Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4393974224', 'doi': 'https://doi.org/10.1002/cncr.35316', 'title': 'Impact of tocilizumab on anti‐CD19 chimeric antigen receptor T‐cell therapy in B‐cell acute lymphoblastic leukemia', 'display_name': 'Impact of tocilizumab on anti‐CD19 chimeric antigen receptor T‐cell therapy in B‐cell acute lymphoblastic leukemia', 'publication_year': 2024, 'publication_date': '2024-04-05', 'ids': {'openalex': 'https://openalex.org/W4393974224', 'doi': 'https://doi.org/10.1002/cncr.35316', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/38578977'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/cncr.35316', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S126033908', 'display_name': 'Cancer', 'issn_l': '0008-543X', 'issn': ['0008-543X', '1045-7410', '1097-0142'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5068990085', 'display_name': 'Xiangmin Wang', 'orcid': 'https://orcid.org/0000-0002-3639-7228'}, 'institutions': [{'id': 'https://openalex.org/I177388780', 'display_name': 'Xuzhou Medical College', 'ror': 'https://ror.org/04fe7hy80', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177388780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiangmin Wang', 'raw_affiliation_strings': ['Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}, {'raw_affiliation_string': 'Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017537574', 'display_name': 'Bingpei Zhang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I177388780', 'display_name': 'Xuzhou Medical College', 'ror': 'https://ror.org/04fe7hy80', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177388780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Bingpei Zhang', 'raw_affiliation_strings': ['Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}, {'raw_affiliation_string': 'Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070330321', 'display_name': 'Qing Zhang', 'orcid': 'https://orcid.org/0000-0001-6871-3435'}, 'institutions': [{'id': 'https://openalex.org/I177388780', 'display_name': 'Xuzhou Medical College', 'ror': 'https://ror.org/04fe7hy80', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177388780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qing Zhang', 'raw_affiliation_strings': ['Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}, {'raw_affiliation_string': 'Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101526629', 'display_name': 'Hongyuan Zhou', 'orcid': 'https://orcid.org/0000-0003-0682-6295'}, 'institutions': [{'id': 'https://openalex.org/I177388780', 'display_name': 'Xuzhou Medical College', 'ror': 'https://ror.org/04fe7hy80', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177388780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hongyuan Zhou', 'raw_affiliation_strings': ['Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}, {'raw_affiliation_string': 'Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101209057', 'display_name': 'Qian Sun', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I177388780', 'display_name': 'Xuzhou Medical College', 'ror': 'https://ror.org/04fe7hy80', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177388780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qian Sun', 'raw_affiliation_strings': ['Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}, {'raw_affiliation_string': 'Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065789169', 'display_name': 'Yi Zhou', 'orcid': 'https://orcid.org/0000-0001-9024-7514'}, 'institutions': [{'id': 'https://openalex.org/I177388780', 'display_name': 'Xuzhou Medical College', 'ror': 'https://ror.org/04fe7hy80', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177388780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yi Zhou', 'raw_affiliation_strings': ['Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}, {'raw_affiliation_string': 'Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101842358', 'display_name': 'Tianci Li', 'orcid': 'https://orcid.org/0009-0009-9680-1171'}, 'institutions': [{'id': 'https://openalex.org/I177388780', 'display_name': 'Xuzhou Medical College', 'ror': 'https://ror.org/04fe7hy80', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177388780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Tianci Li', 'raw_affiliation_strings': ['Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}, {'raw_affiliation_string': 'Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079239100', 'display_name': 'Di Zhou', 'orcid': 'https://orcid.org/0000-0002-9766-860X'}, 'institutions': [{'id': 'https://openalex.org/I177388780', 'display_name': 'Xuzhou Medical College', 'ror': 'https://ror.org/04fe7hy80', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177388780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Dian Zhou', 'raw_affiliation_strings': ['Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}, {'raw_affiliation_string': 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073386987', 'display_name': 'Ziyuan Shen', 'orcid': 'https://orcid.org/0000-0001-6989-9147'}, 'institutions': [{'id': 'https://openalex.org/I197869895', 'display_name': 'Anhui Medical University', 'ror': 