Title: SPECIFICITY OF NATURAL KILLER (NK) CELLS: NATURE OF TARGET CELL STRUCTURES
Abstract: This chapter discusses the specificity of natural killer cells and nature of target cell structures. NK cells have now demonstrated the killing of a wide variety of malignant cells and some normal cells to a lesser extent without any apparent need for prior stimulation. Studies using unlabelled targets in cross competition assays with a panel of Cr labeled target cells have shown that cytotoxicity could be inhibited by some but not all target cells. Those cells most sensitive to NK lysis proved to be the best competitors, and a good correlation was found between susceptibility to direct lysis and competition among a variety of targets. The ability of different cell lines to compete inferred but did not prove the existence of cross reacting target antigens and a complementary receptor on the effector cell. The studies on human target cell lines have demonstrated the presence of neutral 140,000 d glycoproteins which inhibited NK but not antibody-dependent cellular cytotoxicity. Similar structures were not found in supernatants of NK-resistant cell lines. The results from both murine and human systems demonstrate that glycoproteins are effective in inhibiting target cell–effector cell interactions and subsequent cytolysis, suggesting carbohydrate moieties as possible target structures.
Publication Year: 1982
Publication Date: 1982-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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Cited By Count: 4
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