Publication Information

{'id': 'https://openalex.org/W4389224184', 'doi': 'https://doi.org/10.1016/j.molstruc.2023.137224', 'title': 'Discovery and development of quinazoline compounds as irreversible pan-fibroblast growth factor receptor inhibitors with potent antitumor activities', 'display_name': 'Discovery and development of quinazoline compounds as irreversible pan-fibroblast growth factor receptor inhibitors with potent antitumor activities', 'publication_year': 2023, 'publication_date': '2023-12-01', 'ids': {'openalex': 'https://openalex.org/W4389224184', 'doi': 'https://doi.org/10.1016/j.molstruc.2023.137224'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.molstruc.2023.137224', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S203479135', 'display_name': 'Journal of Molecular Structure', 'issn_l': '0022-2860', 'issn': ['0022-2860', '1872-8014'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102861871', 'display_name': 'Shihe Hu', 'orcid': 'https://orcid.org/0009-0005-6136-075X'}, 'institutions': [{'id': 'https://openalex.org/I131434179', 'display_name': 'Nanjing University of Chinese Medicine', 'ror': 'https://ror.org/04523zj19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I131434179']}, {'id': 'https://openalex.org/I4210110502', 'display_name': 'Jiangsu Provincial Academy of Traditional Chinese Medicine', 'ror': 'https://ror.org/01a1w0r26', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210110502']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shihe Hu', 'raw_affiliation_strings': ['Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, China', 'Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu 210028, China', 'SkyRun Pharma Co., Ltd., No. 9 Weidi Road, Nanjing 210046, China'], 'affiliations': [{'raw_affiliation_string': 'SkyRun Pharma Co., Ltd., No. 9 Weidi Road, Nanjing 210046, China', 'institution_ids': []}, {'raw_affiliation_string': 'Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, China', 'institution_ids': ['https://openalex.org/I131434179']}, {'raw_affiliation_string': 'Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu 210028, China', 'institution_ids': ['https://openalex.org/I4210110502']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057073662', 'display_name': 'Cuihua Jiang', 'orcid': 'https://orcid.org/0000-0001-9207-9737'}, 'institutions': [{'id': 'https://openalex.org/I131434179', 'display_name': 'Nanjing University of Chinese Medicine', 'ror': 'https://ror.org/04523zj19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I131434179']}, {'id': 'https://openalex.org/I4210110502', 'display_name': 'Jiangsu Provincial Academy of Traditional Chinese Medicine', 'ror': 'https://ror.org/01a1w0r26', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210110502']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Cuihua Jiang', 'raw_affiliation_strings': ['Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, China', 'Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu 210028, China'], 'affiliations': [{'raw_affiliation_string': 'Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, China', 'institution_ids': ['https://openalex.org/I131434179']}, {'raw_affiliation_string': 'Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu 210028, China', 'institution_ids': ['https://openalex.org/I4210110502']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024534066', 'display_name': 'Meng Gao', 'orcid': 'https://orcid.org/0000-0001-6941-0284'}, 'institutions': [{'id': 'https://openalex.org/I131434179', 'display_name': 'Nanjing University of Chinese Medicine', 'ror': 'https://ror.org/04523zj19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I131434179']}, {'id': 'https://openalex.org/I4210110502', 'display_name': 'Jiangsu Provincial Academy of Traditional Chinese Medicine', 'ror': 'https://ror.org/01a1w0r26', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210110502']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Meng Gao', 'raw_affiliation_strings': ['Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, China', 'Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu 210028, China'], 'affiliations': [{'raw_affiliation_string': 'Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, China', 'institution_ids': ['https://openalex.org/I131434179']}, {'raw_affiliation_string': 'Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu 210028, China', 'institution_ids': ['https://openalex.org/I4210110502']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084351198', 'display_name': 'Dongjian Zhang', 'orcid': 'https://orcid.org/0000-0003-4821-6620'}, 'institutions': [{'id': 'https://openalex.org/I131434179', 'display_name': 