Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W583745604', 'doi': 'https://doi.org/10.1007/s00216-015-8707-1', 'title': 'Characterization of botulinum neurotoxin type A subtypes by immunocapture enrichment and liquid chromatography–tandem mass spectrometry', 'display_name': 'Characterization of botulinum neurotoxin type A subtypes by immunocapture enrichment and liquid chromatography–tandem mass spectrometry', 'publication_year': 2015, 'publication_date': '2015-06-03', 'ids': {'openalex': 'https://openalex.org/W583745604', 'doi': 'https://doi.org/10.1007/s00216-015-8707-1', 'mag': '583745604', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26038189'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s00216-015-8707-1', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S18188872', 'display_name': 'Analytical and Bioanalytical Chemistry', 'issn_l': '1618-2642', 'issn': ['1618-2642', '1618-2650'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://hal-pasteur.archives-ouvertes.fr/pasteur-01783532/file/Characterization%20of%20botulinum%20neurotoxin%20type%20A%20subtypes%20by%20immunocapture%20enrichment%20and%20liquid%20chromatography%E2%80%93tandem%20mass%20spectrometry%20preprint%20%281%29.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5070012733', 'display_name': 'V. Morineaux', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I95583923', 'display_name': "Direction Générale de l'Armement", 'ror': 'https://ror.org/04wsqd844', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I95583923']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Valérie Morineaux', 'raw_affiliation_strings': ["Direction Générale de l'Armement, DGA Maîtrise NRBC, 91710, Vert-le-Petit, France"], 'affiliations': [{'raw_affiliation_string': "Direction Générale de l'Armement, DGA Maîtrise NRBC, 91710, Vert-le-Petit, France", 'institution_ids': ['https://openalex.org/I95583923']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037448066', 'display_name': 'Christelle Mazuet', 'orcid': 'https://orcid.org/0000-0001-7619-9050'}, 'institutions': [{'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Christelle Mazuet', 'raw_affiliation_strings': ['Institut Pasteur, Unité des Bactéries anaérobies et Toxines, 75724, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Institut Pasteur, Unité des Bactéries anaérobies et Toxines, 75724, Paris, France', 'institution_ids': ['https://openalex.org/I157536573']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079608030', 'display_name': 'Didier Hilaire', 'orcid': 'https://orcid.org/0000-0002-5112-4041'}, 'institutions': [{'id': 'https://openalex.org/I95583923', 'display_name': "Direction Générale de l'Armement", 'ror': 'https://ror.org/04wsqd844', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I95583923']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Didier Hilaire', 'raw_affiliation_strings': ["Direction Générale de l'Armement, DGA Maîtrise NRBC, 91710, Vert-le-Petit, France"], 'affiliations': [{'raw_affiliation_string': "Direction Générale de l'Armement, DGA Maîtrise NRBC, 91710, Vert-le-Petit, France", 'institution_ids': ['https://openalex.org/I95583923']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075957046', 'display_name': 'Julien Enche', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I95583923', 'display_name': "Direction Générale de l'Armement", 'ror': 'https://ror.org/04wsqd844', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I95583923']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Julien Enche', 'raw_affiliation_strings': ["Direction Générale de l'Armement, DGA Maîtrise NRBC, 91710, Vert-le-Petit, France"], 'affiliations': [{'raw_affiliation_string': "Direction Générale de l'Armement, DGA Maîtrise NRBC, 91710, Vert-le-Petit, France", 'institution_ids': ['https://openalex.org/I95583923']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5019497452', 'display_name': 'Michel R. Popoff', 'orcid': 'https://orcid.org/0000-0001-9305-8989'}, 'institutions': [{'id': 'https://openalex.org/I157536573', 'display_name': 'Institut Pasteur', 'ror': 'https://ror.org/0495fxg12', 'country_code': 'FR', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I157536573']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Michel R. Popoff', 'raw_affiliation_strings': ['Institut Pasteur, Unité des Bactéries anaérobies et Toxines, 75724, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Institut Pasteur, Unité des Bactéries