Publication Information

{'id': 'https://openalex.org/W55990439', 'doi': None, 'title': 'The heteromeric 5-HT3A/B receptor : the effect of 5-HT3B subunits on receptor structure and ligand recognition', 'display_name': 'The heteromeric 5-HT3A/B receptor : the effect of 5-HT3B subunits on receptor structure and ligand recognition', 'publication_year': 2008, 'publication_date': '2008-01-01', 'ids': {'openalex': 'https://openalex.org/W55990439', 'mag': '55990439'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://eprints.aston.ac.uk/11070/', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'dissertation', 'type_crossref': 'dissertation', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5076519798', 'display_name': 'Paul Herbert', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'Paul Herbert', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5076519798'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 63}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11818', 'display_name': 'Nicotinic Acetylcholine Receptors Study', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11818', 'display_name': 'Nicotinic Acetylcholine Receptors Study', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10493', 'display_name': 'Ion channel regulation and function', 'score': 0.9687, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13124', 'display_name': 'Chemical synthesis and alkaloids', 'score': 0.9549, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/homomeric', 'display_name': 'Homomeric', 'score': 0.97586167}, {'id': 'https://openalex.org/keywords/cys-loop-receptors', 'display_name': 'Cys-loop receptors', 'score': 0.65596986}, {'id': 'https://openalex.org/keywords/competitive-antagonist', 'display_name': 'Competitive antagonist', 'score': 0.49063674}, {'id': 'https://openalex.org/keywords/pentamer', 'display_name': 'Pentamer', 'score': 0.45418018}], 'concepts': [{'id': 'https://openalex.org/C2776104367', 'wikidata': 'https://www.wikidata.org/wiki/Q5891451', 'display_name': 'Homomeric', 'level': 4, 'score': 0.97586167}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.67847717}, {'id': 'https://openalex.org/C19876734', 'wikidata': 'https://www.wikidata.org/wiki/Q5201170', 'display_name': 'Cys-loop receptors', 'level': 5, 'score': 0.65596986}, {'id': 'https://openalex.org/C82617044', 'wikidata': 'https://www.wikidata.org/wiki/Q418536', 'display_name': 'Ligand-gated ion channel', 'level': 4, 'score': 0.57850957}, {'id': 'https://openalex.org/C80161118', 'wikidata': 'https://www.wikidata.org/wiki/Q408520', 'display_name': 'Acetylcholine receptor', 'level': 3, 'score': 0.5700698}, {'id': 'https://openalex.org/C104292427', 'wikidata': 'https://www.wikidata.org/wiki/Q899781', 'display_name': 'Protein subunit', 'level': 3, 'score': 0.5431754}, {'id': 'https://openalex.org/C50254741', 'wikidata': 'https://www.wikidata.org/wiki/Q62536', 'display_name': 'Ion channel', 'level': 3, 'score': 0.5112071}, {'id': 'https://openalex.org/C86811712', 'wikidata': 'https://www.wikidata.org/wiki/Q410943', 'display_name': 'Competitive antagonist', 'level': 4, 'score': 0.49063674}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.4559347}, {'id': 'https://openalex.org/C2777331810', 'wikidata': 'https://www.wikidata.org/wiki/Q3374897', 'display_name': 'Pentamer', 'level': 2, 'score': 0.45418018}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.45069888}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.4460771}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.42372137}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.40656927}, {'id': 'https://openalex.org/C2779570518', 'wikidata': 'https://www.wikidata.org/wiki/Q412256', 'display_name': 'Nicotinic acetylcholine receptor', 'level': 4, 'score': 0.37685445}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'http://eprints.aston.ac.uk/11070/', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Life below water', 'score': 0.5, 'id': 'https://metadata.un.org/sdg/14'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3203750869', 'https://openalex.org/W3201959804', 'https://openalex.org/W3092065697', 