Title: Predictors of retrograde amnesia following ECT
Abstract: Back to table of contents Previous article Next article No AccessPredictors of retrograde amnesia following ECTPublished Online:1 Apr 2006https://doi.org/10.1176/ajp.152.7.995AboutSectionsView articleAbstractPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail View articleAbstractOBJECTIVE: Substantial progress has been made in identifying how the treatment parameters used in ECT impact on cognitive side effects. However, there is limited information regarding individual differences in vulnerability to these side effects. The authors examined patients' pretreatment global cognitive status and postictal orientation recovery time as potential predictors of the magnitude of retrograde amnesia for autobiographical memories after ECT. METHOD: Seventy-one inpatients with major depressive disorder were randomly assigned to four ECT conditions that varied in electrode placement (right unilateral versus bilateral) and stimulus dosage (low versus high intensity). Orientation recovery time was assessed at virtually every session during the course of ECT. Global cognitive status was assessed with the modified Mini- Mental State examination before treatment, during the week after termination of treatment, and 2 months after treatment ended. Retrograde amnesia was assessed at these same time points with the Autobiographical Memory Interview. RESULTS: Pre-ECT global cognitive status and the duration of postictal disorientation were strong predictors of the magnitude of retrograde amnesia in the week after the course of ECT and at 2-month follow-up. In general, these relationships were maintained regardless of technical parameters in the administration of the ECT. CONCLUSIONS: Patients who manifest global cognitive impairment before treatment and patients who experience prolonged disorientation in the acute postictal period may be the most vulnerable to persistent retrograde amnesia for autobiographical information. Access content To read the fulltext, please use one of the options below to sign in or purchase access. Personal login Institutional Login Sign in via OpenAthens Purchase Save for later Item saved, go to cart PPV Articles - American Journal of Psychiatry $35.00 Add to cart PPV Articles - American Journal of Psychiatry Checkout Please login/register if you wish to pair your device and check access availability. Not a subscriber? Subscribe Now / Learn More PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. 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FiguresReferencesCited byDetailsCited bySeizure duration predicts postictal electroencephalographic recovery after electroconvulsive therapy-induced seizuresClinical Neurophysiology, Vol. 148Correlates of electroconvulsive therapy with neurocognitive functioning, subjective memory and depressionJournal of Affective Disorders Reports, Vol. 10Study of effect of nimodipine and acetaminophen on postictal symptoms in depressed patients after electroconvulsive therapy (SYNAPSE)18 April 2022 | Trials, Vol. 23, No. 1Cerebral oxygen saturation in the prefrontal cortex during electroconvulsive therapy and its relation with the postictal reorientation timeJournal of Psychiatric Research, Vol. 155Rivastigmine for ECT-induced cognitive adverse effects in late life depression (RECALL study): A multicenter, randomized, double blind, placebo-controlled, cross-over trial in patients with depression aged 55 years or older: Rationale, objectives and methods15 July 2022 | Frontiers in Psychiatry, Vol. 13Clinicians’ Approach to Cognitive Impairment After Electroconvulsive Therapy: Current Situations and Challenges2 March 2022 | Archives of Neuroscience, Vol. 9, No. 1The utility of the brief ECT cognitive screen (BECS) for early prediction of cognitive adverse effects from ECT: A CARE network studyJournal of Psychiatric Research, Vol. 