Abstract: Objective: To investigate the expression of survivin, PTEN and p16 in their coloncarcinoma and the clinical significance. Methods: Immunohistochemical SP method was used to detect the expression of 3 proteins in 12 cases of normal colon tissue and 43 cases of coloncarcinoma. Results: We found that survivin in tissues of 23 cases of coloncarcinoma had positive expression, survivin was not expressed in normal tissue, over expression of survivin had no relation with histological type and Dukes classification, but it had obviously association with lymph node metastasis (P<0.05), the expression of PTEN and p16 were correlated with histological type, Dukes classification and lymph node metastasis. Conclusion: Abnormal expression of survivin, PTEN and p16 play an important role in occurrence and progression of large intestin carcinoma, associating survivin with PTEN and p16 may be amolecular-biological indicator in forecasting the progress and prognosis of colorectal carcinoma.
Publication Year: 2007
Publication Date: 2007-02-25
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot