Title: Modern biooxidation : enzymes, reactions and applications
Abstract: 1 Biooxidation with PQQ- and FAD-Dependent Dehydrogenases (Osao Adachi, Yoshitaka Ano, Hirohide Toyama, and Kazunobu Matsushita). 1.1 Introduction. 1.2 Basic Technical Information Regarding Membrane-bound Enzymes. 1.3 PQQ-Dependent Dehydrogenases. 1.4 FAD-Dependent Dehydrogenase. 1.5 Miscellaneous. References. 2 Catalytic Applications of Laccase (Feng Xu, Ture Damhus, Steffen Danielsen, and Lars Henrik Ostergaard). 2.1 Properties of Classical Laccase. 2.2 Applications of Laccase for Industrial Oxidation Processes. 2.3 More Recent Developments. 2.4 Further Developing Laccase Catalysis. 3 Biocatalytic Scope of Baeyer-Villiger Monooxygenases (Marco W. Fraaije and Dick B. Janssen). 3.1 Introduction. 3.2 Type I Baeyer-Villiger Monooxygenases: Versatile Oxidative Biocatalysts. 3.3 Concluding Remarks. 4 The Bacterial Cytochrome P450 Monooxygenases: P450cam and P450BM-3 (Vlada B. Urlacher, Stephen G. Bell, and Luet-Lok Wong). 4.1 Introduction. 4.2 Biotransformation by Bacterial P450 Enzymes. 4.3 General Features of P450cam and P450BM-3. 4.4 The Scope of P450 Engineering. 5 Cytochrome P450 Redox Partner Systems: Biodiversity and Biotechnological Implications (Andrew W. Munro, Hazel M. Girvan, Joseph P. McVey, and Kirsty J. McLean). 5.1 Introduction. 5.2 P450 Redox Partners. 5.3 Increasing P450-Redox Partner Complexity: Flavodoxins and Diverse Ferredoxins. 5.4 Natural and Arti. cial P450-Redox Partner Fusion Enzymes and their Biocatalytic Potential. 5.5 Other Routes to Driving P450 Catalytic Function. 5.6 Uncoupling, Enzyme Stability and Coenzyme Issues. 5.7 Future Prospects. 6 Steroid Hydroxylation: Microbial Steroid Biotransformations Using Cytochrome P450 Enzymes (Matthias Bureik and Rita Bernhardt). 6.1 Introduction. 6.2 Cytochrome P450-Dependent Steroid Hydroxylase Systems. 6.3 Native Microorganisms in Steroid Biotransformation. 6.4 Genetically Modi. ed Microorganisms in Steroid Biotransformation. 6.5 Synopsis and Concluding Remarks. 7 A Modular Approach to Biotransformation Using Microbial Cytochrome P450 Monooxygenases (Akira Arisawa and Hitosi Agematu). 7.1 Introduction. 7.2 Experimental Outline. 7.3 Bacterial CYP Expression System in E. coli. 7.4 Construction of a Bacterial CYP Library. 7.5 Construction of a Bacterial CYP Reaction Array. 7.6 Application of the CYP Reaction Array to Biotransformation Screening. 8 Selective Microbial Oxidations in Industry: Oxidations of Alkanes, Fatty Acids, Heterocyclic Compounds, Aromatic Compounds and Glycerol Using Native or Recombinant Microorganisms (Albrecht Weiss). 8.1 Introduction. 8.2 Selective Oxidation of Hydrocarbons and Fatty Acids. 8.3 Aromatic Compounds/Fine Chemicals. 8.4 Heterocyclic Compounds. 8.5 Glycerol Conversion to Dihydroxyacetone. 8.6 Perspectives. 9 Preparation of Drug Metabolites using Fungal and Bacterial Strains (Oreste Ghisalba and Matthias Kittelmann). 9.1 Introduction. 9.2 Phase I Drug-Metabolizing Enzymes. 9.3 Needs and Platforms for the Generation of Drug Metabolites. 9.4 Microbial Models for Oxidative Drug Metabolism. 9.5 Correlation of Microbial and Mammalian Oxidative Drug Metabolism. 9.6 Correlation of Microbial Reactions with Human CYP Isozyme-Speci. c Reactions. 9.7 Novartis Research Examples of Microbial Hydroxylations. 9.8 Microbial Oxidation of Natural Products. 9.9 Conclusions. 10 Recombinant Yeast and Bacteria that Express Human P450s: Bioreactors for Drug Discovery, Development, and Biotechnology (Steven P. Hanlon, Thomas Friedberg, C. Roland Wolf, Oreste Ghisalba, and Matthias Kittelmann). 10.1 Background. 10.2 Comparison of P450 Levels and Enzymic Activities in Various Models. 10.3 Use of E. coli P450 Expression Systems in Bioreactors. 10.4 Conclusion. 11 Human Cytochrome P450 Monooxygenases - a General Model of Substrate Specifi city and Regioselectivity (Jurgen Pleiss). 11.1 Introduction. 11.2 What Can We Learn From Sequence? 11.3 What Can We Learn from Structure? 11.4 Conclusion. 12 Approaches to Recycling and Substituting NAD(P)H as a CYP Cofactor (Dirk Holtmann and Jens Schrader). 12.1 Introduction. 12.2 Chemical Substitution of Cofactors. 12.3 Enzymatic Regeneration of Cofactors. 12.4 Photochemical Approaches to Substituting or Regenerating Cofactors for P450 Systems. 12.5 Electrochemical Systems for Substitution or Regeneration of Cofactors. 12.6 Redox Mediators. 12.7 Molecular Biological Approaches. 12.8 Conclusion and Outlook. Index.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: book
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Cited By Count: 65
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