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309], 'more': [115, 143, 170, 198, 225, 254, 283, 311, 379, 1143, 1312], 'papers': [116, 144, 171, 199, 226, 255, 284, 312], 'by': [117, 145, 172, 200, 227, 256, 285, 313, 448, 525, 696, 1014, 1404, 1787], 'this': [118, 146, 173, 201, 228, 257, 286, 314, 396, 466], 'author': [119, 147, 174, 202, 229, 258, 287, 315, 403], 'MonneyPierre': [122], 'Monney': [123, 1536, 1622], 'https://orcid.org/0000-0002-3083-7333': [124], 'Cardiology,': [128, 183], 'CarronPierre‐Nicolas': [150], 'Carron': [151], 'https://orcid.org/0000-0001-6362-1275': [152], 'Department,': [155, 210], 'TzimasGeorgios': [177], 'Tzimas': [178], 'https://orcid.org/0000-0002-2810-8887': [179], 'BeysardNicolas': [205], 'Beysard': [206], 'https://orcid.org/0000-0003-3561-1250': [207], 'TozziPiergiorgio': [232], 'Tozzi': [233, 1532, 1618], 'https://orcid.org/0000-0002-2608-7568': [234], 'Cardiac': [238, 267], 'Surgery,': [239, 268], 'KirschMatthias': [261], 'https://orcid.org/0000-0002-9213-7578': [263], 'GueryBenoit': [290], 'https://orcid.org/0000-0002-6526-0714': [292], 'Originally': [316], 'published14': [317], 'Feb': [318], '2024https://doi.org/10.1161/JAHA.123.032745Journal': [319], 'Association.': [324], '2024;0:e032745Diagnosing': [325], 'infective': [326, 775, 895, 1448, 1456, 1501, 1548, 1586, 1636], 'endocarditis': [327, 527, 776, 778, 822, 855, 1502], '(IE)': [328], 'is': [329, 1099, 1790, 1817], 'challenging': [330], 'due': [331, 1298], 'its': [333, 1052, 1104, 1754], 'variable': [334, 570], 'clinical': [335, 353, 385, 1497], 'presentation,': [336, 1443], 'with': [337, 428, 435, 478, 558, 567, 649, 690, 983, 1021, 1059, 1075, 1130, 1172, 1230, 1251, 1292, 1507, 1634], 'patients': [338, 427, 434, 470, 578, 638, 664, 689, 981, 1058, 1074, 1129, 1146, 1232, 1250, 1291, 1506, 1633], 'often': [339], 'exhibiting': [340], 'nonspecific': [341], 'symptoms,': [342, 506], 'requiring': [343], 'physicians': [344], 'emergency': [347, 870, 1504], 'department': [348, 871, 1505], '(ED)': [349], 'maintain': [351], 'high': [352, 591, 720, 924], 'suspicion.1': [354], 'The': [355, 389, 444, 986, 1540, 1776], 'ED': [362, 477, 485, 499, 645, 975, 1056, 1208, 1289], '(CREED)': [363], 'score': [364, 376, 574, 979, 1123, 1283, 1314], 'demonstrates': [365], 'promising': [366], 'performance': [367, 1271], 'diagnosing': [369, 1285], 'IE.2This': [370], 'study': [371, 397, 407, 445, 467, 877, 1069, 1085, 1182, 1222, 1229, 1257], 'aims': [372], 'validate': [374], 'a': [378, 383, 479, 1022, 1076, 1100, 1111, 1216, 1227, 1236, 1311, 1459, 1550, 1588, 1660, 1760], 'specific': [380, 1002], 'population': [381, 1237], 'presenting': [382, 982], 'real': [384], 'suspicion': [386, 1037, 1206], 'IE.': [388, 572, 740, 985], 'data': [390, 542], 'that': [391, 959, 1166, 1184, 1238, 1241, 1258], 'support': [392], 'findings': [394, 1157], 'are': [398, 929, 960, 1169, 1196, 1265, 1658, 1667, 1677, 1682, 1690, 1697, 1717], 'available': [399], 'from': [400, 417, 514, 869, 1240, 1592], 'corresponding': [402], 'upon': [404], 'reasonable': [405], 'request.This': [406], 'was': [408, 446, 458, 521, 539, 565, 575, 619, 1017, 1070, 1151, 1226, 1392], 'conducted': [409], 'at': [410, 529], 