Publication Information

{'id': 'https://openalex.org/W4386818473', 'doi': 'https://doi.org/10.1007/s10577-023-09737-5', 'title': 'Disentangling the roles of aneuploidy, chromosomal instability and tumour heterogeneity in developing resistance to cancer therapies', 'display_name': 'Disentangling the roles of aneuploidy, chromosomal instability and tumour heterogeneity in developing resistance to cancer therapies', 'publication_year': 2023, 'publication_date': '2023-09-18', 'ids': {'openalex': 'https://openalex.org/W4386818473', 'doi': 'https://doi.org/10.1007/s10577-023-09737-5', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/37721639'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s10577-023-09737-5', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s10577-023-09737-5.pdf', 'source': {'id': 'https://openalex.org/S141144868', 'display_name': 'Chromosome Research', 'issn_l': '0967-3849', 'issn': ['0967-3849', '1573-6849'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://link.springer.com/content/pdf/10.1007/s10577-023-09737-5.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103074781', 'display_name': 'Joana Andrade', 'orcid': 'https://orcid.org/0009-0003-9828-6982'}, 'institutions': [{'id': 'https://openalex.org/I166337079', 'display_name': 'Queen Mary University of London', 'ror': 'https://ror.org/026zzn846', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I166337079']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Joana Reis Andrade', 'raw_affiliation_strings': ['Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M6BQ, England'], 'affiliations': [{'raw_affiliation_string': 'Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M6BQ, England', 'institution_ids': ['https://openalex.org/I166337079']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040522730', 'display_name': 'A. Gallagher', 'orcid': 'https://orcid.org/0009-0004-4349-2110'}, 'institutions': [{'id': 'https://openalex.org/I166337079', 'display_name': 'Queen Mary University of London', 'ror': 'https://ror.org/026zzn846', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I166337079']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Annie Dinky Gallagher', 'raw_affiliation_strings': ['Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M6BQ, England'], 'affiliations': [{'raw_affiliation_string': 'Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M6BQ, England', 'institution_ids': ['https://openalex.org/I166337079']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017359218', 'display_name': 'Jovanna Maharaj', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I166337079', 'display_name': 'Queen Mary University of London', 'ror': 'https://ror.org/026zzn846', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I166337079']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Jovanna Maharaj', 'raw_affiliation_strings': ['Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M6BQ, England'], 'affiliations': [{'raw_affiliation_string': 'Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M6BQ, England', 'institution_ids': ['https://openalex.org/I166337079']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5041589194', 'display_name': 'Sarah E. McClelland', 'orcid': 'https://orcid.org/0000-0002-9987-4511'}, 'institutions': [{'id': 'https://openalex.org/I166337079', 'display_name': 'Queen Mary University of London', 'ror': 'https://ror.org/026zzn846', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I166337079']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Sarah Elizabeth McClelland', 'raw_affiliation_strings': ['Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M6BQ, England'], 'affiliations': [{'raw_affiliation_string': 'Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, EC1M6BQ, England', 'institution_ids': ['https://openalex.org/I166337079']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3190, 'currency': 'EUR', 'value_usd': 4190, 'provenance': 'doaj'}, 'apc_paid': {'value': 3190, 'currency': 'EUR', 'value_usd': 4190, 'provenance': 'doaj'}, 'fwci': 1.316, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 12, 'citation_normalized_percentile': {'value': 0.239335, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '31', 'issue': '4', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11287', 'display_name': 'Cancer Genomics and Diagnostics', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11287', 'display_name': 'Cancer Genomics and Diagnostics', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10231', 'display_name': 