'https://ror.org/03xb04968', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I197869895']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ziyuan Shen', 'raw_affiliation_strings': ['Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China', 'institution_ids': ['https://openalex.org/I197869895']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046438119', 'display_name': 'Jiaoli Zhang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I177388780', 'display_name': 'Xuzhou Medical College', 'ror': 'https://ror.org/04fe7hy80', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177388780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jiaoli Zhang', 'raw_affiliation_strings': ['Department of Rehabilitation, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Rehabilitation, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100435450', 'display_name': 'Ping Li', 'orcid': 'https://orcid.org/0000-0001-5480-3755'}, 'institutions': [{'id': 'https://openalex.org/I116953780', 'display_name': 'Tongji University', 'ror': 'https://ror.org/03rc6as71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I116953780']}, {'id': 'https://openalex.org/I4210160344', 'display_name': 'Tongji Hospital', 'ror': 'https://ror.org/04xy45965', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160344']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ping Li', 'raw_affiliation_strings': ['Department of Hematology, Tongji Hospital of Tongji University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, Tongji Hospital of Tongji University, Shanghai, China', 'institution_ids': ['https://openalex.org/I116953780', 'https://openalex.org/I4210160344']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037838431', 'display_name': 'Aibin Liang', 'orcid': 'https://orcid.org/0000-0002-8978-1987'}, 'institutions': [{'id': 'https://openalex.org/I116953780', 'display_name': 'Tongji University', 'ror': 'https://ror.org/03rc6as71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I116953780']}, {'id': 'https://openalex.org/I4210160344', 'display_name': 'Tongji Hospital', 'ror': 'https://ror.org/04xy45965', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160344']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Aibin Liang', 'raw_affiliation_strings': ['Department of Hematology, Tongji Hospital of Tongji University, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, Tongji Hospital of Tongji University, Shanghai, China', 'institution_ids': ['https://openalex.org/I116953780', 'https://openalex.org/I4210160344']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050450526', 'display_name': 'Keshu Zhou', 'orcid': 'https://orcid.org/0000-0001-5467-1377'}, 'institutions': [{'id': 'https://openalex.org/I38877650', 'display_name': 'Zhengzhou University', 'ror': 'https://ror.org/04ypx8c21', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I38877650']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Keshu Zhou', 'raw_affiliation_strings': ['Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China', 'institution_ids': ['https://openalex.org/I38877650']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101425086', 'display_name': 'Lu Han', 'orcid': 'https://orcid.org/0000-0002-9004-4458'}, 'institutions': [{'id': 'https://openalex.org/I38877650', 'display_name': 'Zhengzhou University', 'ror': 'https://ror.org/04ypx8c21', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I38877650']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lu Han', 'raw_affiliation_strings': ['Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China', 'institution_ids': ['https://openalex.org/I38877650']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014867753', 'display_name': 'Yongxian Hu', 'orcid': 'https://orcid.org/0000-0002-4102-547X'}, 'institutions': [{'id': 'https://openalex.org/I4210166576', 'display_name': 'First Affiliated Hospital Zhejiang University', 'ror': 'https://ror.org/05m1p5x56', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210166576']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yongxian Hu', 'raw_affiliation_strings': ['Department of Hematology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China', 'institution_ids': ['https://openalex.org/I4210166576']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022438900', 'display_name': 'Yun Yang', 'orcid': 'https://orcid.org/0000-0002-6314-0516'}, 'institutions': [{'id': 'https://openalex.org/I4210131893', 'display_name': "Second Affiliated Hospital of Xi'an Jiaotong University", 'ror': 'https://ror.org/03aq7kf18', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210131893']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yun Yang', 'raw_affiliation_strings': ["Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China"], 'affiliations': [{'raw_affiliation_string': "Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China", 'institution_ids': ['https://openalex.org/I4210131893']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045094860', 'display_name': 'Jiang Cao', 'orcid': 'https://orcid.org/0000-0003-3767-9283'}, 'institutions': [{'id': 'https://openalex.org/I177388780', 'display_name': 'Xuzhou Medical College', 'ror': 'https://ror.org/04fe7hy80', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177388780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jiang