Publication Information

{'id': 'https://openalex.org/W4387537026', 'doi': 'https://doi.org/10.1002/agm2.12267', 'title': 'Icariin attenuates the calcification of vascular smooth muscle cells through <scp>ERα</scp> – <scp>p38MAPK</scp> pathway', 'display_name': 'Icariin attenuates the calcification of vascular smooth muscle cells through <scp>ERα</scp> – <scp>p38MAPK</scp> pathway', 'publication_year': 2023, 'publication_date': '2023-10-10', 'ids': {'openalex': 'https://openalex.org/W4387537026', 'doi': 'https://doi.org/10.1002/agm2.12267', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/38239714'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/agm2.12267', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/agm2.12267', 'source': {'id': 'https://openalex.org/S4210217152', 'display_name': 'Aging Medicine', 'issn_l': '2475-0360', 'issn': ['2475-0360'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'diamond', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/agm2.12267', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5059735600', 'display_name': 'Jieyu He', 'orcid': 'https://orcid.org/0000-0002-3806-9260'}, 'institutions': [{'id': 'https://openalex.org/I4210153856', 'display_name': 'Second Xiangya Hospital of Central South University', 'ror': 'https://ror.org/053v2gh09', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153856']}, {'id': 'https://openalex.org/I139660479', 'display_name': 'Central South University', 'ror': 'https://ror.org/00f1zfq44', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139660479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jieyu He', 'raw_affiliation_strings': ['Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China', 'institution_ids': ['https://openalex.org/I4210153856', 'https://openalex.org/I139660479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109184457', 'display_name': 'Yanjiao Wang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210153856', 'display_name': 'Second Xiangya Hospital of Central South University', 'ror': 'https://ror.org/053v2gh09', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153856']}, {'id': 'https://openalex.org/I139660479', 'display_name': 'Central South University', 'ror': 'https://ror.org/00f1zfq44', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139660479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yanjiao Wang', 'raw_affiliation_strings': ['Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China', 'institution_ids': ['https://openalex.org/I4210153856', 'https://openalex.org/I139660479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109428028', 'display_name': 'Jun‐Kun Zhan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210153856', 'display_name': 'Second Xiangya Hospital of Central South University', 'ror': 'https://ror.org/053v2gh09', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153856']}, {'id': 'https://openalex.org/I139660479', 'display_name': 'Central South University', 'ror': 'https://ror.org/00f1zfq44', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139660479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Junkun Zhan', 'raw_affiliation_strings': ['Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China', 'institution_ids': ['https://openalex.org/I4210153856', 'https://openalex.org/I139660479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100415889', 'display_name': 'Shuang Li', 'orcid': 'https://orcid.org/0000-0001-8857-724X'}, 'institutions': [{'id': 'https://openalex.org/I4210153856', 'display_name': 'Second Xiangya Hospital of Central South University', 'ror': 'https://ror.org/053v2gh09', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153856']}, {'id': 'https://openalex.org/I139660479', 'display_name': 'Central South University', 'ror': 'https://ror.org/00f1zfq44', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139660479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shuang Li', 'raw_affiliation_strings': ['Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China', 'institution_ids': ['https://openalex.org/I4210153856', 'https://openalex.org/I139660479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102891411', 'display_name': 'Yu‐Qing Ni', 'orcid': 'https://orcid.org/0000-0002-0321-5571'}, 'institutions': [{'id': 'https://openalex.org/I4210153856', 'display_name': 'Second Xiangya Hospital of Central South University', 'ror': 'https://ror.org/053v2gh09', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153856']}, {'id': 'https://openalex.org/I139660479', 'display_name': 'Central South University', 'ror': 'https://ror.org/00f1zfq44', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139660479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yuqing Ni', 'raw_affiliation_strings': ['Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China', 'institution_ids': ['https://openalex.org/I4210153856', 'https://openalex.org/I139660479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054167462', 'display_name': 'Wuyang Huang', 'orcid': 'https://orcid.org/0000-0002-3038-0636'}, 'institutions': [{'id': 'https://openalex.org/I139660479', 'display_name': 'Central South University', 'ror': 'https://ror.org/00f1zfq44', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139660479']}, {'id': 'https://openalex.org/I4210153856', 'display_name': 'Second Xiangya Hospital of Central South University', 'ror': 'https://ror.org/053v2gh09', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153856']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wu Huang', 