity,': [150], 'was': [151], 'greatly': [153], 'reduced': [154], 'JCaM1.6': [162], 'LCK.': [169], 'In': [170], 'support': [171], 'role': [174], 'for': [175], 'reconstitution': [180], 'LCK-negative': [183], 'line': [187], 'enforced': [189], 'expression': [190], 'restored': [193], 'TCR-mediated': [194], 'Taken': [197], 'together,': [198], 'data': [200], 'indicate': [201], 'TCR,': [213], 'process': [215], 'likely': [219], 'plays': [220], 'important': [222], 'role.': [223]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2096118127', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-21T07:22:15.382586', 'created_date': '2016-06-24'}