Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4390540586', 'doi': 'https://doi.org/10.2217/epi-2023-0326', 'title': 'Dissecting the Nuances of Cancer Epigenomics in Liquid Biopsy', 'display_name': 'Dissecting the Nuances of Cancer Epigenomics in Liquid Biopsy', 'publication_year': 2024, 'publication_date': '2024-01-01', 'ids': {'openalex': 'https://openalex.org/W4390540586', 'doi': 'https://doi.org/10.2217/epi-2023-0326', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/38166432'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2217/epi-2023-0326', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S42283280', 'display_name': 'Epigenomics', 'issn_l': '1750-192X', 'issn': ['1750-192X', '1750-1911'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310321119', 'host_organization_name': 'Future Medicine', 'host_organization_lineage': ['https://openalex.org/P4310321119'], 'host_organization_lineage_names': ['Future Medicine'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5011928740', 'display_name': 'Valerio Gristina', 'orcid': 'https://orcid.org/0000-0002-2392-0470'}, 'institutions': [{'id': 'https://openalex.org/I900890020', 'display_name': 'University of Palermo', 'ror': 'https://ror.org/044k9ta02', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I900890020']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Valerio Gristina', 'raw_affiliation_strings': ['Department of Surgical, Oncological & Oral Sciences, University of Palermo, Palermo, 90127, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Surgical, Oncological & Oral Sciences, University of Palermo, Palermo, 90127, Italy', 'institution_ids': ['https://openalex.org/I900890020']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5017669867', 'display_name': 'Umberto Malapelle', 'orcid': 'https://orcid.org/0000-0003-3211-9957'}, 'institutions': [], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Umberto Malapelle', 'raw_affiliation_strings': ['Department of Public Health, University Federico II of Naples, Naples, 80131, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Public Health, University Federico II of Naples, Naples, 80131, Italy', 'institution_ids': []}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.112, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.999816, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 86, 'max': 94}, 'biblio': {'volume': '16', 'issue': '2', 'first_page': '79', 'last_page': '83'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11287', 'display_name': 'Genomic Landscape of Cancer and Mutational Signatures', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11287', 'display_name': 'Genomic Landscape of Cancer and Mutational Signatures', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetic Modifications and Their Functional Implications', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10449', 'display_name': 'Renal Cell Carcinoma', 'score': 0.9941, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cancer-epigenetics', 'display_name': 'Cancer Epigenetics', 'score': 0.590585}, {'id': 'https://openalex.org/keywords/liquid-biopsies', 'display_name': 'Liquid Biopsies', 'score': 0.581804}, {'id': 'https://openalex.org/keywords/cancer-genomics', 'display_name': 'Cancer Genomics', 'score': 0.548151}, {'id': 'https://openalex.org/keywords/environmental-epigenomics', 'display_name': 'Environmental Epigenomics', 'score': 0.524938}, {'id': 'https://openalex.org/keywords/clinical-guidelines', 'display_name': 'Clinical Guidelines', 'score': 0.517758}, {'id': 'https://openalex.org/keywords/liquid-biopsy', 'display_name': 'Liquid