Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W52785124', 'doi': None, 'title': 'Increased accuracy in heparin and protamine administration decreases bleeding: a pilot study.', 'display_name': 'Increased accuracy in heparin and protamine administration decreases bleeding: a pilot study.', 'publication_year': 2009, 'publication_date': '2009-03-01', 'ids': {'openalex': 'https://openalex.org/W52785124', 'mag': '52785124', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19361026', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4680217'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19361026', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5008576028', 'display_name': 'Marx Runge', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802567020', 'display_name': 'Copenhagen University Hospital', 'ror': 'https://ror.org/05bpbnx46', 'country_code': 'DK', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802567020']}, {'id': 'https://openalex.org/I2802709434', 'display_name': 'Rigshospitalet', 'ror': 'https://ror.org/03mchdq19', 'country_code': 'DK', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802567020', 'https://openalex.org/I2802709434', 'https://openalex.org/I4210145385']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Marx Runge', 'raw_affiliation_strings': ['Department of Clinical Perfusion, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. [email protected]'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Perfusion, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. [email protected]', 'institution_ids': ['https://openalex.org/I2802567020', 'https://openalex.org/I2802709434']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102258813', 'display_name': 'Christian Möller', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Christian H Møller', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5079248648', 'display_name': 'Daniel A. Steinbrüchel', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Daniel A Steinbrüchel', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 0, 'currency': 'USD', 'value_usd': 0, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.309, 'has_fulltext': False, 'cited_by_count': 12, 'citation_normalized_percentile': {'value': 0.791652, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 85, 'max': 86}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11055', 'display_name': 'Cardiac and Coronary Surgery Techniques', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11055', 'display_name': 'Cardiac and Coronary Surgery Techniques', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10693', 'display_name': 'Blood transfusion and management', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2704', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11116', 'display_name': 'Trauma, Hemostasis, Coagulopathy, Resuscitation', 'score': 0.9957, 'subfield': {'id': 'https://openalex.org/subfields/2706', 'display_name': 'Critical Care and Intensive Care Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/activated-clotting-time', 'display_name': 'Activated clotting time', 'score': 0.8655101}, {'id': 'https://openalex.org/keywords/extracorporeal-circulation', 'display_name': 'Extracorporeal circulation', 'score': 0.69052684}, {'id': 'https://openalex.org/keywords/extracorporeal', 'display_name': 'Extracorporeal', 'score': 0.56980425}, {'id': 'https://openalex.org/keywords/protamine-sulfate', 'display_name': 'Protamine sulfate', 'score': 0.4125387}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8823462}, {'id': 'https://openalex.org/C2777987278', 'wikidata': 'https://www.wikidata.org/wiki/Q4677454', 'display_name': 'Activated clotting time', 'level': 3, 'score': 0.8655101}, {'id': 'https://openalex.org/C2777557582', 'wikidata': 'https://www.wikidata.org/wiki/Q190016', 'display_name': 'Heparin', 'level': 2, 'score': 0.8648499}, {'id': 'https://openalex.org/C2778881276', 'wikidata': 'https://www.wikidata.org/wiki/Q552304', 'display_name': 'Cardiopulmonary bypass', 'level': 2, 'score': 0.7984957}, {'id': 'https://openalex.org/C2780835560', 'wikidata': 'https://www.wikidata.org/wiki/Q5449573', 'display_name': 'Protamine', 'level': 3, 'score': 0.7449797}, {'id': 'https://openalex.org/C2994232697', 