'raw_affiliation_strings': ['Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China', 'institution_ids': ['https://openalex.org/I139660479', 'https://openalex.org/I4210153856']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110377334', 'display_name': 'Limin Long', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210153856', 'display_name': 'Second Xiangya Hospital of Central South University', 'ror': 'https://ror.org/053v2gh09', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153856']}, {'id': 'https://openalex.org/I139660479', 'display_name': 'Central South University', 'ror': 'https://ror.org/00f1zfq44', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139660479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Limin Long', 'raw_affiliation_strings': ['Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China', 'institution_ids': ['https://openalex.org/I4210153856', 'https://openalex.org/I139660479']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064914862', 'display_name': 'Pan Tan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I139660479', 'display_name': 'Central South University', 'ror': 'https://ror.org/00f1zfq44', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139660479']}, {'id': 'https://openalex.org/I4210153856', 'display_name': 'Second Xiangya Hospital of Central South University', 'ror': 'https://ror.org/053v2gh09', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153856']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Pan Tan', 'raw_affiliation_strings': ['Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China', 'institution_ids': ['https://openalex.org/I139660479', 'https://openalex.org/I4210153856']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100365027', 'display_name': 'Yi Wang', 'orcid': 'https://orcid.org/0000-0003-3489-5183'}, 'institutions': [{'id': 'https://openalex.org/I4210153856', 'display_name': 'Second Xiangya Hospital of Central South University', 'ror': 'https://ror.org/053v2gh09', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153856']}, {'id': 'https://openalex.org/I139660479', 'display_name': 'Central South University', 'ror': 'https://ror.org/00f1zfq44', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139660479']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Yi Wang', 'raw_affiliation_strings': ['Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China', 'institution_ids': ['https://openalex.org/I4210153856', 'https://openalex.org/I139660479']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5084766648', 'display_name': 'You‐Shuo Liu', 'orcid': 'https://orcid.org/0000-0001-9835-4074'}, 'institutions': [{'id': 'https://openalex.org/I4210153856', 'display_name': 'Second Xiangya Hospital of Central South University', 'ror': 'https://ror.org/053v2gh09', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153856']}, {'id': 'https://openalex.org/I139660479', 'display_name': 'Central South University', 'ror': 'https://ror.org/00f1zfq44', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I139660479']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Youshuo Liu', 'raw_affiliation_strings': ['Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China', 'institution_ids': ['https://openalex.org/I4210153856', 'https://openalex.org/I139660479']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5100365027'], 'corresponding_institution_ids': ['https://openalex.org/I4210153856', 'https://openalex.org/I139660479'], 'apc_list': {'value': 0, 'currency': 'USD', 'value_usd': 0, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 67}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T14331', 'display_name': 'Medicinal Plant Pharmacodynamics Research', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T14331', 'display_name': 'Medicinal Plant Pharmacodynamics Research', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11219', 'display_name': 'Bone Metabolism and Diseases', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10515', 'display_name': 'Cancer-related molecular mechanisms research', 'score': 0.9892, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/icariin', 'display_name': 'Icariin', 'score': 0.9726944}, {'id': 'https://openalex.org/keywords/runx2', 'display_name': 'RUNX2', 'score': 0.41499215}], 'concepts': [{'id': 'https://openalex.org/C2780685212', 'wikidata': 'https://www.wikidata.org/wiki/Q5985057', 'display_name': 'Icariin', 'level': 3, 'score': 0.9726944}, {'id': 'https://openalex.org/C51551487', 'wikidata': 'https://www.wikidata.org/wiki/Q2043632', 'display_name': 'p38 mitogen-activated protein kinases', 'level': 4, 'score': 0.774631}, {'id': 'https://openalex.org/C2779395532', 'wikidata': 'https://www.wikidata.org/wiki/Q7916469', 'display_name': 'Vascular smooth muscle', 'level': 3, 'score': 0.7441817}, {'id': 'https://openalex.org/C57074206', 'wikidata': 'https://www.wikidata.org/wiki/Q14197552', 'display_name': 'MAPK/ERK pathway', 'level': 3, 'score': 0.73599535}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5905507}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.5352991}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.50790983}, {'id': 'https://openalex.org/C2780309369', 'wikidata': 'https://www.wikidata.org/wiki/Q933382', 'display_name': 'Calcification', 'level': 2, 'score': 0.48761263}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.48098505}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.47293973}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.44021708}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.43544757}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.43212914}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.43072718}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.43064487}, {'id': 