Publication Information

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'abstract_inverted_index': {'Faithful': [0], 'duplication': [1], 'and': [2, 15, 180, 192, 217, 283, 310, 362, 371, 408, 425, 437, 443], 'segregation': [3], 'of': [4, 12, 17, 25, 39, 71, 110, 119, 128, 133, 151, 250, 379, 398], 'undamaged': [5], 'DNA': [6, 40, 51, 81, 89, 139, 165, 215, 245, 293, 393], 'is': [7, 48, 53, 141, 207], 'critical': [8], 'to': [9, 60, 88, 97, 138, 164, 204, 210, 220, 242, 255, 281, 292, 308, 312, 335, 387, 392, 448], 'the': [10, 37, 69, 79, 108, 114, 117, 126, 129, 175, 189, 193, 303, 318, 344, 364, 399, 420, 433, 444], 'survival': [11], 'all': [13], 'organisms': [14], 'prevention': [16], 'oncogenesis': [18], 'in': [19, 36, 68, 86, 116, 136, 162, 214, 229, 231, 240, 275, 290, 323, 368, 390, 416], 'multicellular': [20], 'organisms.': [21], 'To': [22], 'ensure': [23], 'inheritance': [24], 'intact': [26], 'DNA,': [27], 'cells': [28], 'rely': [29], 'on': [30], 'checkpoints.': [31], 'Checkpoints': [32], 'alter': [33], 'cellular': [34], 'processes': [35], 'presence': [38, 70, 118], 'damage': [41, 52, 82, 140, 166, 246], 'preventing': [42], 'cell': [43], 'cycle': [44], 'transitions': [45], 'until': [46], 'replication': [47, 64, 85, 111, 130, 152, 161, 206, 266, 279, 285, 389], 'completed': [49], 'or': [50, 384], 'repaired.': [54], 'Several': [56], 'checkpoints': [57], 'are': [58], 'specific': [59], 'S-phase.': [61], 'The': [62, 199, 395], 'S-M': [63], 'checkpoint': [65, 83, 92, 102, 124, 176, 187, 218, 247], 'prevents': [66, 103], 'mitosis': [67], 'unreplicated': [72], 'DNA.': [73, 121], 'Rather': [74], 'than': [75], 'outright': [76], 'halting': [77], 'replication,': [78], 'S-phase': [80, 244], 'slows': [84, 125], 'response': [87, 137, 163, 219, 291, 391], 'damage.': [90, 221, 294, 394], 'This': [91], 'utilizes': [93], 'two': [94, 269], 'general': [95], 'mechanisms': [96], 'slow': [98, 160, 205, 313, 388], 'replication.': [99], 'First,': [100], 'this': [101, 123, 146, 236], 'origin': [104, 134, 251], 'firing': [105, 135], 'thus': [106], 'limiting': [107], 'number': [109], 'forks': [112], 'traversing': [113], 'genome': [115], 'damaged': [120], 'Second,': [122], 'progression': [127, 154], 'forks.': [131], 'Inhibition': [132], 'well': [142, 184], 'established,': [143], 'however': [144], 'when': [145], 'thesis': [147], 'work': [148], 'began,': [149], 'slowing': [150, 280, 340, 361], 'fork': [153, 286], 'was': [155, 263, 288, 327], 'controversial.': [156], 'Fission': [158], 'yeast': [159, 224, 232], 'utilizing': [167], 'an': [168], 'evolutionarily': [169], 'conserved': [170], 'kinase': [171], 'cascade.': [172], 'Slowing': [173], 'requires': [174], 'kinases': [177], 'Rad3': [178], '(hATR)': [179], 'Cds1': [181], '(hChk2)': [182], 'as': [183, 185, 418], 'additional': [186, 357], 'components,': [188], 'Rad9-Rad1-Hus1': [190], 'complex': [191, 442], 'Mre11-Rad50-Nbs1': [194], '(MRN)': [195], 'recombinational': [196], 'repair': [197], 'complex.': [198], 'exact': [200], 'role': [201], 'MRN': [202, 225, 400], 'serves': [203], 'obscure': [208], 'due': [209], 'its': [211], 'many': [212], 'roles': [213], 'metabolism': [216, 287], 'However,': [222, 268], 'fission': [223], 'mutants': [226, 300, 380], 'display': [227, 243], 'defects': [228, 248], 'recombination': [230, 262, 333, 348], 'and,': [233], 'upon': [234], 'beginning': [235], 'project,': [237], 'were': [238], 'described': [239, 367], 'vertebrates': [241], 'independent': [249], 'firing.': [252], 'Due': [254], 'these': [256], 'observations,': [257], 'I': [258, 277, 352], 'initially': [259], 'hypothesized': [260], 'that': [261, 317], 'required': [264, 328, 359], 'for': [265, 302, 329, 339, 356, 360], 'slowing.': [267, 330], 'observations': [270], 'forced': [271], 'a': [272, 354, 376, 413], 'paradigm': [273], 'shift': [274], 'how': [276, 284], 'thought': [278], 'occur': [282], 'altered': [289], 'We': [295, 315, 374, 431], 'found': [296, 375, 432], 'rhp51': [298], 'Δ': [299, 347, 407, 411, 424, 429, 436, 440], '(mutant': [301], 'central': [304], 'mitotic': 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'Rhp51-mediator': [426], 'sfr1': [428], 'mutants.': [430], 'mus81': [435], 'eme1': [439], 'endonuclease': [441], 'smc6-x': [446], 'hypomorph': [447], 'fail': [450], 'to…': [451]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W781610663', 'counts_by_year': [], 'updated_date': '2024-12-14T07:39:28.180724', 'created_date': '2016-06-24'}