Precision Pharmacotherapy With Zibotentan in Microvascular Angina: a randomized, placebo-controlled, cross-over trial.

Name: Work Video:
Duration: 3 min 30 s
Colin Berry; Andrew Morrow; George Abraham; Stephen P. Hoole; John P. Greenwood; Jayanth R. Arnold; Mayooran Shanmuganathan; Vanessa M. Ferreira; Roby Rakhit; Gavin Galasko; Aish Sinha; Divaka Perera; Rasha Al‐Lamee; Ioakim Spyridopoulos; Ashish Kotecha; Gerald J. Clesham; Thomas J. Ford; Anthony P. Davenport; Lisa Jolly; Peter Kellman; Juan‐Carlos Kaski; Robin A.P. Weir; Naveed Sattar; Paul Welsh; Julie Kennedy; Peter W. Macfarlane; Alex McConnachie; Mohamed El Shibly
{'id': 'https://openalex.org/W4390055916', 'doi': 'https://doi.org/10.21203/rs.3.rs-3714619/v1', 'title': 'Precision Pharmacotherapy With Zibotentan in Microvascular Angina: a randomized, placebo-controlled, cross-over trial.', 'display_name': 'Precision Pharmacotherapy With Zibotentan in Microvascular Angina: a randomized, placebo-controlled, cross-over trial.', 'publication_year': 2023, 'publication_date': '2023-12-21', 'ids': {'openalex': 'https://openalex.org/W4390055916', 'doi': 'https://doi.org/10.21203/rs.3.rs-3714619/v1'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-3714619/v1', 'pdf_url': 'https://www.researchsquare.com/article/rs-3714619/latest.pdf', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.researchsquare.com/article/rs-3714619/latest.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5062232887', 'display_name': 'Colin Berry', 'orcid': 'https://orcid.org/0000-0002-4547-8636'}, 'institutions': [{'id': 'https://openalex.org/I7882870', 'display_name': 'University of Glasgow', 'ror': 'https://ror.org/00vtgdb53', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I7882870']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Colin Berry', 'raw_affiliation_strings': ['University of Glasgow'], 'affiliations': [{'raw_affiliation_string': 'University of Glasgow', 'institution_ids': ['https://openalex.org/I7882870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057939106', 'display_name': 'Andrew Morrow', 'orcid': 'https://orcid.org/0000-0003-4067-8249'}, 'institutions': [{'id': 'https://openalex.org/I7882870', 'display_name': 'University of Glasgow', 'ror': 'https://ror.org/00vtgdb53', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I7882870']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Andrew Morrow', 'raw_affiliation_strings': ['University of Glasgow'], 'affiliations': [{'raw_affiliation_string': 'University of Glasgow', 'institution_ids': ['https://openalex.org/I7882870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040940965', 'display_name': 'George Abraham', 'orcid': 'https://orcid.org/0000-0003-1442-4835'}, 'institutions': [{'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'George Abraham', 'raw_affiliation_strings': ['University of Cambridge'], 'affiliations': [{'raw_affiliation_string': 'University of Cambridge', 'institution_ids': ['https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085330671', 'display_name': 'Stephen P. Hoole', 'orcid': 'https://orcid.org/0000-0002-3530-3808'}, 'institutions': [{'id': 'https://openalex.org/I2799766170', 'display_name': 'Papworth Hospital', 'ror': 'https://ror.org/05mqgrb58', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799766170', 'https://openalex.org/I4210104974']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Stephen Hoole', 'raw_affiliation_strings': ['Papworth Hospital'], 'affiliations': [{'raw_affiliation_string': 'Papworth Hospital', 'institution_ids': ['https://openalex.org/I2799766170']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004676254', 'display_name': 'John P. Greenwood', 'orcid': 'https://orcid.org/0000-0002-2861-0914'}, 'institutions': [{'id': 'https://openalex.org/I142471025', 'display_name': 'Baker Heart and Diabetes Institute', 'ror': 'https://ror.org/03rke0285', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I142471025']}, {'id': 'https://openalex.org/I130828816', 'display_name': 'University of Leeds', 'ror': 'https://ror.org/024mrxd33', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I130828816']}], 'countries': ['AU', 'GB'], 