Abstract:A prognostic factor research study was conducted in January 2022, during the third wave of the COVID-19 pandemic, focusing on identifying homeopathic medicines and their indications for the treatment ...A prognostic factor research study was conducted in January 2022, during the third wave of the COVID-19 pandemic, focusing on identifying homeopathic medicines and their indications for the treatment of confirmed cases, particularly those involving the Omicron variant of the SARS-CoV-2 virus.It was an open-labelled multicentre observational study conducted in integrated COVID Care Centres in Delhi, India.Homeopathic medicines were prescribed alongside conventional treatment for confirmed COVID-19 cases that met specific selection criteria.Out of 362 COVID-19 cases, 263 were selected for analysis based on the selection criteria.Common symptoms such as fatigue, cough, sore throat, myalgia and headache were included in the study.Twenty-one different medicines were prescribed, out of which nine were frequently used: Gelsemium sempervirens, Bryonia alba, Hepar sulphuris, Rhus toxicodendron, Pulsatilla nigricans, Arsenicum album, Belladonna, Nux vomica and Phosphorus.Likelihood ratio of 1.3 or greater was considered meaningful, for identifying indications for the frequently prescribed medicines.It is reported that homeopathic medicines demonstrated promising results as an adjunct therapy during the third wave of COVID-19.Medicines used in earlier waves continued to be useful, and their indications were similar.Some new indications for certain medicines emerged during the third wave, emphasising the need for further research.The importance of not restricting treatment to specific medicines and the on-going collection of data for the improvement of the COVID-19 mini-repertory are highlighted. Comments:The study supported the potential usefulness of homeopathic medicines as adjunct therapy for COVID-19, with a focus on identifying indications based on symptoms, especially in the context of emerging variants like Omicron.Homoeopathic treatment as an adjunct therapy in such cases paves way for similar trials in pandemics/epidemics. a Bayesian reperTory for aCuTe viral infeCTionsRead More