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[104], 'lack': [107], 'three': [110], 'dimensional': [111], 'structure.': [112], 'There': [113], 'consequent': [115], 'controversy': [116], 'about': [117], 'topology': [120], 'VKOR,': [122, 256], 'location': [124], 'binding': [127], 'site': [128], 'for': [129, 209], 'coumarin': [130], 'inhibitors': [131, 205], 'these': [138, 217], 'compounds.': [139], 'Dicoumarol': [140], '(and': [141], 'warfarin)': [142], 'also': [143, 158], 'inhibit': [144], 'second': [146, 243], 'enzyme,': [147], 'NAD(P)H': [148], 'quinone': [149, 252], 'oxidoreductase': [150], '1': [151], '(NQO1).': [152], 'soluble,': [154], 'cytoplasmic': [155], 'enzyme': [156, 176], 'may': [157], 'play': [159], 'minor': [161], 'role': [162], 'K.': [168], 'However,': [169], 'its': [170], 'main': [171], 'cellular': [172], 'roles': [173], 'appear': [177], 'to': [178, 222], 'detoxification': [180], 'prevention': [183], 'build-up': [186], 'reactive': [188], 'oxygen': [189], 'species.': [190], 'NQO1': [191, 204], 'well': [193], 'characterised': [194], 'biochemically': [195], 'structurally.': [197], 'Consequently,': [198], 'structure-based': [199], 'drug': [200], 'design': [201], 'has': [202], 'identified': [203], 'which': [206], 'have': [207, 226], 'potential': [208], 'development': [211], 'anti-cancer': [213], 'drugs.': [214, 246], 'Many': [215], 'compounds': [218], 'are': [219], 'structurally': [220], 'related': [221], 'some': [225], 'reduced': [227], '“off': [228], 'target”': [229], 'effects.': [230], 'Therefore,': [231], 'it': [232], 'possible': [234], 'that': [235], 'will': [237], 'become': [238], 'group': [244], 'Keywords:': [247], 'Anti-cancer': [248], 'anticoagulant,': [250], 'NQO1,': [251], 'cycling,': [253], 'K,': [255]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W986771618', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 3}], 'updated_date': '2024-09-13T07:42:48.504560', 'created_date': '2016-06-24'}