Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4393984900', 'doi': 'https://doi.org/10.1002/fsn3.4157', 'title': '<i>Gracilaria chorda</i> attenuates obesity‐related muscle wasting through activation of <scp>SIRT1</scp>/<scp>PGC1α</scp> in skeletal muscle of mice', 'display_name': '<i>Gracilaria chorda</i> attenuates obesity‐related muscle wasting through activation of <scp>SIRT1</scp>/<scp>PGC1α</scp> in skeletal muscle of mice', 'publication_year': 2024, 'publication_date': '2024-04-04', 'ids': {'openalex': 'https://openalex.org/W4393984900', 'doi': 'https://doi.org/10.1002/fsn3.4157', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/39055231'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/fsn3.4157', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/fsn3.4157', 'source': {'id': 'https://openalex.org/S2764587058', 'display_name': 'Food Science & Nutrition', 'issn_l': '2048-7177', 'issn': ['2048-7177'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/fsn3.4157', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5049506239', 'display_name': 'Ahyoung Yoo', 'orcid': 'https://orcid.org/0000-0002-3474-2016'}, 'institutions': [{'id': 'https://openalex.org/I4210114577', 'display_name': 'Korea Food Research Institute', 'ror': 'https://ror.org/028jp5z02', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114577']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Ahyoung Yoo', 'raw_affiliation_strings': ['Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Korea'], 'affiliations': [{'raw_affiliation_string': 'Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Korea', 'institution_ids': ['https://openalex.org/I4210114577']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025316158', 'display_name': 'Jiyun Ahn', 'orcid': 'https://orcid.org/0000-0002-5930-2957'}, 'institutions': [{'id': 'https://openalex.org/I4210114577', 'display_name': 'Korea Food Research Institute', 'ror': 'https://ror.org/028jp5z02', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114577']}, {'id': 'https://openalex.org/I88761825', 'display_name': 'Korea University of Science and Technology', 'ror': 'https://ror.org/000qzf213', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I88761825']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jiyun Ahn', 'raw_affiliation_strings': ['Division of Food Biotechnology, University of Science and Technology, Daejeon, Korea', 'Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Korea'], 'affiliations': [{'raw_affiliation_string': 'Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Korea', 'institution_ids': ['https://openalex.org/I4210114577']}, {'raw_affiliation_string': 'Division of Food Biotechnology, University of Science and Technology, Daejeon, Korea', 'institution_ids': ['https://openalex.org/I88761825']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5114144079', 'display_name': 'Hyo Deok Seo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210114577', 'display_name': 'Korea Food Research Institute', 'ror': 'https://ror.org/028jp5z02', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114577']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Hyo Deok Seo', 'raw_affiliation_strings': ['Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Korea'], 'affiliations': [{'raw_affiliation_string': 'Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Korea', 'institution_ids': ['https://openalex.org/I4210114577']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058843650', 'display_name': 'Jeong‐Hoon Hahm', 'orcid': 'https://orcid.org/0000-0003-2446-2974'}, 'institutions': [{'id': 'https://openalex.org/I4210114577', 'display_name': 'Korea Food Research Institute', 'ror': 'https://ror.org/028jp5z02', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114577']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jeong‐Hoon Hahm', 'raw_affiliation_strings': ['Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Korea'], 'affiliations': [{'raw_affiliation_string': 'Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Korea', 'institution_ids': ['https://openalex.org/I4210114577']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100360881', 'display_name': 'Min Jung Kim', 'orcid': 'https://orcid.org/0000-0003-0205-016X'}, 'institutions': [{'id': 'https://openalex.org/I4210114577', 'display_name': 'Korea Food Research Institute', 'ror': 'https://ror.org/028jp5z02', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114577']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Min Jung Kim', 'raw_affiliation_strings': ['Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Korea'], 'affiliations': [{'raw_affiliation_string': 'Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Korea', 'institution_ids': ['https://openalex.org/I4210114577']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009496552', 'display_name': 'Chang Hwa Jung', 'orcid': 'https://orcid.org/0000-0002-1076-750X'}, 