'Pancreatic and Hepatic Oncology Research', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/chromosome-instability', 'display_name': 'Chromosome instability', 'score': 0.8797625}, {'id': 'https://openalex.org/keywords/tumour-heterogeneity', 'display_name': 'Tumour heterogeneity', 'score': 0.49830937}, {'id': 'https://openalex.org/keywords/human-genetics', 'display_name': 'Human genetics', 'score': 0.45464665}], 'concepts': [{'id': 'https://openalex.org/C2779672484', 'wikidata': 'https://www.wikidata.org/wiki/Q529622', 'display_name': 'Aneuploidy', 'level': 4, 'score': 0.9482105}, {'id': 'https://openalex.org/C140752955', 'wikidata': 'https://www.wikidata.org/wiki/Q1087752', 'display_name': 'Chromosome instability', 'level': 4, 'score': 0.8797625}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7451594}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.6486863}, {'id': 'https://openalex.org/C178169997', 'wikidata': 'https://www.wikidata.org/wiki/Q2892636', 'display_name': 'Genome instability', 'level': 4, 'score': 0.64245874}, {'id': 'https://openalex.org/C30481170', 'wikidata': 'https://www.wikidata.org/wiki/Q37748', 'display_name': 'Chromosome', 'level': 3, 'score': 0.5232674}, {'id': 'https://openalex.org/C2777306565', 'wikidata': 'https://www.wikidata.org/wiki/Q15917291', 'display_name': 'Tumour heterogeneity', 'level': 3, 'score': 0.49830937}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.468983}, {'id': 'https://openalex.org/C47042493', 'wikidata': 'https://www.wikidata.org/wiki/Q265799', 'display_name': 'Human genetics', 'level': 3, 'score': 0.45464665}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.45003504}, {'id': 'https://openalex.org/C114851261', 'wikidata': 'https://www.wikidata.org/wiki/Q12147416', 'display_name': 'Drug resistance', 'level': 2, 'score': 0.42744946}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.42605665}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.36494952}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.16824695}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.14331862}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.11104447}], 'mesh': [{'descriptor_ui': 'D000782', 'descriptor_name': 'Aneuploidy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005075', 'descriptor_name': 'Biological Evolution', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D043171', 'descriptor_name': 'Chromosomal Instability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002869', 'descriptor_name': 'Chromosome Aberrations', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s10577-023-09737-5', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s10577-023-09737-5.pdf', 'source': {'id': 'https://openalex.org/S141144868', 'display_name': 'Chromosome Research', 'issn_l': '0967-3849', 'issn': ['0967-3849', '1573-6849'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506951', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/37721639', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s10577-023-09737-5', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s10577-023-09737-5.pdf', 'source': {'id': 'https://openalex.org/S141144868', 'display_name': 'Chromosome Research', 'issn_l': '0967-3849', 'issn': ['0967-3849', '1573-6849'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'No poverty', 'score': 0.63, 'id': 'https://metadata.un.org/sdg/1'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 176, 'referenced_works': ['https://openalex.org/W1522090640', 'https://openalex.org/W1544851750', 'https://openalex.org/W1546552389', 'https://openalex.org/W1690531714', 'https://openalex.org/W1965707365', 'https://openalex.org/W1967304777', 'https://openalex.org/W1973221039', 'https://openalex.org/W1974731601', 'https://openalex.org/W1976283094', 'https://openalex.org/W1987229185', 'https://openalex.org/W1987369248', 'https://openalex.org/W1987908519', 'https://openalex.org/W1988963409', 'https://openalex.org/W1998971866', 'https://openalex.org/W2002246796', 'https://openalex.org/W2010819084', 'https://openalex.org/W2016661249', 'https://openalex.org/W2017289276', 'https://openalex.org/W2020099456', 'https://openalex.org/W2023560061', 'https://openalex.org/W2032518018', 'https://openalex.org/W2033346155', 'https://openalex.org/W2040860750', 'https://openalex.org/W2042624690', 'https://openalex.org/W2043071112', 'https://openalex.org/W2043487490', 'https://openalex.org/W2045829974', 'https://openalex.org/W2045897698', 'https://openalex.org/W2056338458', 'https://openalex.org/W2057366353', 