Title: Multipotency and Tissue-Specific Stem Cells
Abstract:The HSC is but one multipotent tissue-specific stem cell. Apparently, each organ contains its specific stem cells, residing in specialized niches. Several of the most studied organ-specific stem cells...The HSC is but one multipotent tissue-specific stem cell. Apparently, each organ contains its specific stem cells, residing in specialized niches. Several of the most studied organ-specific stem cells, such as neuronal stem cells (NSCs), skin stem cells, and intestinal stem cells, are described. Like HSCs, that give rise to all blood cell types, intestinal stem cells differentiate to the variety of mature cells found in the intestine, and are therefore multipotent in nature. Some, but not all of the other tissue-specific stem cells are multipotent, quiescent, and have migration and transplantation capacities. Other alleged tissue-specific stem cells, have an oligopotent or a unipotent phenotype and share only one common property with the others, i.e. being the precursors of mature cells of their organ of residence. This raises doubts as to whether all these cells belong to the same class and whether they are stem cells at all.Read More
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
Access and Citation
Cited By Count: 1
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