Cao', 'raw_affiliation_strings': ['Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}, {'raw_affiliation_string': 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000930830', 'display_name': 'Zhenyu Li', 'orcid': 'https://orcid.org/0000-0003-4610-9135'}, 'institutions': [{'id': 'https://openalex.org/I177388780', 'display_name': 'Xuzhou Medical College', 'ror': 'https://ror.org/04fe7hy80', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177388780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhenyu Li', 'raw_affiliation_strings': ['Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}, {'raw_affiliation_string': 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100666262', 'display_name': 'Kailin Xu', 'orcid': 'https://orcid.org/0000-0003-1375-1084'}, 'institutions': [{'id': 'https://openalex.org/I177388780', 'display_name': 'Xuzhou Medical College', 'ror': 'https://ror.org/04fe7hy80', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177388780']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Kailin Xu', 'raw_affiliation_strings': ['Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}, {'raw_affiliation_string': 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103199459', 'display_name': 'Wei Sang', 'orcid': 'https://orcid.org/0000-0003-3119-5835'}, 'institutions': [{'id': 'https://openalex.org/I177388780', 'display_name': 'Xuzhou Medical College', 'ror': 'https://ror.org/04fe7hy80', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177388780']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Wei Sang', 'raw_affiliation_strings': ['Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}, {'raw_affiliation_string': 'Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 7, 'corresponding_author_ids': ['https://openalex.org/A5100666262', 'https://openalex.org/A5103199459'], 'corresponding_institution_ids': ['https://openalex.org/I177388780', 'https://openalex.org/I177388780'], 'apc_list': {'value': 4740, 'currency': 'USD', 'value_usd': 4740, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 85}, 'biblio': {'volume': '130', 'issue': '15', 'first_page': '2660', 'last_page': '2669'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11491', 'display_name': 'Chimeric Antigen Receptor T Cell Therapy', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11491', 'display_name': 'Chimeric Antigen Receptor T Cell Therapy', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T14117', 'display_name': 'Failure Analysis of Integrated Circuits', 'score': 0.9778, 'subfield': {'id': 'https://openalex.org/subfields/2208', 'display_name': 'Electrical and Electronic Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10558', 'display_name': 'Nanoelectronics and Transistors', 'score': 0.9776, 'subfield': {'id': 'https://openalex.org/subfields/2208', 'display_name': 'Electrical and Electronic Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tocilizumab', 'display_name': 'Tocilizumab', 'score': 0.98215914}, {'id': 'https://openalex.org/keywords/cytokine-release-syndrome', 'display_name': 'Cytokine release syndrome', 'score': 0.90114194}, {'id': 'https://openalex.org/keywords/t-cell-therapy', 'display_name': 'T Cell Therapy', 'score': 0.555828}, {'id': 'https://openalex.org/keywords/car-t-cells', 'display_name': 'CAR T Cells', 'score': 0.544809}], 'concepts': [{'id': 'https://openalex.org/C2777178219', 'wikidata': 'https://www.wikidata.org/wiki/Q425154', 'display_name': 'Tocilizumab', 'level': 3, 'score': 0.98215914}, {'id': 'https://openalex.org/C2780850621', 'wikidata': 'https://www.wikidata.org/wiki/Q3961647', 'display_name': 'Cytokine release syndrome', 'level': 5, 'score': 0.90114194}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8773055}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5837109}, {'id': 'https://openalex.org/C3875195', 'wikidata': 'https://www.wikidata.org/wiki/Q5099363', 'display_name': 'Chimeric antigen receptor', 'level': 4, 'score': 0.46896043}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.44266614}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.43536296}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.3074683}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.22216341}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061067', 'descriptor_name': 'Antibodies, Monoclonal, Humanized', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D018941', 'descriptor_name': 'Antigens, CD19', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D002648', 'descriptor_name': 'Child', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000080424', 'descriptor_name': 'Cytokine Release Syndrome', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016219', 'descriptor_name': 'Immunotherapy, Adoptive', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015452', 'descriptor_name': 'Precursor B-Cell Lymphoblastic Leukemia-Lymphoma', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D000076962', 'descriptor_name': 'Receptors, Chimeric Antigen', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D012189', 'descriptor_name': 'Retrospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055815', 'descriptor_name': 