'January': [418], '2014': [419], 'June': [421], '2023': [422], '(2014–2017:': [423], 'retrospective': [424], 'cohort': [425, 432, 629, 1461, 1551], 'IE,': [429, 632, 666, 675, 1039, 1148, 1177], '2018–2023:': [430], 'prospective': [431, 462, 1460], 'suspected': [436, 631, 984, 1060, 1293, 1635], 'IE)': [437, 657], '(blood': [438], 'cultures': [439], 'drawn': [440], 'echocardiography': [442], 'performed).': [443], 'approved': [447, 1370], 'Swiss': [450], 'ethics': [451], 'committee': [452], '(CER‐VD': [453], '2017–02137),': [454], 'informed': [456], 'consent': [457], 'obtained': [459], 'cohort.Inclusion': [463], 'criteria': [464], 'were': [468, 501, 512, 546, 579, 603, 615, 635, 658, 714, 756, 1142], 'adult': [469], '(≥18': [471], 'years': [472], 'old)': [473], 'admitted': [474], 'temperature': [480, 650, 1077], '>37.5': [481], '°C': [482, 652], '(during': [483], 'stay': [486, 500, 646], 'or': [487, 551, 794, 798, 803, 807, 879, 901, 935], '24': [488, 867], 'hours': [489], 'before': [490], 'admission).': [491], 'whose': [493, 639], 'initial': [494, 640], 'symptoms': [495, 641], 'developed': [496, 642], 'after': [497, 643], 'their': [498, 1161], 'excluded.Data': [502], 'on': [503, 698, 1249, 1628, 1738, 1779], 'demographics,': [504], 'comorbidities,': [505], 'physical': [507], 'signs,': [508], 'laboratory': [510], 'values': [511], 'collected': [513, 1341], "patients'": [515, 1343], 'electronic': [516, 681, 833], 'health': [517, 1175], 'records.': [518], 'A': [519, 1495], 'case': [520], 'characterized': [522], 'as': [523, 716, 931, 994, 996, 1012, 1027, 1110, 1188, 1734], 'IE': [524, 694, 1061, 1095, 1102, 1133, 1198, 1252, 1286, 1294], 'team': [528], 'day': [530], '60.': [531], 'SPSS': [532], 'version': [533], '26.0': [534], '(IBM,': [535], 'Armonk,': [536], 'NY)': [537], 'software': [538], 'used': [540, 1109], 'analysis.': [543], 'Categorical': [544], 'variables': [545, 557, 699, 1118, 1168], 'analyzed': [547], 'using': [548, 605, 742], 'χ2': [550], 'Fisher': [552], 'exact': [553], 'test': [554], 'continuous': [556], 'Mann‐Whitney': [560], 'U': [561], 'test.': [562], 'Bivariate': [563], 'analysis': [564, 1352], 'performed': [566, 1350], 'dependent': [569], 'being': [571], 'CREED': [573, 703, 941, 963, 978, 987, 1122, 1282, 1515], 'calculated,': [576], 'divided': [580], '4': [582], 'risk': [583, 912, 916, 920, 925], 'groups': [584], '(very': [585], 'low,': [586, 587, 718, 719], 'high,': [588], 'very': [590, 717, 722, 1028], 'risk).2': [592], 'Sensitivity,': [593], 'specificity,': [594, 748], 'positive': [595, 749], 'negative': [597, 753, 1048], 'predictive': [598, 750, 754, 1049], 'values,': [599], '95%': [601], 'CIs': [602], 'calculated': [604], 'predefined': [607], 'cutoff': [608], '+2': [610, 744], 'points.2': [611], 'All': [612, 1361], 'statistic': [613], 'tests': [614], '2‐tailed,': [616], 'P<0.05': [618], 'considered': [620], 'statistically': [621], 'significant.Among': [622], '1749': [624], 'episodes': [625], 'included': [626, 961, 1233, 1259], '1137': [633], '(65%)': [634], 'included;': [636], '394': [637], '218': [648, 1091], '≤37.5': [651, 1078], '(of': [653], 'which': [654, 1804], '69': [655, 1094], 'had': [656, 665, 739, 1034], 'excluded.': [659], 