Abstract: Type XI collagen is a minor fibrillar collagen. Type XI collagen is broadly distributed in articular cartilage, testis, trachea, tendon, trabecular bone, skeletal muscle, placenta, lung, and the neoepithelium of the brain. Type XI collagen can regulate fibrillogenesis by maintaining the spacing and diameter of type II collagen fibrils and work as a nucleator for the fibrillogenesis of type I and II collagen. Mutations in type XI collagen are associated with Stickler syndrome, Marshall syndrome, fibrochondrogenesis, otospondylomegaepiphyseal dysplasia deafness, and Weissenbacher–Zweymüller syndrome. Type XI collagen is highly associated with cancer progression and cancer-associated fibroblasts. It binds heparin, heparan sulfate, and dermatan sulfate. Biomarkers of type XI collagen have shown great potential as diagnostic and prognostic markers in cancer diseases.
Publication Year: 2024
Publication Date: 2024-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
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