Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4389732869', 'doi': 'https://doi.org/10.1128/aac.00903-23', 'title': 'Pulsed dosing and extended daily dosing of oral vancomycin do not facilitate clearance of <i>Clostridioides difficile</i> colonization in mice', 'display_name': 'Pulsed dosing and extended daily dosing of oral vancomycin do not facilitate clearance of <i>Clostridioides difficile</i> colonization in mice', 'publication_year': 2024, 'publication_date': '2024-01-10', 'ids': {'openalex': 'https://openalex.org/W4389732869', 'doi': 'https://doi.org/10.1128/aac.00903-23', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/38095427'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/aac.00903-23', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5071235010', 'display_name': 'Basya Pearlmutter', 'orcid': 'https://orcid.org/0000-0003-4609-8421'}, 'institutions': [{'id': 'https://openalex.org/I4210110978', 'display_name': 'Louis Stokes Cleveland VA Medical Center', 'ror': 'https://ror.org/01vrybr67', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210110978', 'https://openalex.org/I4210127612']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Basya S. Pearlmutter', 'raw_affiliation_strings': ['Research Service, Louis Stokes Cleveland VA Medical Center , Cleveland, Ohio, USA'], 'affiliations': [{'raw_affiliation_string': 'Research Service, Louis Stokes Cleveland VA Medical Center , Cleveland, Ohio, USA', 'institution_ids': ['https://openalex.org/I4210110978']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033655749', 'display_name': 'Matthew Carlisle', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210110978', 'display_name': 'Louis Stokes Cleveland VA Medical Center', 'ror': 'https://ror.org/01vrybr67', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210110978', 'https://openalex.org/I4210127612']}, {'id': 'https://openalex.org/I4210110523', 'display_name': 'Geriatric Research Education and Clinical Center', 'ror': 'https://ror.org/01nh3sx96', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210110523', 'https://openalex.org/I4210133905', 'https://openalex.org/I4210147340']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Matthew G. Carlisle', 'raw_affiliation_strings': ['Geriatric Research Education and Clinical Center, Louis Stokes Cleveland VA Medical Center , Cleveland, Ohio, USA'], 'affiliations': [{'raw_affiliation_string': 'Geriatric Research Education and Clinical Center, Louis Stokes Cleveland VA Medical Center , Cleveland, Ohio, USA', 'institution_ids': ['https://openalex.org/I4210110978', 'https://openalex.org/I4210110523']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073280480', 'display_name': 'Brigid Wilson', 'orcid': 'https://orcid.org/0000-0003-2966-2940'}, 'institutions': [{'id': 'https://openalex.org/I58956616', 'display_name': 'Case Western Reserve University', 'ror': 'https://ror.org/051fd9666', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I58956616']}, {'id': 'https://openalex.org/I4210153792', 'display_name': 'University School', 'ror': 'https://ror.org/05ap66461', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I4210153792']}, {'id': 'https://openalex.org/I4210110978', 'display_name': 'Louis Stokes Cleveland VA Medical Center', 'ror': 'https://ror.org/01vrybr67', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210110978', 'https://openalex.org/I4210127612']}, {'id': 'https://openalex.org/I4210110523', 'display_name': 'Geriatric Research Education and Clinical Center', 'ror': 'https://ror.org/01nh3sx96', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210110523', 'https://openalex.org/I4210133905', 'https://openalex.org/I4210147340']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Brigid M. Wilson', 'raw_affiliation_strings': ['Case Western Reserve University School of Medicine , Cleveland, Ohio, USA', 'Geriatric Research Education and Clinical Center, Louis Stokes Cleveland VA Medical Center , Cleveland, Ohio, USA'], 'affiliations': [{'raw_affiliation_string': 'Case Western Reserve University School of Medicine , Cleveland, Ohio, USA', 'institution_ids': ['https://openalex.org/I58956616', 'https://openalex.org/I4210153792']}, {'raw_affiliation_string': 'Geriatric Research Education and Clinical Center, Louis Stokes Cleveland VA Medical Center , Cleveland, Ohio, USA', 'institution_ids': ['https://openalex.org/I4210110978', 'https://openalex.org/I4210110523']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089136921', 'display_name': 'Naseer Sangwan', 'orcid': 'https://orcid.org/0000-0002-2407-769X'}, 'institutions': [{'id': 'https://openalex.org/I58956616', 'display_name': 'Case Western Reserve University', 'ror': 'https://ror.org/051fd9666', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I58956616']}, {'id': 'https://openalex.org/I4210153792', 'display_name': 'University School', 'ror': 'https://ror.org/05ap66461', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I4210153792']}, {'id': 'https://openalex.org/I36373038', 'display_name': 'Cleveland Clinic Lerner College of Medicine', 'ror': 'https://ror.org/02x4b0932', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316902750', 'https://openalex.org/I36373038']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Naseer Sangwan', 'raw_affiliation_strings': ['Case Western Reserve University School of Medicine , Cleveland, Ohio, USA', 'Lerner Research Institute/Lerner College of Medicine of Case Western Reserve University , Cleveland, Ohio, USA'], 'affiliations': [{'raw_affiliation_string': 'Case Western Reserve University School of Medicine , Cleveland, Ohio, USA', 'institution_ids': ['https://openalex.org/I58956616', 'https://openalex.org/I4210153792']}, {'raw_affiliation_string': 'Lerner Research Institute/Lerner College of Medicine of Case Western Reserve University , Cleveland, Ohio, USA', 'institution_ids': ['https://openalex.org/I36373038', 'https://openalex.org/I58956616']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5058899660', 'display_name': 'Curtis J. Donskey', 'orcid': 'https://orcid.org/0000-0003-0990-4498'}, 'institutions': [{'id': 'https://openalex.org/I4210110978', 