An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer

Name: Work Video:
Duration: 3 min 30 s
Description: The BRCA2-RAD51 interaction remains an intriguing target for cancer drug discovery due to its vital role in DNA damage repair mechanisms, which cancer cells become particularly reliant on. Moreover, RAD51 has many synthetically lethal partners, including PARP1-2, which can be exploited to induce synthetic lethality in cancer. In this study, we established a
Samuel H. Myers; Laura Poppi; Francesco Rinaldi; Marina Veronesi; Andrea Ciamarone; Viola Previtali; Greta Bagnolini; Fabrizio Schipani; Jose Antonio Ortega Martínez; Stefania Girotto; Giuseppina Di Stefano; Fulvia Farabegoli; Naomi Walsh; Francesca Franco; Marinella Roberti; Andrea Cavalli
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