anaérobies et Toxines, 75724, Paris, France', 'institution_ids': ['https://openalex.org/I157536573']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2790, 'currency': 'EUR', 'value_usd': 3590, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.657, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 20, 'citation_normalized_percentile': {'value': 0.856636, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '407', 'issue': '19', 'first_page': '5559', 'last_page': '5570'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11274', 'display_name': 'Botulinum Toxin in Neurology and Medicine', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11274', 'display_name': 'Botulinum Toxin in Neurology and Medicine', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12331', 'display_name': 'Genetic Basis of Neuropathies and Related Disorders', 'score': 0.9597, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12499', 'display_name': 'Corynebacterium Infections and Tetanus', 'score': 0.9314, 'subfield': {'id': 'https://openalex.org/subfields/1310', 'display_name': 'Endocrinology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/botulinum-toxin', 'display_name': 'Botulinum Toxin', 'score': 0.474803}, {'id': 'https://openalex.org/keywords/neurotoxin', 'display_name': 'Neurotoxin', 'score': 0.44638962}], 'concepts': [{'id': 'https://openalex.org/C43617362', 'wikidata': 'https://www.wikidata.org/wiki/Q170050', 'display_name': 'Chromatography', 'level': 1, 'score': 0.82915074}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.82093227}, {'id': 'https://openalex.org/C162356407', 'wikidata': 'https://www.wikidata.org/wiki/Q180809', 'display_name': 'Mass spectrometry', 'level': 2, 'score': 0.7882178}, {'id': 'https://openalex.org/C31827203', 'wikidata': 'https://www.wikidata.org/wiki/Q874296', 'display_name': 'Tandem mass spectrometry', 'level': 3, 'score': 0.71779937}, {'id': 'https://openalex.org/C71043704', 'wikidata': 'https://www.wikidata.org/wiki/Q17144692', 'display_name': 'Selected reaction monitoring', 'level': 4, 'score': 0.6611973}, {'id': 'https://openalex.org/C64489805', 'wikidata': 'https://www.wikidata.org/wiki/Q873864', 'display_name': 'Liquid chromatography–mass spectrometry', 'level': 3, 'score': 0.6273918}, {'id': 'https://openalex.org/C119128265', 'wikidata': 'https://www.wikidata.org/wiki/Q900165', 'display_name': 'Detection limit', 'level': 2, 'score': 0.54249877}, {'id': 'https://openalex.org/C172493649', 'wikidata': 'https://www.wikidata.org/wiki/Q7843529', 'display_name': 'Triple quadrupole mass spectrometer', 'level': 5, 'score': 0.49686053}, {'id': 'https://openalex.org/C2780358027', 'wikidata': 'https://www.wikidata.org/wiki/Q407752', 'display_name': 'Neurotoxin', 'level': 2, 'score': 0.44638962}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.16331184}], 'mesh': [{'descriptor_ui': 'D019274', 'descriptor_name': 'Botulinum Toxins, Type A', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D002853', 'descriptor_name': 'Chromatography, Liquid', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D053719', 'descriptor_name': 'Tandem Mass Spectrometry', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019274', 'descriptor_name': 'Botulinum Toxins, Type A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002853', 'descriptor_name': 'Chromatography, Liquid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005506', 'descriptor_name': 'Food Contamination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057230', 'descriptor_name': 'Limit of Detection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053719', 'descriptor_name': 'Tandem Mass Spectrometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s00216-015-8707-1', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S18188872', 'display_name': 'Analytical and Bioanalytical Chemistry', 'issn_l': '1618-2642', 'issn': ['1618-2642', '1618-2650'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hal-pasteur.archives-ouvertes.fr/pasteur-01783532/file/Characterization%20of%20botulinum%20neurotoxin%20type%20A%20subtypes%20by%20immunocapture%20enrichment%20and%20liquid%20chromatography%E2%80%93tandem%20mass%20spectrometry%20preprint%20%281%29.pdf', 'pdf_url': 'https://hal-pasteur.archives-ouvertes.fr/pasteur-01783532/file/Characterization%20of%20botulinum%20neurotoxin%20type%20A%20subtypes%20by%20immunocapture%20enrichment%20and%20liquid%20chromatography%E2%80%93tandem%20mass%20spectrometry%20preprint%20%281%29.pdf', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hal-pasteur.archives-ouvertes.fr/pasteur-01783532', 