145Duration of Electroconvulsive Therapy Postictal Burst Suppression Is Associated With Time to Reorientation22 July 2021 | The Journal of ECT, Vol. 37, No. 4Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for Depression (CREST-MST): study protocol for a randomized non-inferiority trial of magnetic seizure therapy versus electroconvulsive therapy8 November 2021 | Trials, Vol. 22, No. 1Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for Depression (CREST-MST): protocol for identification of novel biomarkers via neurophysiology11 December 2021 | Trials, Vol. 22, No. 1Effects of modifying the electrode placement and pulse width on cognitive side effects with unilateral ECT: A pilot randomised controlled study with computational modellingBrain Stimulation, Vol. 14, No. 6The Neurobiological Basis of Cognitive Side Effects of Electroconvulsive Therapy: A Systematic Review26 September 2021 | Brain Sciences, Vol. 11, No. 10Is There Evidence That Stimulus Parameters and Electrode Placement Affect the Cognitive Side Effects of Electroconvulsive Therapy in Patients With Schizophrenia and Schizoaffective Disorder?23 December 2020 | The Journal of ECT, Vol. 37, No. 2Electroconvulsive therapy related autobiographical amnesia: a review and case report19 January 2021 | Cognitive Neuropsychiatry, Vol. 26, No. 2Need for Standardization of Measurement of Time to Reorientation as a Predictor of Cognitive Adverse Effects of Electroconvulsive Therapy2 July 2020 | The Journal of ECT, Vol. 37, No. 1Factors associated with post-electroconvulsive therapy delirium9 April 2021 | Medicine, Vol. 100, No. 14Treating Posttraumatic Stress Disorder Symptoms With Low Amplitude Seizure Therapy (LAP-ST) Compared With Standard Right Unilateral Electroconvulsive Therapy2 July 2020 | The Journal of ECT, Vol. 36, No. 4Double-Blinded Randomized Pilot Clinical Trial Comparing Cognitive Side Effects of Standard Ultra-Brief Right Unilateral ECT to 0.5 A Low Amplitude Seizure Therapy (LAP-ST)13 December 2020 | Brain Sciences, Vol. 10, No. 12The impact of electroconvulsive therapy on brain grey matter volume: What does it mean?Brain Stimulation, Vol. 13, No. 5A two-site, open-label, non-randomized trial comparing Focal Electrically-Administered Seizure Therapy (FEAST) and right unilateral ultrabrief pulse electroconvulsive therapy (RUL-UBP ECT)Brain Stimulation, Vol. 13, No. 5Brief cognitive screening instruments for electroconvulsive therapy: Which one should I use?21 May 2020 | Australian & New Zealand Journal of Psychiatry, Vol. 54, No. 9Psychotic depressive subtype and white mater hyperintensities do not predict cognitive side effects in ECT: A systematic review of pretreatment predictorsJournal of Affective Disorders, Vol. 272Cognitive effects of brief and ultrabrief pulse bitemporal electroconvulsive therapy: a randomised controlled proof-of-concept trial2 May 2019 | Psychological Medicine, Vol. 50, No. 7Cognitive side-effects of electroconvulsive therapy: what are they, how to monitor them and what to tell patients17 April 2020 | BJPsych Open, Vol. 6, No. 3Effects of the Anaesthetic-ECT time interval and ventilation rate on seizure quality in electroconvulsive therapy: A prospective randomised trialBrain Stimulation, Vol. 13, No. 2Feasibility of the Audio Recorded Cognitive Screen in the Assessment of Individuals Undergoing Electroconvulsive Therapy8 January 2020 | The Journal of ECT, Vol. 36, No. 1Systematic Monitoring of Cognitive Function During Electroconvulsive Therapy28 January 2020 | The Journal of ECT, Vol. 36, No. 1Effects of magnetic seizure therapy on anterograde and retrograde amnesia in treatment‐resistant depression4 November 2019 | Depression and Anxiety, Vol. 37, No. 2Preventive effect of dexmedetomidine on postictal delirium after electroconvulsive therapyEuropean Journal of Anaesthesiology, Vol. 37, No. 1Factors Associated With Delirium Following