biopsy', 'score': 0.45688635}, {'id': 'https://openalex.org/keywords/epigenomics', 'display_name': 'Epigenomics', 'score': 0.4440689}], 'concepts': [{'id': 'https://openalex.org/C2779473830', 'wikidata': 'https://www.wikidata.org/wiki/Q1540899', 'display_name': 'MEDLINE', 'level': 2, 'score': 0.5961344}, {'id': 'https://openalex.org/C2776256026', 'wikidata': 'https://www.wikidata.org/wiki/Q47912', 'display_name': 'Lung cancer', 'level': 2, 'score': 0.59312445}, {'id': 'https://openalex.org/C2779529041', 'wikidata': 'https://www.wikidata.org/wiki/Q22349364', 'display_name': 'Liquid biopsy', 'level': 3, 'score': 0.45688635}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.45683545}, {'id': 'https://openalex.org/C121912465', 'wikidata': 'https://www.wikidata.org/wiki/Q3589153', 'display_name': 'Epigenomics', 'level': 5, 'score': 0.4440689}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.42307508}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.41903654}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.38353556}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.29747695}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.20110828}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.09717071}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D057890', 'descriptor_name': 'Epigenomics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000073890', 'descriptor_name': 'Liquid Biopsy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2217/epi-2023-0326', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S42283280', 'display_name': 'Epigenomics', 'issn_l': '1750-192X', 'issn': ['1750-192X', '1750-1911'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310321119', 'host_organization_name': 'Future Medicine', 'host_organization_lineage': ['https://openalex.org/P4310321119'], 'host_organization_lineage_names': ['Future Medicine'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/38166432', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 27, 'referenced_works': ['https://openalex.org/W2038523604', 'https://openalex.org/W2057401572', 'https://openalex.org/W2065240245', 'https://openalex.org/W2089470652', 'https://openalex.org/W2171237493', 'https://openalex.org/W2202820153', 'https://openalex.org/W2253928581', 'https://openalex.org/W2330612466', 'https://openalex.org/W2414449891', 'https://openalex.org/W2584928759', 'https://openalex.org/W2586629973', 'https://openalex.org/W2593934358', 'https://openalex.org/W2617060850', 'https://openalex.org/W2900295924', 'https://openalex.org/W2947989913', 'https://openalex.org/W2984827653', 'https://openalex.org/W3013924915', 'https://openalex.org/W3170845821', 'https://openalex.org/W3174187171', 'https://openalex.org/W3178692152', 'https://openalex.org/W3194069390', 'https://openalex.org/W4290672586', 'https://openalex.org/W4302024868', 'https://openalex.org/W4309368285', 'https://openalex.org/W4309604973', 'https://openalex.org/W4311290145', 'https://openalex.org/W4313399499'], 'related_works': ['https://openalex.org/W4318204195', 'https://openalex.org/W4295819104', 'https://openalex.org/W4285490847', 'https://openalex.org/W3201524181', 'https://openalex.org/W3131932045', 'https://openalex.org/W2988805143', 'https://openalex.org/W2956040250', 'https://openalex.org/W2795212387', 'https://openalex.org/W2751366772', 'https://openalex.org/W2101726782'], 'abstract_inverted_index': {'EpigenomicsVol.': [0], '16,': [1, 810], 'No.': [2, 811], '2': [3, 812], 'CommentaryDissecting': [4], 'the': [5, 81, 106, 110, 145, 186, 287, 330, 343, 394, 853, 862, 873, 878, 882, 892, 907, 922, 930, 938, 956, 978, 985, 1022, 