Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4390892660', 'doi': 'https://doi.org/10.1101/2024.01.15.575629', 'title': 'MicroRNA-focused CRISPR/Cas9 Screen Identifies miR-142 as a Key Regulator of Epstein-Barr Virus Reactivation', 'display_name': 'MicroRNA-focused CRISPR/Cas9 Screen Identifies miR-142 as a Key Regulator of Epstein-Barr Virus Reactivation', 'publication_year': 2024, 'publication_date': '2024-01-15', 'ids': {'openalex': 'https://openalex.org/W4390892660', 'doi': 'https://doi.org/10.1101/2024.01.15.575629'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2024.01.15.575629', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2024/01/15/2024.01.15.575629.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.biorxiv.org/content/biorxiv/early/2024/01/15/2024.01.15.575629.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100378019', 'display_name': 'Yan Chen', 'orcid': 'https://orcid.org/0000-0001-5325-1151'}, 'institutions': [{'id': 'https://openalex.org/I165690674', 'display_name': 'Oregon Health & Science University', 'ror': 'https://ror.org/009avj582', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165690674']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yan Chen', 'raw_affiliation_strings': ['Vaccine and Gene Therapy Institute, Oregon Health & Science University'], 'affiliations': [{'raw_affiliation_string': 'Vaccine and Gene Therapy Institute, Oregon Health & Science University', 'institution_ids': ['https://openalex.org/I165690674']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001824985', 'display_name': 'Rodney P. Kincaid', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165690674', 'display_name': 'Oregon Health & Science University', 'ror': 'https://ror.org/009avj582', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165690674']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rodney P. Kincaid', 'raw_affiliation_strings': ['Vaccine and Gene Therapy Institute, Oregon Health & Science University'], 'affiliations': [{'raw_affiliation_string': 'Vaccine and Gene Therapy Institute, Oregon Health & Science University', 'institution_ids': ['https://openalex.org/I165690674']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5093687716', 'display_name': 'Kelley Bastin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165690674', 'display_name': 'Oregon Health & Science University', 'ror': 'https://ror.org/009avj582', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165690674']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kelley Bastin', 'raw_affiliation_strings': ['Vaccine and Gene Therapy Institute, Oregon Health & Science University'], 'affiliations': [{'raw_affiliation_string': 'Vaccine and Gene Therapy Institute, Oregon Health & Science University', 'institution_ids': ['https://openalex.org/I165690674']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019510560', 'display_name': 'Devin N. Fachko', 'orcid': 'https://orcid.org/0000-0003-1646-8102'}, 'institutions': [{'id': 'https://openalex.org/I165690674', 'display_name': 'Oregon Health & Science University', 'ror': 'https://ror.org/009avj582', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165690674']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Devin N. Fachko', 'raw_affiliation_strings': ['Vaccine and Gene Therapy Institute, Oregon Health & Science University'], 'affiliations': [{'raw_affiliation_string': 'Vaccine and Gene Therapy Institute, Oregon Health & Science University', 'institution_ids': ['https://openalex.org/I165690674']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5068129114', 'display_name': 'Rebecca L. Skalsky', 'orcid': 'https://orcid.org/0000-0003-2967-9478'}, 'institutions': [{'id': 'https://openalex.org/I165690674', 'display_name': 'Oregon Health & Science University', 'ror': 'https://ror.org/009avj582', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165690674']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rebecca L. Skalsky', 'raw_affiliation_strings': ['Vaccine and Gene Therapy Institute, Oregon Health & Science University'], 'affiliations': [{'raw_affiliation_string': 'Vaccine and Gene Therapy Institute, Oregon Health & Science University', 