Title: Organizational and Cellular Mechanisms Underlying Chemical Inhibition of A Vertebrate Neuron
Abstract: Little is known so far about the cellular principles underlying integration in the vertebrate central nervous system (CNS) because few neuronal constellations permit meaningful comparison between anatomical and functional data; while the former have accumulated in the past, the latter have been obtained infrequently, primarily because of technical limitations. It can be expected, however, that investigations of basic networks may allow us to unravel some operative rules before generalization is attempted for higher brain functions. Such models should include morphologically well-defined post synaptic elements and their associated excitatory and inhibitory inputs. For instance, spinal motoneurons and neocortical pyramidal cells, with their excitatory afferents and intercalated inhibitory interneurons are imbedded in elementary circuits of this nature. This chapter presents analyses of apparently quite disparate arrays, such as those that involve the mammalian Purkinje cells (Pc) and the Mauthner cell (M-cell) of teleosts indicate common patterns that might be present in the other structures as well. This work has been made possible by the fact that both experimental materials, particularly that of the M-cell, are well suited for electrophysiological investigations and for extensive histological correlations.
Publication Year: 1983
Publication Date: 1983-01-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 6
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