Title: Ets Transcription Factor Mutations and Hematopoiesis
Abstract:Abstract The Ets family of transcription factors consists of a large number of winged helix-loop-helix DNA-binding proteins. Members of the Ets family are related by a high degree of sequence identity...Abstract The Ets family of transcription factors consists of a large number of winged helix-loop-helix DNA-binding proteins. Members of the Ets family are related by a high degree of sequence identity within the DNA-binding domain (ETS domain), which recognizes purine-rich DNA motifs centered around the core nucleotides GGAA/T (Karim et al., 1990). The Ets proteins are highly conserved through evolution and are important regulators of development in flies, worms, and mammals. At least eight Ets proteins, including PU. I, Spi-B, Ets-1, Ets-2, Elf-1, Fli-1, TEL, and GABPcx are expressed in hematopoietic cells (see Table 35.1), and binding sites for these Ets proteins have been described in a large number of genes thought to be involved in hematopoietic differentiation and immune system function (reviewed in Bassuk and Leiden, 1997).Read More
Publication Year: 2001
Publication Date: 2001-04-12
Language: en
Type: book-chapter
Indexed In: ['crossref']
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Cited By Count: 1
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