Electroconvulsive Therapy12 July 2019 | The Journal of ECT, Vol. 35, No. 4Study protocol for a parallel-group, double-blinded, randomized, controlled, noninferiority trial: the effect and safety of hybrid electroconvulsive therapy (Hybrid-ECT) compared with routine electroconvulsive therapy in patients with depression6 November 2019 | BMC Psychiatry, Vol. 19, No. 1The anaesthetic-ECT time interval with thiopentone—Impact on seizure qualityJournal of Affective Disorders, Vol. 252The Cognitive Effects of Electroconvulsive Therapy: A Critical ReviewPsychiatric Annals, Vol. 49, No. 4European Neuropsychopharmacology, Vol. 29Acta Psychiatrica Scandinavica, Vol. 140, No. 5Concomitant Transcranial Direct Current Stimulation With Ultrabrief Electroconvulsive TherapyThe Journal of ECT, Vol. 34, No. 4The Clinical Alliance and Research in Electroconvulsive Therapy NetworkThe Journal of ECT, Vol. 34, No. 1Defense Automated Neurobehavioral Assessment Accurately Measures Cognition in Patients Undergoing Electroconvulsive Therapy for Major Depressive DisorderThe Journal of ECT, Vol. 34, No. 1Validation of the 10-Item Orientation QuestionnaireThe Journal of ECT, Vol. 34, No. 1Asian Journal of Psychiatry, Vol. 34The American Journal of Geriatric Psychiatry, Vol. 26, No. 4Selective modulation of brain network dynamics by seizure therapy in treatment-resistant depressionNeuroImage: Clinical, Vol. 20Frontiers in Psychiatry, Vol. 9The use of ketamine in ECT anaesthesia: A systematic review and critical commentary on efficacy, cognitive, safety and seizure outcomes28 November 2016 | The World Journal of Biological Psychiatry, Vol. 18, No. 6The Lancet Psychiatry, Vol. 4, No. 5Computational models of Bitemporal, Bifrontal and Right Unilateral ECT predict differential stimulation of brain regions associated with efficacy and cognitive side effects3 February 2017 | European Psychiatry, Vol. 41, No. 1Journal of Affective Disorders, Vol. 217Journal of Affective Disorders, Vol. 222Journal of Psychiatric Research, Vol. 92Psychological Medicine, Vol. 47, No. 3International Review of Psychiatry, Vol. 29, No. 2Evidence Based Mental Health, Vol. 20, No. 1Efficacy and Mechanism Evaluation, Vol. 4, No. 2Psychology, Vol. 08, No. 04Right Unilateral Ultrabrief Pulse ECT in Geriatric Depression: Phase 1 of the PRIDE StudyCharles H. Kellner, M.D., Mustafa M. Husain, M.D., Rebecca G. Knapp, Ph.D., W. Vaughn McCall, M.D., M.S., Georgios Petrides, M.D., Matthew V. Rudorfer, M.D., Robert C. Young, M.D., Shirlene Sampson, M.D., Shawn M. McClintock, Ph.D., Martina Mueller, Ph.D., Joan Prudic, M.D., Robert M. Greenberg, M.D., Richard D. Weiner, M.D., Ph.D., Samuel H. Bailine, M.D., Peter B. Rosenquist, M.D., Ahmad Raza, M.D., Ph.D., Styliani Kaliora, M.D., Vassilios Latoussakis, M.D., , Kristen G. Tobias, M.A., Mimi C. Briggs, B.A., Lauren S. Liebman, B.A., Emma T. Geduldig, B.A., Abeba A. Teklehaimanot, M.S., Sarah H. Lisanby, M.D., 15 July 2016 | American Journal of Psychiatry, Vol. 173, No. 11Use of Orally Disintegrating Olanzapine During Electroconvulsive Therapy for Prevention of Postictal AgitationJournal of Psychiatric Practice, Vol. 22, No. 6Expanded Safety and Efficacy Data for a New Method of Performing Electroconvulsive TherapyThe Journal of ECT, Vol. 32, No. 3The Clinical Practice of Assessing Cognitive Function in Adults Receiving Electroconvulsive TherapyThe Journal of ECT, Vol. 32, No. 2Bitemporal Versus High-Dose Unilateral Twice-Weekly Electroconvulsive Therapy for Depression (EFFECT-Dep): A Pragmatic, Randomized, Non-Inferiority TrialMaria Semkovska, Ph.D., Sabine Landau, Ph.D., Ross Dunne, M.R.C.Psych., Erik Kolshus, M.R.C.Psych., Adam Kavanagh, Ph.D., Ana Jelovac, B.A., Martha Noone, Ph.D., Mary Carton, Ph.D., Sinead Lambe, M.Sc., Caroline McHugh, M.Sc., Declan M. McLoughlin, Ph.D., M.R.C.P.I., M.R.C.Psych.19 February 2016 | American Journal of Psychiatry, Vol. 173, No. 