'Nanjing University of Chinese Medicine', 'ror': 'https://ror.org/04523zj19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I131434179']}, {'id': 'https://openalex.org/I4210110502', 'display_name': 'Jiangsu Provincial Academy of Traditional Chinese Medicine', 'ror': 'https://ror.org/01a1w0r26', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210110502']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Dongjian Zhang', 'raw_affiliation_strings': ['Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, China', 'Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu 210028, China'], 'affiliations': [{'raw_affiliation_string': 'Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, China', 'institution_ids': ['https://openalex.org/I131434179']}, {'raw_affiliation_string': 'Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu 210028, China', 'institution_ids': ['https://openalex.org/I4210110502']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101642359', 'display_name': 'Nan Yao', 'orcid': 'https://orcid.org/0000-0001-9161-1058'}, 'institutions': [{'id': 'https://openalex.org/I131434179', 'display_name': 'Nanjing University of Chinese Medicine', 'ror': 'https://ror.org/04523zj19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I131434179']}, {'id': 'https://openalex.org/I4210110502', 'display_name': 'Jiangsu Provincial Academy of Traditional Chinese Medicine', 'ror': 'https://ror.org/01a1w0r26', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210110502']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Nan Yao', 'raw_affiliation_strings': ['Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, China', 'Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu 210028, China'], 'affiliations': [{'raw_affiliation_string': 'Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, China', 'institution_ids': ['https://openalex.org/I131434179']}, {'raw_affiliation_string': 'Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu 210028, China', 'institution_ids': ['https://openalex.org/I4210110502']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100409892', 'display_name': 'Jian Zhang', 'orcid': 'https://orcid.org/0000-0001-8338-9426'}, 'institutions': [{'id': 'https://openalex.org/I131434179', 'display_name': 'Nanjing University of Chinese Medicine', 'ror': 'https://ror.org/04523zj19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I131434179']}, {'id': 'https://openalex.org/I4210110502', 'display_name': 'Jiangsu Provincial Academy of Traditional Chinese Medicine', 'ror': 'https://ror.org/01a1w0r26', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210110502']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jian Zhang', 'raw_affiliation_strings': ['Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, China', 'Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu 210028, China'], 'affiliations': [{'raw_affiliation_string': 'Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, China', 'institution_ids': ['https://openalex.org/I131434179']}, {'raw_affiliation_string': 'Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu 210028, China', 'institution_ids': ['https://openalex.org/I4210110502']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5052311485', 'display_name': 'Qiaomei Jin', 'orcid': 'https://orcid.org/0000-0002-8559-9125'}, 'institutions': [{'id': 'https://openalex.org/I131434179', 'display_name': 'Nanjing University of Chinese Medicine', 'ror': 'https://ror.org/04523zj19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I131434179']}, {'id': 'https://openalex.org/I4210110502', 'display_name': 'Jiangsu Provincial Academy of Traditional Chinese Medicine', 'ror': 'https://ror.org/01a1w0r26', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210110502']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Qiaomei Jin', 'raw_affiliation_strings': ['Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, China', 'Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu 210028, China'], 'affiliations': [{'raw_affiliation_string': 'Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, China', 'institution_ids': ['https://openalex.org/I131434179']}, {'raw_affiliation_string': 'Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu 210028, China', 'institution_ids': ['https://openalex.org/I4210110502']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5052311485'], 'corresponding_institution_ids': ['https://openalex.org/I131434179', 'https://openalex.org/I4210110502'], 'apc_list': {'value': 3430, 'currency': 'USD', 'value_usd': 3430, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.26, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.499258, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 