Title: Injection Formulation of Paclitaxel Employing Solid Lipid Nanoparticles (SLN)
Abstract:Many studies have been attempted to overcome the problems of paclitaxel related to the extremely low aqueous solubility of paclitaxel and the unexpected side-effects caused by EL in a commercial pacli...Many studies have been attempted to overcome the problems of paclitaxel related to the extremely low aqueous solubility of paclitaxel and the unexpected side-effects caused by EL in a commercial paclitaxel formulation, . In order to formulate a new delivery system suitable for intravenous administration without toxic excipients, in this study, paclitaxel was incorporated into solid lipid nanoparticles (Px-SLN) by hot homogenization technique using a microfluidizer. Particle size and zeta potential were measured by a Zetasizer. In vitro drug release experiment was performed by a dialysis diffusion method. Each Px-SLN or was intravenously administered to the male Sprague-Dawley rats at a dose of 5 mg/kg as paclitaxel. Blood samples were deproteinated with acetonitrile and assayed for paclitaxel by the validated HPLC/MS/MS method. Mean particle size and zeta potential were measured as 72.1 nm (. The of Px-SLN was 3.4-fold greater than that of . The Px-SLN might be a promising candidate for an alternative formulation for the parenteral delivery of paclitaxel.Read More
Publication Year: 2003
Publication Date: 2003-12-20
Language: en
Type: article
Indexed In: ['crossref']
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