'is_corresponding': False, 'raw_author_name': 'John Greenwood', 'raw_affiliation_strings': ['. Baker Heart and Diabetes Institute, Melbourne VIC 3004, Australia.', 'Leeds University'], 'affiliations': [{'raw_affiliation_string': '. Baker Heart and Diabetes Institute, Melbourne VIC 3004, Australia.', 'institution_ids': ['https://openalex.org/I142471025']}, {'raw_affiliation_string': 'Leeds University', 'institution_ids': ['https://openalex.org/I130828816']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102903284', 'display_name': 'Jayanth R. Arnold', 'orcid': 'https://orcid.org/0000-0003-4533-8374'}, 'institutions': [{'id': 'https://openalex.org/I153648349', 'display_name': 'University of Leicester', 'ror': 'https://ror.org/04h699437', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I153648349']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Jayanth Arnold', 'raw_affiliation_strings': ['University of Leicester'], 'affiliations': [{'raw_affiliation_string': 'University of Leicester', 'institution_ids': ['https://openalex.org/I153648349']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085851683', 'display_name': 'Mayooran Shanmuganathan', 'orcid': 'https://orcid.org/0000-0001-8036-6253'}, 'institutions': [{'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Mayooran Shanmuganathan', 'raw_affiliation_strings': ['University of Oxford'], 'affiliations': [{'raw_affiliation_string': 'University of Oxford', 'institution_ids': ['https://openalex.org/I40120149']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028238617', 'display_name': 'Vanessa M. Ferreira', 'orcid': 'https://orcid.org/0000-0002-0046-7634'}, 'institutions': [{'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Vanessa Ferreira', 'raw_affiliation_strings': ['University of Oxford'], 'affiliations': [{'raw_affiliation_string': 'University of Oxford', 'institution_ids': ['https://openalex.org/I40120149']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091491956', 'display_name': 'Roby Rakhit', 'orcid': 'https://orcid.org/0000-0002-0108-8169'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}, {'id': 'https://openalex.org/I2801138448', 'display_name': 'The Royal Free Hospital', 'ror': 'https://ror.org/01ge67z96', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I169248724', 'https://openalex.org/I2801138448']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Roby Rakhit', 'raw_affiliation_strings': ['Royal Free Hospital'], 'affiliations': [{'raw_affiliation_string': 'Royal Free Hospital', 'institution_ids': ['https://openalex.org/I45129253', 'https://openalex.org/I2801138448']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023675541', 'display_name': 'Gavin Galasko', 'orcid': 'https://orcid.org/0009-0005-0271-3009'}, 'institutions': [{'id': 'https://openalex.org/I169248724', 'display_name': 'Royal Free London NHS Foundation Trust', 'ror': 'https://ror.org/04rtdp853', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I169248724']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Gavin Galasko', 'raw_affiliation_strings': ['. Royal Free Hospital, Royal Free London NHS Foundation Trust London, UK.'], 'affiliations': [{'raw_affiliation_string': '. Royal Free Hospital, Royal Free London NHS Foundation Trust London, UK.', 'institution_ids': ['https://openalex.org/I169248724']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083520114', 'display_name': 'Aish Sinha', 'orcid': 'https://orcid.org/0000-0001-5407-4943'}, 'institutions': [{'id': 'https://openalex.org/I164213776', 'display_name': "King's College - North Carolina", 'ror': 'https://ror.org/022f44628', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I164213776']}, {'id': 'https://openalex.org/I183935753', 'display_name': "King's College London", 'ror': 'https://ror.org/0220mzb33', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I183935753']}], 'countries': ['GB', 'US'], 'is_corresponding': False, 'raw_author_name': 'Aish Sinha', 'raw_affiliation_strings': ['Kings College London'], 'affiliations': [{'raw_affiliation_string': 'Kings College London', 'institution_ids': ['https://openalex.org/I164213776', 'https://openalex.org/I183935753']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042353254', 