1029, 1056], 'nuances': [6], 'of': [7, 19, 26, 40, 46, 112, 134, 148, 176, 185, 207, 234, 282, 289, 414, 449, 456, 486, 540, 593, 600, 614, 643, 665, 748, 773, 877, 887, 906, 921, 934, 937, 1058], 'cancer': [8, 243, 366, 570, 775], 'epigenomics': [9], 'in': [10, 144, 211, 266, 286, 337, 365, 454, 521, 569, 692, 715, 750, 835, 924, 973, 984, 1028, 1055], 'liquid': [11, 180, 331], 'biopsyValerio': [12], 'Gristina': [13, 17, 123, 320], '&': [14, 22, 31, 848], 'Umberto': [15, 32], 'MalapelleValerio': [16], 'https://orcid.org/0000-0002-2392-0470Department': [18], 'Surgical,': [20], 'Oncological': [21], 'Oral': [23], 'Sciences,': [24], 'University': [25, 43], 'Palermo,': [27, 28], '90127,': [29], 'Italy': [30], 'Malapelle': [33], '*Author': [34], 'for': [35, 99, 109, 139, 261, 310, 597, 639, 743, 898, 918, 949], 'correspondence:': [36], 'E-mail': [37], 'Address:': [38], '[email protected]://orcid.org/0000-0003-3211-9957Department': [39], 'Public': [41], 'Health,': [42], 'Federico': [44], 'II': [45], 'Naples,': [47, 48], '80131,': [49], 'ItalyPublished': [50], 'Online:3': [51], 'Jan': [52], '2024https://doi.org/10.2217/epi-2023-0326AboutSectionsView': [53], 'ArticleView': [54], 'Full': [55], 'TextSupplemental': [56], 'MaterialPDF/EPUB': [57], 'ToolsAdd': [58], 'to': [59, 393, 909, 915, 929], 'favoritesDownload': [60], 'CitationsTrack': [61], 'CitationsPermissionsReprints': [62], 'ShareShare': [63], 'onFacebookTwitterLinkedInRedditEmail': [64], 'View': [65], 'articleKeywords:': [66], 'cfDNAepigenomicsfragmentomicsliquid': [67], 'biopsymethylomicsReferences1.': [68], 'McGranahan': [69], 'N,': [70, 126, 441], 'Swanton': [71], 'C.': [72], 'Clonal': [73], 'Heterogeneity': [74], 'and': [75, 80, 213, 371, 418, 460, 489, 512, 516, 571, 641, 746, 771, 875, 885, 943, 953], 'Tumor': [76], 'Evolution:': [77], 'Past,': [78], 'Present,': [79], 'Future.': [82], 'Cell': [83], '168(4),': [84], '613–628': [85], '(2017).Medline': [86, 471], 'CASGoogle': [87, 121, 162, 196, 254, 275, 401, 472, 578, 626, 653, 700, 760, 785, 807], 'Scholar2.': [88], 'Rolfo': [89], 'C,': [90, 199, 730], 'Mack': [91], 'P,': [92, 407, 709], 'Scagliotti': [93], 'GV': [94], 'et': [95, 130, 171, 204, 230, 327, 360, 386, 410, 480, 509, 536, 634, 661, 686, 735, 768, 793], 'al.': [96, 131, 172, 205, 231, 328, 361, 387, 411, 481, 510, 537, 635, 662, 687, 736, 769, 794], 'Liquid': [97], 'Biopsy': [98], 'Advanced': [100], 'NSCLC:': [101], 'A': [102, 153, 306, 535, 633, 740], 'Consensus': [103], 'Statement': [104], 'From': [105], 'International': [107], 'Association': [108], 'Study': [111], 'Lung': [113, 150], 'Cancer.': [114, 312, 752], 'J.': [115, 754], 'Thorac.': [116], 'Oncol.': [117, 250, 348, 525, 554], '16(10),': [118], '1647–1662': [119], '(2021).Medline': [120, 195, 784], 'Scholar3.': [122], 'V,': [124, 321], 'Barraco': [125, 948], 'La': [127, 322], 'Mantia': [128, 323], 'M': [129, 170, 326], 'Clinical': [132, 142, 538], 'Potential': [133], 'Circulating': [135], 'Cell-Free': [136, 737, 799], 'DNA': [137, 210, 238, 263, 285, 388, 424, 488, 567, 615, 668, 690, 718, 738, 778, 800], '(cfDNA)': [138], 'Longitudinally': [140], 'Monitoring': [141], 'Outcomes': [143], 'First-Line': [146], 'Setting': [147], 'Non-Small-Cell': [149], 'Cancer': [151, 390, 573, 649, 797, 802], '(NSCLC):': [152], 'Real-World': [154], 'Prospective': [155], 'Study.': [156], 'Cancers': [157], '(Basel)': [158], '14(23),': [159], '6013': [160], '(2022).Medline': [161, 652, 759], 'Scholar4.': [163], 'Russo': [164], 'A,': [165, 683, 705], 'Incorvaia': [166], 'L,': [167], 'Del': [168], 'Re': [169], 'The': [173], 'molecular': [174], 'profiling': [175, 