'wikidata': 'https://www.wikidata.org/wiki/Q1115882', 'display_name': 'Extracorporeal circulation', 'level': 2, 'score': 0.69052684}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.62001806}, {'id': 'https://openalex.org/C2778589496', 'wikidata': 'https://www.wikidata.org/wiki/Q487937', 'display_name': 'Hemostasis', 'level': 2, 'score': 0.608704}, {'id': 'https://openalex.org/C2779915274', 'wikidata': 'https://www.wikidata.org/wiki/Q1115882', 'display_name': 'Extracorporeal', 'level': 2, 'score': 0.56980425}, {'id': 'https://openalex.org/C2778205648', 'wikidata': 'https://www.wikidata.org/wiki/Q215118', 'display_name': 'Anticoagulant', 'level': 2, 'score': 0.4880301}, {'id': 'https://openalex.org/C2778789114', 'wikidata': 'https://www.wikidata.org/wiki/Q235007', 'display_name': 'Cardiac surgery', 'level': 2, 'score': 0.4443672}, {'id': 'https://openalex.org/C2779354726', 'wikidata': 'https://www.wikidata.org/wiki/Q22075855', 'display_name': 'Protamine sulfate', 'level': 4, 'score': 0.4125387}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.39318204}], 'mesh': [{'descriptor_ui': 'D006493', 'descriptor_name': 'Heparin', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D006494', 'descriptor_name': 'Heparin Antagonists', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D019106', 'descriptor_name': 'Postoperative Hemorrhage', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D011479', 'descriptor_name': 'Protamines', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D013903', 'descriptor_name': 'Thoracic Surgery', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001803', 'descriptor_name': 'Blood Transfusion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002315', 'descriptor_name': 'Cardiopulmonary Bypass', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D002315', 'descriptor_name': 'Cardiopulmonary Bypass', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006493', 'descriptor_name': 'Heparin', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D006493', 'descriptor_name': 'Heparin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006494', 'descriptor_name': 'Heparin Antagonists', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D006494', 'descriptor_name': 'Heparin Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010865', 'descriptor_name': 'Pilot Projects', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010974', 'descriptor_name': 'Platelet Aggregation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019106', 'descriptor_name': 'Postoperative Hemorrhage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011446', 'descriptor_name': 'Prospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011479', 'descriptor_name': 'Protamines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011479', 'descriptor_name': 'Protamines', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D014184', 'descriptor_name': 'Transplantation, Homologous', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19361026', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.8, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 15, 'referenced_works': ['https://openalex.org/W1969699915', 'https://openalex.org/W1986096540', 'https://openalex.org/W2009746221', 'https://openalex.org/W2028259055', 'https://openalex.org/W2029970434', 'https://openalex.org/W2040014460', 'https://openalex.org/W2073670989', 'https://openalex.org/W2080712219', 'https://openalex.org/W2081483302', 'https://openalex.org/W2085793556', 'https://openalex.org/W2125058683', 'https://openalex.org/W2126902771', 'https://openalex.org/W2162076442', 'https://openalex.org/W2946010722', 'https://openalex.org/W95403184'], 'related_works': ['https://openalex.org/W78936952', 'https://openalex.org/W3155730258', 'https://openalex.org/W3086740988', 'https://openalex.org/W2994793952', 'https://openalex.org/W2890973958', 'https://openalex.org/W2884903867', 'https://openalex.org/W2791155984', 'https://openalex.org/W2433586366', 'https://openalex.org/W2417640566', 'https://openalex.org/W2377973121', 'https://openalex.org/W2341503523', 'https://openalex.org/W2335327296', 'https://openalex.org/W2207613807', 'https://openalex.org/W2166605872', 'https://openalex.org/W2079160576', 'https://openalex.org/W2038446001', 