'https://openalex.org/W2974068419', 'https://openalex.org/W2973730274', 'https://openalex.org/W2781727979', 'https://openalex.org/W2412465862', 'https://openalex.org/W2164555843', 'https://openalex.org/W2158824176', 'https://openalex.org/W2126114697', 'https://openalex.org/W2079882316', 'https://openalex.org/W2077682553', 'https://openalex.org/W2064113168', 'https://openalex.org/W2049297654', 'https://openalex.org/W2025406761', 'https://openalex.org/W1992773620', 'https://openalex.org/W1786663574', 'https://openalex.org/W1548473301', 'https://openalex.org/W1511853604', 'https://openalex.org/W1498763558'], 'abstract_inverted_index': {'The': [0, 76, 204], '5-HT3': [1, 77], 'receptors': [2, 100], 'are': [3, 16, 32, 226, 232], 'members': [4], 'of': [5, 9, 49, 98, 109, 138, 151, 187, 206], 'the': [6, 18, 22, 45, 50, 92, 112, 120, 126, 134, 139, 147, 152, 173, 183, 189, 194, 199, 211, 216, 222, 235, 238, 242, 245, 248, 253], 'cys-loop': [7], 'family': [8], 'ligand-gated': [10], 'ion': [11], 'channels.': [12], 'Two': [13], 'functional': [14], 'subtypes': [15], 'known,': [17], 'homomeric': [19, 174], '5HT3A': [20], 'and': [21, 47, 87, 146, 193, 224, 244], 'heteromeric': [23, 51, 127], '5HT3A/B': [24, 52], 'receptors,': [25, 78], 'which': [26], 'exhibit': [27], 'distinct': [28], 'biophysical': [29], 'characteristics': [30], 'but': [31], 'difficult': [33], 'to': [34, 43, 58, 71, 91, 176, 181, 228], 'differentiate': [35], 'pharmacologically.': [36], 'Atomic': [37], 'force': [38, 103], 'microscopy': [39, 104], 'has': [40], 'been': [41], 'used': [42], 'determine': [44], 'stoichiometry': [46], 'architecture': [48], 'receptor.': [53], 'Each': [54], 'subunit': [55, 93, 213, 240, 247], 'was': [56], 'engineered': [57], 'express': [59], 'a': [60, 106], 'unique': [61], 'C-terminal': [62], 'epitope': [63, 95], 'tag,': [64], 'together': [65, 167], 'with': [66, 89, 168, 234], 'six': [67], 'sequential': [68], 'histidine': [69], 'residues': [70, 214], 'facilitate': [72], 'nickel': [73], 'affinity': [74], 'purification.': [75], 'ectopically': [79], 'expressed': [80], 'in': [81, 111], 'HEK293': [82], 'cells,': [83], 'were': [84, 129, 165], 'solubilised,': [85], 'purified': [86], 'decorated': [88], 'antibodies': [90], 'specific': [94], 'tags.': [96], 'Imaging': [97], 'individual': [99], 'by': [101], 'atomic': [102], 'revealed': [105, 209], 'pentameric': [107], 'arrangement': [108], 'subunits': [110], 'order': [113], 'BBABA,': [114], 'reading': [115], 'anti-clockwise': [116], 'when': [117], 'viewed': [118], 'from': [119, 143, 157], 'extracellular': [121], 'face.': [122], 'Homology': [123], 'models': [124, 164, 170], 'for': [125, 172, 198, 220], 'receptor': [128, 202], 'then': [130], 'constructed': [131, 171], 'using': [132], 'both': [133, 188, 221], 'electron': [135], 'microscopic': [136], 'structure': [137, 150], 'nicotinic': [140], 'acetylcholine': [141, 154], 'receptor,': [142, 175], 'Torpedo': [144], 'marmorata,': [145], 'X-ray': [148], 'crystallographic': [149], 'soluble': [153], 'binding': [155, 218, 254], 'protein,': [156], 'Lymnaea': [158], 'stagnalis,': [159], 'as': [160], 'templates.': [161], 'These': [162], 'homology': [163], 'used,': [166], 'equivalent': [169], 'interpret': [177], 'mutagenesis': [178], 'experiments': [179], 'designed': [180], 'explore': [182], 'minimal': [184], 'recognition': [185, 250], 'differences': [186], 'natural': [190], 'agonist,': [191], '5-HT,': [192], 'competitive': [195], 'antagonist,': [196, 225], 'granisetron,': [197], 'two': [200], 'human': [201], 'subtypes.': [203], 'results': [205], 'this': [207], 'work': [208], 'that': [210, 237], '5-HT3B': [212], 'within': [215], 'ligand': [217], 'site,': [219], 'agonist': [223], 'accommodating': [227], 'conservative': [229], 'mutations.': [230], 'They': [231], 'consistent': [233], 'view': [236], '5-HT3A': [239], 'provides': [241], 'principal': [243], '5-HT38': [246], 'complementary': [249], 'interactions': [251], 'at': [252], 'interface.': [255]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W55990439', 'counts_by_year': [], 'updated_date': '2024-12-12T19:05:58.644443', 'created_date': '2016-06-24'}