'institutions': [{'id': 'https://openalex.org/I88761825', 'display_name': 'Korea University of Science and Technology', 'ror': 'https://ror.org/000qzf213', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I88761825']}, {'id': 'https://openalex.org/I4210114577', 'display_name': 'Korea Food Research Institute', 'ror': 'https://ror.org/028jp5z02', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114577']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Chang Hwa Jung', 'raw_affiliation_strings': ['Division of Food Biotechnology, University of Science and Technology, Daejeon, Korea', 'Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Korea'], 'affiliations': [{'raw_affiliation_string': 'Division of Food Biotechnology, University of Science and Technology, Daejeon, Korea', 'institution_ids': ['https://openalex.org/I88761825']}, {'raw_affiliation_string': 'Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Korea', 'institution_ids': ['https://openalex.org/I4210114577']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5058850458', 'display_name': 'Tae Youl Ha', 'orcid': 'https://orcid.org/0000-0001-7583-9490'}, 'institutions': [{'id': 'https://openalex.org/I4210114577', 'display_name': 'Korea Food Research Institute', 'ror': 'https://ror.org/028jp5z02', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210114577']}, {'id': 'https://openalex.org/I88761825', 'display_name': 'Korea University of Science and Technology', 'ror': 'https://ror.org/000qzf213', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I88761825']}], 'countries': ['KR'], 'is_corresponding': True, 'raw_author_name': 'Tae Youl Ha', 'raw_affiliation_strings': ['Division of Food Biotechnology, University of Science and Technology, Daejeon, Korea', 'Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Korea'], 'affiliations': [{'raw_affiliation_string': 'Division of Food Functionality Research, Korea Food Research Institute, Wanju-gun, Korea', 'institution_ids': ['https://openalex.org/I4210114577']}, {'raw_affiliation_string': 'Division of Food Biotechnology, University of Science and Technology, Daejeon, Korea', 'institution_ids': ['https://openalex.org/I88761825']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5058850458'], 'corresponding_institution_ids': ['https://openalex.org/I4210114577', 'https://openalex.org/I88761825'], 'apc_list': {'value': 2550, 'currency': 'EUR', 'value_usd': 2800, 'provenance': 'doaj'}, 'apc_paid': {'value': 2550, 'currency': 'EUR', 'value_usd': 2800, 'provenance': 'doaj'}, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 83}, 'biblio': {'volume': '12', 'issue': '7', 'first_page': '5077', 'last_page': '5086'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11457', 'display_name': 'Adipose Tissue and Metabolism', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11457', 'display_name': 'Adipose Tissue and Metabolism', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11051', 'display_name': 'Sirtuins and Resveratrol in Medicine', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2717', 'display_name': 'Geriatrics and Gerontology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10441', 'display_name': 'Muscle Physiology and Disorders', 'score': 0.9951, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/chorda', 'display_name': 'Chorda', 'score': 0.42996734}], 'concepts': [{'id': 'https://openalex.org/C2779764123', 'wikidata': 'https://www.wikidata.org/wiki/Q7972881', 'display_name': 'Wasting', 'level': 2, 'score': 0.67823935}, {'id': 'https://openalex.org/C2779959927', 'wikidata': 'https://www.wikidata.org/wiki/Q1048687', 'display_name': 'Skeletal muscle', 'level': 2, 'score': 0.59698874}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.47865474}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.43233883}, {'id': 'https://openalex.org/C2775871351', 'wikidata': 'https://www.wikidata.org/wiki/Q18378264', 'display_name': 'Chorda', 'level': 3, 'score': 0.42996734}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.41967282}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.38449162}, {'id': 'https://openalex.org/C31903555', 'wikidata': 'https://www.wikidata.org/wiki/Q1637030', 'display_name': 'Food science', 'level': 1, 'score': 0.37701932}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.31336275}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2699749}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.24138474}, {'id': 'https://openalex.org/C8868529', 'wikidata': 'https://www.wikidata.org/wiki/Q124794', 'display_name': 'Taste', 'level': 2, 'score': 0.1479421}], 'mesh': [], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/fsn3.4157', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/fsn3.4157', 'source': {'id': 'https://openalex.org/S2764587058', 'display_name': 'Food Science & Nutrition', 'issn_l': '2048-7177', 