'https://openalex.org/W2028824864', 'https://openalex.org/W2015437512', 'https://openalex.org/W1999340551', 'https://openalex.org/W1986096540'], 'abstract_inverted_index': {'Three': [0], 'to': [1, 45, 335], '5': [2], 'percent': [3], 'of': [4, 13, 29, 33, 41, 149, 182, 304, 309, 330], 'the': [5, 42, 84, 111, 120, 124, 158, 168, 188, 211, 221, 262, 287, 302], 'patients': [6, 62, 183], 'undergoing': [7], 'cardiac': [8, 319], 'surgery': [9, 320], 'are': [10], 'reoperated': [11], 'because': [12], 'bleeding.': [14, 38, 337], 'When': [15], 'a': [16, 48, 67, 90, 99, 292], 'surgical': [17], 'cause': [18, 36], 'can': [19], 'be': [20, 25], 'excluded,': [21], 'heparin/protamine': [22], 'mismatch': [23], 'may': [24, 35], 'considered.': [26], 'Insufficient': [27], 'reversal': [28], 'heparin': [30, 78, 100, 105, 129, 205, 234, 305, 331], 'and': [31, 58, 79, 137, 306, 332], 'overdosing': [32], 'protamine': [34, 80, 145, 257, 310, 333], 'postoperative': [37, 56, 296], 'The': [39, 70, 232], 'purpose': [40], 'study': [43], 'was': [44, 107, 130, 142, 154, 193, 207, 239, 259], 'evaluate': [46], 'whether': [47], 'heparin-protamine': [49], 'titration': [50], 'system,': [51, 87], 'Hemochron': [52, 85, 288], 'RxDx,': [53, 289], 'could': [54], 'reduce': [55, 336], 'bleeding': [57, 153], 'blood': [59, 185, 297], 'transfusion.': [60], 'Fifty-three': [61], 'were': [63, 117, 281], 'included': [64], 'prospectively': [65], 'over': [66], '6-month': [68], 'period.': [69], 'test': [71], 'group': [72, 126, 160, 170, 213, 223, 264], '(RxDx': [73], 'group;': [74], '28': [75], 'patients)': [76], 'received': [77], 'doses': [81, 116, 308], 'calculated': [82, 108, 118], 'using': [83, 321], 'RxDx': [86, 159, 189, 212, 263], 'which': [88], 'performs': [89], 'baseline': [91], 'activated': [92], 'clotting': [93], 'time': [94], '(ACT)': [95], 'value': [96], 'together': [97], 'with': [98, 144, 167, 220], 'response': [101], 'test.': [102], 'An': [103], 'accurate': [104], 'dose': [106, 206, 258], 'based': [109, 132, 325], 'on': [110, 133, 326], 'Bull': [112], 'dose/response': [113, 322], 'curve.': [114], 'Protamine': [115], 'by': [119, 139], 'same': [121], 'method.': [122], 'In': [123], 'control': [125, 169, 222], '(25': [127], 'patients),': [128], 'administered': [131], 'weight': [134], '(3.5': [135], 'mg/kg)': [136], 'monitored': [138], 'ACT.': [140], 'Heparin': [141], 'reversed': [143], '(1': [146], 'mg/l': [147], 'mg': [148, 249, 270], 'total': [150], 'heparin).': [151], 'Postoperative': [152], 'significantly': [155, 208, 240], 'lower': [156, 241], 'in': [157, 187, 210, 261, 283, 295, 327], '(375': [161], 'mL;': [162, 172, 175], 'range,': [163, 173, 216, 226], '125-700': [164], 'mL)': [165], 'compared': [166, 219], '(600': [171], '250-1920': [174], 'p': [176, 201, 229, 253, 274], '=': [177, 202, 230, 254, 275], '.018).': [178], 'A': [179], 'reduced': [180, 209, 260], 'number': [181], 'needed': [184], 'transfusions': [186], 'group,': [190], 'although': [191], 'this': [192], 'not': [194], 'statistically': [195], 'significant': [196, 293], '(19%': [197], 'vs.': [198, 247, 268], '38%,': [199], 'respectively;': [200], '.13).': [203], 'Initial': [204, 256], '(250': [214], 'mg;': [215, 225, 228], '100-375': [217], 'mg)': [218], '(300': [224], '200-350': [227], '.04).': [231], 'additional': [233], 'during': [235, 312, 318], 'cardiopulmonary': [236], 'bypass': [237], '(CPB)': [238], 'as': [242, 299, 301], 'well': [243, 300], '62': [244], '(range,': [245, 250, 266, 271], '0-185)': [246], '100': [248], '0-350': [251], 'mg);': [252, 273], '.04.': [255], '200': [265], '75-340)': [267], '350': [269], '200-500': [272], '.0001.': [276], 'Satisfactory': [277], 'end': [278], 'ACT': [279], 'values': [280], 'obtained': [282], 'both': [284], 'groups.': [285], 'Using': [286], 'we': [290], 'observed': [291], 'reduction': [294], 'loss,': [298], 'amount': [303], 'initial': [307], 'used': [311], 'CPB.': [313], 'Individual': [314], 'patient': [315], 'managed': [316], 'anticoagulation': [317], 'curve': [323], 'techniques': [324], 'vitro': [328], 'analysis': [329], 'seems': [334]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W52785124', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-14T18:27:51.272387', 'created_date': '2016-06-24'}