638], 'solid': [177], 'tumors': [178], 'by': [179, 422, 616, 669], 'biopsy:': [181], 'a': [182, 245, 541, 970], 'position': [183], 'paper': [184, 859], 'AIOM–SIAPEC-IAP–SIBioC–SIC–SIF': [187], 'Italian': [188], 'Scientific': [189], 'Societies.': [190], 'ESMO': [191], 'Open': [192], '6(3),': [193], '100164': [194], 'Scholar5.': [197], 'Bettegowda': [198], 'Sausen': [200], 'M,': [201, 324, 560, 703, 732], 'Leary': [202], 'RJ': [203], 'Detection': [206, 770], 'circulating': [208, 236, 284, 601, 666, 716], 'tumor': [209, 237, 461, 667], 'early-': [212], 'late-stage': [214], 'human': [215, 267], 'malignancies.': [216], 'Sci.': [217, 430, 673, 756], 'Transl.': [218, 674], 'Med.': [219, 620, 675], '6(224),': [220], '224ra24': [221], '(2014).MedlineGoogle': [222], 'Scholar6.': [223], 'Reichert': [224], 'ZR,': [225], 'Morgan': [226], 'TM,': [227], 'Li': [228], 'G': [229], 'Prognostic': [232], 'value': [233], 'plasma': [235, 423, 465], 'fraction': [239], 'across': [240], 'four': [241], 'common': [242], 'types:': [244], 'real-world': [246], 'outcomes': [247], 'study.': [248], 'Ann.': [249, 524, 553], '34(1),': [251], '111–120': [252], '(2023).Medline': [253, 806], 'Scholar7.': [255], 'Fan': [256], 'S,': [257, 357, 437, 681], 'Chi': [258], 'W.': [259], 'Methods': [260], 'genome-wide': [262], 'methylation': [264, 450, 519, 568], 'analysis': [265, 592], 'cancer.': [268, 290, 695], 'Brief.': [269], 'Funct.': [270], 'Genomics': [271, 723], '15(6),': [272], '432–442': [273], '(2016).Medline': [274, 577], 'Scholar8.': [276], 'Warton': [277], 'K,': [278, 445, 610], 'Samimi': [279], 'G.': [280], 'Methylation': [281, 389], 'cell-free': [283, 487, 522, 602, 689, 717, 777], 'diagnosis': [288], 'Front.': [291, 396], 'Mol.': [292, 313, 755], 'Biosci.': [293], '2,': [294, 316], '13': [295, 826], '(2015).MedlineGoogle': [296, 501, 727], 'Scholar9.': [297], 'Lamb': [298], 'YN,': [299], 'Dhillon': [300], 'S.': [301], 'Epi': [302], 'proColon®': [303], '2.0': [304], 'CE:': [305], 'Blood-Based': [307], 'Screening': [308], 'Test': [309], 'Colorectal': [311], 'Diagnosis': [314], 'Ther.': [315], '225–232': [317], '(2017).Google': [318], 'Scholar10.': [319], 'Peri': [325], 'Navigating': [329], 'biopsy': [332], 'Minimal': [333], 'Residual': [334], 'Disease': [335], '(MRD)': [336], 'non-small': [338], 'cell': [339, 645], 'lung': [340, 646, 774], 'cancer:': [341], 'making': [342], 'invisible': [344], 'visible.': [345], 'Crit.': [346], 'Rev.': [347], 'Hematol.': [349], '182,': [350], '103899': [351], '(2023).MedlineGoogle': [352], 'Scholar11.': [353], 'Chang': [354], 'MT,': [355], 'Asthana': [356], 'Gao': [358], 'SP': [359], 'Identifying': [362], 'recurrent': [363], 'mutations': [364], 'reveals': [367], 'widespread': [368], 'lineage': [369], 'diversity': [370], 'mutational': [372], 'specificity.': [373], 'Nat.': [374, 467, 648, 780], 'Biotechnol.': [375], '(2),': [376], '155–63': [377], '(2016).MedlineGoogle': [378], 'Scholar12.': [379], 'Locke': [380], 'WJ,': [381], 'Guanzon': [382], 'D,': [383, 439, 533, 562, 658, 763], 'Ma': [384], 'C': [385], 'Biomarkers:': [391], 'Translation': [392], 'Clinic.': [395], 'Genet.': [397, 468], '10,': [398], '1150': [399], '(2019).Medline': [400, 699], 'Scholar13.': [402], 'Allen': [403], 'Chan': [404, 408], 'KC,': [405], 'Jiang': [406], 'CWM': [409], 'Noninvasive': [412], 'detection': [413, 515, 546, 640, 664], 'cancer-associated': [415], 'genomewide': [416], 'hypomethylation': [417], 'copy': [419], 'number': [420], 'aberrations': [421], 'bisulfite': [425, 484, 598, 617], 'sequencing.': [426], 'Proc.': [427], 'Natl': [428], 'Acad.': [429], 