Baseline Albumin-Bilirubin grade as a predictor of response and outcome of regorafenib therapy in patients with hepatocellular carcinoma: a systematic review and meta-analysis

Name: Work Video:
Duration: 3 min 30 s
Huilin Xu; Dedong Cao; Dingjie Zhou; Nan Zhao; Xixian Tang; Vishal G. Shelat; Hrishikesh Samant; Sanjaya K. Satapathy; Francisco Tustumi; Giuseppe Aprile; Anbing He; Ximing Xu; Wei Ge
{'id': 'https://openalex.org/W4387774520', 'doi': 'https://doi.org/10.1186/s12885-023-11488-9', 'title': 'Baseline Albumin-Bilirubin grade as a predictor of response and outcome of regorafenib therapy in patients with hepatocellular carcinoma: a systematic review and meta-analysis', 'display_name': 'Baseline Albumin-Bilirubin grade as a predictor of response and outcome of regorafenib therapy in patients with hepatocellular carcinoma: a systematic review and meta-analysis', 'publication_year': 2023, 'publication_date': '2023-10-19', 'ids': {'openalex': 'https://openalex.org/W4387774520', 'doi': 'https://doi.org/10.1186/s12885-023-11488-9', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/37858207'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12885-023-11488-9', 'pdf_url': 'https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-023-11488-9', 'source': {'id': 'https://openalex.org/S192926780', 'display_name': 'BMC Cancer', 'issn_l': '1471-2407', 'issn': ['1471-2407'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-023-11488-9', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100771598', 'display_name': 'Huilin Xu', 'orcid': 'https://orcid.org/0000-0002-7675-8374'}, 'institutions': [{'id': 'https://openalex.org/I4210131162', 'display_name': 'Fifth Hospital In Wuhan', 'ror': 'https://ror.org/02hpna219', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210131162']}, {'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Huilin Xu', 'raw_affiliation_strings': ['Department of Oncology, The Fifth Hospital of Wuhan, #122 Xianzheng Road, Hanyang District, Wuhan, 430000, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The Fifth Hospital of Wuhan, #122 Xianzheng Road, Hanyang District, Wuhan, 430000, China', 'institution_ids': ['https://openalex.org/I4210131162', 'https://openalex.org/I37461747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069721850', 'display_name': 'Dedong Cao', 'orcid': 'https://orcid.org/0000-0002-5777-4176'}, 'institutions': [{'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}, {'id': 'https://openalex.org/I4210140357', 'display_name': 'Renmin Hospital of Wuhan University', 'ror': 'https://ror.org/03ekhbz91', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140357']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Dedong Cao', 'raw_affiliation_strings': ['Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China', 'institution_ids': ['https://openalex.org/I37461747', 'https://openalex.org/I4210140357']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033016530', 'display_name': 'Dingjie Zhou', 'orcid': 'https://orcid.org/0000-0001-5905-575X'}, 'institutions': [{'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}, {'id': 'https://openalex.org/I4210140357', 'display_name': 'Renmin Hospital of Wuhan University', 'ror': 'https://ror.org/03ekhbz91', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140357']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Dingjie Zhou', 'raw_affiliation_strings': ['Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China', 'institution_ids': ['https://openalex.org/I37461747', 'https://openalex.org/I4210140357']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101618953', 'display_name': 'Nan Zhao', 'orcid': 'https://orcid.org/0000-0002-5624-080X'}, 'institutions': [{'id': 'https://openalex.org/I4210140357', 'display_name': 'Renmin Hospital of Wuhan University', 'ror': 'https://ror.org/03ekhbz91', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140357']}, {'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Nan Zhao', 'raw_affiliation_strings': ['Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210140357', 'https://openalex.org/I37461747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082252292', 'display_name': 'Xixian Tang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}, {'id': 