'display_name': 'Divaka Perera', 'orcid': 'https://orcid.org/0000-0001-6362-1291'}, 'institutions': [{'id': 'https://openalex.org/I183935753', 'display_name': "King's College London", 'ror': 'https://ror.org/0220mzb33', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I183935753']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Divaka Perera', 'raw_affiliation_strings': ["King's College London"], 'affiliations': [{'raw_affiliation_string': "King's College London", 'institution_ids': ['https://openalex.org/I183935753']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002322573', 'display_name': 'Rasha Al‐Lamee', 'orcid': 'https://orcid.org/0000-0003-3752-5532'}, 'institutions': [{'id': 'https://openalex.org/I153355300', 'display_name': 'Imperial College Healthcare NHS Trust', 'ror': 'https://ror.org/056ffv270', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I153355300']}, {'id': 'https://openalex.org/I2801748203', 'display_name': 'Hammersmith Hospital', 'ror': 'https://ror.org/05jg8yp15', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I153355300', 'https://openalex.org/I2801748203']}, {'id': 'https://openalex.org/I47508984', 'display_name': 'Imperial College London', 'ror': 'https://ror.org/041kmwe10', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I47508984']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Rasha Al-lamee', 'raw_affiliation_strings': ['. Hammersmith Hospital, Imperial College Healthcare NHS Trust and National Heart and Lung Institute, Imperial College London, UK.'], 'affiliations': [{'raw_affiliation_string': '. Hammersmith Hospital, Imperial College Healthcare NHS Trust and National Heart and Lung Institute, Imperial College London, UK.', 'institution_ids': ['https://openalex.org/I153355300', 'https://openalex.org/I2801748203', 'https://openalex.org/I47508984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043838483', 'display_name': 'Ioakim Spyridopoulos', 'orcid': 'https://orcid.org/0000-0002-2750-2444'}, 'institutions': [{'id': 'https://openalex.org/I84884186', 'display_name': 'Newcastle University', 'ror': 'https://ror.org/01kj2bm70', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I84884186']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Ioakim Spyridopoulos', 'raw_affiliation_strings': ['. Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.'], 'affiliations': [{'raw_affiliation_string': '. Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.', 'institution_ids': ['https://openalex.org/I84884186']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021775333', 'display_name': 'Ashish Kotecha', 'orcid': 'https://orcid.org/0000-0001-6501-4807'}, 'institutions': [{'id': 'https://openalex.org/I2799452589', 'display_name': 'Royal Devon & Exeter NHS Foundation Trust', 'ror': 'https://ror.org/03085z545', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799452589']}, {'id': 'https://openalex.org/I2801242002', 'display_name': 'Royal Devon and Exeter Hospital', 'ror': 'https://ror.org/03jrh3t05', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799452589', 'https://openalex.org/I2801242002']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Ashish Kotecha', 'raw_affiliation_strings': ['. Royal Devon & Exeter Hospital, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK.'], 'affiliations': [{'raw_affiliation_string': '. Royal Devon & Exeter Hospital, Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK.', 'institution_ids': ['https://openalex.org/I2799452589', 'https://openalex.org/I2801242002']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037219789', 'display_name': 'Gerald J. Clesham', 'orcid': 'https://orcid.org/0000-0003-1590-841X'}, 'institutions': [{'id': 'https://openalex.org/I4210127968', 'display_name': 'Basildon Hospital', 'ror': 'https://ror.org/02de7mm40', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I263303288', 'https://openalex.org/I4210127968']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Gerald Clesham', 'raw_affiliation_strings': ['Basildon University Hospital'], 'affiliations': [{'raw_affiliation_string': 'Basildon University Hospital', 