Abstract: This chapter discusses results of studies focusing on analgesics. Research on strong analgesics has shown a relative increase in detailed structure-activity studies and investigations of biochemical and pharmacological mechanisms. Few new candidates have been proposed as non-narcotic replacements for morphine, and none appears to challenge the growing use of pentazocine. In the area of mild analgesics, some novel structures have higher analgesic potency and fewer side effects than the compounds now in use. Tilidine has been studied in over 3000 patients and was said to be an orally effective agent, nearly as potent as meperidine. Although definitive dependence studies in man have not been reported, extensive pharmacological and toxicological studies show little capacity to produce dependence in animals. Pentazocine has properties of both morphine and nalorphine and can cause physical dependence. Clinical studies of the close analog of propoxyphene, Lilly 31518, showed analgesic potency about one-third that of morphine, and some problems of dependence were seen. Other analogs of propoxyphene were active in rat inflamed foot, but unlike propoxyphene not in the normal foot.
Publication Year: 1971
Publication Date: 1971-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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