'institution_ids': ['https://openalex.org/I165690674']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.955556, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 83, 'max': 92}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10685', 'display_name': 'Viral-associated cancers and disorders', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10685', 'display_name': 'Viral-associated cancers and disorders', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10981', 'display_name': 'Cytomegalovirus and herpesvirus research', 'score': 0.975, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9457, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lytic-cycle', 'display_name': 'Lytic cycle', 'score': 0.8870876}, {'id': 'https://openalex.org/keywords/virus-latency', 'display_name': 'Virus latency', 'score': 0.48754355}], 'concepts': [{'id': 'https://openalex.org/C182615771', 'wikidata': 'https://www.wikidata.org/wiki/Q1369386', 'display_name': 'Lytic cycle', 'level': 3, 'score': 0.8870876}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.64384204}, {'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.6268033}, {'id': 'https://openalex.org/C57074206', 'wikidata': 'https://www.wikidata.org/wiki/Q14197552', 'display_name': 'MAPK/ERK pathway', 'level': 3, 'score': 0.594457}, {'id': 'https://openalex.org/C2781375147', 'wikidata': 'https://www.wikidata.org/wiki/Q6900', 'display_name': 'Epstein–Barr virus', 'level': 3, 'score': 0.5550577}, {'id': 'https://openalex.org/C2778852064', 'wikidata': 'https://www.wikidata.org/wiki/Q4115619', 'display_name': 'Virus latency', 'level': 4, 'score': 0.48754355}, {'id': 'https://openalex.org/C6929976', 'wikidata': 'https://www.wikidata.org/wiki/Q3771881', 'display_name': 'Regulator', 'level': 3, 'score': 0.48197168}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4236266}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.39789388}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.3486666}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.34002987}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.2849369}, {'id': 'https://openalex.org/C140704245', 'wikidata': 'https://www.wikidata.org/wiki/Q3933202', 'display_name': 'Viral replication', 'level': 3, 'score': 0.1929957}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.19077939}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.16313556}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2024.01.15.575629', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2024/01/15/2024.01.15.575629.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2024.01.15.575629', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2024/01/15/2024.01.15.575629.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 65, 'referenced_works': ['https://openalex.org/W1838401124', 'https://openalex.org/W1977228190', 'https://openalex.org/W1989917351', 'https://openalex.org/W1992696389', 'https://openalex.org/W1993652391', 'https://openalex.org/W2000581759', 'https://openalex.org/W2000584697', 'https://openalex.org/W2001230322', 'https://openalex.org/W2011913607', 'https://openalex.org/W2015616819', 'https://openalex.org/W2016466911', 'https://openalex.org/W2019130238', 'https://openalex.org/W2036897871', 'https://openalex.org/W2064254099', 'https://openalex.org/W2071222048', 'https://openalex.org/W2073301179', 'https://openalex.org/W2084914593', 'https://openalex.org/W2086504474', 'https://openalex.org/W2087025873', 'https://openalex.org/W2093923054', 'https://openalex.org/W2108234281', 'https://openalex.org/W2108498499', 'https://openalex.org/W2110752409', 'https://openalex.org/W2117092553', 'https://openalex.org/W2120350608', 'https://openalex.org/W2121545342', 'https://openalex.org/W2123029438', 'https://openalex.org/W2124985265', 'https://openalex.org/W2129216514', 'https://openalex.org/W2136010280', 'https://openalex.org/W2143493524', 'https://openalex.org/W2143563122', 'https://openalex.org/W2145613663', 'https://openalex.org/W2150644589', 'https://openalex.org/W2161098338', 'https://openalex.org/W2161146599', 'https://openalex.org/W2161790138', 'https://openalex.org/W2162399226', 'https://openalex.org/W2165371767', 'https://openalex.org/W2170551349', 'https://openalex.org/W2285594441', 'https://openalex.org/W2417294817', 