'https://openalex.org/W2062109911', 'https://openalex.org/W2067708830', 'https://openalex.org/W2076306819', 'https://openalex.org/W2076814468', 'https://openalex.org/W2077145482', 'https://openalex.org/W2081278227', 'https://openalex.org/W2084833108', 'https://openalex.org/W2088580309', 'https://openalex.org/W2093613683', 'https://openalex.org/W2095617425', 'https://openalex.org/W2097750604', 'https://openalex.org/W2098088639', 'https://openalex.org/W2098318897', 'https://openalex.org/W2099610218', 'https://openalex.org/W2102922697', 'https://openalex.org/W2102960342', 'https://openalex.org/W2105660237', 'https://openalex.org/W2107702258', 'https://openalex.org/W2109948920', 'https://openalex.org/W2110216592', 'https://openalex.org/W2117692326', 'https://openalex.org/W2120374074', 'https://openalex.org/W2125157023', 'https://openalex.org/W2125974203', 'https://openalex.org/W2129288227', 'https://openalex.org/W2129319315', 'https://openalex.org/W2133646845', 'https://openalex.org/W2134735385', 'https://openalex.org/W2135509865', 'https://openalex.org/W2137220794', 'https://openalex.org/W2144327200', 'https://openalex.org/W2146629016', 'https://openalex.org/W2150575159', 'https://openalex.org/W2153056550', 'https://openalex.org/W2153304690', 'https://openalex.org/W2154582697', 'https://openalex.org/W2155464138', 'https://openalex.org/W2155582899', 'https://openalex.org/W2159536530', 'https://openalex.org/W2161722719', 'https://openalex.org/W2163280499', 'https://openalex.org/W2166956439', 'https://openalex.org/W2169800519', 'https://openalex.org/W2170490448', 'https://openalex.org/W2171237493', 'https://openalex.org/W2171385762', 'https://openalex.org/W2182664595', 'https://openalex.org/W2296457333', 'https://openalex.org/W2302088846', 'https://openalex.org/W2352719856', 'https://openalex.org/W2410399749', 'https://openalex.org/W2465420247', 'https://openalex.org/W2523567694', 'https://openalex.org/W2531887049', 'https://openalex.org/W2563910203', 'https://openalex.org/W2569996114', 'https://openalex.org/W2573221347', 'https://openalex.org/W2579382924', 'https://openalex.org/W2588778011', 'https://openalex.org/W2604605776', 'https://openalex.org/W2609243345', 'https://openalex.org/W2691929059', 'https://openalex.org/W2693925639', 'https://openalex.org/W2734829443', 'https://openalex.org/W2735449222', 'https://openalex.org/W2738136165', 'https://openalex.org/W2758562604', 'https://openalex.org/W2769426045', 'https://openalex.org/W2772038399', 'https://openalex.org/W2775987701', 'https://openalex.org/W2783667606', 'https://openalex.org/W2792407191', 'https://openalex.org/W2795441313', 'https://openalex.org/W2797542577', 'https://openalex.org/W2800852522', 'https://openalex.org/W2801312275', 'https://openalex.org/W2883560622', 'https://openalex.org/W2889721546', 'https://openalex.org/W2891405227', 'https://openalex.org/W2901978078', 'https://openalex.org/W2903568753', 'https://openalex.org/W2903689260', 'https://openalex.org/W2909020461', 'https://openalex.org/W2915000951', 'https://openalex.org/W2938150871', 'https://openalex.org/W2942952616', 'https://openalex.org/W2946535916', 'https://openalex.org/W2951583018', 'https://openalex.org/W2952728370', 'https://openalex.org/W2970104034', 'https://openalex.org/W2973350525', 'https://openalex.org/W2985155561', 'https://openalex.org/W3001572379', 'https://openalex.org/W3002685488', 'https://openalex.org/W3005053607', 'https://openalex.org/W3005469082', 'https://openalex.org/W3007291850', 'https://openalex.org/W3007511407', 'https://openalex.org/W3008416036', 'https://openalex.org/W3009570993', 'https://openalex.org/W3013282349', 'https://openalex.org/W3015646919', 'https://openalex.org/W3024000125', 'https://openalex.org/W3082714866', 'https://openalex.org/W3090251225', 'https://openalex.org/W3095135394', 'https://openalex.org/W3100513934', 'https://openalex.org/W3116548071', 'https://openalex.org/W3119400275', 'https://openalex.org/W3135937103', 'https://openalex.org/W3142571537', 'https://openalex.org/W3159180476', 'https://openalex.org/W3175892313', 'https://openalex.org/W3187516960', 'https://openalex.org/W3191628783', 'https://openalex.org/W3194457051', 'https://openalex.org/W3196345350', 'https://openalex.org/W3198548668', 'https://openalex.org/W3204399561', 'https://openalex.org/W4200324152', 'https://openalex.org/W4200420202', 'https://openalex.org/W4200550764', 'https://openalex.org/W4210516674', 'https://openalex.org/W4225285147', 'https://openalex.org/W4225369470', 'https://openalex.org/W4225418839', 