Title: Src Protein Kinases in Mouse and Rat Oocytes and Embryos
Abstract: Meiosis of the mammalian oocytes is a specialized cell division, initiated during the female’s embryonic life. It arrests at the germinal vesicle (GV) stage and resumes with GV breakdown, followed by segregation of the chromosomes and extrusion of the first polar body in an asymmetric cell division that concludes the first meiotic division, before arresting at metaphase of the second meiotic division (MII). Once fertilized, the oocyte exits from MII, extrudes the second polar body, and the developing zygote will continue dividing to create a blastocyst. Although the two processes of meiosis and mitosis have different developmental functions, it is believed that they share similar mechanisms. Src family kinases (SFKs) are nine non-receptor protein tyrosine kinases that regulate many key cellular functions including meiotic and mitotic cell cycles. In this review we discuss the involvement of SFKs in meiotic and mitotic cell cycle key processes as nuclear envelope breakdown, spindle stabilization, karyokinetic exit from metaphase, regulation of cortical actin, and cytokinetic cleavage furrow ingression.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 6
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