'Young Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/cncr.35316', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S126033908', 'display_name': 'Cancer', 'issn_l': '0008-543X', 'issn': ['0008-543X', '1045-7410', '1097-0142'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/38578977', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.8}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 26, 'referenced_works': ['https://openalex.org/W1927563864', 'https://openalex.org/W1989542542', 'https://openalex.org/W2118796952', 'https://openalex.org/W2147509059', 'https://openalex.org/W2773804840', 'https://openalex.org/W2787301955', 'https://openalex.org/W2787621143', 'https://openalex.org/W2796821082', 'https://openalex.org/W2905654445', 'https://openalex.org/W2942621614', 'https://openalex.org/W2949232578', 'https://openalex.org/W2952260713', 'https://openalex.org/W2980542859', 'https://openalex.org/W3008376116', 'https://openalex.org/W3047154808', 'https://openalex.org/W3081687748', 'https://openalex.org/W3128956257', 'https://openalex.org/W3129647653', 'https://openalex.org/W3146763078', 'https://openalex.org/W3186991133', 'https://openalex.org/W3206099201', 'https://openalex.org/W3211929629', 'https://openalex.org/W4212835893', 'https://openalex.org/W4220685620', 'https://openalex.org/W4283218904', 'https://openalex.org/W4310671769'], 'related_works': ['https://openalex.org/W4393974224', 'https://openalex.org/W4381594543', 'https://openalex.org/W3214604417', 'https://openalex.org/W3142239825', 'https://openalex.org/W2969241243', 'https://openalex.org/W2952260713', 'https://openalex.org/W2917403768', 'https://openalex.org/W2796022095', 'https://openalex.org/W2594853348', 'https://openalex.org/W2525195860'], 'abstract_inverted_index': {'Abstract': [0], 'Background': [1], 'Tocilizumab': [2, 262], 'is': [3], 'commonly': [4], 'used': [5], 'for': [6], 'the': [7, 30, 48, 106, 111, 134, 143, 156, 174, 201, 218, 243, 252, 266, 275], 'management': [8], 'of': [9, 34, 40, 50, 99, 108, 115, 125, 136, 142, 184, 189, 222, 233, 237, 257, 268, 277], 'chimeric': [10], 'antigen': [11], 'receptor': [12], '(CAR)': [13], 'T‐cell': [14, 36, 54], 'therapy–associated': [15], 'cytokine': [16, 123], 'release': [17], 'syndrome': [18, 215], '(CRS).': [19], 'However,': [20], 'it': [21], 'remains': [22], 'unknown': [23], 'whether': [24], 'tocilizumab': [25, 51, 84, 109, 157, 190, 202, 244, 248], 'or': [26, 198], 'its': [27], 'dosage': [28], 'affects': [29], 'efficacy': [31, 112, 267], 'and': [32, 113, 122, 151, 168, 208, 226, 235, 254], 'safety': [33, 114], 'CAR': [35, 53, 70, 116, 126, 258, 269], 'therapy.': [37, 55], 'The': [38, 101, 139], 'objective': [39], 'this': [41], 'multicenter': [42], 'retrospective': [43], 'study': [44], 'was': [45, 105, 145], 'to': [46, 78, 231], 'explore': [47], 'impact': [49], 'on': [52, 110], 'Methods': [56], 'In': [57, 200, 217, 246], 'total,': [58], '93': [59], 'patients': [60, 82, 89, 95, 144, 179, 205, 223], 'with': [61, 148, 173, 178], 'B‐cell': [62], 'acute': [63], 'lymphoblastic': [64], 'leukemia': [65], '(B‐ALL)': [66], 'receiving': [67, 186], 'humanized': [68], 'anti‐CD19': [69], 'T': [71, 117, 127, 259, 270], 'cells': [72, 128, 271], 'were': [73, 129], 'recruited': [74], 'from': [75], 'May': [76], '2016': [77], 'November': [79], '2022.': [80], 'Forty‐five': [81], 'received': [83, 96, 181], '(tocilizumab': [85], 'group),': [86], 'whereas': [87], '48': [88], 'did': [90, 191, 249], 'not': [91, 192, 250, 264], '(nontocilizumab': [92], 'group).': [93], 'Thirteen': [94], '>1': [97, 187], 'dose': [98, 183, 188], 'tocilizumab.': [100, 137], 'primary': [102], 'end': [103], 'point': [104], 'effect': [107], 'cells.': [118, 260], 'Additionally,': [119], 'proliferation,': [120], 'killing,': [121], 'assays': [124], 'performed': [130], 'in': [131, 133, 155, 242], 'vitro': [132], 'presence': [135], 'Results': [138], 'median': [140], 'age': [141], '33': [146], 'years,': [147], '47': [149], 'males': [150], '46': [152], 'females.': [153], 'Patients': [154], 'group': [158], 'showed': [159], 'similar': [160], 'complete': [161], 'response': [162], '(CR)': [163], 'rate,': [164, 196], 'overall': [165], 'survival': [166, 170], '(OS),': [167], 'event‐free': [169], '(EFS)': [171], 'compared': [172], 'nontocilizumab': [175, 219], 'group.': [176, 245], 'Compared': [177], 'who': [180], '≤1': [182], 'tocilizumab,': [185], 'affect': [193, 265], 'their': [194], 'CR': [195], 'OS,': [197], 'EFS.': [199], 'group,': [203, 220], 'all': [204], 'experienced': [206, 210, 224, 228], 'CRS': [207, 225], '26.7%': [209], 'immune': [211], 'effector': [212], 'cell–associated': [213], 'neurotoxicity': [214], '(ICANS).': [216], '64.6%': [221], '8.3%': [227], 'ICANS.': [229, 278], 'Up': [230], '75%': [232], 'ICANS': [234, 240], '87.5%': [236], 'grade': [238], '≥3': [239], 'occurred': [241], 'vitro,': [247], 'impair': [251], 'proliferation': [253], 'killing': [255], 'effects': [256], 'Conclusions': [261], 'does': [263], 'but': [272], 'may': [273], 'increase': [274], 'likelihood': [276]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4393974224', 'counts_by_year': [], 'updated_date': '2024-09-12T13:32:36.983601', 'created_date': '2024-04-06'}