Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W87952807', 'doi': 'https://doi.org/10.1002/j.1460-2075.1996.tb00671.x', 'title': 'Evidence that a combined activator-repressor protein regulates Dictyostelium stalk cell differentiation.', 'display_name': 'Evidence that a combined activator-repressor protein regulates Dictyostelium stalk cell differentiation.', 'publication_year': 1996, 'publication_date': '1996-06-01', 'ids': {'openalex': 'https://openalex.org/W87952807', 'doi': 'https://doi.org/10.1002/j.1460-2075.1996.tb00671.x', 'mag': '87952807', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8670809', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/450250'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/j.1460-2075.1996.tb00671.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S127916151', 'display_name': 'The EMBO Journal', 'issn_l': '0261-4189', 'issn': ['0261-4189', '1460-2075'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc450250?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5003158540', 'display_name': 'Takefumi Kawata', 'orcid': 'https://orcid.org/0000-0002-3685-4492'}, 'institutions': [{'id': 'https://openalex.org/I4210093127', 'display_name': 'MRC Laboratory for Molecular Cell Biology', 'ror': 'https://ror.org/00fv61j67', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I4210087105', 'https://openalex.org/I4210093127', 'https://openalex.org/I45129253', 'https://openalex.org/I90344618']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'T Kawata', 'raw_affiliation_strings': ['MRC Laboratory of Molecular Cell Biology, University College Lodon, KUK.'], 'affiliations': [{'raw_affiliation_string': 'MRC Laboratory of Molecular Cell Biology, University College Lodon, KUK.', 'institution_ids': ['https://openalex.org/I4210093127']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090351215', 'display_name': 'Anne Early', 'orcid': 'https://orcid.org/0000-0001-9076-1310'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'A Early', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5073887611', 'display_name': 'Jason Williams', 'orcid': 'https://orcid.org/0000-0002-7500-7077'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J Williams', 'raw_affiliation_strings': [], 'affiliations': []}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 0, 'currency': 'USD', 'value_usd': 0, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.909, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 39, 'citation_normalized_percentile': {'value': 0.66038, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '15', 'issue': '12', 'first_page': '3085', 'last_page': '3092'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10379', 'display_name': 'Cell Mechanics and Extracellular Matrix Interactions', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10379', 'display_name': 'Cell Mechanics and Extracellular Matrix Interactions', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10492', 'display_name': 'Regulation and Function of Microtubules in Cell Division', 'score': 0.9773, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10423', 'display_name': 'Neuroscience and Genetics of Drosophila Melanogaster', 'score': 0.9668, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/extracellular-matrix', 'display_name': 'Extracellular Matrix', 'score': 0.442123}, {'id': 'https://openalex.org/keywords/yy1', 'display_name': 'YY1', 'score': 0.42309812}], 'concepts': [{'id': 'https://openalex.org/C158448853', 'wikidata': 'https://www.wikidata.org/wiki/Q425218', 'display_name': 'Repressor', 'level': 4, 'score': 0.93910986}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.89518964}, {'id': 'https://openalex.org/C2775889303', 'wikidata': 'https://www.wikidata.org/wiki/Q17146891', 'display_name': 'Dictyostelium', 'level': 3, 'score': 0.81871486}, {'id': 'https://openalex.org/C88045685', 'wikidata': 'https://www.wikidata.org/wiki/Q174576', 'display_name': 'Activator (genetics)', 'level': 3, 'score': 0.78674555}, {'id': 'https://openalex.org/C101762097', 'wikidata': 'https://www.wikidata.org/wiki/Q224093', 'display_name': 'Promoter', 'level': 4, 'score': 0.5445462}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.51473665}, {'id': 'https://openalex.org/C2775969001', 'wikidata': 'https://www.wikidata.org/wiki/Q134351', 'display_name': 'Dictyostelium discoideum', 'level': 3, 'score': 0.4426031}, {'id': 'https://openalex.org/C62944979', 'wikidata': 'https://www.wikidata.org/wiki/Q18032405', 'display_name': 'YY1', 'level': 5, 'score': 0.42309812}, {'id': 'https://openalex.org/C94966510', 'wikidata': 'https://www.wikidata.org/wiki/Q2252764', 'display_name': 'DNA-binding protein', 'level': 4, 'score': 0.42067537}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4176748}, {'id': 'https://openalex.org/C186310378', 'wikidata': 'https://www.wikidata.org/wiki/Q941796', 'display_name': 'Psychological repression', 'level': 4, 'score': 0.41098782}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.36292356}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.29445428}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.22525448}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.19505599}], 'mesh': [{'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D004023', 'descriptor_name': 'Dictyostelium', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D016326', 