Title: Neuronal Cell Death and Axonal Degeneration: Neurofilaments as Biomarkers
Abstract:The aim of this chapter is to explain why Neurofilaments (Nf) are a useful biomarker for axonal degeneration and can be used as a surrogate endpoint in clinical and experimental research. Definitions...The aim of this chapter is to explain why Neurofilaments (Nf) are a useful biomarker for axonal degeneration and can be used as a surrogate endpoint in clinical and experimental research. Definitions Neurofilaments: Nf are proteins which are exclusively expressed in neurons and their adjacent axons.Nf are particularly abundant in the axon, where they are key building blocks of the axonal cytoskeleton.The complex protein chemistry of Nf is briefly described. Biomarker: A biomarker is a characteristic that is objectively measured and evaluated as an indicator of normal biologic processes, pathogenic processes, or pharmacological responses to therapeutic intervention. Surrogate endpoint : defines a biomarker that is intended to serve as a substitute of a clinically meaningful endpoint and is expected to predict the effect of a therapeutic intervention or the evolution of disease.Read More
Publication Year: 2012
Publication Date: 2012-01-20
Language: en
Type: reference-entry
Indexed In: ['crossref']
Access and Citation
Cited By Count: 1
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot