Publication Information

{'id': 'https://openalex.org/W4389239932', 'doi': 'https://doi.org/10.1158/1535-7163.targ-23-ia006', 'title': 'Abstract IA006: Clinical activity of lirafugratinib (RLY-4008), a highly selective FGFR2 inhibitor, in patients with advanced FGFR2-altered solid tumors: The ReFocus study', 'display_name': 'Abstract IA006: Clinical activity of lirafugratinib (RLY-4008), a highly selective FGFR2 inhibitor, in patients with advanced FGFR2-altered solid tumors: The ReFocus study', 'publication_year': 2023, 'publication_date': '2023-12-01', 'ids': {'openalex': 'https://openalex.org/W4389239932', 'doi': 'https://doi.org/10.1158/1535-7163.targ-23-ia006'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1535-7163.targ-23-ia006', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S48437117', 'display_name': 'Molecular Cancer Therapeutics', 'issn_l': '1535-7163', 'issn': ['1535-7163', '1538-8514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5088495181', 'display_name': 'Alison M. 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'(1': [214], 'nonmeasurable;': [215], '17': [216], 'pending': [218], 'imaging).': [219], 'Twenty': [220], 'f/r': [222, 266], 'ORR': [225, 242, 283], '40%': [227], '(8/20,': [228], '7': [229, 246], 'confirmed/5': [230, 247], 'ongoing)': [231, 248, 291], 'DOR': [233, 250, 293], '8-50+': [235], 'weeks.': [236, 253, 297], 'Twenty-seven': [237], 'amplification': [239, 268], '33%': [244], '(9/27,': [245], '8-32+': [252], 'breast': [256], '(n=7),': [257], 'lung': [258], '(n=3),': [259], 'pancreatic': [261], '(n=5)': [262], 'cancer': [263], 'or': [267], 'ORRs': [271], '43%,': [273], '67%,': [274], '40%,': [276], 'respectively.': [277], 'Response': [278], 'varied': [279], 'mutation': [281], '14.3%': [284], '(2': [285], '[N549K;': [286], 'C382R]/14;': [287], 'both': [288], 'confirmed,': [289], '1': [290], 'each': [294], '40+': [296], 'Most': [298], 'common': [299], 'treatment-related': [300], 'adverse': [301], 'events': [302], '(TRAEs,': [303], 'grades;': [305], 'grade': [306, 347], '3)': [307], 'stomatitis': [309], '(50%;': [310], '10%),': [311], 'nail': [312], 'toxicities': [313], '(44%;': [314], '4%),': [315], 'palmar-plantar': [317], 'erythema': [318], '(45%;': [319], '5%).': [320], 'Typical': [321], 'TRAEs': [323, 349], 'pan-FGFR': [325], 'uncommon,': [328], 'including': [329, 368], 'hyperphosphatemia': [330], '(16%;': [331], '0%)': [332], 'diarrhea': [334], '(9%;': [335], '1%).': [336], 'One': [337], 'discontinued': [341], 'because': [343], 'TRAEs.': [345], 'No': [346], '4/5': [348], 'observed.': [351], 'Conclusion:': [352], 'Beyond': [353], 'CCA,': [354], 'demonstrates': [356], 'promising': [357], 'types': [363], 'diverse': [365], 'f/r,': [369], 'amplification,': [370], 'select': [372], 'mutations.': [373], 'Together': [374], 'lirafugratinib’s': [376], 'differentiated': [377], 'profile': [379], '(minimal': [380], 'toxicity),': [382], 'these': [383], 'data': [385, 410], 'validate': [386], 'a': [389, 535], 'agnostic': [391], 'sensitive': [393], 'to': [394], 'inhibition.': [397], 'Pivotal': [398], 'development': [399], 'across': [400], 'continues': [403], '2': [406], 'ReFocus.': [408], 'Additional/updated': [409], 'will': [411], 'be': [412], 'presented': [413], 'conference.': [416], 'Citation': [417], 'Format:': [418], 'Alison': [419], 'M': [420], 'Schram,': [421], 'Vivek': [422], 'Subbiah,': [423], 'Chih-Yi': [424], '(Andy)': [425], 'Liao,': [426], 'Victor': [427], 'Moreno,': [428, 439], 'Roda': [429], 'Desamparados,': [430], 'Mariano': [431], 'Ponz-Sarvise,': [432], 'Efrat': [433], 'Dotan,': [434], 'Philippe': [435], 'Alexandre': [436], 'Cassier,': [437], 'Irene': [438], 'Andreas': [440], 'Varkaris,': [441], 'Richard': [442], 'D': [443], 'Kim,': [444], 'Elena': [445], 'Garralda,': [446], 'Frans': [447], 'Opdam,': [448], 'David': [449], 'Tai,': [450], 'Antoine': [451, 528], 'Italiano,': [452], 'Do-Youn': [453], 'Oh,': [454], 'Lipika': [455], 'Goyal,': [456], 'Elisa': [457], 'Fontana,': [458], 'Jia': [459], 'Liu,': [460], 'Myrto': [461], 'Boukovala,': [462], 'Francois': [463], 'Ghiringelli,': [464], 'Mitesh': [465], 'J': [466], 'Borad,': [467], 'Hani': [468], 'Babiker,': [469], 'Zhaohui': [470], 'Jin,': [471], 'Michael': [472], 'Millward,': [473], 'Jeffrey': [474], 'Yachnin,': [475], 'Suneel': [476], 'Deepak': [477], 'Kamath,': [478], 'Jermaine': [479], 'M.': [480], 'Coward,': [481], 'Changhoon': [482], 'Yoo,': [483], 'Robin': [484], 'Kate': [485], 'Kelley,': [486], 'Vaibhav': [487], 'Sahai,': [488], 'John': [489], 'Bridgewater,': [490], 'Christoph': [491], 'Springfield,': [492], 'Vaia': [493], 'Florou,': [494], 'Anthony': [495], 'El-Khoueiry,': [496], 'Ferry': [497], 'Eskens,': [498], 'Bruce': [499], 'Lin,': [500], 'Scott': [501], 'Paulson,': [502], 'Giuseppe': [503], 'Curigliano,': [504], 'Meredith': [505], 'Murphy,': [506], 'Alicia': [507], 'Deary,': [508], 'Fabien': [509], 'Ricard,': [510], 'Kai': [511], 'Yu': [512], 'Jen,': [513], 'Florence': [514], '(Tianhui)': [515], 'Ramirez,': [516], 'Rick': [517], 'E.': [518], 'Blakesley,': [519], 'Oleg': [520], 'Schmidt-Kittler,': [521], 'Brenton': [522], 'G.': [523], 'Mar,': [524], 'Joon': [525], 'Oh': [526], 'Park,': [527], 'Hollebecque.': [529], 'Clinical': [530], 'tumors:': [546], 'The': [547], 'ReFocus': [548], '[abstract].': [550], 'In:': [551], 'Proceedings': [552], 'AACR-NCI-EORTC': [555], 'Virtual': [556], 'International': [557], 'Conference': [558], 'on': [559], 'Molecular': [560], 'Targets': [561], 'Cancer': [563, 574], 'Therapeutics;': [564], '2023': [565], 'Oct': [566], '11-15;': [567], 'Boston,': [568], 'MA.': [569], 'Philadelphia': [570], '(PA):': [571], 'AACR;': [572], 'Mol': [573], 'Ther': [575], '2023;22(12': [576], 'Suppl):Abstract': [577], 'nr': [578], 'IA006.': [579]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4389239932', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}], 'updated_date': '2024-12-24T03:05:42.549651', 'created_date': '2023-12-02'}