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'Evolutionary': [110], 'Strategies': [111], 'approach': [112], 'minimize': [114, 144, 225], 'or': [115], 'maximize': [116, 151], 'non-synonymous': [120], 'substitutions': [121], 'costs': [123, 153, 227], 'amino': [125, 156], 'acid': [126, 157], 'replacements': [127], 'depending': [128], 'their': [130, 152], 'physicochemical': [131], 'properties.': [132], 'results': [134], 'show': [135], 'empirical': [138, 218], 'have': [140], 'tendency': [142], 'effects': [146, 185], 'rather': [149, 222], 'than': [150], 'level.': [158], 'They': [159], 'also': [161], 'similar': [162, 238], 'in': [168, 192, 196, 228, 232], 'nucleotide': [170], 'substitution': [171], 'pattern,': [172], 'especially': [173], 'high': [175], 'transitions/transversions': [176], 'ratio.': [177], 'We': [178], 'observed': [179], 'no': [180], 'substantial': [181], 'differences': [182], 'under': [194], 'respect': [197], 'differently': [199], 'replicated': [200], 'DNA': [201], 'strands,': [202], 'cost': [204], 'types': [205], 'properties': [207], 'referenced': [210], 'matrices.': [212], 'findings': [214], 'indicate': [215], 'adapted': [223], 'studied': [230], 'comparison': [233], 'mathematical': [239], 'constraints.': [240]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W797482215', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 3}], 'updated_date': '2024-09-01T01:04:58.183935', 'created_date': '2016-06-24'}