'https://openalex.org/I4210140357', 'display_name': 'Renmin Hospital of Wuhan University', 'ror': 'https://ror.org/03ekhbz91', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140357']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xixian Tang', 'raw_affiliation_strings': ['Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China', 'institution_ids': ['https://openalex.org/I37461747', 'https://openalex.org/I4210140357']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070477645', 'display_name': 'Vishal G. Shelat', 'orcid': 'https://orcid.org/0000-0003-3988-8142'}, 'institutions': [{'id': 'https://openalex.org/I2802408685', 'display_name': 'Tan Tock Seng Hospital', 'ror': 'https://ror.org/032d59j24', 'country_code': 'SG', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802408685']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Vishalkumar G. Shelat', 'raw_affiliation_strings': ['Department of General Surgery, Tan Tock Seng Hospital, Singapore, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery, Tan Tock Seng Hospital, Singapore, Singapore', 'institution_ids': ['https://openalex.org/I2802408685']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103064420', 'display_name': 'Hrishikesh Samant', 'orcid': 'https://orcid.org/0000-0002-6401-9267'}, 'institutions': [{'id': 'https://openalex.org/I4210164123', 'display_name': 'Organ Recovery Systems (United States)', 'ror': 'https://ror.org/05hy2kb37', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210164123']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hrishikesh Samant', 'raw_affiliation_strings': ['Division of Hepatology, Ochsner Multi-Organ Transplant Center, New Orleans, LA, USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Hepatology, Ochsner Multi-Organ Transplant Center, New Orleans, LA, USA', 'institution_ids': ['https://openalex.org/I4210164123']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052934363', 'display_name': 'Sanjaya K. Satapathy', 'orcid': 'https://orcid.org/0000-0003-0153-2829'}, 'institutions': [{'id': 'https://openalex.org/I1302444339', 'display_name': 'Northwell Health', 'ror': 'https://ror.org/02bxt4m23', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1302444339']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sanjaya K. Satapathy', 'raw_affiliation_strings': ['Division of Hepatology, Department of Medicine and Northwell Center for Liver Diseases & Transplantation, Northwell Health, Manhasset, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Hepatology, Department of Medicine and Northwell Center for Liver Diseases & Transplantation, Northwell Health, Manhasset, NY, USA', 'institution_ids': ['https://openalex.org/I1302444339']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020933173', 'display_name': 'Francisco Tustumi', 'orcid': 'https://orcid.org/0000-0001-6695-0496'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Francisco Tustumi', 'raw_affiliation_strings': ['Department of Gastroenterology, Digestive Surgery Division, University of São Paulo Medical School, Sao Paulo, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Department of Gastroenterology, Digestive Surgery Division, University of São Paulo Medical School, Sao Paulo, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090671983', 'display_name': 'Giuseppe Aprile', 'orcid': 'https://orcid.org/0000-0003-2007-4077'}, 'institutions': [{'id': 'https://openalex.org/I4210152245', 'display_name': 'Ospedale San Bortolo', 'ror': 'https://ror.org/05wd86d64', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210152245']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giuseppe Aprile', 'raw_affiliation_strings': ['Department of Oncology, San Bortolo General Hospital, Berica, Vicenza, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, San Bortolo General Hospital, Berica, Vicenza, Italy', 'institution_ids': ['https://openalex.org/I4210152245']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101058062', 'display_name': 'Anbing He', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210131162', 'display_name': 'Fifth Hospital In Wuhan', 'ror': 'https://ror.org/02hpna219', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210131162']}, {'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Anbing