'In': [660, 1757], 'total,': [661], '473': [662], '(42%)': [663], '329': [667], '(70%)': [668], 'native': [669], '127': [671], '(27%)': [672], 'prosthetic': [673], 'valve': [674, 829], '47': [677], '(10%)': [678], 'cardiovascular': [679], 'implantable': [680, 832], 'device‐lead': [682], 'IE.The': [683], 'Table': [684], 'depicts': [685], 'characteristics': [687, 1301], 'without': [692, 1132, 1147], 'final': [693, 1410], 'diagnosis': [695, 896, 1629], 'focusing': [697], 'incorporated': [700, 1119], 'score;': [704], '340': [705], '(30%),': [706], '227': [707], '(20%),': [708], '78': [709], '(7%),': [710], '492': [712], '(43%)': [713], 'classified': [715, 1026], 'high‐risk': [723], 'groups,': [724], 'respectively.': [725], 'Within': [726], 'these': [727, 1202], 'categories,': [728], '42': [729], '(12%),': [730], '71': [731], '(31%),': [732], '43': [733], '(55%),': [734], '317': [736], '(64%),': [737], 'respectively,': [738], 'By': [741], 'points': [745], 'cutoff,': [746], 'sensitivity,': [747], 'value,': [751], 'value': [755], '91%': [757], '(88%–94%),': [758], '45%': [759], '(41%–49%),': [760], '54%': [761], '(52%–56%),': [762], '88%': [763], '(84%–91%),': [764], 'respectively.Table': [765], '1.': [766], 'Characteristics': [767], 'Without': [772], 'Endocarditis.CharacteristicWithout': [774], '(n=664)Infective': [777], '(n=473)P': [779], 'valueDemographicsMale': [780], 'sex': [781], '(+1': [782, 796, 816, 835, 840], 'point)*44767%36076%0.001Age,': [783], 'y6755–776751–770.182Age': [784], '≥65': [785], 'y36555%26055%1.000ComorbiditiesCharlson': [786], 'Comorbidity': [787], 'Index42–741–6<0.001Congestive': [788], 'heart': [789, 842, 858], 'failure548%439%0.591Cirrhosis538%255%0.095Diabetes15824%10923%0.777Chronic': [790], 'kidney': [791], 'disease': [792, 826], '(moderate': [793], 'severe)15423%7917%0.009Hemodialysis': [795], 'point)*24136%9220%<0.001Immunosuppression': [797], 'active': [799], 'malignancy24136%9220%<0.001Malignancy': [800], '(solid': [801, 805], 'organ': [802, 806], 'hematological)14622%439%<0.001Transplantation': [804], 'bone': [808], 'marrow)284%92%0.040HIV': [809], 'infection294%174%0.545Immunosuppressive': [810], 'treatment13320%4710%<0.001Prior': [811], 'hospitalization': [812, 1141], '(within': [813, 847, 866], '1': [814, 848], 'mo)': [815, 849], 'point)*16325%7015%<0.001Cardiac': [817], 'predisposing': [818, 1194], 'factorsIV': [819], 'drug': [820], 'use376%4510%0.014Prior': [821], '(+2': [823, 827, 881], 'points)*213%4810%<0.001Moderate/severe': [824], 'valvular': [825], 'points)*447%7716%<0.001Prosthetic': [828], '(+4': [830], 'points)*548%14731%<0.001Cardiac': [831], 'devices': [834], 'point)*467%8318%<0.001Manifestations/clinical': [836], 'signsMalaise/asthenia56986%45396%<0.001Weight': [837], 'loss406%9320%<0.001Dyspnea12819%15232%<0.001Thoracic': [838], 'pain': [839], 'point)*325%419%0.010Acute': [841], 'failure497%10021%<0.001Neurological': [843], 'symptoms10816%16535%<0.001Temperature': [844], '≥39': [845], '°C21032%14932%1.000Sepsis20230%20644%<0.001Stroke': [846], '(+3': [850, 917], 'points)*274%9220%<0.001Physical': [851], 'signs': [852], 'probable': [854], '(+11': [856], 'points)*16725%29362%<0.001New': [857], 