'https://openalex.org/W4228996933', 'https://openalex.org/W4229335331', 'https://openalex.org/W4229450252', 'https://openalex.org/W4282826843', 'https://openalex.org/W4283391086', 'https://openalex.org/W4283781869', 'https://openalex.org/W4296569450', 'https://openalex.org/W4299541734', 'https://openalex.org/W4304688766', 'https://openalex.org/W4307658070', 'https://openalex.org/W4309013615', 'https://openalex.org/W4318166181', 'https://openalex.org/W4318318144', 'https://openalex.org/W4323926272', 'https://openalex.org/W4364353313', 'https://openalex.org/W4366083617', 'https://openalex.org/W4366267486', 'https://openalex.org/W4379768361', 'https://openalex.org/W4380792117', 'https://openalex.org/W4383313684'], 'related_works': ['https://openalex.org/W4386818473', 'https://openalex.org/W2903689260', 'https://openalex.org/W2902851710', 'https://openalex.org/W2427881106', 'https://openalex.org/W2171385762', 'https://openalex.org/W2152859477', 'https://openalex.org/W2129319315', 'https://openalex.org/W2084475506', 'https://openalex.org/W2006620593', 'https://openalex.org/W1751854865'], 'abstract_inverted_index': {'Abstract': [0], 'Aneuploidy': [1, 29], 'is': [2, 56, 90, 163, 200], 'defined': [3], 'as': [4, 237], 'the': [5, 20, 76, 99, 144, 154, 209, 212], 'cellular': [6], 'state': [7], 'of': [8, 12, 19, 25, 45, 71, 78, 84, 101, 121, 139, 153, 211, 217], 'having': [9], 'a': [10, 17, 26, 34, 68, 119, 137, 182, 201, 238], 'number': [11, 24], 'chromosomes': [13], 'that': [14], 'deviates': [15], 'from': [16], 'multiple': [18], 'normal': [21], 'haploid': [22], 'chromosome': [23, 46], 'given': [27], 'organism.': [28], 'can': [30], 'be': [31], 'present': [32, 58], 'in': [33, 48, 59, 116, 129, 169, 194, 225], 'static': [35], 'state:': [36], 'Down': [37], 'syndrome': [38], 'individuals': [39], 'stably': [40], 'maintain': [41], 'an': [42], 'extra': [43], 'copy': [44], '21': [47], 'their': [49, 187, 191, 235], 'cells.': [50], 'In': [51], 'cancer': [52, 102, 132, 170, 245], 'cells,': [53], 'however,': [54], 'aneuploidy': [55], 'usually': [57], 'combination': [60], 'with': [61, 86, 113], 'chromosomal': [62, 73, 88], 'instability': [63], '(CIN)': [64], 'which': [65], 'leads': [66], 'to': [67, 131, 146, 165, 185, 207, 222, 231], 'continual': [69], 'generation': [70], 'new': [72], 'alterations': [74, 89], 'and': [75, 106, 118, 156, 161, 177, 197, 214, 220, 227, 233], 'development': [77], 'intratumour': [79], 'heterogeneity': [80], '(ITH).': [81], 'The': [82], 'prevalence': [83], 'cells': [85], 'specific': [87], 'further': [91], 'shaped': [92], 'by': [93, 135], 'evolutionary': [94], 'selection,': [95], 'for': [96], 'example,': [97], 'during': [98], 'administration': [100], 'therapies.': [103], 'Aneuploidy,': [104], 'CIN': [105, 160, 219], 'ITH': [107, 162, 221], 'have': [108], 'each': [109], 'been': [110], 'individually': [111], 'associated': [112], 'poor': [114], 'prognosis': [115], 'cancer,': [117, 226], 'wealth': [120], 'evidence': [122], 'suggests': [123], 'they': [124], 'contribute,': [125], 'either': [126], 'alone': [127], 'or': [128, 143], 'combination,': [130], 'therapy': [133, 167, 223], 'resistance': [134, 168, 224], 'providing': [136], 'reservoir': [138], 'potential': [140], 'resistant': [141], 'states,': [142], 'ability': [145], 'rapidly': [147], 'evolve': [148], 'resistance.': [149], 'A': [150], 'full': [151], 'understanding': [152], 'contribution': [155, 210], 'interplay': [157], 'between': [158], 'aneuploidy,': [159, 218], 'required': [164], 'tackle': [166], 'patients.': [171], 'However,': [172], 'these': [173, 242], 'characteristics': [174], 'often': [175], 'co-occur': [176], 'are': [178], 'intrinsically': [179], 'linked,': [180], 'presenting': [181], 'major': [183], 'challenge': [184], 'defining': [186], 'individual': [188, 213], 'contributions.': [189], 'Moreover,': [190], 'accurate': [192], 'measurement': [193], 'both': [195], 'experimental': [196], 'clinical': [198], 'settings': [199], 'technical': [202], 'hurdle.': [203], 'Here,': [204], 'we': [205], 'attempt': [206], 'deconstruct': [208], 'combined': [215], 'roles': [216, 236], 'outline': [228], 'emerging': [229], 'approaches': [230], 'measure': [232], 'disentangle': [234], 'step': [239], 'towards': [240], 'integrating': [241], 'principles': [243], 'into': [244], 'therapeutic': [246], 'strategy.': [247]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4386818473', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}], 'updated_date': '2024-12-14T04:07:10.250338', 'created_date': '2023-09-19'}