He', 'raw_affiliation_strings': ['Department of Oncology, The Fifth Hospital of Wuhan, #122 Xianzheng Road, Hanyang District, Wuhan, 430000, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The Fifth Hospital of Wuhan, #122 Xianzheng Road, Hanyang District, Wuhan, 430000, China', 'institution_ids': ['https://openalex.org/I4210131162', 'https://openalex.org/I37461747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100747123', 'display_name': 'Ximing Xu', 'orcid': 'https://orcid.org/0000-0002-4240-5378'}, 'institutions': [{'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}, {'id': 'https://openalex.org/I4210140357', 'display_name': 'Renmin Hospital of Wuhan University', 'ror': 'https://ror.org/03ekhbz91', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210140357']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ximing Xu', 'raw_affiliation_strings': ['Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China', 'institution_ids': ['https://openalex.org/I37461747', 'https://openalex.org/I4210140357']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5024725065', 'display_name': 'Wei Ge', 'orcid': 'https://orcid.org/0000-0002-9907-512X'}, 'institutions': [{'id': 'https://openalex.org/I4210160344', 'display_name': 'Tongji Hospital', 'ror': 'https://ror.org/04xy45965', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210160344']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wei Ge', 'raw_affiliation_strings': ['Department of Oncology, Taikang Tongji Hospital of Wuhan, Wuhan, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, Taikang Tongji Hospital of Wuhan, Wuhan, China', 'institution_ids': ['https://openalex.org/I4210160344']}]}], 'institution_assertions': [], 'countries_distinct_count': 5, 'institutions_distinct_count': 9, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1790, 'currency': 'GBP', 'value_usd': 2195, 'provenance': 'doaj'}, 'apc_paid': {'value': 1790, 'currency': 'GBP', 'value_usd': 2195, 'provenance': 'doaj'}, 'fwci': 0.509, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.349642, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 88}, 'biblio': {'volume': '23', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10073', 'display_name': 'Hepatocellular Carcinoma Treatment and Prognosis', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10073', 'display_name': 'Hepatocellular Carcinoma Treatment and Prognosis', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13779', 'display_name': 'Cancer Mechanisms and Therapy', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12334', 'display_name': 'Lung Cancer Research Studies', 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/regorafenib', 'display_name': 'Regorafenib', 'score': 0.9683851}, {'id': 'https://openalex.org/keywords/funnel-plot', 'display_name': 'Funnel plot', 'score': 0.48360363}], 'concepts': [{'id': 'https://openalex.org/C2776248978', 'wikidata': 'https://www.wikidata.org/wiki/Q3891664', 'display_name': 'Regorafenib', 'level': 4, 'score': 0.9683851}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.869422}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.7604841}, {'id': 'https://openalex.org/C2778019345', 'wikidata': 'https://www.wikidata.org/wiki/Q1148337', 'display_name': 'Hepatocellular carcinoma', 'level': 2, 'score': 0.7555845}, {'id': 'https://openalex.org/C207103383', 'wikidata': 'https://www.wikidata.org/wiki/Q3930246', 'display_name': 'Hazard ratio', 'level': 3, 'score': 0.5260049}, {'id': 'https://openalex.org/C95190672', 'wikidata': 'https://www.wikidata.org/wiki/Q815382', 'display_name': 'Meta-analysis', 'level': 2, 'score': 0.51948845}, {'id': 'https://openalex.org/C156957248', 'wikidata': 'https://www.wikidata.org/wiki/Q1862216', 'display_name': 'Odds ratio', 'level': 2, 'score': 0.48736507}, {'id': 'https://openalex.org/C82605166', 'wikidata': 'https://www.wikidata.org/wiki/Q967190', 'display_name': 'Funnel plot', 'level': 4, 'score': 0.48360363}, {'id': 'https://openalex.org/C2778695046', 'wikidata': 'https://www.wikidata.org/wiki/Q421136', 'display_name': 'Sorafenib', 'level': 3, 'score': 0.4693609}, {'id': 'https://openalex.org/C2776478404', 'wikidata': 