4Moving Beyond Mood: Is it Time to Recommend Cognitive Training for Depression in Older Adults?2 August 2016Journal of Affective Disorders, Vol. 190Psychiatric Clinics of North America, Vol. 39, No. 3Acta Psychiatrica Scandinavica, Vol. 134, No. 6Electroconvulsive Therapy7 April 2016Depressive Disorders: Major Depressive Disorder and Persistent Depressive Disorder20 February 2015Hirnstimulationsverfahren in der klinischen Anwendung21 January 2015 | NeuroTransmitter, Vol. 26, No. 1Journal of Affective Disorders, Vol. 175The Clinical Neuropsychologist, Vol. 29, No. 4International Journal of Neuropsychopharmacology, Vol. 18, No. 12BMC Psychiatry, Vol. 15, No. 1Iranian Journal of Psychiatry and Behavioral Sciences, Vol. 9, No. 3Current Treatment Options in Psychiatry, Vol. 1, No. 1Journal of Psychiatric Research, Vol. 53Psychosomatics, Vol. 55, No. 3Revista de Psiquiatría y Salud Mental, Vol. 7, No. 1Revista de Psiquiatría y Salud Mental (English Edition), Vol. 7, No. 1The Clinical Neuropsychologist, Vol. 28, No. 7Neuropsychiatry, Vol. 4, No. 1A Feasibility Study of a New Method for Electrically Producing Seizures in Man: Focal Electrically Administered Seizure Therapy [FEAST]Brain Stimulation, Vol. 6, No. 3Journal of Psychiatric Research, Vol. 47, No. 12Psychiatric Clinics of North America, Vol. 36, No. 4International Journal of Neuropsychopharmacology, Vol. 16, No. 1The Psychiatrist, Vol. 37, No. 8Sicherheits- und Nebenwirkungsprofil der EKT4 February 2014Revista Colombiana de Psiquiatría, Vol. 41, No. 2Journal of Affective Disorders, Vol. 142, No. 1-3Resolution of Amnestic Effects of an Extended Course of Electroconvulsive TherapyThe Journal of ECT, Vol. 27, No. 3Self-Evaluation of the Cognitive Effects of Electroconvulsive TherapyThe Journal of ECT, Vol. 27, No. 1Effects of 3 different stimulus intensities of ultrabrief stimuli in right unilateral electroconvulsive therapy in major depression: A randomized, double-blind pilot studyJournal of Psychiatric Research, Vol. 45, No. 2Biological Psychiatry, Vol. 69, No. 8Journal of Psychiatric Research, Vol. 45, No. 5Expert Review of Medical Devices, Vol. 8, No. 6Neuropsychiatry, Vol. 1, No. 5Electroconvulsive therapy-induced persistent retrograde amnesia: Could it be minimised by ketamine or other pharmacological approaches?Journal of Affective Disorders, Vol. 126, No. 1-2New-Onset Dissociative Disorder After Electroconvulsive TherapyThe Journal of ECT, Vol. 26, No. 3Introducing Magnetic Seizure Therapy: A Novel Therapy for Treatment Resistant Depression1 July 2010 | Australian & New Zealand Journal of Psychiatry, Vol. 44, No. 7Impact of Hyperventilation on Stimulus Efficiency During the Early Phase of an Electroconvulsive Therapy CourseThe Journal of ECT, Vol. 26, No. 2Journal of Affective Disorders, Vol. 122, No. 1-2Nature Reviews Neurology, Vol. 6, No. 5British Journal of Psychiatry, Vol. 196, No. 3Effective Utilization and Future Directions for Repetitive Transcranial Magnetic Stimulation: A Guide for Psychiatric Nurses11 November 2009 | Journal of the American Psychiatric Nurses Association, Vol. 15, No. 5Comparison of Propofol and Thiopental as Anesthetic Agents for Electroconvulsive TherapyThe Journal of ECT, Vol. 25, No. 2Drugs, Vol. 69, No. 15Differential Effects of High-Dose Magnetic Seizure Therapy and Electroconvulsive Shock on Cognitive FunctionBiological Psychiatry, Vol. 63, No. 12A Dissociation Between Anterograde and Retrograde Amnesia After Treatment With Electroconvulsive TherapyThe Journal of ECT, Vol. 24, No. 2Neurobiological Correlates of the Cognitive Side Effects of Electroconvulsive TherapyThe Journal of ECT, Vol. 24, No. 1The Cognitive Side Effects of Modern ECTThe Journal of ECT, Vol. 24, No. 1Monitoring of Cognitive Effects During a Course of Electroconvulsive TherapyThe Journal of ECT, Vol. 24, No. 1Strategies to Minimize Cognitive Side Effects With ECTThe Journal of