'USA': [431], '110(47),': [432], '18761–18768': [433], '(2013).MedlineGoogle': [434], 'Scholar14.': [435], 'Guo': [436], 'Diep': [438], 'Plongthongkum': [440], 'Fung': [442], 'HL,': [443], 'Zhang': [444, 446], 'K.': [447], 'Identification': [448], 'haplotype': [451], 'blocks': [452], 'AIDS': [453], 'deconvolution': [455], 'heterogeneous': [457], 'tissue': [458], 'samples': [459], 'tissue-of-origin': [462], 'mapping': [463], 'from': [464], 'DNA.': [466, 523, 603], '49,': [469], '635–642': [470], 'Scholar15.': [473], 'Jensen': [474, 583], 'TJ,': [475], 'Kim': [476], 'SK,': [477], 'Zhu': [478], 'Z': [479], 'Whole': [482], 'genome': [483], 'sequencing': [485], 'its': [490], 'cellular': [491], 'contributors': [492], 'uncovers': [493], 'placenta': [494], 'hypomethylated': [495], 'domains.': [496], 'Genome': [497], 'Biol.': [498], '16(1),': [499], '78': [500], 'Scholar16.': [502], 'Liu': [503], 'MC,': [504], 'Oxnard': [505], 'GR,': [506], 'Klein': [507, 530], 'EA': [508], 'Sensitive': [511], 'specific': [513], 'multi-cancer': [514, 544], 'localization': [517], 'using': [518, 548, 776], 'signatures': [520], '6,': [526], '745–759': [527], '(2020).Google': [528], 'Scholar17.': [529], 'EA,': [531], 'Richards': [532], 'Cohn': [534], 'validation': [539, 551], 'targeted': [542], 'methylation-based': [543], 'early': [545], 'test': [547], 'an': [549], 'independent': [550], 'set.': [552], '9,': [555], '1167–1177': [556], '(2021).Google': [557], 'Scholar18.': [558], 'Klutstein': [559], 'Nejman': [561], 'Greenfield': [563], 'R,': [564], 'Cedar': [565], 'H.': [566], 'aging.': [572], 'Res.': [574], '76(12),': [575], '3446–50': [576], 'Scholar19.': [579], 'Worm': [580], 'Ørntoft': [581], 'MB,': [582], 'SØ,': [584], 'Hansen': [585], 'TB,': [586], 'Bramsen': [587], 'JB,': [588], 'Andersen': [589], 'CL.': [590], 'Comparative': [591], '12': [594], 'different': [595], 'kits': [596], 'conversion': [599], 'Epigenetics': [604], '12(8),': [605], '626–636': [606], '(2017).MedlineGoogle': [607], 'Scholar20.': [608], 'Tanaka': [609], 'Okamoto': [611], 'A.': [612], 'Degradation': [613], 'treatment.': [618], 'Bioorganic': [619], 'Chem.': [621], 'Lett.': [622], '17(7),': [623], '1912–5': [624], '(2007).Medline': [625], 'Scholar21.': [627], 'Chemi': [628], 'F,': [629, 656], 'Pearce': [630], 'SP,': [631], 'Clipson': [632], 'cfDNA': [636], 'methylome': [637], 'subtyping': [642], 'small': [644], 'cancers.': [647], '3,': [650], '1260–1270': [651], 'Scholar22.': [654], 'Mouliere': [655], 'Chandrananda': [657], 'Piskorz': [659], 'AM': [660], 'Enhanced': [663], 'fragment': [670], 'size': [671], 'analysis.': [672], '10(466),': [676], 'eaat4921': [677], '(2018).MedlineGoogle': [678], 'Scholar23.': [679], 'Cristiano': [680, 766], 'Leal': [682], 'Phallen': [684], 'J': [685], 'Genome-wide': [688], 'fragmentation': [691, 713], 'patients': [693], 'with': [694, 881, 964, 969, 977, 1016, 1021], 'Nature': [696], '570,': [697], '385–389': [698], 'Scholar24.': [701], 'Ivanov': [702], 'Baranova': [704], 'Butler': [706], 'T,': [707], 'Spellman': [708], 'Mileyko': [710], 'V.': [711], 'Non-random': [712], 'patterns': [714], 'reflect': [719], 'epigenetic': [720], 'regulation.': [721], 'BMC': [722], '16(Suppl.': [724], '13),': [725], 'S1': [726], 'Scholar25.': [728], 'Gianni': [729], 'Palleschi': [731], 'Merloni': [733], 'F': [734], 'Fragmentomics:': [739], 'Promising': [741], 'Biomarker': [742], 'Diagnosis,': [744], 'Prognosis': [745], 'Prediction': [747], 'Response': [749], 'Breast': [751], 'Int.': [753], '23(22),': [757], '14197': [758], 'Scholar26.': [761], 'Mathios': [762], 'Johansen': [764], 'JS,': [765], 'S': [767], 'characterization': [772], 