Title: Glutamatergic Neurotransmission, Aluminium and Alzheimer’s Disease
Abstract: Glutamate is the main excitatory neurotransmitter in mammals. Glutamatergic neurotransmission modulates many important cerebral processes. Alteration of glutamatergic neurotransmission may lead therefore to neurological alterations and to neurodegeneration and neuronal death. Glutamatergic neurotransmission may be altered at several different steps: the content (expression, synthesis and/or degradation) of the main proteins involved in glutamatergic neurotransmission (e.g. the different types of glutamate receptors or transporters); the regulation of the spatial location of the receptors and transporters; the function of the receptors and transporters, which is modulated in different ways including phosphorylation-dephosphorylation, binding of co-agonists, etc. Alterations in the release or uptake of glutamate may result in altered extracellular glutamate, leading to altered neurotransmission. Also, alterations in any of the steps of the signal transduction pathways associated with the different types of glutamate receptors would also result in impaired glutamatergic neurotransmission. The effects of aluminium and of Alzheimer's disease on different steps of glutamatergic neurotransmission are reviewed.
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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Cited By Count: 1
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