'https://openalex.org/W2493845034', 'https://openalex.org/W2521825474', 'https://openalex.org/W2727479110', 'https://openalex.org/W2762436345', 'https://openalex.org/W2800218175', 'https://openalex.org/W2886933155', 'https://openalex.org/W2888204442', 'https://openalex.org/W2908235148', 'https://openalex.org/W2929311039', 'https://openalex.org/W2965461038', 'https://openalex.org/W2969815104', 'https://openalex.org/W2997022986', 'https://openalex.org/W3092539938', 'https://openalex.org/W3104145505', 'https://openalex.org/W3124064516', 'https://openalex.org/W3156637462', 'https://openalex.org/W3161091975', 'https://openalex.org/W3184147176', 'https://openalex.org/W4200337362', 'https://openalex.org/W4205972999', 'https://openalex.org/W4206896921', 'https://openalex.org/W4291097580', 'https://openalex.org/W4310494031'], 'related_works': ['https://openalex.org/W3006005114', 'https://openalex.org/W2894048792', 'https://openalex.org/W26220906', 'https://openalex.org/W2555413582', 'https://openalex.org/W2138633314', 'https://openalex.org/W2108233169', 'https://openalex.org/W2089038328', 'https://openalex.org/W2015616819', 'https://openalex.org/W2013857388', 'https://openalex.org/W1966334521'], 'abstract_inverted_index': {'Abstract': [0], 'Reactivation': [1], 'from': [2, 55], 'latency': [3, 57], 'plays': [4], 'a': [5, 64, 87, 99], 'significant': [6], 'role': [7], 'in': [8, 67, 119, 158], 'maintaining': [9], 'persistent': [10], 'lifelong': [11], 'Epstein-Barr': [12], 'virus': [13], '(EBV)': [14], 'infection.': [15, 45], 'Mechanisms': [16], 'governing': [17], 'successful': [18], 'activation': [19], 'and': [20, 37, 83, 114, 155, 191], 'progression': [21], 'of': [22, 102, 107, 111, 139, 150, 170], 'the': [23, 50, 59, 78, 140, 189, 197], 'EBV': [24, 31, 56, 103, 194], 'lytic': [25, 60, 116, 198], 'phase': [26], 'are': [27], 'not': [28], 'fully': [29], 'understood.': [30], 'expresses': [32], 'multiple': [33], 'viral': [34, 44], 'microRNAs': [35], '(miRNAs)': [36], 'manipulates': [38], 'several': [39], 'cellular': [40], 'miRNAs': [41, 52], 'to': [42, 76, 132, 160], 'support': [43], 'To': [46], 'gain': [47], 'insight': [48], 'into': [49, 58, 196], 'host': [51], 'regulating': [53], 'transitions': [54], 'stage,': [61], 'we': [62, 95], 'conducted': [63], 'CRISPR/Cas9-based': [65], 'screen': [66], 'EBV+': [68], 'Burkitt': [69], 'lymphoma': [70], '(BL)': [71], 'cells': [72, 127], 'using': [73], 'anti-Ig': [74], 'antibodies': [75], 'crosslink': [77], 'B': [79, 141], 'cell': [80, 142], 'receptor': [81, 143], '(BCR)': [82], 'induce': [84], 'reactivation.': [85, 104], 'Using': [86], 'gRNA': [88], 'library': [89], 'against': [90], '>1500': [91], 'annotated': [92], 'human': [93], 'miRNAs,': [94], 'identified': [96], 'miR-142': [97, 108, 129, 151, 182], 'as': [98], 'key': [100], 'regulator': [101], 'Genetic': [105], 'ablation': [106], 'enhanced': [109, 152], 'levels': [110, 154], 'immediate': [112], 'early': [113, 115], 'gene': [117], 'products': [118], 'infected': [120], 'BL': [121], 'cells.': [122], 'Ago2-PAR-CLIP': [123], 'experiments': [124], 'with': [125, 146], 'reactivated': [126], 'revealed': [128], 'targets': [130], 'related': [131], 'Erk/MAPK': [133], 'signaling,': [134], 'including': [135], 'components': [136], 'directly': [137], 'downstream': [138], '(BCR).': [144], 'Consistent': [145], 'these': [147, 178], 'findings,': [148], 'disruption': [149], 'SOS1': [153], 'Mek': [156, 171], 'phosphorylation': [157], 'response': [159], 'surface': [161], 'Ig': [162], 'cross-linking.': [163], 'Effects': [164], 'could': [165], 'be': [166], 'rescued': [167], 'by': [168], 'inhibitors': [169], '(cobimetinib)': [172], 'or': [173], 'Raf': [174], '(dabrafenib).': [175], 'Taken': [176], 'together,': [177], 'results': [179], 'show': [180], 'that': [181], 'functionally': [183], 'regulates': [184], 'SOS1/Ras/Raf/Mek/Erk': [185], 'signaling': [186], 'initiated': [187], 'through': [188], 'BCR': [190], 'consequently,': [192], 'restricts': [193], 'entry': [195], 'cycle.': [199]}, 'abstract_inverted_index_v3': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4390892660', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}], 'updated_date': '2025-01-20T05:46:38.530501', 'created_date': '2024-01-16'}