Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4393167441', 'doi': 'https://doi.org/10.1016/j.jbc.2024.105917', 'title': 'Abstract 1488 Modeling the Binding of Tetrodotoxin and Saxitoxin to the Nav1.7 Voltage-Gated Sodium Channel', 'display_name': 'Abstract 1488 Modeling the Binding of Tetrodotoxin and Saxitoxin to the Nav1.7 Voltage-Gated Sodium Channel', 'publication_year': 2024, 'publication_date': '2024-03-01', 'ids': {'openalex': 'https://openalex.org/W4393167441', 'doi': 'https://doi.org/10.1016/j.jbc.2024.105917'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.jbc.2024.105917', 'pdf_url': 'http://www.jbc.org/article/S002192582400293X/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.jbc.org/article/S002192582400293X/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5094242836', 'display_name': 'Isabella Fiore', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I203088144', 'display_name': 'Nova Southeastern University', 'ror': 'https://ror.org/042bbge36', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I203088144']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Isabella Fiore', 'raw_affiliation_strings': ['Nova Southeastern University'], 'affiliations': [{'raw_affiliation_string': 'Nova Southeastern University', 'institution_ids': ['https://openalex.org/I203088144']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108911603', 'display_name': 'Smrithi Mukund', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I132801547', 'display_name': 'Southeastern University', 'ror': 'https://ror.org/01b25wz12', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I132801547']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Smrithi Mukund', 'raw_affiliation_strings': ['Southeastern University'], 'affiliations': [{'raw_affiliation_string': 'Southeastern University', 'institution_ids': ['https://openalex.org/I132801547']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5094242837', 'display_name': 'Laasya Buddharaju', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I132801547', 'display_name': 'Southeastern University', 'ror': 'https://ror.org/01b25wz12', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I132801547']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Laasya Buddharaju', 'raw_affiliation_strings': ['Southeastern University'], 'affiliations': [{'raw_affiliation_string': 'Southeastern University', 'institution_ids': ['https://openalex.org/I132801547']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053398816', 'display_name': 'Emily Schmitt Lavin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I132801547', 'display_name': 'Southeastern University', 'ror': 'https://ror.org/01b25wz12', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I132801547']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Emily Schmitt Lavin', 'raw_affiliation_strings': ['Southeastern University'], 'affiliations': [{'raw_affiliation_string': 'Southeastern University', 'institution_ids': ['https://openalex.org/I132801547']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5036085657', 'display_name': 'Arthur Sikora', 'orcid': 'https://orcid.org/0000-0001-6295-9928'}, 'institutions': [{'id': 'https://openalex.org/I132801547', 'display_name': 'Southeastern University', 'ror': 'https://ror.org/01b25wz12', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I132801547']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Arthur Sikora', 'raw_affiliation_strings': ['Southeastern University'], 'affiliations': [{'raw_affiliation_string': 'Southeastern University', 'institution_ids': ['https://openalex.org/I132801547']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 84}, 'biblio': {'volume': '300', 'issue': '3', 'first_page': '105917', 'last_page': '105917'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11985', 'display_name': 'Marine Toxins and Detection Methods', 'score': 0.9932, 'subfield': {'id': 'https://openalex.org/subfields/2304', 'display_name': 'Environmental Chemistry'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11985', 'display_name': 'Marine Toxins and Detection Methods', 'score': 0.9932, 'subfield': {'id': 'https://openalex.org/subfields/2304', 'display_name': 'Environmental Chemistry'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11434', 'display_name': 'Electrochemical Analysis and Applications', 'score': 0.9889, 'subfield': {'id': 'https://openalex.org/subfields/1603', 'display_name': 'Electrochemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11818', 'display_name': 'Nicotinic Acetylcholine