'murmur11117%21345%<0.001Embolic': [859], 'events': [860, 1190], '(other': [861], 'than': [862, 1179, 1707], 'stroke)619%15533%<0.001Osler': [863], 'nodes10.2%112%<0.001Imaging': [864], 'studies': [865, 1264], 'h': [868], 'admission)Cardiac': [872], 'echocardiography10916%20744%<0.001Thoracoabdominal': [873], 'CT': [874], 'scan27041%20143%0.542Cerebral': [875], 'imaging': [876, 1627], '(CT': [878], 'MRI)7511%13128%<0.001LaboratoryAnemia': [880], 'points)*42464%29863%0.803Leukocytosis32249%23149%0.952C‐reactive': [882], 'protein,': [883], 'mg/L': [884], '(n=1078': [885], 'patients)13867–24316283–2620.005Infectious': [886], 'diagnoses49074%473100%<0.001Pneumonia568%30.6%<0.001Urinary': [887], 'tract': [888, 900], 'infection528%10.2%<0.001Abdominal': [889], 'infection396%10.2%<0.001Skin': [890], 'soft': [892, 904], 'tissue': [893, 905], 'infection10416%225%<0.001Bacteremia/candidemia41062%43993%<0.001Ascertained': [894], '(pneumonia,': [897], 'abdominal,': [898], 'urinary': [899], 'skin': [902], 'infection)': [906], '(−2': [907, 913], 'points)*24737%276%<0.001CREED': [908], 'score31–9136–16<0.001CREED': [909], 'groupsVery': [910], 'low': [911, 1029], '+2)29845%429%<0.001Low': [915], '+5)15624%7115%High': [919], '(+6': [921], '+8)355%439%Very': [923], '(+9': [926], '+24)17526%31767%Data': [928], 'presented': [930], 'number': [932], 'percentage': [934], 'median': [936], 'quartile': [938], '1–quartile': [939], '3.': [940], 'indicates': [942], 'Department;': [950], 'CT,': [951], 'computed': [952], 'tomography;': [953], 'MRI,': [955], 'magnetic': [956], 'resonance': [957], 'imaging.*Characteristics': [958], 'score.In': [964], 'our': [965, 1001, 1135, 1221, 1278], 'study,': [966, 1011], 'we': [967], 'sought': [968], 'assess': [970], 'usefulness': [972], 'among': [980, 1057, 1207, 1290], 'score,': [988], 'initially': [989], 'promising,': [990], 'did': [991], 'not': [992, 1107, 1659, 1678, 1691, 1698], 'perform': [993], 'well,': [995], 'expected,': [997], 'when': [998, 1164], 'applied': [999], 'patient': [1003], 'population.2': [1004], 'One': [1005], 'fundamental': [1006], 'issue': [1007, 1695], 'original': [1010, 1068, 1244, 1256, 1815], 'acknowledged': [1013], 'authors,': [1016], "cohort's": [1019], 'composition,': [1020], 'staggering': [1023], '87%': [1024], 'inclusion': [1025], 'risk,': [1030], 'many': [1031], 'whom': [1033], 'no': [1035, 1705], 'true': [1036], 'leading': [1040], 'an': [1042, 1650, 1694, 1791], 'overestimation': [1043], 'specificity': [1046], 'value.2': [1050], 'Consequently,': [1051], 'application': [1053], 'should': [1062, 1106, 1204, 1308, 1647, 1703, 1744], 'be': [1063, 1108, 1704, 1713, 1730, 1745], 'limited.Another': [1064], 'limitation': [1065], 'exclusion': [1072, 1089], '°C.': [1079], 'This': [1080, 1763], 'criterion': [1081], 'present': [1084], 'led': [1086], 'episodes,': [1092], 'including': [1093], 'cases.': [1096], 'Although': [1097], 'fever': [1098], 'prominent': [1101], 'symptom,': [1103], 'absence': [1105], 'reason': [1112], 'exclude': [1114], 'IE.1,': [1115], '3Furthermore,': [1116], 'certain': [1117, 1185], 'into': [1120], 'failed': [1124], 'effectively': [1126], 'discriminate': [1127], 'between': [1128], 'cohort.': [1136], 