Title: Embryonic, Developmental, and Postnatal Perspectives
Abstract: Abstract The neural tube is formed by fusion of the neural folds (Fig. 3-1). The process of neurulation is complex and involves proliferation of neuroblasts or matrix cells, development of the neuroepithelium and surface ectoderm, formation of the neural plate median hinge point, apical constriction of neuroepithelial cells, and expansion of the mesoderm and extracellular matrices. Four stages can be discerned: (a) induction of the neural plate by the notochord; (b) rostrocaudal lengthening and mediolateral narrowing; (c) lateral folding of the neural plate; and (d) apposition and fusion of the apical surfaces of the neural folds. There are three initiation sites of neural tube closure (81, 82) (Fig. 3-2).
Publication Year: 2006
Publication Date: 2006-04-06
Language: en
Type: book-chapter
Indexed In: ['crossref']
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Cited By Count: 1
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