Title: 18th International Conference of the Julian Aleksandrowicz Polish Society for Magnesium Research “The importance of chemical elements in various aspects of human life” Book of Abstracts
Abstract: Magnesium is the second most abundant intracellular cation and one of the most abundant element in the body.Although the total serum magnesium content does not represent more than 1% of total body magnesium, serum magnesium determinations have been routinely used in clinical practice to assess body magnesium status.Hypomagnesemia (low magnesium status), which is associated with many chronic diseases, is diagnosed using the serum magnesium reference range.In the recently published paper [Rosanoff et al. 2022], the authors have discussed the cut off value of the lower level of magnesium normal status in blood serum.However, this recommendation concerns only the total magnesium concentration.It is known for many years that ionized magnesium concentration in blood serum can give us additional and valuable information about body magnesium status [Saaris et al. 2000].Ionized magnesium concentration in blood serum was found significantly lower, compared to control, in acute myocardial infarction and diabetes mellitus type I (D I).Total magnesium level was within physiological range in both cases.Recently, the serum Mg isotopic signature was investigated in a cohort of patients suffering from D I and compared to that in age-and gender-matched reference population (assumed healthy individuals) [Grigoryan et al. 2019].Patient were re-evaluated after one year.Several references materials were measured for validation purposes.The serum Mg isotopic composition of D I patients Year 1 and Year 2 was lighter than the serum Mg isotopic composition of the reference population.To investigate the possible source of isotopic composition changes during Mg transfer through the cellular membrane, diffusion of Mg and Ca through the artificial, ion selective membrane, has been investigated.