'Notably,': [1137], 'hemodialysis': [1138], 'recent': [1140], 'common': [1144, 1174], 'anemia': [1150], 'consistent': [1152], 'both': [1154, 1167], 'groups.': [1155], 'These': [1156], 'raise': [1158], 'concerns': [1159], 'about': [1160], 'relevance,': [1162], 'particularly': [1163], 'considering': [1165], 'predominately': [1170], 'associated': [1171], 'less': [1173], 'care‐associated': [1176], 'rather': [1178], 'community‐acquired': [1180], 'IE.4Our': [1181], 'reaffirmed': [1183], 'factors,': [1186, 1195], 'such': [1187], 'embolic': [1189], 'various': [1192], 'cardiac': [1193], 'robust': [1197], 'indicators.4,': [1199], '5': [1200], 'Recognizing': [1201], 'factors': [1203], 'heighten': [1205], 'clinicians,': [1209], 'especially': [1210], 'febrile': [1212, 1261], 'patients,': [1213, 1318], 'prompt': [1215], 'thorough': [1217], 'investigation': [1218], 'IE.Nonetheless,': [1220], 'has': [1223], 'limitations.': [1224], 'It': [1225], 'single‐center': [1228], 'some': [1231], 'retrospectively': [1234], 'differs': [1239], 'study.': [1245, 1462, 1552], 'We': [1246], 'focused': [1247], 'exclusively': [1248], 'suspicion,': [1253], 'unlike': [1254], 'all': [1260], 'patients.': [1262], 'More': [1263], 'needed': [1266], 'evaluate': [1268], "score's": [1270], 'originally': [1274], 'intended': [1275], 'population.In': [1276], 'conclusion,': [1277], 'evaluation': [1279], 'revealed': [1295], 'limitations,': [1296], 'primarily': [1297], 'tested': [1304], 'population.': [1305], 'Future': [1306], 'research': [1307], 'prioritize': [1309], 'developing': [1310], 'effective': [1313], 'identify': [1316], 'low‐risk': [1317], 'reducing': [1319], 'need': [1321], 'routine': [1323], 'echocardiography.Sources': [1324], 'FundingNone.DisclosuresNone.AcknowledgmentsAuthor': [1326], 'Contributions:': [1327], 'M.P.‐O.': [1328, 1345, 1349, 1357], 'conceived': [1329], 'idea.': [1331], 'M.P.‐O.,': [1332], 'P.M.,': [1333], 'P.‐N.C.,': [1334], 'G.T.,': [1335], 'N.B.,': [1336], 'P.T.,': [1337], 'M.K.,': [1338], 'B.G.': [1340], 'data.': [1344, 1665], 'supervised': [1346], 'project.': [1348], 'interpreted': [1354], 'results.': [1356], 'wrote': [1358], 'article.': [1360], 'authors': [1362], 'contributed': [1363], 'article': [1365, 1391, 1651, 1724, 1794], 'revision': [1366], 'read': [1368], 'submitted': [1372], 'version.Footnotes*': [1373], '[email protected]': [1390], 'sent': [1393], 'Sakima': [1395], 'A.': [1396], 'Smith,': [1397], 'MPH,': [1399], 'Associate': [1400], 'Editor,': [1401], 'review': [1403], 'expert': [1405], 'referees,': [1406], 'editorial': [1407], 'decision,': [1408], 'disposition.For': [1411], 'Sources': [1412], 'Funding': [1414], 'Disclosures,': [1416], 'see': [1417], 'page': [1418], '4.References1': [1419], 'Habib': [1420], 'G,': [1421, 1490], 'Erba': [1422], 'PA,': [1423], 'Iung': [1424], 'B,': [1425, 1429, 1435, 1485, 1529, 1609], 'Donal': [1426], 'E,': [1427, 1527, 1564, 1571], 'Cosyns': [1428], 'Laroche': [1430], 'C,': [1431, 1579], 'Popescu': [1432], 'BA,': [1433], 'Prendergast': [1434], 'Tornos': [1436], 'P,': [1437, 1533, 1537, 1619], 'Sadeghpour': [1438], 'A,': [1439, 1475, 1477, 1481, 1487, 1569, 1577], 'et': [1440, 1493, 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