'https://www.wikidata.org/wiki/Q1105187', 'display_name': 'Cochrane Library', 'level': 3, 'score': 0.46845055}, {'id': 'https://openalex.org/C2780439572', 'wikidata': 'https://www.wikidata.org/wiki/Q919364', 'display_name': 'Publication bias', 'level': 3, 'score': 0.4619745}, {'id': 'https://openalex.org/C44249647', 'wikidata': 'https://www.wikidata.org/wiki/Q208498', 'display_name': 'Confidence interval', 'level': 2, 'score': 0.45260328}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.42545885}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.1545079}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.13447824}], 'mesh': [{'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D001663', 'descriptor_name': 'Bilirubin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012189', 'descriptor_name': 'Retrospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012709', 'descriptor_name': 'Serum Albumin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12885-023-11488-9', 'pdf_url': 'https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-023-11488-9', 'source': {'id': 'https://openalex.org/S192926780', 'display_name': 'BMC Cancer', 'issn_l': '1471-2407', 'issn': ['1471-2407'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10588229', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/37858207', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12885-023-11488-9', 'pdf_url': 'https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-023-11488-9', 'source': {'id': 'https://openalex.org/S192926780', 'display_name': 'BMC Cancer', 'issn_l': '1471-2407', 'issn': ['1471-2407'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.48}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 55, 'referenced_works': ['https://openalex.org/W2042622676', 'https://openalex.org/W2616140900', 'https://openalex.org/W2766922427', 'https://openalex.org/W2796005913', 'https://openalex.org/W2898690597', 'https://openalex.org/W2914676498', 'https://openalex.org/W2938267598', 'https://openalex.org/W2970853489', 'https://openalex.org/W2978795816', 'https://openalex.org/W2996658662', 'https://openalex.org/W3014368645', 'https://openalex.org/W3036939245', 'https://openalex.org/W3042548904', 'https://openalex.org/W3047155119', 'https://openalex.org/W3103326271', 'https://openalex.org/W3108220068', 'https://openalex.org/W3110236571', 'https://openalex.org/W3128646645', 'https://openalex.org/W3130142296', 'https://openalex.org/W3133836342', 'https://openalex.org/W3138551344', 'https://openalex.org/W3139407349', 'https://openalex.org/W3149523732', 'https://openalex.org/W3159795713', 'https://openalex.org/W3161473862', 'https://openalex.org/W3161519448', 'https://openalex.org/W3161823034', 'https://openalex.org/W3183570705', 'https://openalex.org/W3191788410', 'https://openalex.org/W3195905256', 'https://openalex.org/W3199025716', 'https://openalex.org/W3200845995', 'https://openalex.org/W3211505125', 'https://openalex.org/W3211554437', 'https://openalex.org/W3213277274', 'https://openalex.org/W4210612004', 'https://openalex.org/W4210774372', 'https://openalex.org/W4210829994', 'https://openalex.org/W4212895371', 'https://openalex.org/W4213435466', 'https://openalex.org/W4220778376', 'https://openalex.org/W4224031850', 'https://openalex.org/W4225121049', 'https://openalex.org/W4226015699', 'https://openalex.org/W4226072552', 'https://openalex.org/W4281697745', 'https://openalex.org/W4281993675', 'https://openalex.org/W4283257487', 'https://openalex.org/W4283707956', 'https://openalex.org/W4285105157', 'https://openalex.org/W4290702615', 'https://openalex.org/W4293214526', 'https://openalex.org/W4310228491', 'https://openalex.org/W4312126187', 'https://openalex.org/W4315619257'], 'related_works': ['https://openalex.org/W4386893315', 'https://openalex.org/W3105390383', 'https://openalex.org/W2942632018', 'https://openalex.org/W2938267598', 'https://openalex.org/W2922810281', 'https://openalex.org/W2904776407', 'https://openalex.org/W2799933121', 'https://openalex.org/W2755303271', 'https://openalex.org/W2622529806', 'https://openalex.org/W2001059786'], 'abstract_inverted_index': {'Abstract': [0], 'Background': [1], 'The': [2, 170, 219, 328], 'use': [3], 'of': [4, 9, 44, 56, 68, 119, 