Receptors Study', 'score': 0.9822, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/saxitoxin', 'display_name': 'Saxitoxin', 'score': 0.92614985}, {'id': 'https://openalex.org/keywords/nav1', 'display_name': 'NAV1', 'score': 0.8056643}, {'id': 'https://openalex.org/keywords/tetrodotoxin', 'display_name': 'Tetrodotoxin', 'score': 0.6802852}, {'id': 'https://openalex.org/keywords/nav1.5', 'display_name': 'Nav1.5', 'score': 0.67103344}], 'concepts': [{'id': 'https://openalex.org/C2777646408', 'wikidata': 'https://www.wikidata.org/wiki/Q412694', 'display_name': 'Saxitoxin', 'level': 3, 'score': 0.92614985}, {'id': 'https://openalex.org/C50952357', 'wikidata': 'https://www.wikidata.org/wiki/Q424960', 'display_name': 'Sodium channel', 'level': 3, 'score': 0.8800985}, {'id': 'https://openalex.org/C2777589315', 'wikidata': 'https://www.wikidata.org/wiki/Q18048105', 'display_name': 'NAV1', 'level': 4, 'score': 0.8056643}, {'id': 'https://openalex.org/C2776741303', 'wikidata': 'https://www.wikidata.org/wiki/Q379842', 'display_name': 'Tetrodotoxin', 'level': 2, 'score': 0.6802852}, {'id': 'https://openalex.org/C2776250582', 'wikidata': 'https://www.wikidata.org/wiki/Q14905729', 'display_name': 'Nav1.5', 'level': 4, 'score': 0.67103344}, {'id': 'https://openalex.org/C127162648', 'wikidata': 'https://www.wikidata.org/wiki/Q16858953', 'display_name': 'Channel (broadcasting)', 'level': 2, 'score': 0.5039484}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.44402346}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.3963602}, {'id': 'https://openalex.org/C537181965', 'wikidata': 'https://www.wikidata.org/wiki/Q658', 'display_name': 'Sodium', 'level': 2, 'score': 0.28658983}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2536416}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.2027871}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.17277074}, {'id': 'https://openalex.org/C31258907', 'wikidata': 'https://www.wikidata.org/wiki/Q1301371', 'display_name': 'Computer network', 'level': 1, 'score': 0.15470544}, {'id': 'https://openalex.org/C2777367657', 'wikidata': 'https://www.wikidata.org/wiki/Q184651', 'display_name': 'Toxin', 'level': 2, 'score': 0.15100625}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.jbc.2024.105917', 'pdf_url': 'http://www.jbc.org/article/S002192582400293X/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.jbc.2024.105917', 'pdf_url': 'http://www.jbc.org/article/S002192582400293X/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.54, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W747878181', 'https://openalex.org/W4383806430', 'https://openalex.org/W2802607288', 'https://openalex.org/W2789319285', 'https://openalex.org/W2618428365', 'https://openalex.org/W2460047246', 'https://openalex.org/W2123369785', 'https://openalex.org/W2038552554', 'https://openalex.org/W2030887914', 'https://openalex.org/W1558488360'], 'abstract_inverted_index': {'Approximately': [0], '1.5': [1], 'billion': [2], 'people': [3, 11], 'suffer': [4], 'from': [5, 55, 73, 181], 'chronic': [6, 42], 'pain,': [7], 'with': [8], '68': [9], 'million': [10, 38], 'suffering': [12, 72], 'in': [13, 63, 86, 153, 288, 309, 331, 377, 384, 460], 'the': [14, 34, 101, 112, 127, 182, 212, 242, 250, 273, 289, 310, 323, 332, 345, 360, 365, 370, 389, 404, 407, 430, 442, 450, 461, 479], 'U.S': [15], 'alone.': [16], 'Chronic': [17], 'pain': [18, 22, 68, 190, 464], 'is': [19, 150, 357, 364], 'defined': [20], 'as': [21, 91, 107, 120, 241], 'that': [23, 158, 173, 292, 313, 335, 368], 'persists': [24], 'longer': [25], 'than': [26], '12': [27], 'weeks': [28], 'despite': [29], 'medication': [30], 'or': [31, 282], 'treatment.': [32], 'Within': [33], 'U.S,': [35], 'about': [36], '5.5': [37], 'cancer': [39, 48], 'patients': [40], 'experience': [41], 'pain.': [43, 76, 175], 'Around': [44], '20%': [45], 'of': [46, 89, 104, 249, 270, 272, 373, 401, 406, 409, 463, 481], 'these': [47, 378], 'pains': [49], 'have': [50, 277], 'neuropathic': [51, 75], 'origins': [52], 'and': [53, 132, 155, 166, 177, 186, 196, 214, 226, 246, 255, 297, 355, 415, 440, 447, 453, 478], 'develop': [54, 201], 'radiation': [56], 'therapy.': [57], 'Halneuron,': [58], 'a': [59, 82, 108, 133, 140, 202, 420], 'new': [60], 'drug': [61, 78], 'currently': [62], 'development,': [64], 'seeks': [65], 'to': [66, 70, 200, 211, 222, 231, 294, 315, 337, 426, 438, 449], 'provide': [67], 'relief': [69], 'those': [71], 'chemotherapy-induced': [74], 'This': [77, 466], 'includes': [79], 'Tetrodotoxin': [80, 105], '(TTX),': [81], 'potent': [83], 