68, 'max': 79}, 'biblio': {'volume': '1299', 'issue': None, 'first_page': '137224', 'last_page': '137224'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12287', 'display_name': 'Fibroblast Growth Factor Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12287', 'display_name': 'Fibroblast Growth Factor Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12600', 'display_name': 'Eosinophilic Disorders and Syndromes', 'score': 0.985, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13426', 'display_name': 'Kruppel-like factors research', 'score': 0.9813, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/quinazoline', 'display_name': 'Quinazoline', 'score': 0.7436203}, {'id': 'https://openalex.org/keywords/ic50', 'display_name': 'IC50', 'score': 0.57385355}], 'concepts': [{'id': 'https://openalex.org/C82867764', 'wikidata': 'https://www.wikidata.org/wiki/Q24780051', 'display_name': 'Fibroblast growth factor receptor', 'level': 4, 'score': 0.88567203}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.88268715}, {'id': 'https://openalex.org/C49418065', 'wikidata': 'https://www.wikidata.org/wiki/Q14914258', 'display_name': 'Fibroblast growth factor receptor 1', 'level': 4, 'score': 0.87223494}, {'id': 'https://openalex.org/C2778866207', 'wikidata': 'https://www.wikidata.org/wiki/Q426278', 'display_name': 'Quinazoline', 'level': 2, 'score': 0.7436203}, {'id': 'https://openalex.org/C2777752497', 'wikidata': 'https://www.wikidata.org/wiki/Q286779', 'display_name': 'IC50', 'level': 3, 'score': 0.57385355}, {'id': 'https://openalex.org/C74373430', 'wikidata': 'https://www.wikidata.org/wiki/Q24727126', 'display_name': 'Fibroblast growth factor', 'level': 3, 'score': 0.5716249}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5397703}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.45951903}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.44962013}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.4428784}, {'id': 'https://openalex.org/C74187038', 'wikidata': 'https://www.wikidata.org/wiki/Q1418791', 'display_name': 'Drug discovery', 'level': 2, 'score': 0.42572483}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.38775328}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.30566922}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.21635556}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.20492104}, {'id': 'https://openalex.org/C21951064', 'wikidata': 'https://www.wikidata.org/wiki/Q899212', 'display_name': 'Combinatorial chemistry', 'level': 1, 'score': 0.1952672}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.molstruc.2023.137224', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S203479135', 'display_name': 'Journal of Molecular Structure', 'issn_l': '0022-2860', 'issn': ['0022-2860', '1872-8014'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.79, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1608710587', 'https://openalex.org/W1988476050', 'https://openalex.org/W1992595943', 'https://openalex.org/W1993675254', 'https://openalex.org/W2013836042', 'https://openalex.org/W2014689880', 'https://openalex.org/W2077804275', 'https://openalex.org/W2093090488', 'https://openalex.org/W2096258722', 'https://openalex.org/W2098466520', 'https://openalex.org/W2113727201', 'https://openalex.org/W2152905269', 'https://openalex.org/W2167854315', 'https://openalex.org/W2182110379', 'https://openalex.org/W2600903921', 'https://openalex.org/W2724796663', 'https://openalex.org/W2760639821', 'https://openalex.org/W2796108867', 'https://openalex.org/W2907962089', 'https://openalex.org/W2969349514', 'https://openalex.org/W3013682926', 'https://openalex.org/W3103246749', 'https://openalex.org/W3104286060', 'https://openalex.org/W3104553001', 'https://openalex.org/W3108059695', 'https://openalex.org/W3147809641', 'https://openalex.org/W3213769887', 'https://openalex.org/W4310117868', 'https://openalex.org/W4319069485', 'https://openalex.org/W4362638986', 'https://openalex.org/W4380992675', 'https://openalex.org/W4381189637', 'https://openalex.org/W4386083960'], 'related_works': ['https://openalex.org/W3209810', 'https://openalex.org/W2358034211', 'https://openalex.org/W2353864019', 'https://openalex.org/W2080073026', 'https://openalex.org/W2076274660', 'https://openalex.org/W2073425741', 'https://openalex.org/W2049555359', 'https://openalex.org/W2002667085', 'https://openalex.org/W1628634389', 'https://openalex.org/W1530921588'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4389224184', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}], 'updated_date': '2024-12-13T21:08:50.419629', 'created_date': '2023-12-02'}