'descriptor_name': 'Extracellular Matrix Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D006588', 'descriptor_name': 'Hexanones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015800', 'descriptor_name': 'Protozoan Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012045', 'descriptor_name': 'Regulatory Sequences, Nucleic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017868', 'descriptor_name': 'Cyclic AMP-Dependent Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017868', 'descriptor_name': 'Cyclic AMP-Dependent Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004271', 'descriptor_name': 'DNA, Fungal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D004023', 'descriptor_name': 'Dictyostelium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004023', 'descriptor_name': 'Dictyostelium', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016326', 'descriptor_name': 'Extracellular Matrix Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005656', 'descriptor_name': 'Fungal Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005656', 'descriptor_name': 'Fungal Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006588', 'descriptor_name': 'Hexanones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/j.1460-2075.1996.tb00671.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S127916151', 'display_name': 'The EMBO Journal', 'issn_l': '0261-4189', 'issn': ['0261-4189', '1460-2075'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc450250', 'pdf_url': 'https://europepmc.org/articles/pmc450250?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8670809', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc450250', 'pdf_url': 'https://europepmc.org/articles/pmc450250?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.41, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W104716945', 'https://openalex.org/W1879374409', 'https://openalex.org/W1949079829', 'https://openalex.org/W1969527771', 'https://openalex.org/W1972610315', 'https://openalex.org/W1974473949', 'https://openalex.org/W1978947839', 'https://openalex.org/W1988176977', 'https://openalex.org/W1993212786', 'https://openalex.org/W1995639458', 'https://openalex.org/W2004474008', 'https://openalex.org/W2011852078', 'https://openalex.org/W2012975616', 'https://openalex.org/W2021096030', 'https://openalex.org/W2021524912', 'https://openalex.org/W2024654045', 'https://openalex.org/W2026419188', 'https://openalex.org/W2030869191', 'https://openalex.org/W2032464134', 'https://openalex.org/W2032504888', 'https://openalex.org/W2039422775', 'https://openalex.org/W2056378879', 'https://openalex.org/W2061491975', 'https://openalex.org/W2067378307', 'https://openalex.org/W2067393090', 'https://openalex.org/W2072169747', 'https://openalex.org/W2073240421', 'https://openalex.org/W2074041350', 'https://openalex.org/W2075109763', 'https://openalex.org/W2075232957', 'https://openalex.org/W2082246519', 'https://openalex.org/W2091433533', 'https://openalex.org/W2154917200', 'https://openalex.org/W2162422917', 'https://openalex.org/W2162749292', 'https://openalex.org/W2185324773', 'https://openalex.org/W2289014684', 'https://openalex.org/W2471927801', 'https://openalex.org/W338489980', 'https://openalex.org/W4246210234', 'https://openalex.org/W94487769'], 'related_works': ['https://openalex.org/W4243471526', 'https://openalex.org/W3209588668', 'https://openalex.org/W3015698348', 'https://openalex.org/W2913547167', 'https://openalex.org/W2519058576', 'https://openalex.org/W247369369', 'https://openalex.org/W2399065385', 'https://openalex.org/W2071933226', 'https://openalex.org/W2034720620', 'https://openalex.org/W2015897732'], 'abstract_inverted_index': {'The': [0, 20], 'ecmA': [1, 58, 87], 'gene': [2, 22], 'is': [3, 10, 23, 29, 126], 'expressed': [4, 24], 'in': [5, 25, 47, 56, 67, 120], 'Dictyostelium': [6], 'prestalk': [7, 94, 122], 'cells': [8, 27, 119], 'and': [9, 28, 85, 101], 'inducible': [11], 'by': [12, 33, 97], 'differentiation-inducing': [13], 'factor': [14], '(DIF),': [15], 'a': [16, 115], 'low-molecular-weight': [17], 'lipophilic': [18], 'substance.': [19], 'ecmB': [21, 83], 'stalk': [26], 'under': [30], 'negative': [31], 'control': [32], 'two': [34, 41, 63], 'repressor': [35, 38, 84, 116], 'elements.': [36], 'Each': [37], 'element': [39], 'contains': [40], 'copies': [42], 'of': [43, 110], 'the': [44, 57, 68, 77, 82, 86, 103, 108, 121], 'sequence': [45], 'TTGA': [46, 64], 'an': [48], 'inverted': [49], 'relative': [50, 70], 'orientation.': [51, 71], 'There': [52], 'are': [53], 'activator': [54], 'elements': [55], 'promoter': [59], 'that': [60, 76, 91, 102, 117], 'also': [61, 105], 'contain': [62], 'sequences,': [65], 'but': [66], 'same': [69, 78], 'Gel': [72], 'retardation': [73], 'assays': [74], 'suggest': [75], 'protein': [79, 100, 104], 'binds': [80, 106], 'to': [81, 107], 'activator.': [88], 'We': [89], 'propose': [90], 'DIF': [92], 'induces': [93], 'cell': [95], 'differentiation': [96], 'activating': [98], 'this': [99], 'promoters': [109], 'stalk-specific': [111], 'genes,': [112], 'acting': [113], 'as': [114], 'holds': [118], 'state': [123], 'until': [124], 'culmination': [125], 'triggered.': [127]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W87952807', 'counts_by_year': [{'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-08-13T21:09:25.078219', 'created_date': '2016-06-24'}