ECT, Vol. 24, No. 1Cognitive Side Effects of Brief Pulse Electroconvulsive TherapyThe Journal of ECT, Vol. 24, No. 1Pharmacological Attenuation of Electroconvulsive Therapy-Induced Cognitive DeficitsThe Journal of ECT, Vol. 24, No. 1The Effect of Electroconvulsive Therapy on Autobiographical MemoryThe Journal of ECT, Vol. 24, No. 1Early Effects of Electroconvulsive Therapy on Cognitive FunctionThe Journal of ECT, Vol. 24, No. 1A Review of the Cognitive Effects of Electroconvulsive Therapy in Older AdultsThe Journal of ECT, Vol. 24, No. 1Section I – The efficacy and safety of electroconvulsive therapySection II – Focal brain stimulation approaches to psychiatric treatmentInternational Journal of Geriatric Psychiatry, Vol. 23, No. 8Brain Stimulation, Vol. 1, No. 1Brain Stimulation, Vol. 1, No. 2British Journal of Psychiatry, Vol. 193, No. 2Treatment of Post-Electroconvulsive Therapy Delirium and Agitation With DonepezilThe Journal of ECT, Vol. 23, No. 1Journal of Affective Disorders, Vol. 101, No. 1-3Neuropsychopharmacology, Vol. 32, No. 1Therapeutic and Prophylactic Utility of the Memory-Enhancing Drug Donepezil Hydrochloride on Cognition of Patients Undergoing Electroconvulsive TherapyThe Journal of ECT, Vol. 22, No. 3Wiener Medizinische Wochenschrift, Vol. 156, No. 5-6, Vol. 72Clinical Psychology: Science and Practice, Vol. 12, No. 3Building an ECT Service: An Outcomes-Equivalent Approach25 June 2016 | Australasian Psychiatry, Vol. 13, No. 2Der Nervenarzt, Vol. 76, No. 1The American Journal of Geriatric Psychiatry, Vol. 13, No. 4Neuropsychobiology, Vol. 52, No. 4Clinical Neuroscience Research, Vol. 4, No. 1-2Clinical Neuroscience Research, Vol. 4, No. 1-2Neuropsychopharmacology, Vol. 29, No. 4The Journal of ECT, Vol. 20, No. 1The Journal of ECT, Vol. 20, No. 1Indikationsabhängige Durchführung und Bewertung der ElektrokonvulsionstherapieWiener Klinische Wochenschrift, Vol. 115, No. 9Neuropsychopharmacology, Vol. 28, No. 10Neuropsychopharmacology, Vol. 28, No. 11The Journal of ECT, Vol. 19, No. 3Cognitive and Behavioral Neurology, Vol. 16, No. 2Differential response to right unilateral ECT in depressed patients: impact of comorbidity and severity of illness [ISRCTN39974945]17 January 2002 | BMC Psychiatry, Vol. 2, No. 1Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, Vol. 94, No. 4The Journal of ECT, Vol. 18, No. 3Psychogeriatrics, Vol. 2, No. 4The Use of Electroconvulsive Therapy in Special Patient Populations1 October 2001 | The Canadian Journal of Psychiatry, Vol. 46, No. 8Journal of Affective Disorders, Vol. 66, No. 2-3The Journal of ECT, Vol. 17, No. 1The Journal of ECT, Vol. 17, No. 2The Journal of ECT, Vol. 17, No. 3ECT: survivors in the driving seatPractice Nursing, Vol. 11, No. 6Depression and Anxiety, Vol. 12, No. 3Annals of Neurology, Vol. 47, No. 1ReferencesBiological Psychiatry, Vol. 48, No. 3The Journal of ECT, Vol. 16, No. 2The Journal of ECT, Vol. 16, No. 2The Journal of ECT, Vol. 16, No. 2Medical Journal of Australia, Vol. 171, No. 5Effects of electroconvulsive therapy on plasma vasopressin and oxytocinBiological Psychiatry, Vol. 44, No. 7Prolactin response to electroconvulsive therapy: Effects of electrode placement and stimulus dosageBiological Psychiatry, Vol. 43, No. 2Preservation of Temporal Skills in Alzheimer's Disease7 October 2016 | Perceptual and Motor Skills, Vol. 85, No. 1Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 21, No. 8Brain Morphology in Primary Mood Disorders: Implications for Electroconvulsive TherapyPsychiatric Annals, Vol. 26, No. 11Neurocase, Vol. 2, No. 4Current Opinion in Psychiatry, Vol. 9, No. 1 Volume 152Issue 7 July 1995Pages 995-1001 Metrics PDF download History Published online 1 April 2006 Published in print 1 July 1995
Publication Year: 1995
Publication Date: 1995-07-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 249
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