'issn': ['2048-7177'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11266886', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/39055231', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/fsn3.4157', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/fsn3.4157', 'source': {'id': 'https://openalex.org/S2764587058', 'display_name': 'Food Science & Nutrition', 'issn_l': '2048-7177', 'issn': ['2048-7177'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W1977548231', 'https://openalex.org/W1993132387', 'https://openalex.org/W1993476327', 'https://openalex.org/W2009641783', 'https://openalex.org/W2017011351', 'https://openalex.org/W2030401911', 'https://openalex.org/W2031784378', 'https://openalex.org/W2039601869', 'https://openalex.org/W2053765200', 'https://openalex.org/W2096724514', 'https://openalex.org/W2109503539', 'https://openalex.org/W2113515610', 'https://openalex.org/W2135004805', 'https://openalex.org/W2147227155', 'https://openalex.org/W2167370558', 'https://openalex.org/W2406933571', 'https://openalex.org/W2473566980', 'https://openalex.org/W2524988370', 'https://openalex.org/W2529245535', 'https://openalex.org/W2531724552', 'https://openalex.org/W2560911376', 'https://openalex.org/W2593668961', 'https://openalex.org/W2606029369', 'https://openalex.org/W2792924693', 'https://openalex.org/W2885711716', 'https://openalex.org/W2914204801', 'https://openalex.org/W2969781413', 'https://openalex.org/W2995730585', 'https://openalex.org/W3022499895', 'https://openalex.org/W3023180184', 'https://openalex.org/W30273463', 'https://openalex.org/W3146471255', 'https://openalex.org/W4206148911', 'https://openalex.org/W4206728765', 'https://openalex.org/W4207033334', 'https://openalex.org/W4211187374', 'https://openalex.org/W4214904355', 'https://openalex.org/W4220851191', 'https://openalex.org/W4224993404', 'https://openalex.org/W4281620774', 'https://openalex.org/W4293525118', 'https://openalex.org/W4295925898', 'https://openalex.org/W4320491663'], 'related_works': ['https://openalex.org/W4301393061', 'https://openalex.org/W4300179771', 'https://openalex.org/W3194644769', 'https://openalex.org/W3098037799', 'https://openalex.org/W2780989196', 'https://openalex.org/W2607760820', 'https://openalex.org/W2534612903', 'https://openalex.org/W2468482093', 'https://openalex.org/W2160269050', 'https://openalex.org/W2004491733'], 'abstract_inverted_index': {'(GC)': [0], 'is': [1, 7], 'a': [2, 42, 61], 'red': [3], 'algal': [4], 'species': [5], 'that': [6, 115, 130], 'primarily': [8], 'consumed': [9], 'in': [10, 45, 89, 99, 111, 139, 145, 170, 178, 200], 'Asia.': [11], 'Here,': [12], 'we': [13], 'investigated': [14], 'the': [15, 29, 47, 74, 116, 133, 162, 171, 179, 196, 201], 'effect': [16], 'of': [17, 31, 50, 118, 135, 142, 174, 198, 204], 'GC': [18, 84, 103, 121, 131, 184], 'on': [19, 28, 73], 'obesity-related': [20, 186], 'skeletal': [21, 90, 105, 123, 140, 202], 'muscle': [22, 91, 94, 106, 124, 141, 187, 203], 'wasting.': [23], 'Furthermore,': [24, 102], 'elucidating': [25], 'its': [26], 'impact': [27], 'activation': [30, 117, 197], 'sirtuin': [32], '1': [33], '(SIRT1)/peroxisome': [34], 'proliferator-activated': [35], 'receptor': [36], 'gamma': [37], 'coactivator': [38], '1α': [39], '(PGC1α)': [40], 'constituted': [41], 'critical': [43], 'aspect': [44], 'understanding': [46], 'underlying': [48], 'mechanism': [49], 'action.': [51], 'In': [52, 154], 'this': [53], 'study,': [54], '6-week-old': [55], 'male': [56], 'C57BL/6': [57], 'mice': [58, 143], 'were': [59, 159, 168], 'fed': [60], 'high-fat': [62], 'diet': [63], '(HFD)': [64], 'for': [65, 76], '8': [66, 78], 'weeks': [67, 79], 'to': [68], 'induce': [69], 'obesity,': [70], 'then': [71], 'continued': [72], 'HFD': [75], 'another': [77], 'while': [80], 'orally': [81], 'administered': [82], 'GC.': [83], 'decreased': [85], 'ectopic': [86], 'fat': [87], 'accumulation': [88], 'and': [92, 97, 108, 126, 137, 144, 152, 176, 193], 'increased': [93, 109, 132, 149], 'weight,': [95], 'size,': [96], 'function': [98, 151, 192], 'obese': [100], 'mice.': [101, 112, 205], 'reduced': [104], 'atrophy': [107, 125], 'hypertrophy': [110], 'We': [113, 128], 'hypothesized': [114], 'SIRT1/PGC1α': [119, 199], 'by': [120, 189], 'regulates': [122], 'hypertrophy.': [127], 'observed': [129, 169], 'expression': [134], 'SIRT1': [136, 175], 'PGC1α': [138, 177], 'C2C12': [146, 157, 181], 'cells,': [147], 'which': [148], 'mitochondrial': [150, 191], 'biogenesis.': [153], 'addition,': [155], 'when': [156], 'cells': [158], 'treated': [160], 'with': [161], 'SIRT1-specific': [163], 'inhibitor': [164], 'EX-527,': [165], 'no': [166], 'changes': [167], 'protein': [172], 'levels': [173], 'GC-treated': [180], 'cells.': [182], 'Therefore,': [183], 'attenuated': [185], 'wasting': [188], 'improving': [190], 'biogenesis': [194], 'through': [195]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4393984900', 'counts_by_year': [], 'updated_date': '2025-01-13T05:06:36.116487', 'created_date': '2024-04-06'}