'institution_ids': ['https://openalex.org/I4210127968']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079308912', 'display_name': 'Thomas J. Ford', 'orcid': 'https://orcid.org/0000-0003-4009-6652'}, 'institutions': [{'id': 'https://openalex.org/I2801163298', 'display_name': 'Gosford Hospital', 'ror': 'https://ror.org/01jg3a168', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1311436738', 'https://openalex.org/I2801163298', 'https://openalex.org/I2801351115', 'https://openalex.org/I4210140905']}, {'id': 'https://openalex.org/I78757542', 'display_name': 'University of Newcastle Australia', 'ror': 'https://ror.org/00eae9z71', 'country_code': 'AU', 'type': 'funder', 'lineage': ['https://openalex.org/I78757542']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Tom Ford', 'raw_affiliation_strings': ['. Department of Cardiology, Gosford Hospital -Central Coast LHD, and The University of Newcastle, University Dr, Callaghan, New South Wales 2308, Australia.'], 'affiliations': [{'raw_affiliation_string': '. Department of Cardiology, Gosford Hospital -Central Coast LHD, and The University of Newcastle, University Dr, Callaghan, New South Wales 2308, Australia.', 'institution_ids': ['https://openalex.org/I2801163298', 'https://openalex.org/I78757542']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060689377', 'display_name': 'Anthony P. Davenport', 'orcid': 'https://orcid.org/0000-0002-2096-3117'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Anthony Davenport', 'raw_affiliation_strings': ['University Of Cambridge'], 'affiliations': [{'raw_affiliation_string': 'University Of Cambridge', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008825793', 'display_name': 'Lisa Jolly', 'orcid': 'https://orcid.org/0009-0000-7709-4701'}, 'institutions': [{'id': 'https://openalex.org/I2800201399', 'display_name': 'NHS Greater Glasgow and Clyde', 'ror': 'https://ror.org/05kdz4d87', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800201399']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Lisa Jolly', 'raw_affiliation_strings': ['NHS Greater Glasgow and Clyde Health Board'], 'affiliations': [{'raw_affiliation_string': 'NHS Greater Glasgow and Clyde Health Board', 'institution_ids': ['https://openalex.org/I2800201399']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019338538', 'display_name': 'Peter Kellman', 'orcid': 'https://orcid.org/0000-0002-9875-6070'}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210106489', 'display_name': 'National Heart Lung and Blood Institute', 'ror': 'https://ror.org/012pb6c26', 'country_code': 'US', 'type': 'funder', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210106489']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Peter Kellman', 'raw_affiliation_strings': ['. Medical Signal and Image Processing Program, National Heart, Lung, and Blood Institute,', 'National Institutes of Health, Bethesda, MD, United States of American.'], 'affiliations': [{'raw_affiliation_string': 'National Institutes of Health, Bethesda, MD, United States of American.', 'institution_ids': ['https://openalex.org/I1299303238']}, {'raw_affiliation_string': '. Medical Signal and Image Processing Program, National Heart, Lung, and Blood Institute,', 'institution_ids': ['https://openalex.org/I4210106489']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110914922', 'display_name': 'Juan‐Carlos Kaski', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Juan-Carlos Kaski', 'raw_affiliation_strings': ["St George's Hospital"], 'affiliations': [{'raw_affiliation_string': "St George's Hospital", 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035800669', 'display_name': 'Robin A.P. Weir', 'orcid': 'https://orcid.org/0000-0001-9895-2795'}, 'institutions': [{'id': 'https://openalex.org/I2802322126', 'display_name': 'Hairmyres Hospital', 'ror': 'https://ror.org/0488ndr53', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801443577', 'https://openalex.org/I2802322126']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Robin Weir', 'raw_affiliation_strings': ['University Hospital Hairmyres'], 'affiliations': [{'raw_affiliation_string': 'University Hospital Hairmyres', 