Abstract: Basic science principles of tissue engineering and regeneration of skeletal tissue tissue engineering and morphogenesis - role of morphogenetic proteins - Harri Reddiarr cell-based approaches to orthopaedic tissue engineering - E.J. Caterson, Rocky Tuant, and Scott Bruder Intraoperative harvest and concentration of human bone marrow osteoprogenitors for enhancement of spinal fusion - James E. Fleming, Jr. genomics - Matthew Warman biodegradable scaffolds - Johnna Temenoff, Emily Steinbis, and Antonio Miklos biomechanical factors in tissue engineering of articular cartilage - Farshid Guilak bioreactors for orthopaedic tissue engineering - Gordana Vunjak-Novakovic, B. Oradovici, H. Madry, G. Altman, and D.L Kaplan clinically applicable animal models in tissue engineering - Ernst Hunziker clinical application bone tissue engineering - basic science and clinical concepts - Safdar Khan and Joseph Lane overview - articular cartilage - Joseph Buckwalter cartilage - current applications, Bernd Kinner and Myron Spector tissue engineering of meniscus - Brian Johnstone, Peter Angele, Jung Yoo, and Victor Goldberg tissue engineering of intervertebral disc - Jung Yoo and Brian Johnstone clinical applications of orthopaedic tissue engineering - ligament/tendon - Lee Kaplan and Freddie Fu functional engineered skeletal muscle - Robert G. Dennis gene therapy to enhance bone and cartilage repair - Jay Lieberman.