Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W54674007', 'doi': 'https://doi.org/10.1042/bj2660707', 'title': 'Cobalamin neuropathy. Is <i>S</i>-adenosylhomocysteine toxicity a factor?', 'display_name': 'Cobalamin neuropathy. Is <i>S</i>-adenosylhomocysteine toxicity a factor?', 'publication_year': 1990, 'publication_date': '1990-03-15', 'ids': {'openalex': 'https://openalex.org/W54674007', 'doi': 'https://doi.org/10.1042/bj2660707', 'mag': '54674007', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2327959', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1131197'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/bj2660707', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44425019', 'display_name': 'Biochemical Journal', 'issn_l': '0264-6021', 'issn': ['0264-6021', '1470-8728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc1131197?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5062115759', 'display_name': 'E Vieira-Makings', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I192619145', 'display_name': 'University of the Witwatersrand', 'ror': 'https://ror.org/03rp50x72', 'country_code': 'ZA', 'type': 'education', 'lineage': ['https://openalex.org/I192619145']}], 'countries': ['ZA'], 'is_corresponding': False, 'raw_author_name': 'E Vieira-Makings', 'raw_affiliation_strings': ['*Department of Haematology, School of Pathology of the South African Institute for Medical Research and the University of Witwatersrand, P.O. Box 1038, Johannesburg 2000, South Africa'], 'affiliations': [{'raw_affiliation_string': '*Department of Haematology, School of Pathology of the South African Institute for Medical Research and the University of Witwatersrand, P.O. Box 1038, Johannesburg 2000, South Africa', 'institution_ids': ['https://openalex.org/I192619145']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087276858', 'display_name': 'J. Metz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I192619145', 'display_name': 'University of the Witwatersrand', 'ror': 'https://ror.org/03rp50x72', 'country_code': 'ZA', 'type': 'education', 'lineage': ['https://openalex.org/I192619145']}], 'countries': ['ZA'], 'is_corresponding': False, 'raw_author_name': 'J Metz', 'raw_affiliation_strings': ['*Department of Haematology, School of Pathology of the South African Institute for Medical Research and the University of Witwatersrand, P.O. Box 1038, Johannesburg 2000, South Africa'], 'affiliations': [{'raw_affiliation_string': '*Department of Haematology, School of Pathology of the South African Institute for Medical Research and the University of Witwatersrand, P.O. Box 1038, Johannesburg 2000, South Africa', 'institution_ids': ['https://openalex.org/I192619145']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012261854', 'display_name': 'Justin Westhuyzen', 'orcid': 'https://orcid.org/0000-0002-4812-8973'}, 'institutions': [{'id': 'https://openalex.org/I192619145', 'display_name': 'University of the Witwatersrand', 'ror': 'https://ror.org/03rp50x72', 'country_code': 'ZA', 'type': 'education', 'lineage': ['https://openalex.org/I192619145']}], 'countries': ['ZA'], 'is_corresponding': False, 'raw_author_name': 'J Van der Westhuyzen', 'raw_affiliation_strings': ['*Department of Haematology, School of Pathology of the South African Institute for Medical Research and the University of Witwatersrand, P.O. Box 1038, Johannesburg 2000, South Africa'], 'affiliations': [{'raw_affiliation_string': '*Department of Haematology, School of Pathology of the South African Institute for Medical Research and the University of Witwatersrand, P.O. Box 1038, Johannesburg 2000, South Africa', 'institution_ids': ['https://openalex.org/I192619145']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048484701', 'display_name': 'Teodoro Bottiglieri', 'orcid': 'https://orcid.org/0000-0002-4199-7551'}, 'institutions': [{'id': 'https://openalex.org/I2802052328', 'display_name': 'Northwick Park Hospital', 'ror': 'https://ror.org/030j6qm79', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800484787', 'https://openalex.org/I2802052328']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'T Bottiglieri', 'raw_affiliation_strings': ['Section of Haematology, MRC Clinical Research Centre, Northwick Park Hospital, Harrow, Middx., U.K.'], 'affiliations': [{'raw_affiliation_string': 'Section of Haematology, MRC Clinical Research Centre, Northwick Park Hospital, Harrow, Middx., U.K.', 'institution_ids': ['https://openalex.org/I2802052328']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5089784134', 'display_name': 'I. Chanarin', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'I Chanarin', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.847, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 23, 'citation_normalized_percentile': {'value': 0.844023, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '266', 'issue': '3', 'first_page': '707', 'last_page': '711'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11027', 'display_name': 'Metabolic Disorders and Biochemical Genetics', 'score': 0.9951, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11027', 'display_name': 'Metabolic Disorders and Biochemical Genetics', 'score': 0.9951, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11072', 'display_name': 'Peroxisome Proliferator-Activated Receptors', 'score': 0.993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10499', 'display_name': 'Role of Homocysteine in Health and Disease', 'score': 0.9908, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/inborn-errors-of-metabolism', 