'institution_ids': ['https://openalex.org/I2802322126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078498803', 'display_name': 'Naveed Sattar', 'orcid': 'https://orcid.org/0000-0002-1604-2593'}, 'institutions': [{'id': 'https://openalex.org/I7882870', 'display_name': 'University of Glasgow', 'ror': 'https://ror.org/00vtgdb53', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I7882870']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Naveed Sattar', 'raw_affiliation_strings': ['University of Glasgow'], 'affiliations': [{'raw_affiliation_string': 'University of Glasgow', 'institution_ids': ['https://openalex.org/I7882870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021225266', 'display_name': 'Paul Welsh', 'orcid': 'https://orcid.org/0000-0002-7970-3643'}, 'institutions': [{'id': 'https://openalex.org/I7882870', 'display_name': 'University of Glasgow', 'ror': 'https://ror.org/00vtgdb53', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I7882870']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Paul Welsh', 'raw_affiliation_strings': ['Institute of Cardiovascular and Medical Sciences, University of Glasgow'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cardiovascular and Medical Sciences, University of Glasgow', 'institution_ids': ['https://openalex.org/I7882870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108633574', 'display_name': 'Julie Kennedy', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2800666604', 'display_name': 'Glasgow Royal Infirmary', 'ror': 'https://ror.org/00bjck208', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800201399', 'https://openalex.org/I2800666604']}, {'id': 'https://openalex.org/I7882870', 'display_name': 'University of Glasgow', 'ror': 'https://ror.org/00vtgdb53', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I7882870']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Julie Kennedy', 'raw_affiliation_strings': ['. Electrocardiology Group, Royal Infirmary, School of Health and Wellbeing, University of Glasgow, UK.'], 'affiliations': [{'raw_affiliation_string': '. Electrocardiology Group, Royal Infirmary, School of Health and Wellbeing, University of Glasgow, UK.', 'institution_ids': ['https://openalex.org/I2800666604', 'https://openalex.org/I7882870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081878109', 'display_name': 'Peter W. Macfarlane', 'orcid': 'https://orcid.org/0000-0002-5390-1596'}, 'institutions': [{'id': 'https://openalex.org/I7882870', 'display_name': 'University of Glasgow', 'ror': 'https://ror.org/00vtgdb53', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I7882870']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Peter Macfarlane', 'raw_affiliation_strings': ['Institute of Health and Wellbeing, University of Glasgow'], 'affiliations': [{'raw_affiliation_string': 'Institute of Health and Wellbeing, University of Glasgow', 'institution_ids': ['https://openalex.org/I7882870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078354802', 'display_name': 'Alex McConnachie', 'orcid': 'https://orcid.org/0000-0002-7262-7000'}, 'institutions': [{'id': 'https://openalex.org/I7882870', 'display_name': 'University of Glasgow', 'ror': 'https://ror.org/00vtgdb53', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I7882870']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Alex McConnachie', 'raw_affiliation_strings': ['University of Glasgow'], 'affiliations': [{'raw_affiliation_string': 'University of Glasgow', 'institution_ids': ['https://openalex.org/I7882870']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5093551151', 'display_name': 'Mohamed El Shibly', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802040150', 'display_name': 'Glenfield Hospital', 'ror': 'https://ror.org/048a96r61', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802040150', 'https://openalex.org/I2802445252']}, {'id': 'https://openalex.org/I153648349', 'display_name': 'University of Leicester', 'ror': 'https://ror.org/04h699437', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I153648349']}, {'id': 'https://openalex.org/I4210166781', 'display_name': 'NIHR Leicester Biomedical Research Centre', 'ror': 