'fragmentomes.': [779], 'Commun.': [781], '12,': [782], '5060': [783], 'Scholar27.': [786], 'Foda': [787], 'ZH,': [788], 'Annapragada': [789], 'AV,': [790], 'Boyapati': [791], 'K': [792], 'Detecting': [795], 'Liver': [796], 'Using': [798], 'Fragmentomes.': [801], 'Discov.': [803], '13(3),': [804], '616–631': [805], 'ScholarFiguresReferencesRelatedDetails': [808], 'Vol.': [809], 'STAY': [813], 'CONNECTED': [814], 'Supplemental': [815], 'MaterialsMetrics': [816], 'Downloaded': [817], '45': [818], 'times': [819], 'History': [820], 'Received': [821], '11': [822], 'September': [823], '2023': [824, 828], 'Accepted': [825], 'December': [827], 'Published': [829, 834], 'online': [830], '3': [831], 'January': [832, 837], '2024': [833, 838, 840], 'print': [836], 'Information©': [839], 'Expert': [841], 'Publishing': [842], 'Medicine': [843], 'Ltd': [844], 'trading': [845], 'as': [846], 'Taylor': [847], 'FrancisKeywordscfDNAepigenomicsfragmentomicsliquid': [849], 'biopsymethylomicsSupplementary': [850], 'dataTo': [851], 'view': [852], 'supplementary': [854], 'data': [855, 888], 'that': [856, 926], 'accompany': [857], 'this': [858, 1059], 'please': [860], 'visit': [861], 'journal': [863], 'website': [864], 'at:': [865], 'www.futuremedicine.com/doi/suppl/10.2217/epi-2023-0326Author': [866], 'contributionsThe': [867], 'authors': [868, 945, 959, 1008], 'equally': [869], 'contributed': [870], 'to:': [871], '(a)': [872], 'conception': [874], 'design': [876], 'work': [879, 893, 923, 939], 'together': [880], 'acquisition,': [883], 'analysis,': [884], 'interpretation': [886], 'AND': [889, 902, 912], '(b)': [890], 'drafting': [891], 'or': [894, 932, 967, 974, 981, 994, 999, 1002, 1004, 1013, 1019, 1025, 1038, 1043, 1046, 1048], 'revising': [895], 'it': [896], 'critically': [897], 'important': [899], 'intellectual': [900], 'content;': [901], '(c)': [903], 'final': [904], 'approval': [905], 'version': [908], 'be': [910, 916], 'published;': [911], '(d)': [913], 'agreement': [914], 'accountable': [917], 'all': [919], 'aspects': [920], 'ensuring': [925], 'questions': [927], 'related': [928], 'accuracy': [931], 'integrity': [933], 'any': [935, 965, 1017], 'part': [936], 'are': [940], 'appropriately': [941], 'investigated': [942], 'resolved.AcknowledgmentsThe': [944], 'thank': [946], 'Nadia': [947], 'her': [950], 'graphical': [951], 'assistance': [952, 1052], 'comments': [954], 'on': [955], 'manuscript.Financial': [957], 'disclosureThe': [958, 1007], 'have': [960, 1009], 'no': [961, 1010], 'financial': [962, 971, 975], 'involvement': [963], 'organization': [966, 1018], 'entity': [968, 1020], 'interest': [972], 'conflict': [976], 'subject': [979, 1023], 'matter': [980, 1024], 'materials': [982, 1026], 'discussed': [983, 1027], 'manuscript.': [986, 1030], 'This': [987, 1031], 'includes': [988, 1032], 'employment,': [989, 1033], 'consultancies,': [990, 1034], 'honoraria,': [991, 1035], 'stock': [992, 1036], 'ownership': [993, 1037], 'options,': [995, 1039], 'expert': [996, 1040], 'testimony,': [997, 1041], 'grants': [998, 1042], 'patents': [1000, 1044], 'received': [1001, 1045], 'pending,': [1003, 1047], 'royalties.Competing': [1005], 'interests': [1006, 1012], 'competing': [1011], 'relevant': [1014], 'affiliations': [1015], 'royalties.Writing': [1049], 'disclosureNo': [1050], 'writing': [1051], 'was': [1053], 'utilized': [1054], 'production': [1057], 'manuscript.PDF': [1060], 'download': [1061]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4390540586', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}], 'updated_date': '2024-08-28T12:21:06.062757', 'created_date': '2024-01-04'}