'display_name': 'Louis Stokes Cleveland VA Medical Center', 'ror': 'https://ror.org/01vrybr67', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210110978', 'https://openalex.org/I4210127612']}, {'id': 'https://openalex.org/I4210110523', 'display_name': 'Geriatric Research Education and Clinical Center', 'ror': 'https://ror.org/01nh3sx96', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210110523', 'https://openalex.org/I4210133905', 'https://openalex.org/I4210147340']}, {'id': 'https://openalex.org/I36373038', 'display_name': 'Cleveland Clinic Lerner College of Medicine', 'ror': 'https://ror.org/02x4b0932', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316902750', 'https://openalex.org/I36373038']}, {'id': 'https://openalex.org/I58956616', 'display_name': 'Case Western Reserve University', 'ror': 'https://ror.org/051fd9666', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I58956616']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Curtis J. Donskey', 'raw_affiliation_strings': ['Geriatric Research Education and Clinical Center, Louis Stokes Cleveland VA Medical Center , Cleveland, Ohio, USA', 'Lerner Research Institute/Lerner College of Medicine of Case Western Reserve University , Cleveland, Ohio, USA'], 'affiliations': [{'raw_affiliation_string': 'Geriatric Research Education and Clinical Center, Louis Stokes Cleveland VA Medical Center , Cleveland, Ohio, USA', 'institution_ids': ['https://openalex.org/I4210110978', 'https://openalex.org/I4210110523']}, {'raw_affiliation_string': 'Lerner Research Institute/Lerner College of Medicine of Case Western Reserve University , Cleveland, Ohio, USA', 'institution_ids': ['https://openalex.org/I36373038', 'https://openalex.org/I58956616']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 85}, 'biblio': {'volume': '68', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11288', 'display_name': 'Clostridium difficile Infection and Treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11288', 'display_name': 'Clostridium difficile Infection and Treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10066', 'display_name': 'Diversity and Function of Gut Microbiome', 'score': 0.9863, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13569', 'display_name': 'Epidemiology and Treatment of Microscopic Colitis', 'score': 0.9725, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/vancomycin-and-metronidazole-treatment', 'display_name': 'Vancomycin and Metronidazole Treatment', 'score': 0.555392}, {'id': 'https://openalex.org/keywords/clostridioides', 'display_name': 'Clostridioides', 'score': 0.47707307}], 'concepts': [{'id': 'https://openalex.org/C2777288759', 'wikidata': 'https://www.wikidata.org/wiki/Q4164182', 'display_name': 'Dosing', 'level': 2, 'score': 0.9551461}, {'id': 'https://openalex.org/C2778980435', 'wikidata': 'https://www.wikidata.org/wiki/Q424027', 'display_name': 'Vancomycin', 'level': 4, 'score': 0.93766093}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.63206613}, {'id': 'https://openalex.org/C2994496256', 'wikidata': 'https://www.wikidata.org/wiki/Q27031090', 'display_name': 'Clostridium difficile', 'level': 3, 'score': 0.4805851}, {'id': 'https://openalex.org/C2910067853', 'wikidata': 'https://www.wikidata.org/wiki/Q27438828', 'display_name': 'Clostridioides', 'level': 2, 'score': 0.47707307}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.37509334}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.37384456}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.36146337}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3395596}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2515204}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.21867234}, {'id': 'https://openalex.org/C2779489039', 'wikidata': 'https://www.wikidata.org/wiki/Q188121', 'display_name': 'Staphylococcus aureus', 'level': 3, 'score': 0.16249189}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.07248497}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D016360', 'descriptor_name': 'Clostridioides difficile', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003015', 'descriptor_name': 'Clostridium Infections', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014640', 'descriptor_name': 'Vancomycin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/aac.00903-23', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/38095427', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.53}], 'grants': [{'funder': 'https://openalex.org/F4320306127', 'funder_display_name': 'U.S. Department of Veterans Affairs', 'award_id': 'CX001848'}], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W1994090985', 'https://openalex.org/W2056279562', 'https://openalex.org/W2080549997', 'https://openalex.org/W2110853644', 'https://openalex.org/W2113585244', 'https://openalex.org/W2118954244', 'https://openalex.org/W2155317599', 'https://openalex.org/W2196848880', 'https://openalex.org/W2300152708', 'https://openalex.org/W2339519864', 'https://openalex.org/W2401404581', 'https://openalex.org/W2623637425', 'https://openalex.org/W2765215648', 'https://openalex.org/W2792003290', 'https://openalex.org/W2943312000', 'https://openalex.org/W3137700519', 'https://openalex.org/W3175883958', 'https://openalex.org/W3208087302', 'https://openalex.org/W4221058294', 'https://openalex.org/W4226239267', 'https://openalex.org/W4249109700', 'https://openalex.org/W4283319490'], 'related_works': ['https://openalex.org/W4393709490', 'https://openalex.org/W4389732869', 'https://openalex.org/W4283034770', 'https://openalex.org/W4223534033', 'https://openalex.org/W4221095273', 'https://openalex.org/W3138397568', 'https://openalex.org/W3128876904', 'https://openalex.org/W2902050180', 'https://openalex.org/W2167016769', 'https://openalex.org/W1911417339'], 'abstract_inverted_index': {'Vancomycin': [0], 'taper': [1], 'and': [2], 'pulse': [3], 'regimens': [4], 'are': [5], 'commonly': [6], 'used': [7], 'to': [8], 'treat': [9], 'recurrent': [10]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4389732869', 'counts_by_year': [], 'updated_date': '2024-09-12T12:43:08.344963', 'created_date': '2023-12-15'}