'https://openalex.org/C2781249067', 'wikidata': 'https://www.wikidata.org/wiki/Q17142288', 'display_name': 'MEK inhibitor', 'level': 4, 'score': 0.4271995}, {'id': 'https://openalex.org/C2776363554', 'wikidata': 'https://www.wikidata.org/wiki/Q14907085', 'display_name': 'RUNX2', 'level': 4, 'score': 0.41499215}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.21909463}, {'id': 'https://openalex.org/C2778260815', 'wikidata': 'https://www.wikidata.org/wiki/Q917177', 'display_name': 'Osteoblast', 'level': 3, 'score': 0.16366646}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.15759477}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15155703}, {'id': 'https://openalex.org/C2992686903', 'wikidata': 'https://www.wikidata.org/wiki/Q208453', 'display_name': 'Smooth muscle', 'level': 2, 'score': 0.089028865}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.043746382}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/agm2.12267', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/agm2.12267', 'source': {'id': 'https://openalex.org/S4210217152', 'display_name': 'Aging Medicine', 'issn_l': '2475-0360', 'issn': ['2475-0360'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10792338', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/38239714', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/agm2.12267', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/agm2.12267', 'source': {'id': 'https://openalex.org/S4210217152', 'display_name': 'Aging Medicine', 'issn_l': '2475-0360', 'issn': ['2475-0360'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '82101663'}], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W1168383324', 'https://openalex.org/W1492550623', 'https://openalex.org/W1976659133', 'https://openalex.org/W1989686604', 'https://openalex.org/W2005356261', 'https://openalex.org/W2009136713', 'https://openalex.org/W2015041187', 'https://openalex.org/W2027109809', 'https://openalex.org/W2027375975', 'https://openalex.org/W2028261415', 'https://openalex.org/W2062290662', 'https://openalex.org/W2066634056', 'https://openalex.org/W2068700160', 'https://openalex.org/W2071054065', 'https://openalex.org/W2075372492', 'https://openalex.org/W2082385204', 'https://openalex.org/W2096301411', 'https://openalex.org/W2102235351', 'https://openalex.org/W2109249428', 'https://openalex.org/W2137408120', 'https://openalex.org/W2137602565', 'https://openalex.org/W2150026598', 'https://openalex.org/W2152707286', 'https://openalex.org/W2156595626', 'https://openalex.org/W2165529185', 'https://openalex.org/W2316592271', 'https://openalex.org/W2534244686', 'https://openalex.org/W2791143394', 'https://openalex.org/W2991561640', 'https://openalex.org/W3110705497', 'https://openalex.org/W3204059188'], 'related_works': ['https://openalex.org/W4387537026', 'https://openalex.org/W4200611837', 'https://openalex.org/W3159126471', 'https://openalex.org/W3028873988', 'https://openalex.org/W2999492163', 'https://openalex.org/W2802233807', 'https://openalex.org/W2759664936', 'https://openalex.org/W2369024798', 'https://openalex.org/W2038529559', 'https://openalex.org/W2016487780'], 'abstract_inverted_index': {'Abstract': [0], 'Objective': [1], 'To': [2], 'investigate': [3], 'the': [4, 9, 19, 38, 101, 141, 148], 'relationship': [5], 'between': [6], 'icariin': [7, 46, 80, 105], 'and': [8, 18, 53, 64, 73, 118, 146], 'osteoblastic': [10, 62, 107, 142], 'differentiation': [11, 63, 143], 'of': [12, 31, 49, 66, 97, 104, 111, 129, 135, 144], 'vascular': [13], 'smooth': [14], 'muscle': [15], 'cells': [16], '(VSMCs)': [17], 'signal': [20], 'pathway': [21], 'involved.': [22], 'Methods': [23], 'We': [24], 'applied': [25], 'a': [26, 119], 'universally': [27], 'accepted': [28], 'calcification': [29, 40], 'model': [30], 'VSMCs': [32, 39, 67, 112, 130], 'induced': [33], 'by': [34, 43, 153], 'β': [35], 'glycerophosphate.': [36], 'Then': [37], 'was': [41], 'observed': [42], 'treatment': [44, 110], 'with': [45, 113, 133], 'and/or': [47], 'inhibitors': [48], 'estrogen': [50], 'receptors': [51], '(ERs)': [52], 'p38‐mitogen‐activated': [54], 'protein': [55], 'kinase': [56], '(MAPK)': [57], 'signaling.': [58], 'Results': [59], 'Icariin': [60, 139], 'inhibited': [61, 140], 'mineralization': [65], 'due': [68], 'to': [69], 'decreased': [70], 'ALP': [71], 'activity': [72], 'Runx2': [74], 'expression.': [75], 'Further': [76], 'study': [77], 'demonstrated': [78], 'that': [79, 147], 'exerted': [81], 'this': [82], 'suppression': [83, 134], 'effect': [84, 128], 'through': [85, 156], 'activating': [86], 'p38‐MAPK': [87, 98, 136, 154], 'but': [88], 'not': [89], 'extracellular‐regulated': [90], 'kinase,': [91], 'JNK': [92], 'or': [93], 'Akt.': [94], 'An': [95], 'inhibitor': [96], 'partially': [99], 'reversed': [100], 'inhibitory': [102, 149], 'effects': [103, 150], 'on': [106], 'differentiation.': [108], 'Interestingly,': [109], 'an': [114], 'ER': [115], 'antagonist': [116, 123], 'ICI182780': [117], 'selective': [120], 'ERα': [121], 'receptor': [122], 'PPT': [124], 'attenuated': [125], 'icariin‐mediated': [126], 'inhibition': [127], 'calcification,': [131], 'associated': [132], 'phosphorylation.': [137], 'Conclusions': [138], 'VSMCs,': [145], 'were': [151], 'mediated': [152], 'pathways': [155], 'ERα.': [157]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4387537026', 'counts_by_year': [], 'updated_date': '2025-01-20T09:04:04.449014', 'created_date': '2023-10-12'}