'https://ror.org/05xqxa525', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I143804889', 'https://openalex.org/I153648349', 'https://openalex.org/I2802445252', 'https://openalex.org/I34931013', 'https://openalex.org/I4210166781']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Mohamed El Shibly', 'raw_affiliation_strings': ['. University of Leicester and The NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.'], 'affiliations': [{'raw_affiliation_string': '. University of Leicester and The NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.', 'institution_ids': ['https://openalex.org/I2802040150', 'https://openalex.org/I153648349', 'https://openalex.org/I4210166781']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 28, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 67}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10372', 'display_name': 'Cardiac Imaging and Diagnostics', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10372', 'display_name': 'Cardiac Imaging and Diagnostics', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10821', 'display_name': 'Cardiovascular Function and Risk Factors', 'score': 0.9932, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10924', 'display_name': 'Cardiovascular Health and Disease Prevention', 'score': 0.9879, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/crossover-study', 'display_name': 'Crossover study', 'score': 0.70810556}], 'concepts': [{'id': 'https://openalex.org/C27081682', 'wikidata': 'https://www.wikidata.org/wiki/Q269829', 'display_name': 'Placebo', 'level': 3, 'score': 0.8269613}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.7859676}, {'id': 'https://openalex.org/C87813604', 'wikidata': 'https://www.wikidata.org/wiki/Q1242899', 'display_name': 'Crossover study', 'level': 4, 'score': 0.70810556}, {'id': 'https://openalex.org/C2778425758', 'wikidata': 'https://www.wikidata.org/wiki/Q180762', 'display_name': 'Angina', 'level': 3, 'score': 0.66693753}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.5883499}, {'id': 'https://openalex.org/C168563851', 'wikidata': 'https://www.wikidata.org/wiki/Q1436668', 'display_name': 'Randomized controlled trial', 'level': 2, 'score': 0.54260457}, {'id': 'https://openalex.org/C84393581', 'wikidata': 'https://www.wikidata.org/wiki/Q82642', 'display_name': 'Blood pressure', 'level': 2, 'score': 0.5418722}, {'id': 'https://openalex.org/C144980905', 'wikidata': 'https://www.wikidata.org/wiki/Q24721308', 'display_name': 'Endothelin receptor', 'level': 3, 'score': 0.5068477}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.49948168}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.49538863}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.4387352}, {'id': 'https://openalex.org/C500558357', 'wikidata': 'https://www.wikidata.org/wiki/Q12152', 'display_name': 'Myocardial infarction', 'level': 2, 'score': 0.13344318}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.07019243}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-3714619/v1', 'pdf_url': 'https://www.researchsquare.com/article/rs-3714619/latest.pdf', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.21203/rs.3.rs-3714619/v1', 'pdf_url': 'https://www.researchsquare.com/article/rs-3714619/latest.pdf', 'source': {'id': 'https://openalex.org/S4306402450', 'display_name': 'Research Square (Research Square)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210096694', 'host_organization_name': 'Research Square (United States)', 'host_organization_lineage': ['https://openalex.org/I4210096694'], 'host_organization_lineage_names': ['Research Square (United States)'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'score': 0.85, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 47, 'referenced_works': ['https://openalex.org/W1966155696', 'https://openalex.org/W1966190213', 'https://openalex.org/W1971926213', 'https://openalex.org/W1991312489', 'https://openalex.org/W1991979617', 'https://openalex.org/W1999065942', 'https://openalex.org/W1999221496', 'https://openalex.org/W1999386078', 'https://openalex.org/W2012817441', 'https://openalex.org/W2013939523', 'https://openalex.org/W2016422645', 'https://openalex.org/W2022919186', 