'display_name': 'Inborn Errors of Metabolism', 'score': 0.462077}], 'concepts': [{'id': 'https://openalex.org/C2780676250', 'wikidata': 'https://www.wikidata.org/wiki/Q187706', 'display_name': 'Cobalamin', 'level': 3, 'score': 0.9977204}, {'id': 'https://openalex.org/C29730261', 'wikidata': 'https://www.wikidata.org/wiki/Q274160', 'display_name': 'Toxicity', 'level': 2, 'score': 0.61336184}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4539355}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.36805317}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.36613637}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.31633526}, {'id': 'https://openalex.org/C2779750884', 'wikidata': 'https://www.wikidata.org/wiki/Q187706', 'display_name': 'Vitamin B12', 'level': 2, 'score': 0.27775148}], 'mesh': [{'descriptor_ui': 'D006710', 'descriptor_name': 'Homocysteine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D009468', 'descriptor_name': 'Neuromuscular Diseases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012435', 'descriptor_name': 'S-Adenosylhomocysteine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014806', 'descriptor_name': 'Vitamin B 12 Deficiency', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001923', 'descriptor_name': 'Brain Chemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002685', 'descriptor_name': 'Chiroptera', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002851', 'descriptor_name': 'Chromatography, High Pressure Liquid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006710', 'descriptor_name': 'Homocysteine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D008715', 'descriptor_name': 'Methionine', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D008715', 'descriptor_name': 'Methionine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009468', 'descriptor_name': 'Neuromuscular Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009468', 'descriptor_name': 'Neuromuscular Diseases', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D012435', 'descriptor_name': 'S-Adenosylhomocysteine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012436', 'descriptor_name': 'S-Adenosylmethionine', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D012436', 'descriptor_name': 'S-Adenosylmethionine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014633', 'descriptor_name': 'Valine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014633', 'descriptor_name': 'Valine', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D014806', 'descriptor_name': 'Vitamin B 12 Deficiency', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014806', 'descriptor_name': 'Vitamin B 12 Deficiency', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/bj2660707', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44425019', 'display_name': 'Biochemical Journal', 'issn_l': '0264-6021', 'issn': ['0264-6021', '1470-8728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1131197', 'pdf_url': 'https://europepmc.org/articles/pmc1131197?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1131197', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2327959', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1131197', 'pdf_url': 'https://europepmc.org/articles/pmc1131197?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Life below water', 'score': 0.51, 'id': 'https://metadata.un.org/sdg/14'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 12, 'referenced_works': ['https://openalex.org/W1976679361', 'https://openalex.org/W2028596519', 'https://openalex.org/W2031480421', 'https://openalex.org/W2048199226', 'https://openalex.org/W2048445421', 'https://openalex.org/W2054808116', 'https://openalex.org/W2078009330', 'https://openalex.org/W2100567394', 'https://openalex.org/W2132109062', 'https://openalex.org/W2158069984', 'https://openalex.org/W2267835480', 'https://openalex.org/W2300507016'], 'related_works': ['https://openalex.org/W4249176446', 'https://openalex.org/W2391409986', 'https://openalex.org/W2140569197', 'https://openalex.org/W2132898409', 'https://openalex.org/W2064362993', 'https://openalex.org/W2037631372', 'https://openalex.org/W2030889776', 'https://openalex.org/W1979139803', 'https://openalex.org/W1966775726', 'https://openalex.org/W1966504330'], 'abstract_inverted_index': {'Cobalamin': [0], 'neuropathy': [1, 57], 'was': [2], 'produced': [3], 'in': [4, 29, 32], 'cape': [5], 'fruit': [6], 'bats': [7], '(Rousettus': [8], 'aegyptiacus)': [9], 'by': [10], 'a': [11, 53], 'cobalamin-free': [12], 'diet': [13], 'combined': [14], 'with': [15, 43], 'intermittent': [16], 'exposure': [17], 'to': [18], 'nitrous': [19], 'oxide,': [20], 'which': [21], 'inactivates': [22], 'cobalamin.': [23], 'There': [24], 'were': [25], 'no': [26, 48], 'significant': [27], 'differences': [28], 'S-adenosylmethionine/S-adenosylhomocysteine': [30], 'ratios': [31], 'the': [33, 59], 'central': [34], 'nervous': [35], 'system': [36], 'of': [37, 50, 61], 'cobalamin-deficient': [38], 'and': [39], 'cobalamin-replete': [40], 'bats.': [41], 'Taken': [42], 'other': [44], 'data': [45], 'there': [46], 'are': [47], 'grounds': [49], 'support': [51], 'for': [52], 'hypothesis': [54], 'that': [55], 'cobalamin': [56], 'is': [58], 'result': [60], 'impaired': [62], 'methylation,': [63], 'however': [64], 'produced.': [65]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W54674007', 'counts_by_year': [{'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-09-13T21:36:18.945658', 'created_date': '2016-06-24'}