159], 'regorafenib': [5, 27, 60, 90, 198, 204, 262], 'in': [6, 49, 167, 187, 343], 'the': [7, 42, 45, 51, 117, 120, 168, 181, 188, 256, 292, 314], 'treatment': [8, 205, 226], 'hepatocellular': [10], 'carcinoma': [11], '(HCC)': [12], 'is': [13], 'widespread.': [14], 'Albumin-Bilirubin': [15], '(ALBI)': [16], 'has': [17], 'been': [18], 'shown': [19], 'to': [20, 40, 82, 115, 128, 140, 152, 180], 'be': [21, 333], 'a': [22, 38, 95, 192, 334], 'potential': [23], 'prognostic': [24, 31, 336], 'marker': [25], 'for': [26, 203, 338], 'treatment,': [28], 'but': [29, 312], 'its': [30], 'value': [32, 43], 'remains': [33], 'controversial.': [34], 'Therefore,': [35], 'we': [36], 'conducted': [37], 'meta-analysis': [39], 'investigate': [41], 'baseline': [46, 183, 221, 258, 329], 'ALBI': [47, 93, 184, 222, 259, 293, 330], 'grade': [48, 294, 331], 'predicting': [50, 339], 'efficacy': [52], 'and': [53, 74, 91, 101, 134, 147, 199, 244, 279, 341], 'survival': [54, 99, 103, 194], 'outcomes': [55, 342], 'HCC': [57, 87, 344], 'patients': [58, 88, 186, 345], 'after': [59, 196], 'treatment.': [61], 'Methods': [62], 'PubMed,': [63], 'Embase,': [64], 'Cochrane': [65], 'library,': [66], 'Web': [67], 'Science,': [69], 'CNKI,': [70], 'Wan': [71], 'Fang': [72], 'Data,': [73], 'Vip': [75], 'Database': [76], 'were': [77, 108, 138, 150, 165, 173], 'searched': [78], 'from': [79], 'January': [80], '2010': [81], 'October': [83], '2022.': [84], 'Studies': [85], 'treating': [86], 'with': [89, 92, 230, 267, 298, 347], 'as': [94, 105, 176], 'categorical': [96], 'variable,': [97], 'overall': [98], '(OS)': [100], 'progression-free': [102], '(PFS)': [104], 'outcome': [106], 'indicators': [107], 'included.': [109], 'After': [110], 'applying': [111], 'Newcastle–Ottawa': [112], 'Scale': [113], '(NOS)': [114], 'evaluate': [116, 153], 'quality': [118], 'included': [121, 166, 171], 'studies,': [122, 161], 'Review': [123], 'Manager': [124], '5.4': [125], 'was': [126, 227, 263, 295], 'used': [127, 139, 151], 'statistically': [129], 'analyze.': [130], 'Chi-square': [131], 'Q': [132], 'test': [133, 149], 'I': [135], '2': [136], 'statistics': [137], 'detect': [141], 'heterogeneity.': [142], 'Funnel': [143], 'plot': [144], 'asymmetry,': [145], 'Egger’s': [146], 'Begg’s': [148], 'publication': [154], 'bias.': [155], 'Results': [156], 'A': [157], 'total': [158], '12': [160], 'comprising': [162], '1,918': [163], 'patients,': [164], 'meta-analysis.': [169], 'studies': [172], 'all': [174], 'evaluated': [175], 'high': [177], 'quality.': [178], 'Compared': [179], 'high-grade': [182], 'group,': [185], 'low-grade': [189, 220, 257], 'group': [190, 223, 260], 'had': [191], 'longer': [193], 'time': [195], 'receiving': [197], 'also': [200, 264], 'more': [201], 'suitable': [202], '[odds': [206], 'ratio': [207, 234], '(OR)': [208], '=': [209, 236, 247, 253, 271, 277, 282, 288, 304, 310, 319, 325], '6.50,': [210], '95%': [211, 238, 249, 273, 284, 306, 321], 'confidence': [212], 'interval': [213], '(CI):': [214], '2.22–18.96,': [215], 'P': [216, 241, 252, 276, 287, 309, 324], '&lt;': [217, 242], '0.01].': [218], 'before': [224, 261], 'sorafenib': [225], 'significantly': [228, 265, 296], 'correlated': [229, 266, 297], 'better': [231, 268], 'OS': [232, 269], '[hazard': [233], '(HR)': [235], '2.36,': [237], 'CI:': [239, 250, 274, 285, 307, 322], '1.68–3.31,': [240], '0.00001]': [243], 'PFS': [245, 280], '(HR': [246, 270, 281], '1.56,': [248, 272], '1.16–2.08,': [251], '0.003).': [254], 'Likewise,': [255], '1.15–2.13,': [275], '0.005)': [278], '2.06,': [283], '1.37–3.11,': [286], '0.0005).': [289], 'In': [290], 'addition,': [291], 'disease': [299], 'control': [300], 'rate': [301, 317], '(DCR)': [302], '(OR': [303, 318], '2.90,': [305], '1.45–5.79,': [308], '0.003),': [311], 'not': [313], 'objective': [315], 'response': [316, 340], '1.98,': [320], '0.71–5.46,': [323], '0.19).': [326], 'Conclusions': [327], 'could': [332], 'valuable': [335], 'indicator': [337], 'treated': [346], 'regorafenib.': [348]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4387774520', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}], 'updated_date': '2025-01-06T09:11:57.193251', 'created_date': '2023-10-20'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
