Title: Chapter 2 Steroidal Alkaloids of Apocynaceae and Buxaceae
Abstract: This chapter deals with recent advances made in the field of steroidal alkaloids of Apocynaceae and Buxaceae. Steroidal alkaloids of Apocynaceae are conveniently classified into three main structural groups: the conanine group, the pregnane group, and the paravallarine group. Amino-glyco-steroids represent a new class of glyco-alkaloids in which an amino-sugar is linked to a steroidal unit. When the amino-sugar is attached to a cardenolide, then the substances are known as amino-glyco-cardenolides. The alkaloids of Buxaceae are regarded as derivatives of 9β,19-cyclo- and 9(10→19)-abeo-pregnane and are further subdivided according to the number of nitrogen atoms incorporated. Isolation and structure elucidation of these groups have been presented along with their mass spectroscopy analysis. The configuration and conformation of steroidal amino alcohols may be ascertained by chemical ionization mass spectrometry. The chapter also presents syntheses and chemical transformations of steroidal alkaloids. Biosynthesis and pharmacology of these alkaloids are also presented. The early suggestions concerned with the biosynthesis of Apocynaceae and Buxaceae alkaloids involved the intermediacy of 3- or 20-ketones bearing the sterol or triterpene skeleton.
Publication Year: 1988
Publication Date: 1988-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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Cited By Count: 3
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