'https://openalex.org/W2060618473', 'https://openalex.org/W2100683916', 'https://openalex.org/W2103089817', 'https://openalex.org/W2104840130', 'https://openalex.org/W2109647832', 'https://openalex.org/W2115923319', 'https://openalex.org/W2155965977', 'https://openalex.org/W2163438871', 'https://openalex.org/W2169700609', 'https://openalex.org/W2342311534', 'https://openalex.org/W2605037578', 'https://openalex.org/W2739458618', 'https://openalex.org/W2752887640', 'https://openalex.org/W2761080014', 'https://openalex.org/W2766491028', 'https://openalex.org/W2903873335', 'https://openalex.org/W2920428737', 'https://openalex.org/W3001500183', 'https://openalex.org/W3004328961', 'https://openalex.org/W3005940509', 'https://openalex.org/W3011371150', 'https://openalex.org/W3013755535', 'https://openalex.org/W3043501420', 'https://openalex.org/W3048904211', 'https://openalex.org/W3142360237', 'https://openalex.org/W4238548964', 'https://openalex.org/W4242012253', 'https://openalex.org/W4249237384', 'https://openalex.org/W4281848047', 'https://openalex.org/W4313594766', 'https://openalex.org/W4387392092', 'https://openalex.org/W4387950706', 'https://openalex.org/W4388218502', 'https://openalex.org/W4388289334', 'https://openalex.org/W4388591774'], 'related_works': ['https://openalex.org/W4311679548', 'https://openalex.org/W2169836118', 'https://openalex.org/W2132710482', 'https://openalex.org/W2119160676', 'https://openalex.org/W2085830368', 'https://openalex.org/W2085650940', 'https://openalex.org/W2081991953', 'https://openalex.org/W1974781192', 'https://openalex.org/W1966127473', 'https://openalex.org/W1859326399'], 'abstract_inverted_index': {'Abstract': [0], 'Microvascular': [1], 'angina,': [2], 'linked': [3], 'to': [4, 74, 110, 138, 151], 'endothelin': [5, 26], 'system': [6], 'dysregulation,': [7], 'was': [8, 131], 'the': [9, 52, 105], 'focus': [10], 'of': [11, 118], 'this': [12], 'double-blind,': [13], 'placebo-controlled,': [14], 'randomized,': [15], 'sequential': [16], 'crossover': [17], 'trial': [18, 21], '(NCT04097314).': [19], 'The': [20, 58], 'compared': [22, 109], 'zibotentan,': [23], 'an': [24], 'oral': [25], 'A': [27], 'receptor': [28], 'selective': [29], 'antagonist,': [30], 'with': [31, 36, 51, 67, 134, 149], 'placebo': [32, 111], 'in': [33, 64, 147], '118': [34], 'patients': [35], 'microvascular': [37], 'angina.': [38], 'Over': [39], '12': [40, 123], 'weeks,': [41], 'participants': [42], 'received': [43], 'either': [44], '10': [45, 119], 'mg': [46, 120], 'daily': [47, 116], 'zibotentan': [48, 68, 78, 106, 121, 145], 'or': [49], 'placebo,': [50], 'primary': [53], 'outcome': [54], 'treadmill': [55], 'exercise': [56, 65, 128], 'duration.': [57], 'study': [59], 'found': [60], 'no': [61], 'significant': [62], 'difference': [63], 'duration': [66, 129], '(-4.26': [69], 'seconds;': [70], '95%': [71], 'CI:': [72], '-19.60': [73], '11.06;': [75], 'P=0.5871).': [76], 'However,': [77], 'increased': [79], 'plasma': [80], 'big': [81], 'endothelin-1,': [82, 83], 'and': [84, 93, 130, 155], 'global': [85], 'myocardial': [86], 'blood': [87, 95], 'flow,': [88], 'while': [89], 'reducing': [90], 'hemoglobin,': [91], 'diastolic,': [92], 'systolic': [94], 'pressure': [96], '(all': [97], 'p&lt;0.001).': [98, 113], 'Adverse': [99], 'events': [100], 'were': [101], 'more': [102], 'common': [103], 'during': [104], 'period': [107], '(60.2%)': [108], '(14.4%,': [112], 'In': [114], 'conclusion,': [115], 'administration': [117], 'for': [122], 'weeks': [124], 'did': [125], 'not': [126], 'enhance': [127], 'commonly': [132], 'associated': [133], 'adverse': [135], 'effects': [136], 'related': [137], 'fluid': [139, 153], 'retention.': [140], 'Further': [141], 'trials': [142], 'exploring': [143], 'lower': [144], 'doses': [146], 'combination': [148], 'agents': [150], 'mitigate': [152], 'retention,': [154], 'longer': [156], 'treatment': [157], 'durations,': [158], 'are': [159], 'warranted.': [160]}, 'abstract_inverted_index_v3': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4390055916', 'counts_by_year': [], 'updated_date': '2025-01-28T06:42:03.784064', 'created_date': '2023-12-22'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