'neurotoxin': [84], 'found': [85], 'most': [87, 151], 'species': [88], 'pufferfish,': [90], 'its': [92, 118], 'main': [93], 'active': [94], 'ingredient.': [95], 'Our': [96, 235], '3D': [97, 203], 'printed': [98], 'model': [99, 124, 205, 236, 435, 485], 'displays': [100], 'structural': [102, 128], 'details': [103], '(TTX)': [106], 'pore': [109, 171], 'blocker': [110], 'within': [111], 'Nav1.7': [113, 169, 251, 290, 311, 333, 451], 'channel,': [114, 452], 'providing': [115], 'insight': [116, 456], 'into': [117], 'use': [119], 'an': [121], 'analgesic.': [122], 'The': [123, 192, 218, 253, 266, 349, 382, 417], 'also': [125], 'shows': [126], 'differences': [129, 444], 'between': [130, 385, 445], 'TTX': [131, 165, 176, 298, 341, 446], 'similar': [134], 'toxin,': [135], 'saxitoxin': [136], '(STX),': [137], 'which': [138], 'has': [139], 'lower': [141], 'binding': [142, 233, 443], 'affinity.': [143], 'A': [144], 'toxin': [145], 'produced': [146], 'by': [147, 471, 490], 'algae,': [148], 'STX': [149, 167, 178, 296, 338, 448], 'concentrated': [152], 'mussels': [154], 'other': [156], 'shellfish': [157, 162], 'can': [159], 'induce': [160], 'paralytic': [161], 'poisoning.': [163], 'Both': [164], 'are': [168, 258, 264, 299, 320, 342, 397], 'channel': [170, 213], 'blockers': [172], 'inhibit': [174, 215], 'were': [179, 198, 220, 229], 'chosen': [180], 'Protein': [183, 484], 'Data': [184], 'Bank': [185], 'related': [187], 'literature': [188], 'studying': [189], 'inhibition.': [191], 'PDB': [193], 'files': [194, 219], '6J8J': [195], '6J8H': [197], 'used': [199], 'molecular': [204], 'showing': [206], 'how': [207], 'both': [208, 295], 'toxins': [209], 'bind': [210, 293, 314, 336], 'action': [216], 'potentials.': [217], 'imported': [221], 'Jmol,': [223], 'where': [224], 'interactions': [225], 'amino': [227], 'acids': [228, 287, 308, 330], 'highlighted': [230, 321, 343], 'display': [232], 'differences.': [234], 'contains': [237, 388], 'key': [238], 'features': [239], 'such': [240], 'alpha': [243, 247], 'subunit,': [244], 'backbone,': [245], 'helices': [248], 'channel.': [252, 431], 'N': [254], 'C': [256], 'terminals': [257], 'intracellular,': [259], 'while': [260], 'voltage': [261, 274, 379], 'sensing': [262, 275], 'domains': [263, 276], 'extracellular.': [265], 'helix': [267], '4': [268, 398], '(S4)': [269], 'each': [271], 'their': [278], 'positively': [279], 'charged': [280], 'lysine': [281], 'arginine': [283], 'residues': [284, 400], 'highlighted.': [285], 'Amino': [286, 307, 329], 'receptor': [291, 312, 334], 'shown:': [300], 'tyr362,': [301], 'glu364,': [302], 'arg922,': [303], 'glu927,': [304], 'glu930,': [305, 353], 'thr1409.': [306], 'TTX,': [316], 'but': [317, 339], 'not': [318, 340], 'STX,': [319], 'on': [322, 344, 359, 403], 'backbone:': [324, 346], 'gly1407,': [325], 'gly1699,': [326], 'phe1405,': [327], 'ala1698.': [328], 'trp1700,': [347], 'asp1744.': [348], 'DEKA': [350], 'motif': [351, 392], '(asp361,': [352], 'lys1406,': [354], 'ala1698)': [356], 'marked': [358], 'backbone.': [361], 'Lys': [362], '1406': [363], 'critical': [366], 'determinant': [367], 'specifies': [369], 'selective': [371], 'permeability': [372], 'sodium': [374, 424], 'over': [375], 'potassium': [376], 'gated': [380], 'channels.': [381], 'linker': [383], 'segments': [386], 'III-IV': [387], 'fast': [390], 'inactivation': [391], '(Ile1472,': [393], 'Phe1473,': [394], 'Met1471).': [395], 'There': [396], 'hydrophobic': [399], 'note': [402], 'locus': [405], 'S6': [408], 'VSD': [410], 'IV:': [411], 'Leu398,': [412], 'Leu964,': [413], 'Ile1453,': [414], 'Tyr1755.': [416], 'tyrosine': [418], 'forms': [419], 'down': [421], 'confirmation': [422], 'allowing': [423], 'ions': [425], 'be': [427], 'pushed': [428], 'through': [429], 'Overall,': [432], 'constructing': [433], 'this': [434], 'allowed': [436], 'us': [437], 'understand': [439], 'visualize': [441], 'simultaneously': [454], 'obtain': [455], 'regarding': [457], 'future': [458], 'applications': [459], 'treatment': [462], 'disorders.': [465], 'work': [467], 'was': [468, 487], 'made': [469, 488], 'possible': [470, 489], 'Nova': [472], 'Southeastern': [473], "University's": [474], 'Farquhar': [475], 'Honors': [476], 'College': [477], 'Dept.': [480], 'Biological': [482], 'Sciences.': [483], 'printing': [486], 'Mark': [491], 'Hoelzer': [492], 'at': [493], '3d': [494], 'Molecular': [495], 'Designs.': [496]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4393167441', 'counts_by_year': [], 'updated_date': '2024-12-10T05:04:00.084398', 'created_date': '2024-03-26'}