'pdf_url': 'https://hal-pasteur.archives-ouvertes.fr/pasteur-01783532/document', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26038189', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://hal-pasteur.archives-ouvertes.fr/pasteur-01783532/file/Characterization%20of%20botulinum%20neurotoxin%20type%20A%20subtypes%20by%20immunocapture%20enrichment%20and%20liquid%20chromatography%E2%80%93tandem%20mass%20spectrometry%20preprint%20%281%29.pdf', 'pdf_url': 'https://hal-pasteur.archives-ouvertes.fr/pasteur-01783532/file/Characterization%20of%20botulinum%20neurotoxin%20type%20A%20subtypes%20by%20immunocapture%20enrichment%20and%20liquid%20chromatography%E2%80%93tandem%20mass%20spectrometry%20preprint%20%281%29.pdf', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W1225540085', 'https://openalex.org/W145644793', 'https://openalex.org/W1483437518', 'https://openalex.org/W1967616883', 'https://openalex.org/W1973125376', 'https://openalex.org/W1975957967', 'https://openalex.org/W1981764249', 'https://openalex.org/W1985297128', 'https://openalex.org/W2009018979', 'https://openalex.org/W2021258548', 'https://openalex.org/W2021537592', 'https://openalex.org/W2027872729', 'https://openalex.org/W2038370483', 'https://openalex.org/W2045061466', 'https://openalex.org/W2057554063', 'https://openalex.org/W2058376979', 'https://openalex.org/W2062776650', 'https://openalex.org/W2066834424', 'https://openalex.org/W2088811284', 'https://openalex.org/W2088975164', 'https://openalex.org/W2090002615', 'https://openalex.org/W2096738649', 'https://openalex.org/W2108780469', 'https://openalex.org/W2111510216', 'https://openalex.org/W2113569765', 'https://openalex.org/W2126213235', 'https://openalex.org/W2136626748', 'https://openalex.org/W2157512308', 'https://openalex.org/W2159675295', 'https://openalex.org/W2167563543', 'https://openalex.org/W2330182625', 'https://openalex.org/W4252071217'], 'related_works': ['https://openalex.org/W4293032825', 'https://openalex.org/W341504801', 'https://openalex.org/W2800973557', 'https://openalex.org/W2375352280', 'https://openalex.org/W2332951358', 'https://openalex.org/W2120155947', 'https://openalex.org/W2082209745', 'https://openalex.org/W2049616422', 'https://openalex.org/W2018493658', 'https://openalex.org/W1177195036'], 'abstract_inverted_index': {'Botulinum': [0], 'neurotoxins': [1], '(BoNT)': [2], 'are': [3], 'divided': [4], 'into': [5], 'seven': [6], 'toxinotypes': [7], 'based': [8], 'on': [9, 88], 'their': [10, 21], 'immunological': [11], 'properties': [12], 'and': [13, 45, 61, 109, 130], 'each': [14], 'toxinotype': [15], 'contains': [16], 'several': [17], 'subtypes': [18, 36, 57, 102], 'according': [19], 'to': [20, 33, 55, 59, 63, 77, 124], 'amino': [22], 'acid': [23], 'sequences.': [24], 'Here,': [25], 'we': [26], 'designed': [27], 'a': [28, 89, 118, 132], 'mass': [29, 85, 92], 'spectrometry': [30, 86], 'method': [31, 68], 'able': [32], 'identify': [34], 'BoNT/A': [35, 78, 101], 'in': [37, 95, 106, 110, 135], 'complex': [38], 'matrices': [39], 'including': [40], 'crude': [41], 'culture': [42, 107], 'supernatants,': [43], 'food,': [44], 'environmental': [46], 'samples.': [47, 137], 'Peptides': [48], 'from': [49], 'BoNT': [50], 'light': [51], 'chain': [52], '(L)': [53], 'specific': [54, 76], 'the': [56], 'BoNT/A1': [58], 'A3': [60], 'BoNT/A5': [62], 'A8': [64], 'were': [65, 103], 'identified.': [66], 'The': [67], 'consists': [69], 'of': [70, 120, 122], 'an': [71], 'immunocapture': [72], 'step': [73], 'with': [74, 117, 131], 'antibodies': [75], 'L': [79], 'chains': [80], 'followed': [81], 'by': [82], 'liquid': [83], 'chromatography-tandem': [84], '(LC-MS/MS)': [87], 'triple': [90], 'quadrupole': [91], 'spectrometer': [93], '(QqQ)': [94], 'multiple': [96], 'reaction': [97], 'monitoring': [98], '(MRM)': [99], 'mode.': [100], 'correctly': [104], 'identified': [105], 'supernatants': [108], 'tap': [111], 'water': [112], 'or': [113], 'orange': [114], 'juice': [115], 'samples': [116], 'limit': [119], 'detection': [121], '20': [123], '150': [125], 'mouse': [126], 'lethal': [127], 'doses': [128], '(MLD)': [129], 'lower': [133], 'sensitivity': [134], 'serum': [136]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W583745604', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 3}], 'updated_date': '2024-08-17T14:18:58.045108', 'created_date': '2016-06-24'}