POS0237 TRANSCRIPTOMIC LANDSCAPES IN IDIOPATHIC INFLAMMATORY MYOPATHY: DIVERGENT PATHWAYS AND IMMUNE CELLS POTENTIALLY DRIVING MUSCLE DAMAGE.

Name: Work Video:
Duration: 3 min 30 s
Shinji Izuka; Natsuka Umezawa; Toshihiko Komai; Yasuhiro Sugimori; Naoki Kimura; Fumitaka Mizoguchi; Y. Fujieda; Keita Ninagawa; Takeshi Iwasaki; Katsuya Suzuki; Tsutomu Takeuchi; K. Ohmura; Tsuneyo Mimori; Takashi Atsumi; E. Kawakami; Akari Suzuki; Yuta Kochi; K. Yamamoto; Satoshi Yasuda; Tomonori Okamura; Mineto Ota; K. Fujio
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'this': [30], 'study': [31], 'was': [32, 50, 315, 348], 'to': [33, 66, 113, 136, 262, 311], 'investigate': [34, 137], 'the': [35, 67, 138, 150, 198, 260, 271, 301, 351], 'transcriptome': [36], 'immunophenotypic': [38], 'features': [39], 'biopsies': [42, 327], 'from': [43, 56, 328], 'patients': [44, 57, 75, 154, 219, 237, 275, 329], 'with': [45, 58, 145, 155, 169, 176, 259, 288, 317, 330], 'IIM.': [46], '<h3>Methods:</h3>': [47], 'Bulk': [48], 'RNA-sequencing': [49], 'performed': [51], 'on': [52], 'biopsy': [54], 'samples': [55], 'IIM': [59, 331], '(PM;': [60], 'n=9,': [61], 'DM;': [62], 'n=16,': [63], 'classified': [64], 'according': [65], 'Bohan': [68], 'Peter': [70], 'criteria)': [71], '(Figure': [72, 185, 216], '1).': [73], 'DM': [74, 218, 249, 255, 272, 308, 314], 'were': [76, 111, 121, 134, 166, 174, 193, 233, 256, 286], 'further': [77], 'divided': [78], 'into': [79], 'subgroups': [80], 'negative': [81, 202], 'or': [82], 'positive': [83, 191, 206], 'for': [84, 354], 'anti-aminoacyl': [85], 'tRNA': [86], 'synthetase': [87], '(ARS)': [88], 'antibodies': [89], '(n=9': [90], 'n=7,': [92], 'respectively).': [93, 252], 'Weighted': [94], 'gene': [95, 102, 106, 171, 322], 'coexpression': [96], 'network': [97], 'analysis': [98, 109], '(WGCNA),': [99], 'differentially': [100], 'expressed': [101], '(DEG)': [103], 'analysis,': [104], 'set': [107], 'variation': [108], '(GSVA)': [110], 'conducted': [112], 'evaluate': [114], 'specific': [115, 170], 'pathways': [116], 'functions.': [118], 'Cell': [119], 'proportions': [120, 142, 199, 222, 229], 'estimated': [122], 'through': [123], 'a': [124, 277], 'deconvolution': [125], 'approach.': [126], 'Mann-Whitney': [127], 'U': [128], 'test': [129], 'Spearman': [131], 'correlation': [132], 'analyses': [133], 'used': [135], 'differences': [139], 'in': [140, 235, 248, 254, 307, 325, 340], 'cell': [141], 'relationships': [144], 'clinical': [146], 'features.': [147], '<h3>Results:</h3>': [148], 'Among': [149, 270], 'total': [151], '25': [153], 'IIM,': [156], 'WGCNA': [157], 'revealed': [158, 240], 'serum': [159], 'creatine': [160], 'kinase': [161], '(CK)': [162], 'aldolase': [164], 'levels': [165], 'significantly': [167], 'correlated': [168], 'modules': [172], 'that': [173, 333], 'associated': [175, 258, 287, 316], 'cellular': [177], 'respiration,': [178], 'mitochondrial': [179], 'translation,': [180], 'phagocytosis,': [181], 'cytokine': [183], 'production': [184], '2A': [186], '2B).': [188], 'Additionally,': [189], 'significant': [190, 302], 'correlations': [192], 'observed': [194], 'between': [195], 'CK': [196], 'CD16': [201], '(CD16n': [203], 'Mono)': [204], 'monocytes': [207], '(CD16p': [208], 'Mono),': [209], 'well': [211], 'myeloid': [213, 305], 'dendritic': [214], 'cells': [215, 232, 282, 306], '2C).': [217], 'demonstrated': [220], 'higher': [221, 228, 278, 318], 'CD16n': [224], 'Mono': [225], '(p=0.043),': [226], 'whereas': [227], 'Th2': [231], 'found': [234], 'PM': [236], '(p=0.049).': [238], 'GSVA': [239], 'elevated': [241], 'interferon': [242], '(IFN)-α': [243], 'response': [244, 261], 'complement': [246, 268, 319], 'signatures': [247], '(p=0.017,': [250], '0.008,': [251], 'DEGs': [253, 285], 'also': [257], 'type': [263], 'I': [264], 'IFN': [265], 'pathway': [266], 'system.': [269], 'patients,': [273], 'ARS-DM': [274], 'exhibited': [276], 'proportion': [279], 'Th1': [281], '(p=0.007)': [283], 'oxidative': [289], 'phosphorylation.': [290], '<h3>Conclusion:</h3>': [291], 'This': [292, 346], 'research': [293, 347], 'elucidates': [294], 'potential': [295], 'damage,': [299], 'highlighting': [300], 'involvement': [303], 'compared': [310], 'PM.': [312], 'Furthermore,': [313], 'signaling.': [320], 'Distinctive': [321], 'expression': [323], 'variations': [324], 'suggest': [332], 'different': [334], 'pathologic': [335], 'underlie': [337], 'each': [341], 'phenotype.': [342], '<h3>REFERENCES:</h3>': [343], '<b>NIL.</b>': [344], '<h3>Acknowledgements:</h3>': [345], 'supported': [349], 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